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dkoslicki/response.json

Last active May 17, 2022 20:11
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Creative DTD answer
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response.json
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{
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{
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{
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"value": "Homogentisic acid, also known as melanic acid, is an intermediate in the breakdown or catabolism of tyrosine and phenylalanine. It is generated from the compound p-hydroxyphenylpyruvate through the enzyme p-hydroxyphenylpyruvate dehydrogenase. The resulting homogentisic acid is then broken down into 4-maleylacetoacetate via the enzyme homogentisate 1,2-dioxygenase. Homogentisic acid is also found in other organisms. For instance, it can found in Arbutus unedo (strawberry-tree) honey, in the bacterial plant pathogen Xanthomonas campestris as well as in the yeast Yarrowia lipolytica where it is associated with the production of brown pigments. Homogentisic acid can be oxidatively dimerized to form hipposudoric acid, one of the main constituents of the 'blood sweat' of hippopotamuses. When present in sufficiently high levels, homogentisic acid can function as an osteotoxin and a renal toxin. An osteotoxin is a substance that causes damage to bones and/or joints. A renal toxin causes damage to the kidneys. Chronically high levels of homogentisic acid are associated with alkaptonuria (OMIM: 203500), an inborn error of metabolism. Alkaptonuria is a rare inherited genetic disorder in which the body cannot process the amino acids phenylalanine and tyrosine. It is caused by a mutation in the enzyme homogentisate 1,2-dioxygenase (EC 1.13.11.5), which leads to an accumulation of homogentisic acid in the blood and tissues. Homogentisic acid and its oxidized form benzoquinone acetic acid are excreted in the urine, giving it an unusually dark color. The accumulating homogentisic acid (and benzoquinone acetic acid) causes damage to cartilage (ochronosis, leading to osteoarthritis) and heart valves as well as precipitating as kidney stones and stones in other organs. More specifically, homogentisic acid can be converted to benzoquinone acetic acid (BQA), and the resulting BQA can be readily converted to polymers that resemble the dark skin pigment melanin. These polymers are deposited in the collagen, a connective tissue protein, of particular tissues such as cartilage. This process is called ochronosis (as the tissue looks ochre); ochronotic tissue is stiffened and unusually brittle, impairing its normal function and causing damage. Homogentisic acid is the primary precursor of melanin synthesis in Vibrio cholerae.",
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"value": "-!- CATALYTIC ACTIVITY: Reaction=homogentisate + O2 = 4-maleylacetoacetate + H(+); Xref=Rhea:RHEA:15449, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16169, ChEBI:CHEBI:17105; EC=1.13.11.5; -!- COFACTOR: Name=Fe cation; Xref=ChEBI:CHEBI:24875; -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. -!- SUBUNIT: Homohexamer arranged as a dimer of trimers. {ECO:0000269|PubMed:10876237}. -!- INTERACTION: Q93099; Q93099: HGD; NbExp=4; IntAct=EBI-3907760, EBI-3907760; Q93099; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-3907760, EBI-741158; Q93099; P54274: TERF1; NbExp=2; IntAct=EBI-3907760, EBI-710997; -!- TISSUE SPECIFICITY: Highest expression in the prostate, small intestine, colon, kidney and liver. -!- DISEASE: Alkaptonuria (AKU) [MIM:203500]: An autosomal recessive error of metabolism characterized by an increase in the level of homogentisic acid. The clinical manifestations are urine that turns dark on standing and alkalinization, black ochronotic pigmentation of cartilage and collagenous tissues, and spine arthritis. {ECO:0000269|PubMed:10205262, ECO:0000269|PubMed:10340975, ECO:0000269|PubMed:10482952, ECO:0000269|PubMed:10594001, ECO:0000269|PubMed:19862842, ECO:0000269|PubMed:21437689, ECO:0000269|PubMed:23353776, ECO:0000269|PubMed:23430897, ECO:0000269|PubMed:25681086, ECO:0000269|PubMed:8782815, ECO:0000269|PubMed:9154114, ECO:0000269|PubMed:9529363, ECO:0000269|PubMed:9630082}. Note=The disease is caused by variants affecting the gene represented in this entry. -!- SIMILARITY: Belongs to the homogentisate dioxygenase family. {ECO:0000305}. Evidence Codes from Name: ",
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"value": [
"PMID:15166677",
"PMID:2845082",
"PMID:8254623",
"PMID:191614",
"PMID:8884658",
"PMID:10454528",
"PMID:21129985",
"PMID:22626821",
"PMID:16799554",
"PMID:7154001"
],
"value_type_id": "biolink:Uriorcurie",
"attribute_source": null,
"value_url": null,
"description": null,
"attributes": null
}
]
},
"UniProtKB:P00439": {
"name": "PAH",
"categories": [
"biolink:Gene",
"biolink:Protein"
],
"attributes": [
{
"attribute_type_id": "biolink:IriType",
"original_attribute_name": null,
"value": "https://identifiers.org/uniprot:P00439",
"value_type_id": "metatype:Uri",
"attribute_source": null,
"value_url": "https://identifiers.org/uniprot:P00439",
"description": null,
"attributes": null
},
{
"attribute_type_id": "biolink:description",
"original_attribute_name": null,
"value": "A phenylalanine-4-hydroxylase that is encoded in the genome of Dictyostelium discoideum. // COMMENTS: Category=organism-gene.",
"value_type_id": "metatype:String",
"attribute_source": null,
"value_url": null,
"description": null,
"attributes": null
},
{
"attribute_type_id": "biolink:category",
"original_attribute_name": null,
"value": [
"biolink:BiologicalEntity",
"biolink:Gene",
"biolink:Protein"
],
"value_type_id": "metatype:Uriorcurie",
"attribute_source": null,
"value_url": null,
"description": "Categories of all nodes in this synonym set in RTX-KG2.",
"attributes": null
},
{
"attribute_type_id": "biolink:synonym",
"original_attribute_name": null,
"value": [
"phenylalanine-4-hydroxylase (Dictyostelium discoideum)",
"PAH gene",
"PAH",
"phenylalanine-4-hydroxylase (human)",
"Pah (rat)",
"PAH S40L [cytosol]",
"PAH (human)",
"PAH [cytosol]",
"Pah (mouse)",
"phenylalanine-4-hydroxylase (mouse)"
],
"value_type_id": "metatype:String",
"attribute_source": null,
"value_url": null,
"description": "Names of all nodes in this synonym set in RTX-KG2.",
"attributes": null
},
{
"attribute_type_id": "biolink:xref",
"original_attribute_name": null,
"value": [
"PR:P00439",
"UMLS:C1418251",
"REACT:R-HSA-71066",
"OMIM:612349",
"RGD:3248",
"PR:Q54XS1",
"REACT:R-HSA-5649486",
"LOINC:LP63593-5",
"HGNC:8582",
"MGI:97473",
"ENSEMBL:ENSG00000171759",
"UniProtKB:P00439",
"PR:P16331",
"NCBIGene:5053"
],
"value_type_id": "metatype:Nodeidentifier",
"attribute_source": null,
"value_url": null,
"description": "Identifiers of all nodes in this synonym set in RTX-KG2.",
"attributes": null
},
{
"attribute_type_id": "biolink:publications",
"original_attribute_name": null,
"value": [
"DOI:10.1002/(sici)1098-1004(1998)12:5<314::aid-humu4>3.0.co",
"DOI:10.1016/j.ajhg.2008.05.013",
"PMID:8364546",
"PMID:9450897",
"DOI:10.1056/nejmoa021654",
"PMID:2840952",
"PMID:10679941",
"DOI:10.1007/bf00197152",
"PMID:10694386",
"PMID:1679029"
],
"value_type_id": "biolink:Uriorcurie",
"attribute_source": null,
"value_url": null,
"description": null,
"attributes": null
}
]
},
"UniProtKB:P04637": {
"name": "TP53",
"categories": [
"biolink:Gene",
"biolink:Protein"
],
"attributes": [
{
"attribute_type_id": "biolink:IriType",
"original_attribute_name": null,
"value": "https://identifiers.org/uniprot:P04637",
"value_type_id": "metatype:Uri",
"attribute_source": null,
"value_url": "https://identifiers.org/uniprot:P04637",
"description": null,
"attributes": null
},
{
"attribute_type_id": "biolink:description",
"original_attribute_name": null,
"value": "Cellular tumor antigen p53 (393 aa, ~44 kDa) is encoded by the human TP53 gene. This protein plays a role in the regulation of both the cell cycle and apoptosis.; UMLS Semantic Type: STY:T123; UMLS Semantic Type: STY:T116",
"value_type_id": "metatype:String",
"attribute_source": null,
"value_url": null,
"description": null,
"attributes": null
},
{
"attribute_type_id": "biolink:category",
"original_attribute_name": null,
"value": [
"biolink:BiologicalEntity",
"biolink:Gene",
"biolink:Protein",
"biolink:NamedThing"
],
"value_type_id": "metatype:Uriorcurie",
"attribute_source": null,
"value_url": null,
"description": "Categories of all nodes in this synonym set in RTX-KG2.",
"attributes": null
},
{
"attribute_type_id": "biolink:synonym",
"original_attribute_name": null,
"value": [
"TP53 D281Efs*26 [nucleoplasm]",
"TP53 P92Afs*57 [nucleoplasm]",
"TP53 R290Kfs*53 [nucleoplasm]",
"TP53 K319Rfs*26 [nucleoplasm]",
"TP53 L93Cfs*30 [nucleoplasm]",
"TP53 L43Cfs*9 [nucleoplasm]",
"TP53 H115Ffs*33 [nucleoplasm]",
"TP53 L264Sfs*8 [nucleoplasm]",
"TP53 L145Afs*4 [nucleoplasm]",
"p-T55-TP53 [nucleoplasm]",
"TP53 H214Rfs*25 [nucleoplasm]",
"TP53 L252Pfs*92 [nucleoplasm]",
"TP53 T231Ffs*15 [nucleoplasm]",
"TP53 D207Mfs*40 [nucleoplasm]",
"TP53 R283Pfs*24 [nucleoplasm]",
"TP53 V73Rfs*51 [nucleoplasm]",
"TP53 E51Dfs*72 [nucleoplasm]",
"TP53 V272Gfs*73 [nucleoplasm]",
"TP53 W53Yfs*2 [nucleoplasm]",
"TP53 E68* [nucleoplasm]",
"TP53 G244Afs*3 [nucleoplasm]",
"TP53 Q52Pfs*5 [nucleoplasm]",
"TP53 L111Qfs*13 [nucleoplasm]",
"TP53 C135Sfs*35 [nucleoplasm]",
"TP53 V274Afs*33 [nucleoplasm]",
"TP53 N210Kfs*6 [nucleoplasm]",
"TP53 T150Afs*16 [nucleoplasm]",
"TP53 S33Pfs*11 [nucleoplasm]",
"TP53 L299Afs*6 [nucleoplasm]",
"TP53 N239Wfs*4 [nucleoplasm]",
"TP53 A276Lfs*29 [nucleoplasm]",
"TP53 I232Sfs*15 [nucleoplasm]",
"TP53 D208Efs*38 [nucleoplasm]",
"TP53 L188Tfs*21 [nucleoplasm]",
"TP53 Y205Ifs*42 [nucleoplasm]",
"TP53 K139* [nucleoplasm]",
"TP53 G334V [nucleoplasm]",
"TP53 Q167Afs*13 [nucleoplasm]",
"TP53 A74Sfs*71 [nucleoplasm]",
"TP53 C242Afs*5 [nucleoplasm]",
"TP53 H115Afs*34 [nucleoplasm]",
"TP53 C124Lfs*25 [nucleoplasm]",
"TP53 H168Rfs*4 [nucleoplasm]",
"TP53 T155Hfs*26 [nucleoplasm]",
"TP53 P152Lfs*29 [nucleoplasm]",
"TP53 P190Lfs*53 [nucleoplasm]",
"TP53 E56Rfs*6 [nucleoplasm]",
"TP53 R249Sfs*96 [nucleoplasm]",
