build-pex.sh

#!/bin/bash
set -ex
rm -rf build
mkdir build
python -m virtualenv ./build/venv/
./build/venv/bin/pip install --upgrade wheel pex setuptools
./build/venv/bin/python setup.py bdist_wheel
./build/venv/bin/pex --cache-dir build/pex-cache --repo dist/ -r myprogram -e myprogram:main -o dist/myprogram

requirements.txt

boto==2.36.0
flask==0.10.1

setup.py

from setuptools import setup
import os

directory = os.path.dirname(__file__)
with open(os.path.join(directory, 'requirements.txt')) as requirements_file:
    requirements = requirements_file.read().splitlines()

setup(
    name='myprogram',
    version='0.0.1',
    url='https://example.com/myprogram',
    license='Public Domain',
    author='dln@eintr.org',
    description='My incredible program',
    long_description=__doc__,
    packages=[
        'myprogram',
    ],
    zip_safe=False,
    platforms='any',
    install_requires=requirements,
    entry_points={
        'console_scripts': ['myprogram=myprogram:main']
    }
)