Pumas Error from doing solve(LinearProblem(A, b)) in @pre

gistfile1.txt

ERROR: TaskFailedException
Stacktrace:
  [1] wait
    @ .\task.jl:349 [inlined]
  [2] fetch
    @ .\task.jl:369 [inlined]
  [3] __tmapreduce(f::Pumas.var"#731#732"{Pumas.ThreadedBayesLogDensity{PumasModel{(tv_kf_AT = 1, tv_Kd_AT = 1, tv_kf_BT = 1, tv_Kd_BT = 1, tv_kf_CT = 1, tv_Kd_CT = 1, tv_kf_DT = 1, tv_Kd_DT = 1, tv_mα = 1, tv_α₀ = 1, σ = 1), 1, (:DMn_s, :CaDMn_s, :DMn_f, :CaDMn_f, :PP, :CaPP, :OGB5, :CaOGB5, :T0, :T_A, :T_B, :T_C, :T_D, :T_AB, :T_AC, :T_AD, :T_BC, :T_BD, :T_CD, :T_ABC, :T_ABD, :T_ACD, :T_BCD, :T_ABCD, :Ca), ParamSet{NamedTuple{(:tv_kf_AT, :tv_Kd_AT, :tv_kf_BT, :tv_Kd_BT, :tv_kf_CT, :tv_Kd_CT, :tv_kf_DT, :tv_Kd_DT, :tv_mα, :tv_α₀, :σ), Tuple{Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, RealDomain{Float64, Int64, Float64}, RealDomain{TransformVariables.Infinity{false}, TransformVariables.Infinity{true}, Float64}, RealDomain{Float64, TransformVariables.Infinity{true}, Int64}}}}, var"#531#540", Pumas.TimeDispatcher{var"#532#541", var"#533#542"}, Nothing, var"#535#544", ODEProblem{Nothing, Tuple{Nothing, Nothing}, true, SciMLBase.NullParameters, ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.ODEFunctionClosure{var"#536#545", var"#537#546"}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Vector{Symbol}, Symbol, Vector{Symbol}, typeof(SciMLBase.DEFAULT_OBSERVED), Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Tuple{}, NamedTuple{(), Tuple{}}}, SciMLBase.StandardODEProblem}, var"#538#547", var"#539#548", ModelingToolkit.ODESystem}, NamedTuple{(:tv_kf_AT, :tv_Kd_AT, :tv_kf_BT, :tv_Kd_BT, :tv_kf_CT, :tv_Kd_CT, :tv_kf_DT, :tv_Kd_DT, :tv_mα, :tv_α₀, :σ), Tuple{Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Int64}}, Vector{Subject{NamedTuple{(:F_F0,), Tuple{Vector{Float64}}}, Pumas.ConstantCovar{NamedTuple{(:cov_f_frac, :cov_τ_f, :cov_τ_s, :cov_kon_DMn, :cov_koff_DMn, :cov_Kd_DMn, :cov_koff_PP, :cov_DMn_t, :cov_CaM_t, :cov_OGB5_t, :cov_Ca_free, :PCD), Tuple{Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Int64}}}, Nothing, Vector{Float64}}}, Vector{Vector{Float64}}, Vector{Vector{Float64}}, Vector{ForwardDiff.GradientConfig{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6, Vector{ForwardDiff.Dual{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6}}}}, Vector{DiffResults.MutableDiffResult{1, Float64, Tuple{Vector{Float64}}}}, NamedTuple{(:alg,), Tuple{Rodas5P{0, true, Nothing, typeof(OrdinaryDiffEq.DEFAULT_PRECS), Val{:forward}, true, nothing}}}}, Vector{Float64}, TransformVariables.TransformTuple{NamedTuple{(:tv_kf_AT, :tv_Kd_AT, :tv_kf_BT, :tv_Kd_BT, :tv_kf_CT, :tv_Kd_CT, :tv_kf_DT, :tv_Kd_DT, :tv_mα, :tv_α₀, :σ), Tuple{TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.Identity, TransformVariables.ShiftedExp{true, Float64}}}}, Vector{Float64}}, op::typeof(+), tasks::Vector{Task}, len::Int64, init::Float64, src::Tuple{UnitRange{Int64}}, batchargs::Tuple{Vector{Vector{Float64}}, Vector{Vector{Float64}}, Vector{DiffResults.MutableDiffResult{1, Float64, Tuple{Vector{Float64}}}}, Vector{ForwardDiff.GradientConfig{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6, Vector{ForwardDiff.Dual{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6}}}}})
    @ Pumas C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\Pumas\VyE8h\src\estimation\bayes\logdensity.jl:426
  [4] _tmapreduce
    @ C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\Pumas\VyE8h\src\estimation\bayes\logdensity.jl:448 [inlined]
  [5] tmapreduce(f::Function, ::Type{Float64}, op::Function, src::Tuple{UnitRange{Int64}}, batchargs::Tuple{Vector{Vector{Float64}}, Vector{Vector{Float64}}, Vector{DiffResults.MutableDiffResult{1, Float64, Tuple{Vector{Float64}}}}, Vector{ForwardDiff.GradientConfig{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6, Vector{ForwardDiff.Dual{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6}}}}}; init::Float64, tasks::Vector{Task})
