cancer abbreviations and terms

abbreviations_keyterms.md

A

B

BAM: Binary Alignment Map; a type of Bioinformatics analysis file.

C

chromoanagenesis: events that generate complex structural chromosomal abnormalities, which can include chromoplexy and chromothripsis

• link: https://www.ncbi.nlm.nih.gov/pubmed/31038674

chromoplexy: complex restructuring or ‘weaving’ of a tumor’s genome

• link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854035/

chromothripsis: when a chromosome is fragmented into numerous pieces, then stitched back together via DNA repair, usually NHEJ

• link: https://www.cell.com/current-biology/comments/S0960-9822(15)00202-X

D

DNA: Deoxy Ribonucleic Acid

E

F

G

H

I

J

K

kataegis: hypermutation in localized genomic regions

• link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972030/

L

M

MM1,MM2,...,MM10: Malignant Mesothelioma cell line 1 (2,3,...,etc); cell line identifier for malignant mesothelioma cell line. See Relan et al 2013 for more information.

N

NHEJ: Non-Homologous End Joining DNA repair pathway

O

P

PCR: Polymerase Chain Reaction

Q

R

RNA: RiboNucleic Acid

S

SAM: Sequence Alignment Map; a type of Bioinformatics analysis file.

SNV: Single Nucleotide Variant

SNP: Single Nucleotide Polymorphism

subclonal event: within the context of a tumor cell population, a subclonal event occurs when a subgroup of daughter cells exhibits distinct mutational differences from the original or other cells

• link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811390/

SV: Structural Variation

T

U

V

VAF: Variant Allele Frequency

W

X

Y

Z