"TP53 R110Qfs*15 [nucleoplasm]",
"TP53 S95Ffs*53 [nucleoplasm]",
"TP53 E224Gfs*4 [nucleoplasm]",
"TP53 H296Tfs*49 [nucleoplasm]",
"TP53 K292Rfs*13 [nucleoplasm]",
"TP53 G244Rfs*19 [nucleoplasm]",
"TP53 T256Hfs*89 [nucleoplasm]",
"TP53 Y163Qfs*17 [nucleoplasm]",
"TP53 N288Kfs*15 [nucleoplasm]",
"TP53 S260Pfs*85 [nucleoplasm]",
"TP53 M133Ifs*36 [nucleoplasm]",
"TP53 P152Afs*28 [nucleoplasm]",
"TP53 F270Lfs*72 [nucleoplasm]",
"TP53 G325* [nucleoplasm]",
"TP53 H233Vfs*8 [nucleoplasm]",
"TP53 R174Mfs*68 [nucleoplasm]",
"TP53 T170Lfs*2 [nucleoplasm]",
"TP53 C242Hfs*18 [nucleoplasm]",
"TP53 Q317Pfs*20 [nucleoplasm]",
"TP53 G244Efs*17 [nucleoplasm]",
"TP53 P60Vfs*64 [nucleoplasm]",
"TP53 Q144Ffs*32 [nucleoplasm]",
"TP53 E298Cfs*46 [nucleoplasm]",
"TP53 P27Lfs*17 [nucleoplasm]",
"TP53 A86Pfs*34 [nucleoplasm]",
"TP53 S20Qfs*24 [nucleoplasm]",
"TP53 R280Efs*26 [nucleoplasm]",
"TP53 E51Pfs*59 [nucleoplasm]",
"TP53 Q52* [nucleoplasm]",
"TP53 S185Afs*62 [nucleoplasm]",
"TP53 M66Nfs*83 [nucleoplasm]",
"TP53 S315* [nucleoplasm]",
"TP53 G187Vfs*60 [nucleoplasm]",
"TP53 R249Kfs*15 [nucleoplasm]",
"TP53 V122Afs*46 [nucleoplasm]",
"TP53 G226Dfs*3 [nucleoplasm]",
"TP53 I254Hfs*8 [nucleoplasm]",
"TP53 L111Ifs*8 [nucleoplasm]",
"TP53 C238* [nucleoplasm]",
"TP53 E221* [nucleoplasm]",
"TP53 G266* [nucleoplasm]",
"TP53 R342P [nucleoplasm]",
"TP53 V225Ffs*23 [nucleoplasm]",
"TP53 I195Mfs*13 [nucleoplasm]",
"TP53 P152Rfs*24 [nucleoplasm]",
"TP53 R181Lfs*4 [nucleoplasm]",
"TP53 R306Efs*39 [nucleoplasm]",
"TP53 N210Hfs*5 [nucleoplasm]",
"TP53 Y103Tfs*20 [nucleoplasm]",
"TP53 Q167Nfs*4 [nucleoplasm]",
"TP53 L323Wfs*22 [nucleoplasm]",
"TP53 Q136Wfs*33 [nucleoplasm]",
"TP53 R209Kfs*38 [nucleoplasm]",
"TP53 A307Lfs*32 [nucleoplasm]",
"TP53 T125Sfs*45 [nucleoplasm]",
"TP53 S121Ifs*28 [nucleoplasm]",
"TP53 S183Tfs*65 [nucleoplasm]",
"TP53 A138Pfs*30 [nucleoplasm]",
"TP53 P98Lfs*25 [nucleoplasm]",
"TP53 W146Lfs*23 [nucleoplasm]",
"TP53 D259Qfs*3 [nucleoplasm]",
"TP53 A63Tfs*66 [nucleoplasm]",
"TP53 P278Lfs*67 [nucleoplasm]",
"TP53 Q38Sfs*4 [nucleoplasm]",
"TP53 A138Pfs*32 [nucleoplasm]",
"TP53 E294Vfs*12 [nucleoplasm]",
"TP53 K292Lfs*54 [nucleoplasm]",
"TP53 P87Lfs*59 [nucleoplasm]",
"TP53 S215Ifs*33 [nucleoplasm]",
"TP53 R209Hfs*5 [nucleoplasm]",
"TP53 S313Afs*32 [nucleoplasm]",
"TP53 D207Lfs*41 [nucleoplasm]",
"TP53 A161Tfs*7 [nucleoplasm]",
"TP53 L35Ffs*7 [nucleoplasm]",
"TP53 G154Rfs*27 [nucleoplasm]",
"TP53 (human)",
"TP53 P177Tfs*69 [nucleoplasm]",
"TP53 Q144Cfs*25 [nucleoplasm]",
"TP53 S121Cfs*27 [nucleoplasm]",
"TP53 R175Afs*6 [nucleoplasm]",
"TP53 L130Dfs*16 [nucleoplasm]",
"TP53 H178Pfs*70 [nucleoplasm]",
"TP53 S313Lfs*45 [nucleoplasm]",
"TP53 P295Lfs*50 [nucleoplasm]",
"TP53 M133Pfs*13 [nucleoplasm]",
"TP53 R249Tfs*14 [nucleoplasm]",
"TP53 H179Lfs*68 [nucleoplasm]",
"TP53 R158Afs*12 [nucleoplasm]",
"TP53 R290Qfs*15 [nucleoplasm]",
"TP53 A70Rfs*76 [nucleoplasm]",
"TP53 Y234Lfs*4 [nucleoplasm]",
"TP53 L206Wfs*41 [nucleoplasm]",
"TP53 V218Sfs*26 [nucleoplasm]",
"TP53 S127Ffs*36 [nucleoplasm]",
"TP53 D324Afs*29 [nucleoplasm]",
"TP53 I195Nfs*14 [nucleoplasm]",
"TP53 W53Mfs*4 [nucleoplasm]",
"TP53 I255Sfs*90 [nucleoplasm]",
"TP53 G112Lfs*7 [nucleoplasm]",
"TP53 G154Afs*16 [nucleoplasm]",
"TP53 K120Qfs*29 [nucleoplasm]",
"TP53 P191Lfs*53 [nucleoplasm]",
"TP53 P85Hfs*37 [nucleoplasm]",
"TP53 C238Vfs*9 [nucleoplasm]",
"TP53 E68Rfs*81 [nucleoplasm]",
"TP53 D186Mfs*61 [nucleoplasm]",
"TP53 T304Yfs*2 [nucleoplasm]",
"TP53 C124Afs*46 [nucleoplasm]",
"TP53 E294Afs*11 [nucleoplasm]",
"TP53 P278Sfs*28 [nucleoplasm]",
"TP53 A129Pfs*41 [nucleoplasm]",
"TP53 V73Lfs*43 [nucleoplasm]",
"TP53 T155Pfs*25 [nucleoplasm]",
"TP53 P142Gfs*24 [nucleoplasm]",
"TP53 M133Ifs*12 [nucleoplasm]",
"TP53 S33* [nucleoplasm]",
"TP53 P80Rfs*41 [nucleoplasm]",
"TP53 gene",
"TP53 E204Wfs*44 [nucleoplasm]",
"TP53 L348S [nucleoplasm]",
"TP53 E294Gfs*12 [nucleoplasm]",
"TP53 N263Tfs*7 [nucleoplasm]",
"TP53 R209* [nucleoplasm]",
"TP53 S106Rfs*16 [nucleoplasm]",
"TP53 P75Lfs*74 [nucleoplasm]",
"TP53 L130Tfs*39 [nucleoplasm]",
"TP53 C229Yfs*10 [nucleoplasm]",
"TP53 Y163Tfs*14 [nucleoplasm]",
"TP53 L188Pfs*19 [nucleoplasm]",
"TP53 N247Tfs*98 [nucleoplasm]",
"TP53 C141Afs*29 [nucleoplasm]",
"TP53 S99Pfs*24 [nucleoplasm]",
"TP53 M237Cfs*10 [nucleoplasm]",
"TP53 D57Tfs*72 [nucleoplasm]",
"TP53 P60Qfs*63 [nucleoplasm]",
"TP53 A84Vfs*65 [nucleoplasm]",
"TP53 Y163Hfs*4 [nucleoplasm]",
"TP53 C141Wfs*8 [nucleoplasm]",
"TP53 S269Gfs*34 [nucleoplasm]",
"TP53 I162Wfs*10 [nucleoplasm]",
"TP53 C124* [nucleoplasm]",
"TP53 S95Ifs*54 [nucleoplasm]",
"TP53 R273Vfs*72 [nucleoplasm]",
"TP53 P34Lfs*8 [nucleoplasm]",
"TP53 S116Vfs*23 [nucleoplasm]",
"TP53 T155Pfs*15 [nucleoplasm]",
"TP53 T150Hfs*20 [nucleoplasm]",
"TP53 P71Sfs*78 [nucleoplasm]",
"TP53 E286* [nucleoplasm]",
"TP53 C135Yfs*9 [nucleoplasm]",
"TP53 Y103Rfs*19 [nucleoplasm]",
"TP53 N268Qfs*3 [nucleoplasm]",
"TP53 C275Lfs*70 [nucleoplasm]",
"TP53 C229* [nucleoplasm]",
"TP53 P75Lfs*48 [nucleoplasm]",
"TP53 D228* [nucleoplasm]",
"TP53 E286Sfs*17 [nucleoplasm]",
"TP53 L93Pfs*59 [nucleoplasm]",
"TP53 D208Efs*7 [nucleoplasm]",
"TP53 A86Vfs*55 [nucleoplasm]",
"TP53 D61* [nucleoplasm]",
"TP53 H214Ifs*33 [nucleoplasm]",
"TP53 C242Gfs*20 [nucleoplasm]",
"TP53 K120Mfs*25 [nucleoplasm]",
"TP53 N288Afs*55 [nucleoplasm]",
"TP53 D57Sfs*86 [nucleoplasm]",
"TP53 D207Ffs*3 [nucleoplasm]",
"TP53 M44Tfs*75 [nucleoplasm]",
"TP53 M246Ifs*92 [nucleoplasm]",
"TP53 A347T [nucleoplasm]",
"TP53 A88Sfs*61 [nucleoplasm]",
"TP53 N311Kfs*34 [nucleoplasm]",
"TP53 E204Tfs*39 [nucleoplasm]",
"TP53 E286Hfs*22 [nucleoplasm]",
"TP53 D207Efs*6 [nucleoplasm]",
"TP53 R209Lfs*36 [nucleoplasm]",
"TP53 P300Qfs*44 [nucleoplasm]",
"TP53 S94Pfs*24 [nucleoplasm]",
"TP53 Q144Hfs*4 [nucleoplasm]",
"TP53 L265Pfs*5 [nucleoplasm]",
"TP53 S261Tfs*2 [nucleoplasm]",
"TP53 P36Afs*7 [nucleoplasm]",
"TP53 N288Sfs*17 [nucleoplasm]",
"TP53 P191Sfs*15 [nucleoplasm]",
"TP53 T81Nfs*68 [nucleoplasm]",
"TP53 M237* [nucleoplasm]",
"TP53 H233Pfs*6 [nucleoplasm]",
"TP53 L206* [nucleoplasm]",
"TP53 D259Rfs*5 [nucleoplasm]",
"TP53 R283Afs*62 [nucleoplasm]",
"TP53 T230Pfs*17 [nucleoplasm]",
"TP53 R213* [nucleoplasm]",
"TP53 P82Afs*70 [nucleoplasm]",
"TP53 S314Lfs*22 [nucleoplasm]",
"p-S15,S20,S269,T284-TP53 [nucleoplasm]",
"TP53 Q167* [nucleoplasm]",
"TP53 C277* [nucleoplasm]",
"TP53 gene [nucleoplasm]",
"TP53 Y163* [nucleoplasm]",
"TP53 L257Vfs*84 [nucleoplasm]",
"TP53 Q144Pfs*5 [nucleoplasm]",
"TP53 E221Gfs*26 [nucleoplasm]",
"TP53 L330H [nucleoplasm]",
"TP53 Y103Lfs*46 [nucleoplasm]",
"TP53 N29Kfs*13 [nucleoplasm]",
"TP53 A83Rfs*40 [nucleoplasm]",
"TP53 R283Sfs*23 [nucleoplasm]",
"TP53 Q144Afs*4 [nucleoplasm]",
"TP53 F134Lfs*14 [nucleoplasm]",
"TP53 D48* [nucleoplasm]",
"TP53 Q38* [nucleoplasm]",
"TP53 E271Gfs*74 [nucleoplasm]",
"TP53 P82Rfs*41 [nucleoplasm]",
"TP53 G302Hfs*2 [nucleoplasm]",
"TP53 N310Qfs*27 [nucleoplasm]",
"TP53 D184Efs*64 [nucleoplasm]",
"TP53 H179Mfs*68 [nucleoplasm]",
"TP53 R110Pfs*39 [nucleoplasm]",
"TP53 P87Ifs*54 [nucleoplasm]",
"TP53 E180Afs*65 [nucleoplasm]",
"TP53 P190Sfs*12 [nucleoplasm]",
"TP53 N288Qfs*15 [nucleoplasm]",
"TP53 K139Nfs*9 [nucleoplasm]",
"TP53 S185Rfs*23 [nucleoplasm]",
"TP53 E271* [nucleoplasm]",
"TP53 T118Qfs*5 [nucleoplasm]",
"TP53 D324Rfs*13 [nucleoplasm]",
"TP53 N268Tfs*77 [nucleoplasm]",
"TP53 F109Sfs*14 [nucleoplasm]",
"TP53 A83Gfs*66 [nucleoplasm]",
"TP53 Q192Afs*16 [nucleoplasm]",
"TP53 Q52Hfs*71 [nucleoplasm]",
"TP53 R283Lfs*23 [nucleoplasm]",
"TP53 C277Vfs*68 [nucleoplasm]",
"TP53 Q165Hfs*5 [nucleoplasm]",
"p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]",
"TP53 L308Afs*6 [nucleoplasm]",
"TP53 V157Rfs*24 [nucleoplasm]",
"TP53 E51Gfs*6 [nucleoplasm]",
"TP53 T211Ifs*4 [nucleoplasm]",
"TP53 W146Pfs*19 [nucleoplasm]",
"TP53 S46Vfs*6 [nucleoplasm]",
"TP53 D148Gfs*2 [nucleoplasm]",
"TP53 T140Pfs*30 [nucleoplasm]",
"TP53 G334W [nucleoplasm]",
"TP53 Y107Tfs*44 [nucleoplasm]",
"TP53 A189Gfs*20 [nucleoplasm]",
"TP53 Q104Pfs*45 [nucleoplasm]",
"TP53 T155Afs*28 [nucleoplasm]",
"TP53 T284Hfs*22 [nucleoplasm]",
"TP53 A138Rfs*31 [nucleoplasm]",
"TP53 S96Lfs*27 [nucleoplasm]",
"TP53 H179Pfs*2 [nucleoplasm]",
"TP53 E56Kfs*67 [nucleoplasm]",
"TP53 E224Afs*2 [nucleoplasm]",
"TP53 F341C [nucleoplasm]",
"TP53 C124Wfs*25 [nucleoplasm]",
"TP53 T170Sfs*8 [nucleoplasm]",
"TP53 L252Pfs*12 [nucleoplasm]",
"TP53 A69Cfs*79 [nucleoplasm]",
"TP53 D49Efs*3 [nucleoplasm]",
"TP53 T256Ifs*90 [nucleoplasm]",
"TP53 N200Kfs*9 [nucleoplasm]",
"TP53 T140Mfs*28 [nucleoplasm]",
"TP53 D48Efs*75 [nucleoplasm]",
"TP53 G154Vfs*18 [nucleoplasm]",
"TP53 N239Kfs*25 [nucleoplasm]",
"TP53 L43Afs*7 [nucleoplasm]",
"TP53 Y220Hfs*5 [nucleoplasm]",
"TP53 G108Afs*39 [nucleoplasm]",
"TP53 G199Ifs*42 [nucleoplasm]",
"TP53 S313Pfs*33 [nucleoplasm]",
"TP53 T284Rfs*19 [nucleoplasm]",
"TP53 M237Vfs*9 [nucleoplasm]",
"TP53 T118Cfs*27 [nucleoplasm]",
"TP53 G117Wfs*32 [nucleoplasm]",
"TP53 R158Sfs*23 [nucleoplasm]",
"TP53 G105Afs*18 [nucleoplasm]",
"TP53 P316Sfs*21 [nucleoplasm]",
"TP53 D207Gfs*8 [nucleoplasm]",
"TP53 Q136Hfs*34 [nucleoplasm]",
"TP53 H168Pfs*2 [nucleoplasm]",
"TP53 F113Lfs*11 [nucleoplasm]",
"p-S15,S20,S392-TP53 [nucleoplasm]",
"TP53 V157Pfs*9 [nucleoplasm]",
"TP53 Q100Sfs*54 [nucleoplasm]",
"TP53 C238Hfs*21 [nucleoplasm]",
"TP53 L26Qfs*13 [nucleoplasm]",
"TP53 P72Rfs*76 [nucleoplasm]",
"TP53 R174Kfs*24 [nucleoplasm]",
"TP53 C275Lfs*67 [nucleoplasm]",
"TP53 S95Lfs*28 [nucleoplasm]",
"TP53 N268* [nucleoplasm]",
"TP53 R290Afs*55 [nucleoplasm]",
"TP53 V97Lfs*25 [nucleoplasm]",
"TP53 R249Afs*14 [nucleoplasm]",
"TP53 S37Cfs*79 [nucleoplasm]",
"TP53 E171Mfs*61 [nucleoplasm]",
"TP53 L93Afs*57 [nucleoplasm]",
"TP53 K164* [nucleoplasm]",
"TP53 P67Rfs*81 [nucleoplasm]",
"TP53 P222Gfs*4 [nucleoplasm]",
"TP53 S269Kfs*3 [nucleoplasm]",
"TP53 E285* [nucleoplasm]",
"TP53 I251Hfs*11 [nucleoplasm]",
"TP53 P77Cfs*73 [nucleoplasm]",
"TP53 K292Nfs*7 [nucleoplasm]",
"TP53 Gene",
"TP53 Q167Hfs*4 [nucleoplasm]",
"TP53 P67Lfs*54 [nucleoplasm]",
"TP53 C277Ffs*68 [nucleoplasm]",
"TP53 S240Kfs*24 [nucleoplasm]",
"TP53 L299Afs*7 [nucleoplasm]",
"TP53 R306Afs*31 [nucleoplasm]",
"TP53 T55Mfs*68 [nucleoplasm]",
"TP53 V122Dfs*26 [nucleoplasm]",
"TP53 K164Sfs*3 [nucleoplasm]",
"TP53 P322Tfs*15 [nucleoplasm]",
"TP53 L201Ffs*8 [nucleoplasm]",