    @ Pumas C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\Pumas\VyE8h\src\estimation\bayes\logdensity.jl:459
  [6] tmapreduce
    @ C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\Pumas\VyE8h\src\estimation\bayes\logdensity.jl:450 [inlined]
  [7] _logdensitygrad(b::Pumas.ThreadedBayesLogDensity{PumasModel{(tv_kf_AT = 1, tv_Kd_AT = 1, tv_kf_BT = 1, tv_Kd_BT = 1, tv_kf_CT = 1, tv_Kd_CT = 1, tv_kf_DT = 1, tv_Kd_DT = 1, tv_mα = 1, tv_α₀ = 1, σ = 1), 1, (:DMn_s, :CaDMn_s, :DMn_f, :CaDMn_f, :PP, :CaPP, 
:OGB5, :CaOGB5, :T0, :T_A, :T_B, :T_C, :T_D, :T_AB, :T_AC, :T_AD, :T_BC, :T_BD, :T_CD, :T_ABC, :T_ABD, :T_ACD, :T_BCD, :T_ABCD, :Ca), ParamSet{NamedTuple{(:tv_kf_AT, :tv_Kd_AT, :tv_kf_BT, :tv_Kd_BT, :tv_kf_CT, :tv_Kd_CT, :tv_kf_DT, :tv_Kd_DT, :tv_mα, :tv_α₀, :σ), Tuple{Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, RealDomain{Float64, Int64, Float64}, RealDomain{TransformVariables.Infinity{false}, TransformVariables.Infinity{true}, Float64}, RealDomain{Float64, TransformVariables.Infinity{true}, Int64}}}}, var"#531#540", Pumas.TimeDispatcher{var"#532#541", var"#533#542"}, Nothing, var"#535#544", ODEProblem{Nothing, Tuple{Nothing, Nothing}, true, SciMLBase.NullParameters, ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.ODEFunctionClosure{var"#536#545", var"#537#546"}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Vector{Symbol}, Symbol, Vector{Symbol}, typeof(SciMLBase.DEFAULT_OBSERVED), Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Tuple{}, NamedTuple{(), Tuple{}}}, SciMLBase.StandardODEProblem}, var"#538#547", var"#539#548", ModelingToolkit.ODESystem}, NamedTuple{(:tv_kf_AT, :tv_Kd_AT, :tv_kf_BT, 
:tv_Kd_BT, :tv_kf_CT, :tv_Kd_CT, :tv_kf_DT, :tv_Kd_DT, :tv_mα, :tv_α₀, :σ), Tuple{Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Int64}}, Vector{Subject{NamedTuple{(:F_F0,), Tuple{Vector{Float64}}}, Pumas.ConstantCovar{NamedTuple{(:cov_f_frac, :cov_τ_f, :cov_τ_s, :cov_kon_DMn, :cov_koff_DMn, :cov_Kd_DMn, :cov_koff_PP, :cov_DMn_t, :cov_CaM_t, :cov_OGB5_t, :cov_Ca_free, :PCD), Tuple{Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Int64}}}, Nothing, Vector{Float64}}}, Vector{Vector{Float64}}, Vector{Vector{Float64}}, Vector{ForwardDiff.GradientConfig{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6, Vector{ForwardDiff.Dual{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6}}}}, Vector{DiffResults.MutableDiffResult{1, Float64, Tuple{Vector{Float64}}}}, NamedTuple{(:alg,), Tuple{Rodas5P{0, true, Nothing, typeof(OrdinaryDiffEq.DEFAULT_PRECS), Val{:forward}, true, nothing}}}}, v::Vector{Float64})
    @ Pumas C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\Pumas\VyE8h\src\estimation\bayes\logdensity.jl:371
  [8] logdensitygrad(b::Pumas.ThreadedBayesLogDensity{PumasModel{(tv_kf_AT = 1, tv_Kd_AT = 1, tv_kf_BT = 1, tv_Kd_BT = 1, tv_kf_CT = 1, tv_Kd_CT = 1, tv_kf_DT = 1, tv_Kd_DT = 1, tv_mα = 1, tv_α₀ = 1, σ = 1), 1, (:DMn_s, :CaDMn_s, :DMn_f, :CaDMn_f, :PP, :CaPP, :OGB5, :CaOGB5, :T0, :T_A, :T_B, :T_C, :T_D, :T_AB, :T_AC, :T_AD, :T_BC, :T_BD, :T_CD, :T_ABC, :T_ABD, :T_ACD, :T_BCD, :T_ABCD, :Ca), ParamSet{NamedTuple{(:tv_kf_AT, :tv_Kd_AT, :tv_kf_BT, :tv_Kd_BT, :tv_kf_CT, :tv_Kd_CT, :tv_kf_DT, :tv_Kd_DT, :tv_mα, :tv_α₀, :σ), Tuple{Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, RealDomain{Float64, Int64, Float64}, RealDomain{TransformVariables.Infinity{false}, TransformVariables.Infinity{true}, Float64}, RealDomain{Float64, TransformVariables.Infinity{true}, Int64}}}}, var"#531#540", Pumas.TimeDispatcher{var"#532#541", var"#533#542"}, Nothing, var"#535#544", ODEProblem{Nothing, Tuple{Nothing, Nothing}, true, SciMLBase.NullParameters, ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.ODEFunctionClosure{var"#536#545", var"#537#546"}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Vector{Symbol}, Symbol, Vector{Symbol}, typeof(SciMLBase.DEFAULT_OBSERVED), Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Tuple{}, NamedTuple{(), Tuple{}}}, SciMLBase.StandardODEProblem}, var"#538#547", var"#539#548", ModelingToolkit.ODESystem}, NamedTuple{(:tv_kf_AT, :tv_Kd_AT, :tv_kf_BT, :tv_Kd_BT, :tv_kf_CT, :tv_Kd_CT, :tv_kf_DT, :tv_Kd_DT, :tv_mα, :tv_α₀, :σ), Tuple{Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Int64}}, Vector{Subject{NamedTuple{(:F_F0,), Tuple{Vector{Float64}}}, Pumas.ConstantCovar{NamedTuple{(:cov_f_frac, :cov_τ_f, :cov_τ_s, :cov_kon_DMn, :cov_koff_DMn, :cov_Kd_DMn, :cov_koff_PP, :cov_DMn_t, :cov_CaM_t, :cov_OGB5_t, :cov_Ca_free, :PCD), Tuple{Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Int64}}}, Nothing, Vector{Float64}}}, Vector{Vector{Float64}}, Vector{Vector{Float64}}, Vector{ForwardDiff.GradientConfig{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6, Vector{ForwardDiff.Dual{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6}}}}, Vector{DiffResults.MutableDiffResult{1, Float64, Tuple{Vector{Float64}}}}, NamedTuple{(:alg,), Tuple{Rodas5P{0, true, Nothing, typeof(OrdinaryDiffEq.DEFAULT_PRECS), Val{:forward}, true, nothing}}}}, v::Vector{Float64})
    @ Pumas C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\Pumas\VyE8h\src\estimation\bayes\logdensity.jl:145
  [9] (::Pumas.var"#844#845"{Pumas.ThreadedBayesLogDensity{PumasModel{(tv_kf_AT = 1, tv_Kd_AT = 1, tv_kf_BT = 1, tv_Kd_BT = 1, tv_kf_CT = 1, tv_Kd_CT = 1, tv_kf_DT = 1, tv_Kd_DT = 1, tv_mα = 1, tv_α₀ = 1, σ = 1), 1, (:DMn_s, :CaDMn_s, :DMn_f, :CaDMn_f, :PP, :CaPP, :OGB5, :CaOGB5, :T0, :T_A, :T_B, :T_C, :T_D, :T_AB, :T_AC, :T_AD, :T_BC, :T_BD, :T_CD, :T_ABC, :T_ABD, :T_ACD, :T_BCD, :T_ABCD, :Ca), ParamSet{NamedTuple{(:tv_kf_AT, :tv_Kd_AT, :tv_kf_BT, :tv_Kd_BT, :tv_kf_CT, :tv_Kd_CT, :tv_kf_DT, :tv_Kd_DT, :tv_mα, :tv_α₀, :σ), Tuple{Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, RealDomain{Float64, Int64, Float64}, RealDomain{TransformVariables.Infinity{false}, TransformVariables.Infinity{true}, Float64}, RealDomain{Float64, TransformVariables.Infinity{true}, Int64}}}}, var"#531#540", Pumas.TimeDispatcher{var"#532#541", var"#533#542"}, Nothing, var"#535#544", ODEProblem{Nothing, Tuple{Nothing, Nothing}, true, SciMLBase.NullParameters, ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.ODEFunctionClosure{var"#536#545", var"#537#546"}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Vector{Symbol}, Symbol, Vector{Symbol}, typeof(SciMLBase.DEFAULT_OBSERVED), Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Tuple{}, NamedTuple{(), Tuple{}}}, SciMLBase.StandardODEProblem}, var"#538#547", var"#539#548", ModelingToolkit.ODESystem}, NamedTuple{(:tv_kf_AT, :tv_Kd_AT, :tv_kf_BT, :tv_Kd_BT, :tv_kf_CT, :tv_Kd_CT, :tv_kf_DT, :tv_Kd_DT, :tv_mα, :tv_α₀, :σ), Tuple{Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Int64}}, Vector{Subject{NamedTuple{(:F_F0,), Tuple{Vector{Float64}}}, Pumas.ConstantCovar{NamedTuple{(:cov_f_frac, :cov_τ_f, :cov_τ_s, :cov_kon_DMn, :cov_koff_DMn, :cov_Kd_DMn, :cov_koff_PP, :cov_DMn_t, :cov_CaM_t, :cov_OGB5_t, :cov_Ca_free, :PCD), Tuple{Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Int64}}}, Nothing, Vector{Float64}}}, Vector{Vector{Float64}}, Vector{Vector{Float64}}, Vector{ForwardDiff.GradientConfig{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6, Vector{ForwardDiff.Dual{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6}}}}, Vector{DiffResults.MutableDiffResult{1, Float64, Tuple{Vector{Float64}}}}, NamedTuple{(:alg,), Tuple{Rodas5P{0, true, Nothing, typeof(OrdinaryDiffEq.DEFAULT_PRECS), Val{:forward}, true, nothing}}}}})(f::Float64, g::Vector{Float64}, vparam::Vector{Float64})
    @ Pumas C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\Pumas\VyE8h\src\estimation\bayes\jointmap.jl:89
