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    <span class="box-label">Box 1</span>
    Resources to support smoking cessation
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    <span class="table-label">Table 1</span> Efficacy of daclatasvir and sofosbuvir in hepatitis C
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    <colgroup><col width="13.93%">
      <col width="11.24%">
      <col width="31.79%">
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        <th rowspan="2" scope="col"><strong>Study</strong></th>
        <th rowspan="2" scope="col"><strong>Viral genotype</strong></th>
        <th rowspan="2" scope="col"><strong>Treatment regimen</strong></th>
        <th colspan="2" scope="colgroup"><strong>Sustained virological response<sup>‡</sup></strong></th>
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        <th colspan="1" scope="colgroup"><strong>Treatment-naïve patients</strong></th>
        <th scope="col"><strong>Treatment-experienced patients</strong></th>
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        <td rowspan="4" scope="row">Sulkowski<a class="xref" href="#r2" data-ref-type="bibr"><sup>2</sup></a>
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        <td rowspan="2">1</td>
        <td>daclatasvir + sofosbuvir<sup><sup>§</sup></sup>
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        <td>100% (70/70)</td>
        <td>100% (21/21)</td>
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        <td colspan="1">daclatasvir + sofosbuvir + ribavirin<sup><sup>§</sup></sup>
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        <td>98% (55/56)</td>
        <td>100% (20/20)</td>
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        <td rowspan="2" colspan="1">2 or 3</td>
        <td>daclatasvir + sofosbuvir<sup><sup>§</sup></sup>
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        <td>93% (28/30)</td>
        <td>-</td>
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        <td colspan="1" scope="row">daclatasvir + sofosbuvir + ribavirin<sup><sup>§</sup></sup>
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        <td>93% (13/14)</td>
        <td>-</td>
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        <td rowspan="2" scope="row">Nelson<a class="xref" href="#r3" data-ref-type="bibr"><sup>3</sup></a>
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        <td rowspan="2">3</td>
        <td rowspan="2">daclatasvir + sofosbuvir<sup><sup>#</sup></sup>
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        <td>Overall<br><br>90% (91/101)</td>
        <td>Overall<br><br>86% (44/51)</td>
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        <td colspan="1" scope="row">Patients with cirrhosis<br><br>58% (11/19)</td>
        <td>Patients with cirrhosis<br><br>69% (9/13)</td>
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    <p><sup>‡</sup> Defined as proportion of patients with viral RNA less than the lower limit of quantification in serum, measured 12 weeks after the end of treatment.</p>
    <p><sup><sup>§</sup></sup> Treatment given for 12 or 24 weeks in treatment-naïve patients and for 24 weeks in treatment-experienced patients.</p>
    <p><sup><sup>#</sup></sup> Treatment given for 12 weeks.</p>
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