"TP53 Y107Vfs*13 [nucleoplasm]",
"TP53 R283Hfs*22 [nucleoplasm]",
"TP53 L130Sfs*40 [nucleoplasm]",
"TP53 L14Sfs*15 [nucleoplasm]",
"TP53 R267Gfs*78 [nucleoplasm]",
"TP53 G302Vfs*44 [nucleoplasm]",
"TP53 P222Sfs*26 [nucleoplasm]",
"TP53 A159Pfs*11 [nucleoplasm]",
"TP53 P322Hfs*23 [nucleoplasm]",
"TP53 G262Lfs*2 [nucleoplasm]",
"TP53 D148Efs*23 [nucleoplasm]",
"TP53 L257Wfs*88 [nucleoplasm]",
"TP53 A83Cfs*30 [nucleoplasm]",
"TP53 S106Tfs*17 [nucleoplasm]",
"TP53 C141Afs*5 [nucleoplasm]",
"TP53 V173Rfs*23 [nucleoplasm]",
"TP53 M66Sfs*57 [nucleoplasm]",
"TP53 D57Vfs*64 [nucleoplasm]",
"TP53 S106Vfs*15 [nucleoplasm]",
"TP53 E298* [nucleoplasm]",
"TP53 [nucleoplasm]",
"TP53 D228Lfs*11 [nucleoplasm]",
"TP53 E180* [nucleoplasm]",
"TP53 L206Ffs*35 [nucleoplasm]",
"TP53 Q317Sfs*28 [nucleoplasm]",
"TP53 E198* [nucleoplasm]",
"TP53 R290Lfs*50 [nucleoplasm]",
"TP53 L308Sfs*30 [nucleoplasm]",
"TP53 N131Cfs*27 [nucleoplasm]",
"TP53 G244Afs*4 [nucleoplasm]",
"TP53 R196Pfs*13 [nucleoplasm]",
"TP53 I255Hfs*8 [nucleoplasm]",
"TP53 A129Cfs*20 [nucleoplasm]",
"TP53 V97Tfs*66 [nucleoplasm]",
"TP53 A39Mfs*3 [nucleoplasm]",
"TP53 K351R [nucleoplasm]",
"TP53 R280Afs*62 [nucleoplasm]",
"TP53 H168Tfs*69 [nucleoplasm]",
"TP53 S33Vfs*6 [nucleoplasm]",
"TP53 S269Cfs*32 [nucleoplasm]",
"TP53 G244Tfs*19 [nucleoplasm]",
"TP53 P153Sfs*28 [nucleoplasm]",
"TP53 L35Cfs*9 [nucleoplasm]",
"TP53 V97Sfs*26 [nucleoplasm]",
"TP53 T211Lfs*36 [nucleoplasm]",
"TP53 L111Ffs*40 [nucleoplasm]",
"TP53 V143Lfs*28 [nucleoplasm]",
"TP53 S149Yfs*31 [nucleoplasm]",
"TP53 I195Sfs*52 [nucleoplasm]",
"TP53 L188* [nucleoplasm]",
"TP53 E204Gfs*46 [nucleoplasm]",
"TP53 R209Kfs*6 [nucleoplasm]",
"TP53 F270Vfs*72 [nucleoplasm]",
"TP53 Q100* [nucleoplasm]",
"TP53 R196Cfs*46 [nucleoplasm]",
"TP53 K120Sfs*3 [nucleoplasm]",
"TP53 N239Tfs*8 [nucleoplasm]",
"TP53 I195Yfs*14 [nucleoplasm]",
"TP53 K132Rfs*38 [nucleoplasm]",
"TP53 G245Pfs*16 [nucleoplasm]",
"TP53 A86Gfs*63 [nucleoplasm]",
"TP53 N239Lfs*22 [nucleoplasm]",
"TP53 Q192* [nucleoplasm]",
"TP53 R158Pfs*12 [nucleoplasm]",
"TP53 L344R [nucleoplasm]",
"TP53 S227Lfs*20 [nucleoplasm]",
"TP53 L114Cfs*30 [nucleoplasm]",
"TP53 A84Pfs*35 [nucleoplasm]",
"TP53 Y234Ifs*6 [nucleoplasm]",
"TP53 R213Sfs*3 [nucleoplasm]",
"TP53 L114* [nucleoplasm]",
"TP53 R202Kfs*9 [nucleoplasm]",
"TP53 P153Rfs*22 [nucleoplasm]",
"TP53 G108Vfs*13 [nucleoplasm]",
"TP53 V203Gfs*5 [nucleoplasm]",
"TP53 K320Efs*17 [nucleoplasm]",
"TP53 V157Sfs*13 [nucleoplasm]",
"TP53 L114Cfs*9 [nucleoplasm]",
"TP53 Q136Sfs*13 [nucleoplasm]",
"TP53 R156Pfs*14 [nucleoplasm]",
"TP53 P278Wfs*27 [nucleoplasm]",
"TP53 A276Lfs*31 [nucleoplasm]",
"TP53 A161Pfs*9 [nucleoplasm]",
"TP53 Y220* [nucleoplasm]",
"TP53 P77Sfs*71 [nucleoplasm]",
"TP53 I251Tfs*94 [nucleoplasm]",
"TP53 G293Efs*3 [nucleoplasm]",
"TP53 L308Afs*28 [nucleoplasm]",
"TP53 G226Pfs*17 [nucleoplasm]",
"TP53 R213Vfs*32 [nucleoplasm]",
"TP53 H214Tfs*2 [nucleoplasm]",
"TP53 C141* [nucleoplasm]",
"p-S315-TP53 [nucleoplasm]",
"TP53 V143Rfs*6 [nucleoplasm]",
"TP53 S94Ffs*28 [nucleoplasm]",
"TP53 D41Gfs*2 [nucleoplasm]",
"TP53 T284Rfs*21 [nucleoplasm]",
"TP53 R175Pfs*72 [nucleoplasm]",
"TP53 Q136Nfs*34 [nucleoplasm]",
"TP53 S260Lfs*4 [nucleoplasm]",
"TP53 S240Qfs*24 [nucleoplasm]",
"TP53 T304Qfs*44 [nucleoplasm]",
"TP53 V225Lfs*22 [nucleoplasm]",
"TP53 S315Pfs*31 [nucleoplasm]",
"TP53 I50Nfs*72 [nucleoplasm]",
"TP53 S127Lfs*42 [nucleoplasm]",
"TP53 P71Wfs*50 [nucleoplasm]",
"TP53 F341V [nucleoplasm]",
"TP53 G199Efs*48 [nucleoplasm]",
"TP53 S90Lfs*59 [nucleoplasm]",
"TP53 A86Cfs*63 [nucleoplasm]",
"TP53 N131Tfs*39 [nucleoplasm]",
"TP53 D259Afs*86 [nucleoplasm]",
"TP53 P318Efs*16 [nucleoplasm]",
"TP53 F270Lfs*2 [nucleoplasm]",
"TP53 H168Rfs*3 [nucleoplasm]",
"TP53 P36Wfs*4 [nucleoplasm]",
"TP53 R175Lfs*5 [nucleoplasm]",
"TP53 Y103Efs*23 [nucleoplasm]",
"TP53 G154Wfs*10 [nucleoplasm]",
"TP53 E68Gfs*80 [nucleoplasm]",
"TP53 S149Pfs*21 [nucleoplasm]",
"TP53 I50Mfs*73 [nucleoplasm]",
"TP53 C176Afs*65 [nucleoplasm]",
"TP53 S94Yfs*29 [nucleoplasm]",
"TP53 D228Tfs*19 [nucleoplasm]",
"TP53 Y163Lfs*18 [nucleoplasm]",
"TP53 T123Hfs*24 [nucleoplasm]",
"TP53 D208* [nucleoplasm]",
"TP53 S183* [nucleoplasm]",
"TP53 P128Tfs*21 [nucleoplasm]",
"TP53 W146Ifs*22 [nucleoplasm]",
"TP53 Q100Gfs*37 [nucleoplasm]",
"TP53 R156Lfs*25 [nucleoplasm]",
"TP53 K291* [nucleoplasm]",
"TP53 W91Vfs*13 [nucleoplasm]",
"TP53 S215Ifs*36 [nucleoplasm]",
"TP53 R65* [nucleoplasm]",
"TP53 S269Rfs*74 [nucleoplasm]",
"TP53 H168Rfs*23 [nucleoplasm]",
"TP53 Y220Mfs*27 [nucleoplasm]",
"TP53 Y126Sfs*44 [nucleoplasm]",
"TP53 P223Lfs*24 [nucleoplasm]",
"TP53 H233Lfs*6 [nucleoplasm]",
"TP53 V173Efs*7 [nucleoplasm]",
"TP53 E258* [nucleoplasm]",
"TP53 I50* [nucleoplasm]",
"TP53 V157Afs*24 [nucleoplasm]",
"TP53 P142Afs*7 [nucleoplasm]",
"TP53 L264Yfs*81 [nucleoplasm]",
"TP53 P222Rfs*25 [nucleoplasm]",
"TP53 S227Hfs*9 [nucleoplasm]",
"TP53 D281Efs*18 [nucleoplasm]",
"TP53 K120Tfs*2 [nucleoplasm]",
"TP53 N239Pfs*6 [nucleoplasm]",
"TP53 Y126* [nucleoplasm]",
"TP53 R248* [nucleoplasm]",
"TP53 Q167Tfs*14 [nucleoplasm]",
"TP53 P152Hfs*29 [nucleoplasm]",
"TP53 E198Afs*7 [nucleoplasm]",
"TP53 R174Sfs*73 [nucleoplasm]",
"TP53 P77Qfs*46 [nucleoplasm]",
"TP53 N288Ifs*57 [nucleoplasm]",
"TP53 K164Nfs*6 [nucleoplasm]",
"TP53 T125Afs*46 [nucleoplasm]",
"TP53 C176Sfs*67 [nucleoplasm]",
"TP53 P82Gfs*66 [nucleoplasm]",
"TP53 D21Tfs*23 [nucleoplasm]",
"TP53 G245Vfs*19 [nucleoplasm]",
"TP53 C242Hfs*21 [nucleoplasm]",
"TP53 V157Rfs*22 [nucleoplasm]",
"TP53 V216Gfs*31 [nucleoplasm]",
"TP53 Y205Tfs*37 [nucleoplasm]",
"TP53 D184Efs*24 [nucleoplasm]",
"TP53 L201Cfs*46 [nucleoplasm]",
"TP53 K101Lfs*42 [nucleoplasm]",
"TP53 H115Ifs*8 [nucleoplasm]",
"TP53 G154Afs*14 [nucleoplasm]",
"TP53 T304Lfs*41 [nucleoplasm]",
"TP53 E298Tfs*48 [nucleoplasm]",
"TP53 R280Sfs*66 [nucleoplasm]",
"TP53 N239Afs*5 [nucleoplasm]",
"TP53 L194Sfs*52 [nucleoplasm]",
"cellular tumor antigen p53 (human)",
"TP53 R248Qfs*15 [nucleoplasm]",
"TP53 N239Kfs*22 [nucleoplasm]",
"TP53 E204Wfs*41 [nucleoplasm]",
"TP53 E221Sfs*26 [nucleoplasm]",
"TP53 K24Nfs*20 [nucleoplasm]",
"TP53 K305* [nucleoplasm]",
"TP53 W23* [nucleoplasm]",
"TP53 F341L [nucleoplasm]",
"TP53 H168Qfs*2 [nucleoplasm]",
"TP53 G245Afs*14 [nucleoplasm]",
"TP53 K320Mfs*21 [nucleoplasm]",
"TP53 H178Tfs*69 [nucleoplasm]",
"TP53 Q52Lfs*68 [nucleoplasm]",
"TP53 L32Cfs*12 [nucleoplasm]",
"TP53 A276Vfs*68 [nucleoplasm]",
"TP53 D48Gfs*4 [nucleoplasm]",
"TP53 T253Hfs*11 [nucleoplasm]",
"TP53 R267Tfs*5 [nucleoplasm]",
"TP53 L93Rfs*30 [nucleoplasm]",
"TP53 E285Rfs*54 [nucleoplasm]",
"TP53 D281Afs*26 [nucleoplasm]",
"TP53 P309Lfs*31 [nucleoplasm]",
"TP53 R213Tfs*2 [nucleoplasm]",
"TP53 P152Afs*14 [nucleoplasm]",
"TP53 E56* [nucleoplasm]",
"TP53 R248Gfs*97 [nucleoplasm]",
"TP53 A119Qfs*5 [nucleoplasm]",
"TP53 R337P [nucleoplasm]",
"TP53 Q192Pfs*17 [nucleoplasm]",
"TP53 R280Tfs*64 [nucleoplasm]",
"TP53 R175Afs*72 [nucleoplasm]",
"TP53 D41Mfs*3 [nucleoplasm]",
"TP53 V73Rfs*76 [nucleoplasm]",
"TP53 L299Cfs*46 [nucleoplasm]",
"TP53 D184Vfs*63 [nucleoplasm]",
"TP53 R290Gfs*12 [nucleoplasm]",
"TP53 I195Cfs*46 [nucleoplasm]",
"TP53 Y327* [nucleoplasm]",
"TP53 S227* [nucleoplasm]",
"TP53 E221Vfs*4 [nucleoplasm]",
"TP53 T81Nfs*42 [nucleoplasm]",
"TP53 D207Kfs*6 [nucleoplasm]",
"TP53 S227Vfs*2 [nucleoplasm]",
"TP53 N29Kfs*14 [nucleoplasm]",
"TP53 Q317Rfs*28 [nucleoplasm]",
"TP53 R196Sfs*12 [nucleoplasm]",
"TP53 S149Ffs*32 [nucleoplasm]",
"TP53 M133Nfs*34 [nucleoplasm]",
"p-S37-TP53 [nucleoplasm]",
"TP53 L130Pfs*19 [nucleoplasm]",
"TP53 Q38Wfs*4 [nucleoplasm]",
"TP53 S96Yfs*53 [nucleoplasm]",
"TP53 C124Yfs*24 [nucleoplasm]",
"TP53 Q144Afs*16 [nucleoplasm]",
"TP53 Y220Rfs*25 [nucleoplasm]",
"TP53 K351N [nucleoplasm]",
"TP53 H178Pfs*3 [nucleoplasm]",
"TP53 P71Gfs*75 [nucleoplasm]",
"TP53 Q354* [nucleoplasm]",
"TP53 [cytosol]",
"TP53 C275Vfs*70 [nucleoplasm]",
"TP53 Q167Sfs*3 [nucleoplasm]",
"TP53 C277Lfs*67 [nucleoplasm]",
"TP53 S96Ffs*53 [nucleoplasm]",
"TP53 A74Gfs*75 [nucleoplasm]",
"TP53 H168Rfs*5 [nucleoplasm]",
"TP53 R283Kfs*59 [nucleoplasm]",
"TP53 V274Cfs*32 [nucleoplasm]",
"TP53 T55Pfs*52 [nucleoplasm]",
"TP53 T231Nfs*9 [nucleoplasm]",
"TP53 A69Lfs*54 [nucleoplasm]",
"TP53 K139Afs*4 [nucleoplasm]",
"TP53 L22Yfs*22 [nucleoplasm]",
"TP53 R337L [nucleoplasm]",
"TP53 S94Cfs*30 [nucleoplasm]",
"TP53 G112Cfs*9 [nucleoplasm]",
"Tp53 (rat)",
"TP53 T123Ifs*47 [nucleoplasm]",
"TP53 M66Ifs*76 [nucleoplasm]",
"TP53 P153Sfs*13 [nucleoplasm]",
"TP53 T155Hfs*21 [nucleoplasm]",
"TP53 V147Lfs*23 [nucleoplasm]",
"TP53 K321Nfs*24 [nucleoplasm]",
"TP53 R209Sfs*5 [nucleoplasm]",
"TP53 R181Pfs*66 [nucleoplasm]",
"TP53 T155Pfs*23 [nucleoplasm]",
"TP53 L111Rfs*37 [nucleoplasm]",
"TP53 V143Cfs*27 [nucleoplasm]",
"TP53 Q104* [nucleoplasm]",
"TP53 P223Rfs*4 [nucleoplasm]",
"TP53 R306Lfs*32 [nucleoplasm]",
"TP53 L257Pfs*85 [nucleoplasm]",
"TP53 L344P [nucleoplasm]",
"TP53 I195Lfs*53 [nucleoplasm]",
"TP53 V157Pfs*23 [nucleoplasm]",
"TP53 G108Rfs*41 [nucleoplasm]",
"TP53 S90Pfs*34 [nucleoplasm]",
"TP53 Y234* [nucleoplasm]",
"TP53 M133Cfs*37 [nucleoplasm]",
"TP53 H214Qfs*7 [nucleoplasm]",
"TP53 H193Qfs*48 [nucleoplasm]",
"TP53 E271Gfs*73 [nucleoplasm]",
"TP53 A63Lfs*60 [nucleoplasm]",
"TP53 W91Cfs*52 [nucleoplasm]",
"TP53 R196Efs*51 [nucleoplasm]",
"TP53 K321Efs*16 [nucleoplasm]",
"TP53 I195Sfs*12 [nucleoplasm]",
"TP53 L130Pfs*39 [nucleoplasm]",
"TP53 P85Lfs*59 [nucleoplasm]",
"TP53 E171Lfs*2 [nucleoplasm]",
"TP53 Q144Rfs*26 [nucleoplasm]",
"TP53 K291Rfs*54 [nucleoplasm]",
"TP53 P67Qfs*56 [nucleoplasm]",
"TP53 P142Afs*5 [nucleoplasm]",
"TP53 M44Sfs*79 [nucleoplasm]",
"TP53 Q167Hfs*3 [nucleoplasm]",
"TP53 K320* [nucleoplasm]",
"TP53 Y234Sfs*15 [nucleoplasm]",
"TP53 N268Kfs*4 [nucleoplasm]",
"TP53 L26Pfs*11 [nucleoplasm]",
"TP53 S149Pfs*17 [nucleoplasm]",
"TP53 S149Afs*72 [nucleoplasm]",
"TP53 L130Cfs*20 [nucleoplasm]",
"TP53 G112Afs*11 [nucleoplasm]",
"TP53 T18Hfs*26 [nucleoplasm]",
"TP53 C176Mfs*68 [nucleoplasm]",
"TP53 Y205Sfs*4 [nucleoplasm]",
"TP53 P190Sfs*17 [nucleoplasm]",
"TP53 G279* [nucleoplasm]",
"TP53 Y234Qfs*5 [nucleoplasm]",
"TP53 S269Lfs*75 [nucleoplasm]",
"TP53 A74Pfs*49 [nucleoplasm]",
"TP53 S95Hfs*29 [nucleoplasm]",
"TP53 S185Tfs*62 [nucleoplasm]",
"TP53 G302Afs*42 [nucleoplasm]",
"TP53 R213Ffs*35 [nucleoplasm]",