 [10] (::NLSolversBase.var"#69#70"{NLSolversBase.InplaceObjective{Nothing, Pumas.var"#844#845"{Pumas.ThreadedBayesLogDensity{PumasModel{(tv_kf_AT = 1, tv_Kd_AT = 1, tv_kf_BT = 1, tv_Kd_BT = 1, tv_kf_CT = 1, tv_Kd_CT = 1, tv_kf_DT = 1, tv_Kd_DT = 1, tv_mα = 1, tv_α₀ = 1, σ = 1), 1, (:DMn_s, :CaDMn_s, :DMn_f, :CaDMn_f, :PP, :CaPP, :OGB5, :CaOGB5, :T0, :T_A, :T_B, :T_C, :T_D, :T_AB, :T_AC, :T_AD, :T_BC, :T_BD, :T_CD, :T_ABC, :T_ABD, :T_ACD, :T_BCD, :T_ABCD, :Ca), ParamSet{NamedTuple{(:tv_kf_AT, :tv_Kd_AT, :tv_kf_BT, :tv_Kd_BT, :tv_kf_CT, :tv_Kd_CT, :tv_kf_DT, :tv_Kd_DT, :tv_mα, :tv_α₀, :σ), Tuple{Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, RealDomain{Float64, Int64, Float64}, RealDomain{TransformVariables.Infinity{false}, TransformVariables.Infinity{true}, Float64}, RealDomain{Float64, TransformVariables.Infinity{true}, Int64}}}}, var"#531#540", Pumas.TimeDispatcher{var"#532#541", var"#533#542"}, Nothing, var"#535#544", ODEProblem{Nothing, Tuple{Nothing, Nothing}, true, SciMLBase.NullParameters, ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.ODEFunctionClosure{var"#536#545", var"#537#546"}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Vector{Symbol}, Symbol, Vector{Symbol}, typeof(SciMLBase.DEFAULT_OBSERVED), Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Tuple{}, NamedTuple{(), Tuple{}}}, SciMLBase.StandardODEProblem}, var"#538#547", var"#539#548", ModelingToolkit.ODESystem}, NamedTuple{(:tv_kf_AT, :tv_Kd_AT, :tv_kf_BT, :tv_Kd_BT, :tv_kf_CT, :tv_Kd_CT, :tv_kf_DT, :tv_Kd_DT, :tv_mα, :tv_α₀, :σ), Tuple{Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Int64}}, Vector{Subject{NamedTuple{(:F_F0,), Tuple{Vector{Float64}}}, Pumas.ConstantCovar{NamedTuple{(:cov_f_frac, :cov_τ_f, :cov_τ_s, :cov_kon_DMn, :cov_koff_DMn, :cov_Kd_DMn, :cov_koff_PP, :cov_DMn_t, :cov_CaM_t, :cov_OGB5_t, :cov_Ca_free, :PCD), Tuple{Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Int64}}}, Nothing, Vector{Float64}}}, Vector{Vector{Float64}}, Vector{Vector{Float64}}, Vector{ForwardDiff.GradientConfig{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6, Vector{ForwardDiff.Dual{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6}}}}, Vector{DiffResults.MutableDiffResult{1, Float64, Tuple{Vector{Float64}}}}, NamedTuple{(:alg,), Tuple{Rodas5P{0, true, Nothing, typeof(OrdinaryDiffEq.DEFAULT_PRECS), Val{:forward}, true, nothing}}}}}, 
Nothing, Nothing, Nothing}, Float64})(G::Vector{Float64}, x::Vector{Float64})
    @ NLSolversBase C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\NLSolversBase\kavn7\src\objective_types\incomplete.jl:54
 [11] value_gradient!!(obj::NLSolversBase.OnceDifferentiable{Float64, Vector{Float64}, Vector{Float64}}, x::Vector{Float64})
    @ NLSolversBase C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\NLSolversBase\kavn7\src\interface.jl:82
 [12] initial_state(method::Optim.BFGS{LineSearches.InitialStatic{Float64}, LineSearches.BackTracking{Float64, Int64}, Nothing, Float64, Optim.Flat}, options::Optim.Options{Float64, Pumas.var"#598#600"{Pumas.DefaultOptimizeFN{Optim.BFGS{LineSearches.InitialStatic{Float64}, LineSearches.BackTracking{Float64, Int64}, Nothing, Float64, Optim.Flat}, NamedTuple{(:show_trace, :store_trace, :extended_trace, :g_tol, :allow_f_increases, :iterations), Tuple{Bool, Bool, Bool, Float64, Bool, Int64}}}, Pumas.var"#840#842"}}, d::NLSolversBase.OnceDifferentiable{Float64, Vector{Float64}, Vector{Float64}}, initial_x::Vector{Float64})
    @ Optim C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\Optim\Adqv3\src\multivariate\solvers\first_order\bfgs.jl:94
