Fish shell has `fish_add_path` to add directories to PATH. But doesn't have a remove function, so here it is.

fish_remove_path.fish

# Source: superuser.com/questions/776008
function fish_remove_path --description "Remove paths from the PATH"
    if set -l index (contains -i $argv[1] $PATH)
        set --erase --universal fish_user_paths[$index]
        echo "Updated PATH: $PATH"
    else
        echo "$argv[1] not found in PATH: $PATH"
    end
end