"TP53 N200Vfs*4 [nucleoplasm]",
"TP53 G154Pfs*28 [nucleoplasm]",
"TP53 T312Nfs*25 [nucleoplasm]",
"TP53 T304Lfs*3 [nucleoplasm]",
"TP53 D148Ifs*22 [nucleoplasm]",
"TP53 A138Gfs*11 [nucleoplasm]",
"TP53 T125Lfs*25 [nucleoplasm]",
"TP53 Q136Pfs*13 [nucleoplasm]",
"TP53 P128Tfs*12 [nucleoplasm]",
"TP53 N288Kfs*18 [nucleoplasm]",
"TP53 S240* [nucleoplasm]",
"TP53 A307Gfs*30 [nucleoplasm]",
"TP53 Q192Sfs*55 [nucleoplasm]",
"TP53 M243* [nucleoplasm]",
"TP53 V122Hfs*24 [nucleoplasm]",
"TP53 N288Efs*14 [nucleoplasm]",
"TP53 S315Lfs*30 [nucleoplasm]",
"TP53 T123Rfs*48 [nucleoplasm]",
"Ac-K120,p-S15,S20-TP53 [nucleoplasm]",
"TP53 Q317Afs*19 [nucleoplasm]",
"TP53 R248Pfs*16 [nucleoplasm]",
"TP53 S96Cfs*52 [nucleoplasm]",
"TP53 P316Afs*19 [nucleoplasm]",
"TP53 H297Pfs*48 [nucleoplasm]",
"TP53 T256Nfs*8 [nucleoplasm]",
"TP53 S303Afs*42 [nucleoplasm]",
"TP53 A86Pfs*33 [nucleoplasm]",
"TP53 W91Cfs*32 [nucleoplasm]",
"TP53 G266Efs*4 [nucleoplasm]",
"TP53 Q136Pfs*30 [nucleoplasm]",
"TP53 T304Ifs*41 [nucleoplasm]",
"TP53 S240Vfs*7 [nucleoplasm]",
"TP53 P278Lfs*28 [nucleoplasm]",
"TP53 P13Lfs*2 [nucleoplasm]",
"TP53 Q38Kfs*6 [nucleoplasm]",
"TP53 C176* [nucleoplasm]",
"TP53 Y205Ffs*8 [nucleoplasm]",
"TP53 E287* [nucleoplasm]",
"TP53 N310Kfs*27 [nucleoplasm]",
"TP53 N268Pfs*45 [nucleoplasm]",
"TP53 G59Vfs*64 [nucleoplasm]",
"TP53 A189Pfs*19 [nucleoplasm]",
"TP53 A189Cfs*20 [nucleoplasm]",
"TP53 G112Lfs*36 [nucleoplasm]",
"TP53 L330I [nucleoplasm]",
"TP53 E287Sfs*17 [nucleoplasm]",
"TP53 S94Hfs*29 [nucleoplasm]",
"TP53 Q52Kfs*67 [nucleoplasm]",
"TP53 T125Ifs*47 [nucleoplasm]",
"TP53 E224Rfs*23 [nucleoplasm]",
"TP53 Q144Afs*5 [nucleoplasm]",
"TP53 I162Sfs*8 [nucleoplasm]",
"TP53 V216Afs*28 [nucleoplasm]",
"TP53 F109Tfs*16 [nucleoplasm]",
"TP53 T253Nfs*11 [nucleoplasm]",
"TP53 L257Hfs*89 [nucleoplasm]",
"TP53 R196Ffs*8 [nucleoplasm]",
"TP53 P82Hfs*42 [nucleoplasm]",
"SUMO2,3-K386-TP53 [nucleoplasm]",
"TP53 T256Hfs*8 [nucleoplasm]",
"TP53 D42Qfs*5 [nucleoplasm]",
"TP53 W146* [nucleoplasm]",
"TP53 G279Pfs*69 [nucleoplasm]",
"TP53 I195Wfs*50 [nucleoplasm]",
"TP53 E198Ifs*47 [nucleoplasm]",
"TP53 G279Efs*26 [nucleoplasm]",
"TP53 R158Hfs*21 [nucleoplasm]",
"TP53 M246Rfs*19 [nucleoplasm]",
"TP53 R273Cfs*32 [nucleoplasm]",
"TP53 R110Sfs*14 [nucleoplasm]",
"TP53 H178Afs*65 [nucleoplasm]",
"TP53 L130Pfs*41 [nucleoplasm]",
"TP53 H179Qfs*64 [nucleoplasm]",
"TP53 R209Ffs*35 [nucleoplasm]",
"TP53 G59Qfs*84 [nucleoplasm]",
"TP53 Y126Tfs*44 [nucleoplasm]",
"TP53 W53* [nucleoplasm]",
"TP53 G293* [nucleoplasm]",
"TP53 N288Tfs*55 [nucleoplasm]",
"TP53 G108Vfs*15 [nucleoplasm]",
"TP53 R283Pfs*16 [nucleoplasm]",
"TP53 S15Rfs*28 [nucleoplasm]",
"TP53 E285Rfs*21 [nucleoplasm]",
"TP53 T211Ifs*33 [nucleoplasm]",
"TP53 M40Ifs*3 [nucleoplasm]",
"TP53 L289Pfs*56 [nucleoplasm]",
"TP53 C182Afs*66 [nucleoplasm]",
"TP53 R280* [nucleoplasm]",
"TP53 A86Gfs*32 [nucleoplasm]",
"TP53 A307Sfs*30 [nucleoplasm]",
"TP53 Y220Lfs*2 [nucleoplasm]",
"TP53 P128Lfs*42 [nucleoplasm]",
"TP53 T102Pfs*21 [nucleoplasm]",
"TP53 E258Kfs*87 [nucleoplasm]",
"TP53 H178Qfs*3 [nucleoplasm]",
"TP53 P85Lfs*58 [nucleoplasm]",
"TP53 W91Cfs*57 [nucleoplasm]",
"TP53 N311Qfs*26 [nucleoplasm]",
"TP53 P222Lfs*24 [nucleoplasm]",
"TP53 Q5* [nucleoplasm]",
"TP53 D208Ffs*42 [nucleoplasm]",
"TP53 G262Wfs*80 [nucleoplasm]",
"TP53 T118Gfs*6 [nucleoplasm]",
"TP53 M66Tfs*60 [nucleoplasm]",
"TP53 Q165Sfs*5 [nucleoplasm]",
"TP53 L130Qfs*17 [nucleoplasm]",
"TP53 P152Rfs*27 [nucleoplasm]",
"TP53 T253Qfs*3 [nucleoplasm]",
"TP53 V203Wfs*44 [nucleoplasm]",
"TP53 E287Kfs*53 [nucleoplasm]",
"TP53 G266Dfs*79 [nucleoplasm]",
"TP53 K291Tfs*48 [nucleoplasm]",
"TP53 Q136* [nucleoplasm]",
"TP53 K319Afs*19 [nucleoplasm]",
"TP53 V274Ffs*71 [nucleoplasm]",
"TP53 R196Ffs*35 [nucleoplasm]",
"TP53 L35Ffs*8 [nucleoplasm]",
"TP53 L330P [nucleoplasm]",
"TP53 Q100Rfs*23 [nucleoplasm]",
"TP53 E294* [nucleoplasm]",
"TP53 Q52Nfs*71 [nucleoplasm]",
"TP53 V73Wfs*50 [nucleoplasm]",
"TP53",
"TP53 R267Efs*65 [nucleoplasm]",
"TP53 A161Hfs*19 [nucleoplasm]",
"TP53 F109Lfs*36 [nucleoplasm]",
"TP53 A84Gfs*65 [nucleoplasm]",
"TP53 N235Tfs*12 [nucleoplasm]",
"TP53 A88Gfs*44 [nucleoplasm]",
"TP53 M243Wfs*4 [nucleoplasm]",
"TP53 L45Pfs*5 [nucleoplasm]",
"TP53 E298Gfs*43 [nucleoplasm]",
"TP53 S261Vfs*84 [nucleoplasm]",
"TP53 V218Gfs*30 [nucleoplasm]",
"TP53 G279Efs*65 [nucleoplasm]",
"TP53 M169Ifs*12 [nucleoplasm]",
"TP53 C229Yfs*8 [nucleoplasm]",
"TP53 S90Pfs*33 [nucleoplasm]",
"TP53 K291Nfs*49 [nucleoplasm]",
"TP53 A189Pfs*58 [nucleoplasm]",
"cellular tumor antigen p53 (zebrafish)",
"TP53 E285Rfs*60 [nucleoplasm]",
"TP53 Q136Sfs*26 [nucleoplasm]",
"TP53 R110Pfs*14 [nucleoplasm]",
"p-S15,S33,S46-TP53 [nucleoplasm]",
"TP53 P77Lfs*44 [nucleoplasm]",
"TP53 A78Qfs*45 [nucleoplasm]",
"TP53 S106Qfs*43 [nucleoplasm]",
"TP53 R196* [nucleoplasm]",
"TP53 R174Gfs*73 [nucleoplasm]",
"TP53 E171Gfs*4 [nucleoplasm]",
"TP53 P301Rfs*4 [nucleoplasm]",
"TP53 R337S [nucleoplasm]",
"TP53 R202Afs*7 [nucleoplasm]",
"TP53 T140Cfs*6 [nucleoplasm]",
"TP53 R249Gfs*96 [nucleoplasm]",
"TP53 P151Tfs*30 [nucleoplasm]",
"TP53 V272Afs*33 [nucleoplasm]",
"PolyUb,p-S15,S20-TP53 [nucleoplasm]",
"Me2-K373-TP53 [nucleoplasm]",
"TP53 N263Tfs*5 [nucleoplasm]",
"TP53 P47Gfs*4 [nucleoplasm]",
"TP53 Y236Tfs*11 [nucleoplasm]",
"TP53 L308Pfs*15 [nucleoplasm]",
"TP53 C141Sfs*26 [nucleoplasm]",
"TP53 A276Tfs*64 [nucleoplasm]",
"TP53 E198Kfs*49 [nucleoplasm]",
"TP53 E258Gfs*6 [nucleoplasm]",
"TP53 V216Gfs*5 [nucleoplasm]",
"TP53 A161Dfs*19 [nucleoplasm]",
"TP53 P153Lfs*28 [nucleoplasm]",
"TP53 K291Gfs*12 [nucleoplasm]",
"TP53 A119Rfs*6 [nucleoplasm]",
"TP53 V218Cfs*29 [nucleoplasm]",
"TP53 C124Ffs*47 [nucleoplasm]",
"TP53 R156Afs*14 [nucleoplasm]",
"TP53 M44Afs*7 [nucleoplasm]",
"TP53 C275Lfs*31 [nucleoplasm]",
"TP53 I232Qfs*5 [nucleoplasm]",
"TP53 E204* [nucleoplasm]",
"TP53 S303Efs*3 [nucleoplasm]",
"TP53 G154Pfs*25 [nucleoplasm]",
"TP53 P75Yfs*68 [nucleoplasm]",
"TP53 H297Sfs*10 [nucleoplasm]",
"TP53 H178Pfs*2 [nucleoplasm]",
"TP53 S215Cfs*29 [nucleoplasm]",
"TP53 P128Qfs*17 [nucleoplasm]",
"TP53 L114Ffs*33 [nucleoplasm]",
"TP53 M243Hfs*18 [nucleoplasm]",
"TP53 F109Gfs*37 [nucleoplasm]",
"TP53 F19Ifs*10 [nucleoplasm]",
"TP53 A39Qfs*5 [nucleoplasm]",
"TP53 Q165Hfs*4 [nucleoplasm]",
"TP53 C135Lfs*14 [nucleoplasm]",
"TP53 I195Kfs*9 [nucleoplasm]",
"TP53 A138Cfs*27 [nucleoplasm]",
"TP53 P128Rfs*20 [nucleoplasm]",
"TP53 M44Cfs*79 [nucleoplasm]",
"TP53 V143Afs*21 [nucleoplasm]",
"TP53 H115Qfs*4 [nucleoplasm]",
"p-S15,S392-TP53 [nucleoplasm]",
"TP53 S121Lfs*2 [nucleoplasm]",
"TP53 T230Hfs*9 [nucleoplasm]",
"TP53 D48Tfs*75 [nucleoplasm]",
"TP53 A78Yfs*68 [nucleoplasm]",
"TP53 K164Sfs*6 [nucleoplasm]",
"TP53 S227Wfs*3 [nucleoplasm]",
"Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]",
"TP53 H214Qfs*2 [nucleoplasm]",
"TP53 D228Vfs*18 [nucleoplasm]",
"TP53 L43* [nucleoplasm]",
"TP53 N235Lfs*4 [nucleoplasm]",
"TP53 T284Ifs*57 [nucleoplasm]",
"TP53 P191Yfs*14 [nucleoplasm]",
"TP53 C229Vfs*18 [nucleoplasm]",
"TP53 S46Pfs*77 [nucleoplasm]",
"TP53 P301Qfs*44 [nucleoplasm]",
"TP53 C182Afs*65 [nucleoplasm]",
"TP53 L265Wfs*80 [nucleoplasm]",
"TP53 R282Gfs*63 [nucleoplasm]",
"TP53 V73Gfs*50 [nucleoplasm]",
"TP53 T81Sfs*43 [nucleoplasm]",
"TP53 D184Afs*62 [nucleoplasm]",
"TP53 protein, human",
"TP53 S315Wfs*22 [nucleoplasm]",
"TP53 L93Vfs*55 [nucleoplasm]",
"TP53 F341S [nucleoplasm]",
"TP53 N311Tfs*34 [nucleoplasm]",
"TP53 M160Wfs*10 [nucleoplasm]",
"TP53 F54Sfs*69 [nucleoplasm]",
"TP53 R110Vfs*13 [nucleoplasm]",
"TP53 S99Rfs*23 [nucleoplasm]",
"TP53 N263Tfs*8 [nucleoplasm]",
"TP53 S314Rfs*25 [nucleoplasm]",
"TP53 R65Qfs*84 [nucleoplasm]",
"TP53 P58Rfs*6 [nucleoplasm]",
"TP53 V173Afs*6 [nucleoplasm]",
"TP53 T256Kfs*87 [nucleoplasm]",
"TP53 D148Pfs*23 [nucleoplasm]",
"TP53 L114Ffs*35 [nucleoplasm]",
"TP53 H233Tfs*14 [nucleoplasm]",
"TP53 T230Sfs*11 [nucleoplasm]",
"TP53 S166Ifs*15 [nucleoplasm]",
"TP53 A83Pfs*35 [nucleoplasm]",
"TP53 K351E [nucleoplasm]",
"TP53 E285Rfs*13 [nucleoplasm]",
"TP53 L137Rfs*33 [nucleoplasm]",
"TP53 K351* [nucleoplasm]",
"TP53 A159Hfs*21 [nucleoplasm]",
"TP53 P92Hfs*57 [nucleoplasm]",
"MeK-370,p-S15,S20-TP53 [nucleoplasm]",
"TP53 V218Gfs*4 [nucleoplasm]",
"TP53 P47Rfs*76 [nucleoplasm]",
"PolyUb-TP53 [nucleoplasm]",
"TP53 V143Afs*4 [nucleoplasm]",
"TP53 L111Nfs*14 [nucleoplasm]",
"TP53 L289Sfs*56 [nucleoplasm]",
"TP53 H115Lfs*8 [nucleoplasm]",
"TP53 S183Rfs*2 [nucleoplasm]",
"TP53 C176Afs*71 [nucleoplasm]",
"TP53 R280Efs*65 [nucleoplasm]",
"TP53 D228Tfs*12 [nucleoplasm]",
"TP53 A83Pfs*39 [nucleoplasm]",
"TP53 Y234Pfs*7 [nucleoplasm]",
"TP53 T253Ifs*93 [nucleoplasm]",
"TP53 D207Gfs*2 [nucleoplasm]",
"TP53 N247Rfs*97 [nucleoplasm]",
"TP53 E271Gfs*34 [nucleoplasm]",
"TP53 G59Efs*58 [nucleoplasm]",
"TP53 E62* [nucleoplasm]",
"TP53 G154Afs*18 [nucleoplasm]",
"TP53 E258Pfs*85 [nucleoplasm]",
"TP53 N30Kfs*13 [nucleoplasm]",
"TP53 T102Nfs*47 [nucleoplasm]",
"cellular tumor antigen p53 (rat)",
"TP53 H214Cfs*29 [nucleoplasm]",
"TP53 Q144Hfs*26 [nucleoplasm]",
"TP53 G226Afs*21 [nucleoplasm]",
"TP53 P316Lfs*30 [nucleoplasm]",
"TP53 D208Ffs*35 [nucleoplasm]",
"TP53 K320Rfs*25 [nucleoplasm]",
"TP53 R282Pfs*64 [nucleoplasm]",
"TP53 Q165* [nucleoplasm]",
"TP53 V173* [nucleoplasm]",
"TP53 R273Lfs*33 [nucleoplasm]",
"TP53 N288Kfs*59 [nucleoplasm]",
"TP53 Q52Lfs*73 [nucleoplasm]",
"TP53 V216Gfs*4 [nucleoplasm]",
"TP53 Q104Rfs*19 [nucleoplasm]",
"TP53 R110Lfs*13 [nucleoplasm]",
"TP53 Y126Qfs*18 [nucleoplasm]",
"TP53 P47Hfs*2 [nucleoplasm]",
"TP53 T123Dfs*26 [nucleoplasm]",
"TP53 L137Wfs*33 [nucleoplasm]",
"TP53 S241Wfs*19 [nucleoplasm]",
"TP53 N210Tfs*7 [nucleoplasm]",
"TP53 S127Pfs*43 [nucleoplasm]",
"TP53 D148Pfs*21 [nucleoplasm]",
"TP53 H178Pfs*69 [nucleoplasm]",
"TP53 C135Ffs*36 [nucleoplasm]",
"TP53 P309Qfs*26 [nucleoplasm]",
"TP53 P36Tfs*75 [nucleoplasm]",
"TP53 A347D [nucleoplasm]",
"TP53 T211Ffs*4 [nucleoplasm]",
"TP53 M133Sfs*37 [nucleoplasm]",
"TP53 P278Lfs*68 [nucleoplasm]",
"TP53 F113Sfs*10 [nucleoplasm]",
"TP53 Q104Afs*18 [nucleoplasm]",
"TP53 R156Afs*12 [nucleoplasm]",
"p-S15,S20,S46-TP53 [nucleoplasm]",
"TP53 F109Sfs*38 [nucleoplasm]",
"TP53 W53Gfs*70 [nucleoplasm]",
"TP53 H179* [nucleoplasm]",
"TP53 P152Rfs*18 [nucleoplasm]",
"TP53 R273Cfs*73 [nucleoplasm]",
"TP53 E298Dfs*7 [nucleoplasm]",
"TP53 D57Kfs*67 [nucleoplasm]",