 [13] (::Pumas.DefaultOptimizeFN{Optim.BFGS{LineSearches.InitialStatic{Float64}, LineSearches.BackTracking{Float64, Int64}, Nothing, Float64, Optim.Flat}, NamedTuple{(:show_trace, :store_trace, :extended_trace, :g_tol, :allow_f_increases, :iterations), Tuple{Bool, Bool, Bool, Float64, Bool, Int64}}})(cost::NLSolversBase.OnceDifferentiable{Float64, Vector{Float64}, Vector{Float64}}, p::Vector{Float64}, callback::Pumas.var"#840#842", optim_state::Nothing, model::Nothing)
    @ Pumas C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\Pumas\VyE8h\src\estimation\likelihoods.jl:3061
 [14] (::Pumas.DefaultOptimizeFN{Optim.BFGS{LineSearches.InitialStatic{Float64}, LineSearches.BackTracking{Float64, Int64}, Nothing, Float64, Optim.Flat}, NamedTuple{(:show_trace, :store_trace, :extended_trace, :g_tol, :allow_f_increases, :iterations), Tuple{Bool, Bool, Bool, Float64, Bool, Int64}}})(cost::NLSolversBase.OnceDifferentiable{Float64, Vector{Float64}, Vector{Float64}}, p::Vector{Float64}, callback::Function)
    @ Pumas C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\Pumas\VyE8h\src\estimation\likelihoods.jl:3051
 [15] _fit(model::PumasModel{(tv_kf_AT = 1, tv_Kd_AT = 1, tv_kf_BT = 1, tv_Kd_BT = 1, tv_kf_CT = 1, tv_Kd_CT = 1, tv_kf_DT = 1, tv_Kd_DT = 1, tv_mα = 1, tv_α₀ = 1, σ = 1), 1, (:DMn_s, :CaDMn_s, :DMn_f, :CaDMn_f, :PP, :CaPP, :OGB5, :CaOGB5, :T0, :T_A, :T_B, :T_C, :T_D, :T_AB, :T_AC, :T_AD, :T_BC, :T_BD, :T_CD, :T_ABC, :T_ABD, :T_ACD, :T_BCD, :T_ABCD, :Ca), ParamSet{NamedTuple{(:tv_kf_AT, :tv_Kd_AT, :tv_kf_BT, :tv_Kd_BT, :tv_kf_CT, :tv_Kd_CT, :tv_kf_DT, :tv_Kd_DT, :tv_mα, :tv_α₀, :σ), Tuple{Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, RealDomain{Float64, Int64, Float64}, RealDomain{TransformVariables.Infinity{false}, TransformVariables.Infinity{true}, Float64}, RealDomain{Float64, TransformVariables.Infinity{true}, Int64}}}}, var"#531#540", Pumas.TimeDispatcher{var"#532#541", var"#533#542"}, Nothing, var"#535#544", ODEProblem{Nothing, Tuple{Nothing, Nothing}, true, SciMLBase.NullParameters, ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.ODEFunctionClosure{var"#536#545", var"#537#546"}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Vector{Symbol}, Symbol, Vector{Symbol}, typeof(SciMLBase.DEFAULT_OBSERVED), Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Tuple{}, NamedTuple{(), Tuple{}}}, SciMLBase.StandardODEProblem}, var"#538#547", var"#539#548", ModelingToolkit.ODESystem}, data::Vector{Subject{NamedTuple{(:F_F0,), Tuple{Vector{Float64}}}, Pumas.ConstantCovar{NamedTuple{(:cov_f_frac, :cov_τ_f, :cov_τ_s, :cov_kon_DMn, :cov_koff_DMn, :cov_Kd_DMn, :cov_koff_PP, :cov_DMn_t, :cov_CaM_t, :cov_OGB5_t, :cov_Ca_free, :PCD), Tuple{Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Int64}}}, Nothing, Vector{Float64}}}, param::NamedTuple{(:tv_kf_AT, :tv_Kd_AT, :tv_kf_BT, :tv_Kd_BT, :tv_kf_CT, :tv_Kd_CT, :tv_kf_DT, :tv_Kd_DT, :tv_mα, :tv_α₀, :σ), Tuple{Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, 
Float64, Int64}}, alg::JointMAP{EnsembleThreads, NamedTuple{(:alg,), Tuple{Rodas5P{0, true, Nothing, typeof(OrdinaryDiffEq.DEFAULT_PRECS), Val{:forward}, true, nothing}}}, Pumas.DefaultOptimizeFN{Optim.BFGS{LineSearches.InitialStatic{Float64}, LineSearches.BackTracking{Float64, Int64}, Nothing, Float64, Optim.Flat}, NamedTuple{(:show_trace, :store_trace, :extended_trace, :g_tol, :allow_f_increases, :iterations), Tuple{Bool, Bool, Bool, Float64, Bool, Int64}}}, Nothing, NamedTuple{(:iterations, :store_trace), Tuple{Int64, Bool}}, Pumas.var"#840#842", Nothing, Int64, NamedTuple{(), Tuple{}}})
    @ Pumas C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\Pumas\VyE8h\src\estimation\bayes\jointmap.jl:117
 [16] #fit#843
    @ C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\Pumas\VyE8h\src\estimation\bayes\jointmap.jl:61 [inlined]
 [17] top-level scope
    @ c:\Users\domli\.julia\dev\Faas_calmodulin\main.jl:52

    nested task error: MethodError: *(::Num, ::ForwardDiff.Dual{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6}) is ambiguous.

