Plop.pm6

use v6.d;

class A {
    multi method put-address(Int $addr, Blob $data, :$space = 'SNES') {
        say "int-blob";
    }

    multi method put-address(**@args, :$space = 'SNES') {
        my @params;
        my @datas;
        for @args -> $arg {
            say $arg.raku, $arg.WHAT.raku;
            say "I am a list" if $arg ~~ List;
            @params.push(($arg[0].base(16), $arg[1].base(16))) if $arg ~~ List;
            @datas.push($arg) if $arg ~~ Blob;
        }
        say @params.raku, @datas.raku;
        return;
    }
}

A.new.put-address((0xF50050, 4), (0xF50054, 2), Buf.new(<1 2 3 4>), Buf.new(<5 6>));

__END__
$ raku x.raku 
$(16056400, 4)List
I am a list
$(16056404, 2)List
I am a list
Buf.new(1,2,3,4)Buf
Buf.new(5,6)Buf
[("F50050", "4"), ("F50054", "2")][Buf.new(1,2,3,4), Buf.new(5,6)]