"TP53 R290Sfs*56 [nucleoplasm]",
"TP53 G199Rfs*10 [nucleoplasm]",
"TP53 A189Dfs*14 [nucleoplasm]",
"TP53 L330R [nucleoplasm]",
"TP53 D281Pfs*24 [nucleoplasm]",
"TP53 N210Kfs*37 [nucleoplasm]",
"TP53 Q100Lfs*42 [nucleoplasm]",
"TP53 V172Lfs*2 [nucleoplasm]",
"TP53 A161Gfs*20 [nucleoplasm]",
"TP53 L35* [nucleoplasm]",
"TP53 Q144Gfs*2 [nucleoplasm]",
"TP53 A74Qfs*45 [nucleoplasm]",
"TP53 E56Vfs*73 [nucleoplasm]",
"TP53 L188Pfs*58 [nucleoplasm]",
"TP53 L201Ifs*47 [nucleoplasm]",
"TP53 R156Sfs*8 [nucleoplasm]",
"TP53 D186Wfs*22 [nucleoplasm]",
"TP53 V143Gfs*2 [nucleoplasm]",
"TP53 I251Sfs*94 [nucleoplasm]",
"TP53 Y107Sfs*38 [nucleoplasm]",
"TP53 P223Sfs*26 [nucleoplasm]",
"TP53 G108Ffs*40 [nucleoplasm]",
"TP53 P85Cfs*63 [nucleoplasm]",
"TP53 D61Vfs*62 [nucleoplasm]",
"TP53 L93Ffs*53 [nucleoplasm]",
"TP53 A83Gfs*65 [nucleoplasm]",
"TP53 L330F [nucleoplasm]",
"TP53 A307Tfs*29 [nucleoplasm]",
"TP53 R158Sfs*8 [nucleoplasm]",
"TP53 E62Kfs*65 [nucleoplasm]",
"TP53 E298Dfs*47 [nucleoplasm]",
"TP53 A69Vfs*54 [nucleoplasm]",
"TP53 K291Qfs*15 [nucleoplasm]",
"TP53 C229Lfs*18 [nucleoplasm]",
"TP53 D208Afs*39 [nucleoplasm]",
"TP53 E285Gfs*20 [nucleoplasm]",
"TP53 E298Sfs*47 [nucleoplasm]",
"TP53 M237Vfs*2 [nucleoplasm]",
"TP53 P316Lfs*21 [nucleoplasm]",
"TP53 I254Tfs*7 [nucleoplasm]",
"TP53 K292* [nucleoplasm]",
"TP53 S94Ffs*55 [nucleoplasm]",
"TP53 A88Vfs*55 [nucleoplasm]",
"TP53 L194Hfs*14 [nucleoplasm]",
"TP53 N210Tfs*37 [nucleoplasm]",
"TP53 R110Wfs*12 [nucleoplasm]",
"TP53 P153Afs*28 [nucleoplasm]",
"TP53 T118Dfs*31 [nucleoplasm]",
"TP53 A129Vfs*20 [nucleoplasm]",
"TP53 L257Gfs*6 [nucleoplasm]",
"TP53 R248Pfs*92 [nucleoplasm]",
"TP53 N310Kfs*26 [nucleoplasm]",
"TP53 M160Rfs*10 [nucleoplasm]",
"TP53 T118Nfs*31 [nucleoplasm]",
"TP53 T230Lfs*6 [nucleoplasm]",
"TP53 S241Lfs*22 [nucleoplasm]",
"Me-K382,p-S15,S20-TP53 [nucleoplasm]",
"TP53 V122Cfs*27 [nucleoplasm]",
"TP53 H214Lfs*33 [nucleoplasm]",
"TP53 E204Sfs*43 [nucleoplasm]",
"TP53 S261* [nucleoplasm]",
"TP53 R65Tfs*84 [nucleoplasm]",
"TP53 N29Tfs*15 [nucleoplasm]",
"p-S15,S20-TP53 [nucleoplasm]",
"TP53 S215Kfs*7 [nucleoplasm]",
"TP53 W91Gfs*32 [nucleoplasm]",
"TP53 D184Ifs*63 [nucleoplasm]",
"TP53 K101* [nucleoplasm]",
"TP53 E221Afs*2 [nucleoplasm]",
"TP53 R273Ffs*71 [nucleoplasm]",
"TP53 R273Lfs*72 [nucleoplasm]",
"TP53 T150Nfs*20 [nucleoplasm]",
"TP53 S215Vfs*32 [nucleoplasm]",
"TP53 P92Vfs*55 [nucleoplasm]",
"TP53 S99Ffs*55 [nucleoplasm]",
"TP53 M169Dfs*11 [nucleoplasm]",
"TP53 E224* [nucleoplasm]",
"TP53 G302Rfs*4 [nucleoplasm]",
"TP53 C242Tfs*98 [nucleoplasm]",
"TP53 R337G [nucleoplasm]",
"TP53 K139Dfs*9 [nucleoplasm]",
"TP53 K164Sfs*5 [nucleoplasm]",
"TP53 P190Lfs*57 [nucleoplasm]",
"TP53 S215Wfs*31 [nucleoplasm]",
"TP53 A307Rfs*39 [nucleoplasm]",
"TP53 D184Rfs*2 [nucleoplasm]",
"TP53 M133Dfs*16 [nucleoplasm]",
"TP53 F113Qfs*5 [nucleoplasm]",
"TP53 H214Gfs*5 [nucleoplasm]",
"TP53 H115Cfs*27 [nucleoplasm]",
"TP53 P152Tfs*30 [nucleoplasm]",
"TP53 E180Sfs*67 [nucleoplasm]",
"TP53 T253Sfs*91 [nucleoplasm]",
"TP53 T256Nfs*89 [nucleoplasm]",
"TP53 V73Afs*76 [nucleoplasm]",
"TP53 P77Rfs*71 [nucleoplasm]",
"TP53 R306* [nucleoplasm]",
"TP53 M40Lfs*7 [nucleoplasm]",
"TP53 T284Qfs*61 [nucleoplasm]",
"TP53 H297Lfs*9 [nucleoplasm]",
"TP53 R248Pfs*95 [nucleoplasm]",
"TP53 H297Tfs*48 [nucleoplasm]",
"TP53 V217Gfs*31 [nucleoplasm]",
"TP53 Y103Gfs*44 [nucleoplasm]",
"TP53 H296Rfs*8 [nucleoplasm]",
"TP53 F212Sfs*3 [nucleoplasm]",
"cellular tumor antigen p53 (chicken)",
"TP53 L206Yfs*4 [nucleoplasm]",
"TP53 C135Afs*35 [nucleoplasm]",
"TP53 A86Lfs*59 [nucleoplasm]",
"TP53 N288Rfs*13 [nucleoplasm]",
"TP53 Q144Sfs*26 [nucleoplasm]",
"TP53 A129Pfs*42 [nucleoplasm]",
"TP53 C242* [nucleoplasm]",
"TP53 Q317* [nucleoplasm]",
"TP53 L188Wfs*59 [nucleoplasm]",
"TP53 E198Gfs*11 [nucleoplasm]",
"TP53 R174* [nucleoplasm]",
"TP53 N131Pfs*19 [nucleoplasm]",
"TP53 A88Pfs*35 [nucleoplasm]",
"TP53 A119Sfs*3 [nucleoplasm]",
"TP53 D324Vfs*21 [nucleoplasm]",
"TP53 N239Kfs*15 [nucleoplasm]",
"Me1-K372,p-S15,S20-TP53 [nucleoplasm]",
"TP53 L201* [nucleoplasm]",
"TP53 C275Gfs*20 [nucleoplasm]",
"TP53 A69Gfs*80 [nucleoplasm]",
"TP53 M246Afs*19 [nucleoplasm]",
"TP53 T253Pfs*92 [nucleoplasm]",
"TP53 I50Mfs*4 [nucleoplasm]",
"TP53 E11* [nucleoplasm]",
"TP53 Y103* [nucleoplasm]",
"TP53 R337H [nucleoplasm]",
"TP53 Y205Lfs*4 [nucleoplasm]",
"TP53 E171Rfs*3 [nucleoplasm]",
"TP53 K319Nfs*18 [nucleoplasm]",
"TP53 W53Cfs*4 [nucleoplasm]",
"TP53 S269Rfs*21 [nucleoplasm]",
"TP53 P142Lfs*28 [nucleoplasm]",
"TP53 P223* [nucleoplasm]",
"TP53 Q317Hfs*28 [nucleoplasm]",
"TP53 P191Lfs*56 [nucleoplasm]",
"TP53 Y107* [nucleoplasm]",
"TP53 P295Rfs*12 [nucleoplasm]",
"TP53 G199* [nucleoplasm]",
"TP53 L252Sfs*93 [nucleoplasm]",
"TP53 M133Rfs*38 [nucleoplasm]",
"TP53 R65Kfs*84 [nucleoplasm]",
"TP53 Q16Rfs*28 [nucleoplasm]",
"TP53 T312Pfs*20 [nucleoplasm]",
"TP53 G245Afs*2 [nucleoplasm]",
"TP53 V157Wfs*10 [nucleoplasm]",
"TP53 Y103Lfs*42 [nucleoplasm]",
"TP53 G334E [nucleoplasm]",
"TP53 I255Nfs*9 [nucleoplasm]",
"TP53 N131Kfs*39 [nucleoplasm]",
"TP53 V272Cfs*73 [nucleoplasm]",
"TP53 Y234Tfs*11 [nucleoplasm]",
"TP53 W146Vfs*3 [nucleoplasm]",
"TP53 L188Rfs*59 [nucleoplasm]",
"TP53 P219Afs*3 [nucleoplasm]",
"TP53 L299Hfs*2 [nucleoplasm]",
"TP53 R156Pfs*25 [nucleoplasm]",
"TP53 Y103Vfs*15 [nucleoplasm]",
"TP53 P98Yfs*26 [nucleoplasm]",
"TP53 N288Ifs*18 [nucleoplasm]",
"TP53 R282Afs*23 [nucleoplasm]",
"TP53 L257Hfs*9 [nucleoplasm]",
"TP53 S215Mfs*32 [nucleoplasm]",
"TP53 G117Dfs*26 [nucleoplasm]",
"TP53 N263Ifs*82 [nucleoplasm]",
"TP53 L257Rfs*6 [nucleoplasm]",
"TP53 G187Afs*21 [nucleoplasm]",
"TP53 G154Rfs*22 [nucleoplasm]",
"TP53 Q167Lfs*2 [nucleoplasm]",
"TP53 A76Vfs*55 [nucleoplasm]",
"TP53 L265Tfs*7 [nucleoplasm]",
"TP53 R156Lfs*18 [nucleoplasm]",
"TP53 A74Gfs*50 [nucleoplasm]",
"TP53 A76Hfs*47 [nucleoplasm]",
"TP53 S215Cfs*6 [nucleoplasm]",
"TP53 M237Sfs*10 [nucleoplasm]",
"TP53 P151Rfs*27 [nucleoplasm]",
"TP53 F113Pfs*37 [nucleoplasm]",
"TP53 D207Afs*39 [nucleoplasm]",
"TP53 I254Sfs*91 [nucleoplasm]",
"TP53 N239* [nucleoplasm]",
"TP53 A78Sfs*71 [nucleoplasm]",
"TP53 K321* [nucleoplasm]",
"TP53 R65Cfs*79 [nucleoplasm]",
"TP53 Y163Tfs*7 [nucleoplasm]",
"TP53 S94Ifs*54 [nucleoplasm]",
"TP53 E294Sfs*51 [nucleoplasm]",
"TP53 N268Efs*4 [nucleoplasm]",
"TP53 P128Qfs*18 [nucleoplasm]",
"TP53 P87Qfs*36 [nucleoplasm]",
"TP53 L201Afs*7 [nucleoplasm]",
"TP53 G293Rfs*13 [nucleoplasm]",
"TP53 E171Gfs*9 [nucleoplasm]",
"TP53 T81Pfs*49 [nucleoplasm]",
"TP53 E286Kfs*59 [nucleoplasm]",
"TP53 R337C [nucleoplasm]",
"TP53 R283Sfs*56 [nucleoplasm]",
"TP53 A83Cfs*63 [nucleoplasm]",
"TP53 C182* [nucleoplasm]",
"TP53 K319* [nucleoplasm]",
"TP53 S215Mfs*27 [nucleoplasm]",
"TP53 A84Pfs*39 [nucleoplasm]",
"TP53 S33Ffs*10 [nucleoplasm]",
"TP53 S116Afs*34 [nucleoplasm]",
"TP53 Q16* [nucleoplasm]",
"TP53 G279Sfs*68 [nucleoplasm]",
"Ac-K382,p-S15,S20-TP53 [nucleoplasm]",
"TP53 D281Tfs*64 [nucleoplasm]",
"TP53 P191Sfs*18 [nucleoplasm]",
"TP53 E171* [nucleoplasm]",
"TP53 I195Tfs*52 [nucleoplasm]",
"TP53 V218Wfs*30 [nucleoplasm]",
"TP53 R213Dfs*34 [nucleoplasm]",
"TP53 G154Afs*28 [nucleoplasm]",
"TP53 M246Ifs*99 [nucleoplasm]",
"TP53 G279Pfs*24 [nucleoplasm]",
"TP53 V143Afs*5 [nucleoplasm]",
"TP53 A347P [nucleoplasm]",
"TP53 Q167Rfs*3 [nucleoplasm]",
"TP53 M246* [nucleoplasm]",
"TP53 P177Lfs*3 [nucleoplasm]",
"Me2K-370,382-TP53 [nucleoplasm]",
"TP53 T125Rfs*45 [nucleoplasm]",
"TP53 M169Ifs*5 [nucleoplasm]",
"TP53 M66Qfs*56 [nucleoplasm]",
"TP53 D148Ffs*32 [nucleoplasm]",
"TP53 Y107Tfs*16 [nucleoplasm]",
"TP53 V143Afs*29 [nucleoplasm]",
"TP53 I162Vfs*15 [nucleoplasm]",
"TP53 P153Afs*16 [nucleoplasm]",
"TP53 I162Tfs*8 [nucleoplasm]",
"TP53 P301Lfs*41 [nucleoplasm]",
"TP53 E51Nfs*72 [nucleoplasm]",
"TP53 S240Ffs*23 [nucleoplasm]",
"TP53 M133Lfs*42 [nucleoplasm]",
"TP53 K291Sfs*51 [nucleoplasm]",
"TP53 V225Wfs*3 [nucleoplasm]",
"TP53 F54Lfs*69 [nucleoplasm]",
"TP53 E68Rfs*55 [nucleoplasm]",
"TP53 V173Tfs*69 [nucleoplasm]",
"TP53 K132Cfs*37 [nucleoplasm]",
"p-S15-TP53 [nucleoplasm]",
"TP53 V217Gfs*30 [nucleoplasm]",
"TP53 V157Hfs*21 [nucleoplasm]",
"TP53 E198Wfs*44 [nucleoplasm]",
"TP53 S95Gfs*37 [nucleoplasm]",
"TP53 L299Rfs*46 [nucleoplasm]",
"TP53 Q165Hfs*17 [nucleoplasm]",
"TP53 C275* [nucleoplasm]",
"TP53 E51* [nucleoplasm]",
"TP53 T211Pfs*28 [nucleoplasm]",
"TP53 V73Afs*51 [nucleoplasm]",
"TP53 S149Hfs*31 [nucleoplasm]",
"TP53 P72Lfs*48 [nucleoplasm]",
"TP53 A189Vfs*53 [nucleoplasm]",
"TP53 L264Hfs*81 [nucleoplasm]",
"TP53 A129Rfs*38 [nucleoplasm]",
"TP53 I251Pfs*12 [nucleoplasm]",
"TP53 G199Ffs*8 [nucleoplasm]",
"TP53 D259Tfs*86 [nucleoplasm]",
"TP53 Y205* [nucleoplasm]",
"TP53 E204Vfs*4 [nucleoplasm]",
"TP53 T170Rfs*4 [nucleoplasm]",
"TP53 L45Vfs*6 [nucleoplasm]",
"TP53 P58Qfs*65 [nucleoplasm]",
"TP53 K292Gfs*52 [nucleoplasm]",
"TP53 P80Lfs*43 [nucleoplasm]",
"TP53 N210Ffs*35 [nucleoplasm]",
"TP53 R209Cfs*6 [nucleoplasm]",
"TP53 V157Hfs*19 [nucleoplasm]",
"TP53 L206Ffs*42 [nucleoplasm]",
"TP53 T312Pfs*33 [nucleoplasm]",
"TP53 S94* [nucleoplasm]",
"TP53 I195Pfs*13 [nucleoplasm]",
"TP53 V147Rfs*27 [nucleoplasm]",
"TP53 R156Hfs*26 [nucleoplasm]",
"TP53 L35Pfs*10 [nucleoplasm]",
"TP53 C242Lfs*22 [nucleoplasm]",
"TP53 N310Tfs*35 [nucleoplasm]",
"TP53 S269Tfs*76 [nucleoplasm]",
"TP53 G108Afs*34 [nucleoplasm]",
"TP53 E221Gfs*25 [nucleoplasm]",
"TP53 S166* [nucleoplasm]",
"TP53 P85Lfs*38 [nucleoplasm]",
"TP53 T140Dfs*9 [nucleoplasm]",
"TP53 D148* [nucleoplasm]",
"TP53 G262Vfs*83 [nucleoplasm]",
"TP53 S260Qfs*3 [nucleoplasm]",
"TP53 T102Pfs*45 [nucleoplasm]",
"TP53 R282Pfs*24 [nucleoplasm]",
"PolyUb-TP53 [cytosol]",
"TP53 L32Pfs*11 [nucleoplasm]",
"TP53 A88Gfs*32 [nucleoplasm]",
"TP53 G245Efs*17 [nucleoplasm]",
"TP53 S315Nfs*24 [nucleoplasm]",
"TP53 T125Hfs*24 [nucleoplasm]",
"TP53 Q165Afs*6 [nucleoplasm]",
"TP53 K120* [nucleoplasm]",
"TP53 P36Rfs*8 [nucleoplasm]",
"TP53 M66Gfs*80 [nucleoplasm]",
"TP53 K132* [nucleoplasm]",
"TP53 R174Pfs*70 [nucleoplasm]",
"TP53 G279Kfs*59 [nucleoplasm]",
"TP53 R158Pfs*11 [nucleoplasm]",
"TP53 S20* [nucleoplasm]",
"TP53 S106Gfs*44 [nucleoplasm]",
"TP53 N200Ifs*47 [nucleoplasm]",
"TP53 S241Pfs*6 [nucleoplasm]",
"TP53 D49Yfs*2 [nucleoplasm]",
"TP53 Q144* [nucleoplasm]",
"TP53 D186* [nucleoplasm]",
"TP53 N311Kfs*26 [nucleoplasm]",
"TP53 Y236* [nucleoplasm]",