    Candidates:
      *(x::Real, y::ForwardDiff.Dual{Ty}) where Ty
        @ ForwardDiff C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\ForwardDiff\vXysl\src\dual.jl:145
      *(a::Num, b::Real)
        @ Symbolics C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\SymbolicUtils\qulQp\src\methods.jl:68
      *(a::Num, b::Number)
        @ Symbolics C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\SymbolicUtils\qulQp\src\methods.jl:70

    Possible fix, define
      *(::Num, ::ForwardDiff.Dual{Ty}) where Ty

    Stacktrace:
      [1] (::var"#532#541")(_param#10184::NamedTuple{(:tv_kf_AT, :tv_Kd_AT, :tv_kf_BT, :tv_Kd_BT, :tv_kf_CT, :tv_Kd_CT, :tv_kf_DT, :tv_Kd_DT, :tv_mα, :tv_α₀, :σ), NTuple{11, ForwardDiff.Dual{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6}}}, _random#10185::NamedTuple{(:η,), Tuple{ForwardDiff.Dual{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6}}}, _subject#10182::Subject{NamedTuple{(:F_F0,), Tuple{Vector{Float64}}}, Pumas.ConstantCovar{NamedTuple{(:cov_f_frac, :cov_τ_f, :cov_τ_s, :cov_kon_DMn, :cov_koff_DMn, :cov_Kd_DMn, :cov_koff_PP, :cov_DMn_t, :cov_CaM_t, :cov_OGB5_t, :cov_Ca_free, :PCD), Tuple{Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Int64}}}, Nothing, Vector{Float64}})
        @ Main C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\Pumas\VyE8h\src\dsl\model_macro.jl:822
      [2] TimeDispatcher
        @ C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\Pumas\VyE8h\src\dsl\model_macro.jl:502 [inlined]
      [3] TimeDispatcher
        @ C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\Pumas\VyE8h\src\dsl\model_macro.jl:499 [inlined]
      [4] #_derived#334
        @ C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\Pumas\VyE8h\src\models\model_api.jl:1311 [inlined]
      [5] _derived
        @ C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\Pumas\VyE8h\src\models\model_api.jl:1289 [inlined]
      [6] #conditional_nll#509
        @ C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\Pumas\VyE8h\src\estimation\likelihoods.jl:903 [inlined]
      [7] conditional_nll
        @ C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\Pumas\VyE8h\src\estimation\likelihoods.jl:894 [inlined]
      [8] _penalized_conditional_nll(model::PumasModel{(tv_kf_AT = 1, tv_Kd_AT = 1, tv_kf_BT = 1, tv_Kd_BT = 1, tv_kf_CT = 1, tv_Kd_CT = 1, tv_kf_DT = 1, tv_Kd_DT = 1, tv_mα = 1, tv_α₀ = 1, σ = 1), 1, (:DMn_s, :CaDMn_s, :DMn_f, :CaDMn_f, :PP, :CaPP, :OGB5, :CaOGB5, :T0, :T_A, :T_B, :T_C, :T_D, :T_AB, :T_AC, :T_AD, :T_BC, :T_BD, :T_CD, :T_ABC, :T_ABD, :T_ACD, :T_BCD, :T_ABCD, :Ca), ParamSet{NamedTuple{(:tv_kf_AT, :tv_Kd_AT, :tv_kf_BT, :tv_Kd_BT, :tv_kf_CT, :tv_Kd_CT, :tv_kf_DT, :tv_Kd_DT, :tv_mα, :tv_α₀, :σ), Tuple{Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, RealDomain{Float64, Int64, Float64}, RealDomain{TransformVariables.Infinity{false}, TransformVariables.Infinity{true}, 
Float64}, RealDomain{Float64, TransformVariables.Infinity{true}, Int64}}}}, var"#531#540", Pumas.TimeDispatcher{var"#532#541", var"#533#542"}, Nothing, var"#535#544", ODEProblem{Nothing, Tuple{Nothing, Nothing}, true, SciMLBase.NullParameters, ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.ODEFunctionClosure{var"#536#545", var"#537#546"}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Vector{Symbol}, Symbol, Vector{Symbol}, typeof(SciMLBase.DEFAULT_OBSERVED), Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Tuple{}, NamedTuple{(), Tuple{}}}, SciMLBase.StandardODEProblem}, var"#538#547", var"#539#548", ModelingToolkit.ODESystem}, subject::Subject{NamedTuple{(:F_F0,), Tuple{Vector{Float64}}}, Pumas.ConstantCovar{NamedTuple{(:cov_f_frac, :cov_τ_f, :cov_τ_s, :cov_kon_DMn, :cov_koff_DMn, :cov_Kd_DMn, :cov_koff_PP, :cov_DMn_t, :cov_CaM_t, :cov_OGB5_t, :cov_Ca_free, :PCD), Tuple{Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Int64}}}, Nothing, Vector{Float64}}, param::NamedTuple{(:tv_kf_AT, :tv_Kd_AT, :tv_kf_BT, :tv_Kd_BT, :tv_kf_CT, :tv_Kd_CT, :tv_kf_DT, :tv_Kd_DT, :tv_mα, :tv_α₀, :σ), NTuple{11, ForwardDiff.Dual{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6}}}, vrandeffsorth::SubArray{ForwardDiff.Dual{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6}, 1, Vector{ForwardDiff.Dual{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6}}, Tuple{UnitRange{Int64}}, true}, diffeq_options::NamedTuple{(:alg,), Tuple{Rodas5P{0, true, Nothing, typeof(OrdinaryDiffEq.DEFAULT_PRECS), Val{:forward}, true, nothing}}})
        @ Pumas C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\Pumas\VyE8h\src\estimation\likelihoods.jl:961