"Unfolded TP53 [cytosol]",
"TP53 Q167Hfs*12 [nucleoplasm]",
"TP53 L264Tfs*7 [nucleoplasm]",
"TP53 A161Sfs*8 [nucleoplasm]",
"TP53 L206Ffs*3 [nucleoplasm]",
"TP53 P153Hfs*26 [nucleoplasm]",
"TP53 R65Efs*58 [nucleoplasm]",
"TP53 V225Gfs*20 [nucleoplasm]",
"TP53 K139Rfs*31 [nucleoplasm]",
"TP53 A78Gfs*73 [nucleoplasm]",
"TP53 N30Tfs*14 [nucleoplasm]",
"TP53 C135* [nucleoplasm]",
"TP53 F338I [nucleoplasm]",
"TP53 T231Pfs*16 [nucleoplasm]",
"TP53 W91* [nucleoplasm]"
],
"value_type_id": "metatype:String",
"attribute_source": null,
"value_url": null,
"description": "Names of all nodes in this synonym set in RTX-KG2.",
"attributes": null
},
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}
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},
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"name": "tat (Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1))",
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"biolink:Protein"
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},
{
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"value": "This HIV gene, which encodes protein tat, is involved in the positive regulation of viral gene transcription.; UMLS Semantic Type: STY:T028",
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},
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"attributes": null
},
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"value": [
"TAT gene",
"Tat (mouse)",
"TAT Gene",
"tyrosine aminotransferase (Dictyostelium discoideum)",
"TAT (human)",
"tyrosine aminotransferase (mouse)",
"TAT",
"Tat (rat)",
"tat (Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1))",
"PXLP-K280-TAT [cytosol]",
"tyrosine aminotransferase (rat)",
"alpha-tubulin N-acetyltransferase 1 (fruit fly)",
"tyrosine aminotransferase (human)"
],
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"attributes": null
},
{
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"value": [
"PR:Q9VSY4",
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"MGI:98487",
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"OMIM:613018",
"UMLS:C1420590",
"NCBIGene:6898",
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"HGNC:11573",
"UniProtKB:P17735"
],
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{
"attribute_type_id": "biolink:publications",
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"DOI:10.1073/pnas.89.19.9297",
"DOI:10.1021/bi035612l",
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"DOI:10.1093/nar/gkr1224",
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"DOI:10.1089/aid.1987.3.57",
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}
]
},
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"name": "ASPIRIN",
"categories": [
"biolink:ChemicalEntity"
],
"attributes": [
{
"attribute_type_id": "biolink:IriType",
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"value": "Aspirin is only found in individuals who have consumed this drug. Aspirin or acetylsalicylic acid (acetosal) is a drug in the family of salicylates, often used as an analgesic (against minor pains and aches), antipyretic (against fever), and anti-inflammatory. It has also an anticoagulant effect and is used in long-term low-doses to prevent heart attacks and cancer. It was isolated from meadowsweet (Filipendula ulmaria, formerly classified as Spiraea ulmaria) by German researchers in 1839. While their extract was somewhat effective, it also caused digestive problems such as irritated stomach and diarrhoea, and even death when consumed in high doses. In 1853, a French chemist named Charles Frederic Gerhardt neutralized salicylic acid by buffering it with sodium (sodium salicylate) and acetyl chloride, creating acetosalicylic anhydride. Gerhardt's product worked, but he had no desire to market it and abandoned his discovery. In 1897, researcher Arthur Eichengrun and Felix Hoffmann, a research assistant at Friedrich Bayer & Co. in Germany, derivatized one of the hydroxyl functional groups in salicylic acid with an acetyl group (forming the acetyl ester), which greatly reduced the negative effects. This was the first synthetic drug, not a copy of something that existed in nature, and the start of the pharmaceuticals industry. The name 'aspirin' is composed of a- (from the acetyl group) -spir- (from the plant genus Spiraea) and -in (a common ending for drugs at the time). It has also been stated that the name originated by another means. As referring to AcetylSalicylic and 'pir' in reference to one of the scientists who was able to isolate it in crystalline form, Raffaele Piria. Finally 'in' due to the same reasons as stated above. Salicylic acid (which is a naturally occurring substance found in many plants) can be acetylated using acetic anhydride, yielding aspirin and acetic acid as a byproduct. It is a common experiment performed in organic chemistry labs, and generally tends to produce low yields due to the relative difficulty of its extraction from an aqueous state. The trick to getting the reaction to work is to acidify with phosphoric acid and heat the reagents under reflux with a boiling water bath for between 40 minutes and an hour. Aspirin acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5).",
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"attributes": null
},
{
"attribute_type_id": "biolink:synonym",
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"value": [
"Acetylsalicylic acid",
"Acetyl salicylate",
"Polopiryna",
"Acetysal",
"aspirin",
"Aspirin",
"acetylsalicylic acid",
"acetyl salicylate",
"Aspirin (JP18/USP)",
"ASPIRIN"
],
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"value_url": null,
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"attributes": null
},
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"PathWhiz.Compound:1251",
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"CHEMBL.COMPOUND:CHEMBL25",
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"NCIT:C287",
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"NDDF:001587",
"HMDB:HMDB0001879",
"MESH:D001241",
"UMLS:C0004057",
"UMLS:C0699278",
"LOINC:LA26702-3",
"KEGG.DRUG:D00109",
"KEGG.COMPOUND:C01405",
"CHEBI:15365",
"DrugCentral:74",
"DRUGBANK:DB00945"
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"attributes": null
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"PMID:9597150",
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"name": "ACE",
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"biolink:Protein"
],
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"value": "Angiotensin-converting enzyme (1306 aa, ~150 kDa) is encoded by the human ACE gene. This protein plays a role in the hydrolysis of angiotensin I to form angiotensin II and the solubilization of glycophophoinositol-anchored proteins from the plasma membrane.; UMLS Semantic Type: STY:T123; UMLS Semantic Type: STY:T116",
"value_type_id": "metatype:String",
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"attributes": null
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"description": "Categories of all nodes in this synonym set in RTX-KG2.",
"attributes": null
},
{
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"value": [
"angiotensin-converting enzyme (rat)",
"Ace",
"Ace (mouse)",
"ACE (human)",
"ACE protein, human",
"Ace (rat)",
"ACE(30-1306) [plasma membrane]",
"angiotensin-converting enzyme (mouse)",
"ACE",
"ACE Gene",
"ACE(30-1232) [extracellular region]",
"acetylcholinesterase (fruit fly)",
"ACE gene",
"angiotensin-converting enzyme (human)"
],
"value_type_id": "metatype:String",
"attribute_source": null,
"value_url": null,
"description": "Names of all nodes in this synonym set in RTX-KG2.",
"attributes": null
},
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"value": [
"MESH:C488034",
"RGD:2493",
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"UMLS:C1413931",
"UniProtKB:P12821",
"LOINC:LP95187-8",
"REACT:R-HSA-2065414",
"NCBIGene:1636",
"OMIM:106180",
"REACT:R-HSA-508496",
"PR:P07140",
"LOINC:LP230189-5",
"PR:P12821",
"PR:P47820",
"UMLS:C1452534",
"ENSEMBL:ENSG00000159640",
"NCIT:C91295",
"MGI:87874",
"PR:P09470"
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"attributes": null
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"value": [
"DOI:10.1006/bbrc.1998.8813",
"PMID:16476442",
"PMID:12459472",
"DOI:10.1021/bi00243a012",
"PMID:16625196",
"PMID:15671045",
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"PMID:1649623",
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"DOI:10.1038/nature01370"
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"name": "HYDROCORTISONE BUTYRATE",
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"biolink:ChemicalEntity"
],
"attributes": [
{
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"original_attribute_name": null,
"value": "https://identifiers.org/chembl.compound:CHEMBL1683",
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"value": "Cortisol is the main glucocorticoid secreted by the adrenal cortex and it is involved in the stress response. Its synthetic counterpart hydrocortisone is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. Hydrocortisone is synthesized from pregnenolone and is used as an immunosuppressive drug given by injection in the treatment of severe allergic reactions such as anaphylaxis and angioedema, in place of prednisolone in patients who need steroid treatment but cannot take oral medication, and peri-operatively in patients on long-term steroid treatment to prevent an Addisonian crisis. Cortisol increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. The amount of cortisol present in the serum undergoes diurnal variation, with the highest levels present in the early morning and lower levels in the evening, several hours after the onset of sleep. Cortisol is found to be associated with ACTH deficiency and glucocorticoid deficiency, which are inborn errors of metabolism. Cortisol binds to the cytosolic glucocorticoid receptor. After binding the receptor, the newly formed receptor-ligand complex translocates itself into the cell nucleus where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA-bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes. The anti-inflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Specifically, glucocorticoids induce lipocortin-1 (annexin-1) synthesis, which then binds to cell membranes and prevents phospholipase A2 from coming into contact with its substrate arachidonic acid. This leads to diminished eicosanoid production. The cyclooxygenase (both COX-1 and COX-2) expression is also suppressed, potentiating the effect. In other words, the two main products of inflammation, prostaglandins and leukotrienes, are inhibited by the action of glucocorticoids. Glucocorticoids also stimulate the escape of lipocortin-1 into the extracellular space, where it binds to the leukocyte membrane receptors and inhibits various inflammatory events: epithelial adhesion, emigration, chemotaxis, phagocytosis, respiratory burst, and the release of various inflammatory mediators (lysosomal enzymes, cytokines, tissue plasminogen activator, chemokines, etc.) from neutrophils, macrophages, and mastocytes. Additionally, the immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.",