      [9] (::Pumas._L_rfx{TransformVariables.TransformTuple{NamedTuple{(:tv_kf_AT, :tv_Kd_AT, :tv_kf_BT, :tv_Kd_BT, :tv_kf_CT, :tv_Kd_CT, :tv_kf_DT, :tv_Kd_DT, :tv_mα, :tv_α₀, :σ), Tuple{TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.Identity, TransformVariables.ShiftedExp{true, Float64}}}}, PumasModel{(tv_kf_AT = 1, tv_Kd_AT = 1, tv_kf_BT = 1, tv_Kd_BT = 1, tv_kf_CT = 1, tv_Kd_CT = 1, tv_kf_DT = 1, tv_Kd_DT = 1, tv_mα = 1, tv_α₀ = 1, σ = 1), 1, (:DMn_s, :CaDMn_s, :DMn_f, :CaDMn_f, :PP, :CaPP, :OGB5, :CaOGB5, :T0, :T_A, :T_B, :T_C, :T_D, :T_AB, :T_AC, :T_AD, :T_BC, :T_BD, :T_CD, :T_ABC, :T_ABD, :T_ACD, :T_BCD, :T_ABCD, :Ca), ParamSet{NamedTuple{(:tv_kf_AT, :tv_Kd_AT, :tv_kf_BT, :tv_Kd_BT, :tv_kf_CT, :tv_Kd_CT, :tv_kf_DT, :tv_Kd_DT, :tv_mα, :tv_α₀, :σ), Tuple{Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, RealDomain{Float64, Int64, Float64}, RealDomain{TransformVariables.Infinity{false}, TransformVariables.Infinity{true}, Float64}, RealDomain{Float64, TransformVariables.Infinity{true}, Int64}}}}, var"#531#540", Pumas.TimeDispatcher{var"#532#541", var"#533#542"}, Nothing, var"#535#544", ODEProblem{Nothing, Tuple{Nothing, Nothing}, true, SciMLBase.NullParameters, ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.ODEFunctionClosure{var"#536#545", var"#537#546"}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Vector{Symbol}, Symbol, Vector{Symbol}, typeof(SciMLBase.DEFAULT_OBSERVED), Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Tuple{}, NamedTuple{(), Tuple{}}}, SciMLBase.StandardODEProblem}, var"#538#547", var"#539#548", ModelingToolkit.ODESystem}, Subject{NamedTuple{(:F_F0,), Tuple{Vector{Float64}}}, Pumas.ConstantCovar{NamedTuple{(:cov_f_frac, :cov_τ_f, :cov_τ_s, :cov_kon_DMn, :cov_koff_DMn, :cov_Kd_DMn, :cov_koff_PP, :cov_DMn_t, :cov_CaM_t, :cov_OGB5_t, :cov_Ca_free, :PCD), Tuple{Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Int64}}}, Nothing, Vector{Float64}}, NamedTuple{(:alg,), Tuple{Rodas5P{0, true, Nothing, typeof(OrdinaryDiffEq.DEFAULT_PRECS), Val{:forward}, true, nothing}}}})(u::Vector{ForwardDiff.Dual{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6}})
        @ Pumas C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\Pumas\VyE8h\src\estimation\bayes\logdensity.jl:224
     [10] chunk_mode_gradient!(result::DiffResults.MutableDiffResult{1, Float64, Tuple{Vector{Float64}}}, f::Pumas._L_rfx{TransformVariables.TransformTuple{NamedTuple{(:tv_kf_AT, :tv_Kd_AT, :tv_kf_BT, :tv_Kd_BT, :tv_kf_CT, :tv_Kd_CT, :tv_kf_DT, :tv_Kd_DT, :tv_mα, :tv_α₀, :σ), Tuple{TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.Identity, TransformVariables.ShiftedExp{true, Float64}}}}, PumasModel{(tv_kf_AT = 1, tv_Kd_AT = 1, tv_kf_BT = 1, tv_Kd_BT = 1, tv_kf_CT = 1, tv_Kd_CT = 1, tv_kf_DT = 1, tv_Kd_DT = 1, tv_mα = 1, tv_α₀ = 1, σ = 1), 1, (:DMn_s, :CaDMn_s, :DMn_f, :CaDMn_f, :PP, :CaPP, :OGB5, :CaOGB5, :T0, :T_A, :T_B, :T_C, :T_D, :T_AB, :T_AC, :T_AD, :T_BC, :T_BD, :T_CD, :T_ABC, :T_ABD, :T_ACD, :T_BCD, :T_ABCD, :Ca), ParamSet{NamedTuple{(:tv_kf_AT, :tv_Kd_AT, :tv_kf_BT, :tv_Kd_BT, :tv_kf_CT, :tv_Kd_CT, :tv_kf_DT, :tv_Kd_DT, :tv_mα, :tv_α₀, :σ), Tuple{Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, RealDomain{Float64, Int64, Float64}, RealDomain{TransformVariables.Infinity{false}, TransformVariables.Infinity{true}, Float64}, RealDomain{Float64, TransformVariables.Infinity{true}, Int64}}}}, var"#531#540", Pumas.TimeDispatcher{var"#532#541", var"#533#542"}, Nothing, var"#535#544", ODEProblem{Nothing, Tuple{Nothing, Nothing}, true, SciMLBase.NullParameters, ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.ODEFunctionClosure{var"#536#545", var"#537#546"}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Vector{Symbol}, Symbol, Vector{Symbol}, typeof(SciMLBase.DEFAULT_OBSERVED), Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Tuple{}, NamedTuple{(), Tuple{}}}, SciMLBase.StandardODEProblem}, var"#538#547", var"#539#548", ModelingToolkit.ODESystem}, Subject{NamedTuple{(:F_F0,), Tuple{Vector{Float64}}}, Pumas.ConstantCovar{NamedTuple{(:cov_f_frac, :cov_τ_f, :cov_τ_s, :cov_kon_DMn, :cov_koff_DMn, :cov_Kd_DMn, :cov_koff_PP, :cov_DMn_t, :cov_CaM_t, :cov_OGB5_t, :cov_Ca_free, :PCD), Tuple{Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Int64}}}, Nothing, Vector{Float64}}, NamedTuple{(:alg,), Tuple{Rodas5P{0, true, Nothing, typeof(OrdinaryDiffEq.DEFAULT_PRECS), Val{:forward}, true, nothing}}}}, x::Vector{Float64}, cfg::ForwardDiff.GradientConfig{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6, Vector{ForwardDiff.Dual{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6}}})
        @ ForwardDiff C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\ForwardDiff\vXysl\src\gradient.jl:123
     [11] gradient!