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"attributes": null
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{
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"value": [
"Kendall's compound F",
"hydrocortisone",
"Hydrocortisone Valerate",
"hydrocortamate hydrochloride",
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"Hydrocortisone butyrate",
"Reichstein's substance M",
"Hydrocortamate Hydrochloride",
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"Hydrocortisone aceponate",
"pentanoic acid [11-hydroxy-17-(2-hydroxy-1-oxoethyl)-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] ester",
"Pentanoic acid 11-hydroxy-17-(2-hydroxy-acetyl)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester",
"hydrocortisone-17-butyrate",
"Hydrocortisone",
"HYDROCORTISONE",
"Hydrocortamate",
"Locoid",
"HYDROCORTISONE VALERATE",
"Hydrocortisone valerate",
"HYDROCORTISONE CYPIONATE",
"cortisol 17-butyrate",
"cortisol",
"HYDROCORTISONE BUTYRATE",
"Hydrocortisone Cypionate",
"hydrocortamate",
"HYDROCORTISONE ACEPONATE",
"Hydrocortisone cypionate",
"Hydrocortisone Aceponate",
"hydrocortisone valerate",
"CORT [nucleoplasm]",
"Hydrocortisone Butyrate",
"Hydrocortamate hydrochloride",
"Westcort",
"hydrocortisone cypionate",
"CORT [mitochondrial matrix]",
"hydrocortisone aceponate",
"cortisol 17-valerate",
"CORT [cytosol]",
"HYDROCORTAMATE",
"CORT [extracellular region]",
"Cortisol",
"Hydrocortisone valerate (USP)",
"hydrocortisone butyrate",
"Hydrocortisone aceponate (INN)"
],
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"attributes": null
},
{
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"value": [
"PathWhiz.Compound:45",
"NCIT:C65864",
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"LOINC:MTHU035101",
"LOINC:MTHU001562",
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"UMLS:C0020268",
"REACT:R-ALL-5618097",
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"DrugCentral:1389",
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"attributes": null
},
{
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"original_attribute_name": null,
"value": [
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"PMID:24660966",
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"PMID:25454267",
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"PMID:23033255",
"PMID:25282654",
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"PMID:25156301"
],
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"attribute_source": null,
"value_url": null,
"description": null,
"attributes": null
}
]
},
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"name": "VDR",
"categories": [
"biolink:Gene",
"biolink:Protein"
],
"attributes": [
{
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"value": "https://identifiers.org/uniprot:P11473",
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"attribute_source": null,
"value_url": "https://identifiers.org/uniprot:P11473",
"description": null,
"attributes": null
},
{
"attribute_type_id": "biolink:description",
"original_attribute_name": null,
"value": "Vitamin D3 receptor (427 aa, ~48 kDa) is encoded by the human VDR gene. This protein is involved in vitamin D-mediated transcriptional regulation.; UMLS Semantic Type: STY:T192; UMLS Semantic Type: STY:T116",
"value_type_id": "metatype:String",
"attribute_source": null,
"value_url": null,
"description": null,
"attributes": null
},
{
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"value": [
"biolink:BiologicalEntity",
"biolink:Gene",
"biolink:Protein",
"biolink:Polypeptide"
],
"value_type_id": "metatype:Uriorcurie",
"attribute_source": null,
"value_url": null,
"description": "Categories of all nodes in this synonym set in RTX-KG2.",
"attributes": null
},
{
"attribute_type_id": "biolink:synonym",
"original_attribute_name": null,
"value": [
"vitamin D3 receptor (human)",
"VDR protein, human",
"Vdr (rat)",
"vitamin D3 receptor (cow)",
"SUMO2-VDR [nucleoplasm]",
"VDR (chicken)",
"vitamin D3 receptor (rat)",
"vitamin D3 receptor (chicken)",
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"value": "-!- FUNCTION: Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. {ECO:0000250, ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:11831900, ECO:0000269|PubMed:15990874}. -!- CATALYTIC ACTIVITY: Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:17544; EC=4.2.1.1; -!- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:11076507, ECO:0000269|PubMed:12499545, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:1433293, ECO:0000269|PubMed:1909891, ECO:0000269|PubMed:19583303, ECO:0000269|PubMed:3151019, ECO:0000269|PubMed:3151020, ECO:0000269|PubMed:7761440, ECO:0000269|PubMed:7803386, ECO:0000269|PubMed:7901850, ECO:0000269|PubMed:8218160, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:8331673, ECO:0000269|PubMed:8399159, ECO:0000269|PubMed:8431430, ECO:0000269|PubMed:8451242, ECO:0000269|PubMed:8482389, ECO:0000269|PubMed:8639494, ECO:0000269|PubMed:8987974, ECO:0000269|PubMed:9398308, ECO:0000269|PubMed:9865942}; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence={ECO:0000269|PubMed:19583303}; Note=Zinc. Can also use cobalt(II) with lower efficiency, but not copper(II), nickel(II) and manganese(II). {ECO:0000269|PubMed:19583303}; -!- ACTIVITY REGULATION: Activated by X-ray, histamine, L-adrenaline, L- and D-phenylalanine, L- and D-histidine, L-His-OMe and beta-Ala-His (carnosine). Competitively inhibited by saccharin, thioxolone, coumarins, 667-coumate, celecoxib (Celebrex), valdecoxib (Bextra), SC-125, SC-560, diclofenac, acetate, azide, bromide, sulfonamide derivatives such as acetazolamide (AZA), methazolamide (MZA), ethoxzolamide (EZA), dichlorophenamide (DCP), brinzolamide, dansylamide, thiabendazole-5-sulfonamide, trifluoromethane sulfonamide and N-hydroxysulfamide, fructose-based sugar sulfamate RWJ-37497, and Foscarnet (phosphonoformate trisodium salt). Repressed strongly by hydrogen sulfide(HS) and weakly by nitrate (NO(3)). Esterase activity weakly reduced by cyanamide. N-hydroxyurea interfers with zinc binding and inhibit activity. {ECO:0000269|PubMed:11802772, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:14736236, ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:16290146, ECO:0000269|PubMed:16686544, ECO:0000269|PubMed:16759856, ECO:0000269|PubMed:16807956, ECO:0000269|PubMed:17127057, ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17540563, ECO:0000269|PubMed:17588751, ECO:0000269|PubMed:17705204, ECO:0000269|PubMed:18024029, ECO:0000269|PubMed:18162396, ECO:0000269|PubMed:18266323, ECO:0000269|PubMed:18374572, ECO:0000269|PubMed:18481843, ECO:0000269|PubMed:18618712, ECO:0000269|PubMed:18640037, ECO:0000269|PubMed:1910042, ECO:0000269|PubMed:19170619, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230, ECO:0000269|PubMed:19520834, ECO:0000269|PubMed:19778001, ECO:0000269|PubMed:9265618}. -!- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=9.3 mM for CO(2) {ECO:0000269|PubMed:18618712, ECO:0000269|PubMed:7761440}; KM=11 mM for CO(2) {ECO:0000269|PubMed:1909891}; KM=8.2 mM for CO(2) {ECO:0000269|PubMed:9398308}; KM=82 mM for H(2)CO(3) {ECO:0000269|PubMed:8262987}; KM=2.9 mM for 4-nitrophenyl acetate {ECO:0000269|PubMed:10550681}; pH dependence: Optimum pH is 6-8. {ECO:0000269|PubMed:15667203, ECO:0000269|PubMed:17330962, ECO:0000269|PubMed:18942852, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:9398308}; -!- SUBUNIT: Interacts with SLC4A4. Interaction with SLC4A7 regulates SLC4A7 transporter activity. Interacts with SLC26A6 isoform 4 (via C-terminus cytoplasmic domain). {ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:11015219, ECO:0000269|PubMed:11076507, ECO:0000269|PubMed:11327835, ECO:0000269|PubMed:11572683, ECO:0000269|PubMed:11802772, ECO:0000269|PubMed:11818565, ECO:0000269|PubMed:11831900, ECO:0000269|PubMed:12056894, ECO:0000269|PubMed:12166932, ECO:0000269|PubMed:12499545, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:1433293, ECO:0000269|PubMed:14567693, ECO:0000269|PubMed:14736236, ECO:0000269|PubMed:14736710, ECO:0000269|PubMed:1474587, ECO:0000269|PubMed:15218065, ECO:0000269|PubMed:15299481, ECO:0000269|PubMed:15299482, ECO:0000269|PubMed:15453828, ECO:0000269|PubMed:15865431, ECO:0000269|PubMed:15990874, ECO:0000269|PubMed:16134940, ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:16290146, ECO:0000269|PubMed:16506782, ECO:0000269|PubMed:16686544, ECO:0000269|PubMed:16759856, ECO:0000269|PubMed:16787097, ECO:0000269|PubMed:16807956, ECO:0000269|PubMed:16820676, ECO:0000269|PubMed:16942027, ECO:0000269|PubMed:17000110, ECO:0000269|PubMed:17071654, ECO:0000269|PubMed:17125255, ECO:0000269|PubMed:17127057, ECO:0000269|PubMed:17181151, ECO:0000269|PubMed:17251017, ECO:0000269|PubMed:17346964, ECO:0000269|PubMed:17407288, ECO:0000269|PubMed:17540563, ECO:0000269|PubMed:17588751, ECO:0000269|PubMed:17705204, ECO:0000269|PubMed:18024029, ECO:0000269|PubMed:18161740, ECO:0000269|PubMed:18162396, ECO:0000269|PubMed:18260615, ECO:0000269|PubMed:18266323, ECO:0000269|PubMed:18359629, ECO:0000269|PubMed:18374572, ECO:0000269|PubMed:18461940, ECO:0000269|PubMed:18481843, ECO:0000269|PubMed:18640037, ECO:0000269|PubMed:18723489, ECO:0000269|PubMed:18768466, ECO:0000269|PubMed:1909891, ECO:0000269|PubMed:19115843, ECO:0000269|PubMed:19170619, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230, ECO:0000269|PubMed:1932029, ECO:0000269|PubMed:19520834, ECO:0000269|PubMed:19583303, ECO:0000269|PubMed:19731956, ECO:0000269|PubMed:19778001, ECO:0000269|PubMed:19827837, ECO:0000269|PubMed:3151019, ECO:0000269|PubMed:3151020, ECO:0000269|PubMed:7608893, ECO:0000269|PubMed:7696263, ECO:0000269|PubMed:7761440, ECO:0000269|PubMed:7803386, ECO:0000269|PubMed:7901850, ECO:0000269|PubMed:8070585, ECO:0000269|PubMed:8142888, ECO:0000269|PubMed:8218160, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:8331673, ECO:0000269|PubMed:8399159, ECO:0000269|PubMed:8431430, ECO:0000269|PubMed:8451242, ECO:0000269|PubMed:8482389, ECO:0000269|PubMed:8557623, ECO:0000269|PubMed:8639494, ECO:0000269|PubMed:8987974, ECO:0000269|PubMed:9265618, ECO:0000269|PubMed:9398308, ECO:0000269|PubMed:9541386, ECO:0000269|PubMed:9865942}. -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15990874}. Cell membrane {ECO:0000269|PubMed:15990874}. Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells. -!- DISEASE: Osteopetrosis, autosomal recessive 3 (OPTB3) [MIM:259730]: A rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. Osteopetrosis occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Recessive osteopetrosis commonly manifests in early infancy with macrocephaly, feeding difficulties, evolving blindness and deafness, bone marrow failure, severe anemia, and hepatosplenomegaly. Deafness and blindness are generally thought to represent effects of pressure on nerves. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation. {ECO:0000269|PubMed:15300855, ECO:0000269|PubMed:1542674, ECO:0000269|PubMed:1928091, ECO:0000269|PubMed:8834238, ECO:0000269|PubMed:9143915}. Note=The disease is caused by variants affecting the gene represented in this entry. -!- MISCELLANEOUS: Target of drugs used in treatments against glaucoma disorder and breast cancer. -!- SIMILARITY: Belongs to the alpha-carbonic anhydrase family. {ECO:0000305}. ; Short=CAC; Short=CA-IIEvidence Codes from Name: ",
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"value": "Tyrosine (Tyr) or L-tyrosine is an alpha-amino acid. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). Amino acids are organic compounds that contain amino (\u201a\u00c4\u00ecNH2) and carboxyl (\u201a\u00c4\u00ecCOOH) functional groups, along with a side chain (R group) specific to each amino acid. L-tyrosine is one of 20 proteinogenic amino acids, i.e., the amino acids used in the biosynthesis of proteins. Tyrosine is found in all organisms ranging from bacteria to plants to animals. It is classified as a non-polar, uncharged (at physiological pH) aromatic amino acid. Tyrosine is a non-essential amino acid, meaning the body can synthesize it \u201a\u00c4\u00ec usually from phenylalanine. The conversion of phenylalanine to tyrosine is catalyzed by the enzyme phenylalanine hydroxylase, a monooxygenase. This enzyme catalyzes the reaction causing the addition of a hydroxyl group to the end of the 6-carbon aromatic ring of phenylalanine, such that it becomes tyrosine. Tyrosine is found in many high-protein food products such as chicken, turkey, fish, milk, yogurt, cottage cheese, cheese, peanuts, almonds, pumpkin seeds, sesame seeds, soy products, lima beans, avocados and bananas. Tyrosine is one of the few amino acids that readily passes the blood-brain barrier. Once in the brain, it is a precursor for the neurotransmitters dopamine, norepinephrine and epinephrine, better known as adrenalin. These neurotransmitters are an important part of the body's sympathetic nervous system, and their concentrations in the body and brain are directly dependent upon dietary tyrosine. Tyrosine is not found in large concentrations throughout the body, probably because it is rapidly metabolized. Folic acid, copper and vitamin C are cofactor nutrients of these reactions. Tyrosine is also the precursor for hormones, including thyroid hormones (diiodotyrosine), catecholestrogens and the major human pigment, melanin. Tyrosine is an important amino acid in many proteins, peptides and even enkephalins, the body's natural pain reliever. Valine and other branched amino acids, and possibly tryptophan and phenylalanine may reduce tyrosine absorption. A number of genetic errors of tyrosine metabolism have been identified, such as hawkinsinuria and tyrosinemia I. The most common feature of these diseases is the increased amount of tyrosine in the blood, which is marked by decreased motor activity, lethargy and poor feeding. Infection and intellectual deficits may occur. Vitamin C supplements can help reverse these disease symptoms. Some adults also develop elevated tyrosine in their blood. This typically indicates a need for more vitamin C. More tyrosine is needed under stress, and tyrosine supplements prevent the stress-induced depletion of norepinephrine and can help aleviate biochemical depression. However, tyrosine may not be good for treating psychosis. Many antipsychotic medications apparently function by inhibiting tyrosine metabolism. L-Dopa, which is directly used in Parkinson's, is made from tyrosine. Tyrosine, the nutrient, can be used as an adjunct in the treatment of Parkinson's. Peripheral metabolism of tyrosine necessitates large doses of tyrosine, however, compared to L-Dopa (http://www.dcnutrition.com). In addition to its role as a precursor for neurotransmitters, tyrosine plays an important role for the function of many proteins. Within many proteins or enzymes, certain tyrosine residues can be tagged (at the hydroxyl group) with a phosphate group (phosphorylated) by specialized protein kinases. In its phosphorylated form, tyrosine is called phosphotyrosine. Tyrosine phosphorylation is considered to be one of the key steps in signal transduction and regulation of enzymatic activity. Tyrosine (or its precursor phenylalanine) is also needed to synthesize the benzoquinone structure which forms part of coenzyme Q10.",
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"value": "Phenylalanine (Phe), also known as L-phenylalanine is an alpha-amino acid. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). Amino acids are organic compounds that contain amino (\u201a\u00c4\u00ecNH2) and carboxyl (\u201a\u00c4\u00ecCOOH) functional groups, along with a side chain (R group) specific to each amino acid. L-phenylalanine is one of 20 proteinogenic amino acids, i.e., the amino acids used in the biosynthesis of proteins. Phenylalanine is found in all organisms ranging from bacteria to plants to animals. It is classified as an aromatic, non-polar amino acid. In humans, phenylalanine is an essential amino acid and the precursor of the amino acid tyrosine. Like tyrosine, phenylalanine is also a precursor for catecholamines including tyramine, dopamine, epinephrine, and norepinephrine. Catecholamines are neurotransmitters that act as adrenalin-like substances. Interestingly, several psychotropic drugs (mescaline, morphine, codeine, and papaverine) also have phenylalanine as a constituent. Phenylalanine is highly concentrated in the human brain and plasma. Normal metabolism of phenylalanine requires biopterin, iron, niacin, vitamin B6, copper, and vitamin C. An average adult ingests 5 g of phenylalanine per day and may optimally need up to 8 g daily. Phenylalanine is highly concentrated in a number of high protein foods, such as meat, cottage cheese, and wheat germ. An additional dietary source of phenylalanine is artificial sweeteners containing aspartame (a methyl ester of the aspartic acid/phenylalanine dipeptide). As a general rule, aspartame should be avoided by phenylketonurics and pregnant women. When present in sufficiently high levels, phenylalanine can act as a neurotoxin and a metabotoxin. A neurotoxin is a compound that disrupts or attacks neural cells and neural tissue. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Chronically high levels of phenylalanine are associated with at least five inborn errors of metabolism, including Hartnup disorder, hyperphenylalaninemia due to guanosine triphosphate cyclohydrolase deficiency, phenylketonuria (PKU), tyrosinemia type 2 (or Richner-Hanhart syndrome), and tyrosinemia type III (TYRO3). Phenylketonurics have elevated serum plasma levels of phenylalanine up to 400 times normal. High plasma concentrations of phenylalanine influence the blood-brain barrier transport of large neutral amino acids. The high plasma phenylalanine concentrations increase phenylalanine entry into the brain and restrict the entry of other large neutral amino acids (PMID: 19191004). Phenylalanine has been found to interfere with different cerebral enzyme systems. Untreated phenylketonuria (PKU) can lead to intellectual disability, seizures, behavioural problems, and mental disorders. It may also result in a musty smell and lighter skin. Classic PKU dramatically affects myelination and white matter tracts in untreated infants; this may be one major cause of neurological disorders associated with phenylketonuria. Mild phenylketonuria can act as an unsuspected cause of hyperactivity, learning problems, and other developmental problems in children. It has been recently suggested that PKU may resemble amyloid diseases, such as Alzheimer's disease and Parkinson's disease, due to the formation of toxic amyloid-like assemblies of phenylalanine (PMID: 22706200). Phenylalanine also has some potential benefits. Phenylalanine can act as an effective pain reliever. Its use in premenstrual syndrome and Parkinson's may enhance the effects of acupuncture and electric transcutaneous nerve stimulation (TENS). Phenylalanine and tyrosine, like L-DOPA, produce a catecholamine-like effect. Phenylalanine is better absorbed than tyrosine and may cause fewer headaches. Low phenylalanine diets have been prescribed for certain cancers with mixed results. For instance, some tumours use more phenylalanine than others (particularly melatonin-producing tumours called melanomas).",
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