        @ C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\ForwardDiff\vXysl\src\gradient.jl:39 [inlined]
     [12] (::Pumas.var"#731#732"{Pumas.ThreadedBayesLogDensity{PumasModel{(tv_kf_AT = 1, tv_Kd_AT = 1, tv_kf_BT = 1, tv_Kd_BT = 1, tv_kf_CT = 1, tv_Kd_CT = 1, tv_kf_DT = 1, tv_Kd_DT = 1, tv_mα = 1, tv_α₀ = 1, σ = 1), 1, (:DMn_s, :CaDMn_s, :DMn_f, :CaDMn_f, :PP, :CaPP, :OGB5, :CaOGB5, :T0, :T_A, :T_B, :T_C, :T_D, :T_AB, :T_AC, :T_AD, :T_BC, :T_BD, :T_CD, :T_ABC, :T_ABD, :T_ACD, :T_BCD, :T_ABCD, :Ca), ParamSet{NamedTuple{(:tv_kf_AT, :tv_Kd_AT, :tv_kf_BT, :tv_Kd_BT, :tv_kf_CT, :tv_Kd_CT, :tv_kf_DT, :tv_Kd_DT, :tv_mα, :tv_α₀, :σ), Tuple{Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, RealDomain{Float64, Int64, Float64}, RealDomain{TransformVariables.Infinity{false}, TransformVariables.Infinity{true}, Float64}, RealDomain{Float64, TransformVariables.Infinity{true}, Int64}}}}, var"#531#540", Pumas.TimeDispatcher{var"#532#541", var"#533#542"}, Nothing, var"#535#544", ODEProblem{Nothing, Tuple{Nothing, Nothing}, true, SciMLBase.NullParameters, ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.ODEFunctionClosure{var"#536#545", var"#537#546"}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Vector{Symbol}, Symbol, Vector{Symbol}, typeof(SciMLBase.DEFAULT_OBSERVED), Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Tuple{}, NamedTuple{(), Tuple{}}}, SciMLBase.StandardODEProblem}, var"#538#547", var"#539#548", ModelingToolkit.ODESystem}, NamedTuple{(:tv_kf_AT, :tv_Kd_AT, :tv_kf_BT, :tv_Kd_BT, :tv_kf_CT, :tv_Kd_CT, :tv_kf_DT, :tv_Kd_DT, :tv_mα, :tv_α₀, :σ), Tuple{Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Int64}}, Vector{Subject{NamedTuple{(:F_F0,), Tuple{Vector{Float64}}}, Pumas.ConstantCovar{NamedTuple{(:cov_f_frac, :cov_τ_f, :cov_τ_s, :cov_kon_DMn, :cov_koff_DMn, :cov_Kd_DMn, :cov_koff_PP, :cov_DMn_t, :cov_CaM_t, :cov_OGB5_t, :cov_Ca_free, :PCD), Tuple{Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Int64}}}, Nothing, Vector{Float64}}}, Vector{Vector{Float64}}, Vector{Vector{Float64}}, Vector{ForwardDiff.GradientConfig{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6, Vector{ForwardDiff.Dual{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6}}}}, Vector{DiffResults.MutableDiffResult{1, Float64, Tuple{Vector{Float64}}}}, NamedTuple{(:alg,), Tuple{Rodas5P{0, true, Nothing, typeof(OrdinaryDiffEq.DEFAULT_PRECS), Val{:forward}, true, nothing}}}}, Vector{Float64}, TransformVariables.TransformTuple{NamedTuple{(:tv_kf_AT, :tv_Kd_AT, :tv_kf_BT, :tv_Kd_BT, :tv_kf_CT, :tv_Kd_CT, :tv_kf_DT, :tv_Kd_DT, :tv_mα, :tv_α₀, :σ), Tuple{TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.Identity, TransformVariables.ShiftedExp{true, Float64}}}}, Vector{Float64}})(i::Int64, buf1::Vector{Float64}, buf2::Vector{Float64}, res::DiffResults.MutableDiffResult{1, Float64, Tuple{Vector{Float64}}}, cfg::ForwardDiff.GradientConfig{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6, Vector{ForwardDiff.Dual{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6}}})
        @ Pumas C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\Pumas\VyE8h\src\estimation\bayes\logdensity.jl:389
     [13] macro expansion
        @ C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\Pumas\VyE8h\src\estimation\bayes\logdensity.jl:440 [inlined]
     [14] macro expansion
        @ .\simdloop.jl:77 [inlined]
     [15] batch_mapreduce
        @ C:\a\PumasSystemImages\PumasSystemImages\julia_depot\packages\Pumas\VyE8h\src\estimation\bayes\logdensity.jl:438 [inlined]
     [16] (::Pumas.var"#733#734"{Float64, UnitRange{Int64}, Pumas.var"#731#732"{Pumas.ThreadedBayesLogDensity{PumasModel{(tv_kf_AT = 1, tv_Kd_AT = 1, tv_kf_BT = 1, tv_Kd_BT = 1, tv_kf_CT = 1, tv_Kd_CT = 1, tv_kf_DT = 1, tv_Kd_DT = 1, tv_mα = 1, tv_α₀ = 1, σ = 1), 1, (:DMn_s, :CaDMn_s, :DMn_f, :CaDMn_f, :PP, :CaPP, :OGB5, :CaOGB5, :T0, :T_A, :T_B, :T_C, :T_D, :T_AB, :T_AC, :T_AD, :T_BC, :T_BD, :T_CD, :T_ABC, :T_ABD, :T_ACD, :T_BCD, :T_ABCD, :Ca), ParamSet{NamedTuple{(:tv_kf_AT, :tv_Kd_AT, :tv_kf_BT, :tv_Kd_BT, :tv_kf_CT, :tv_Kd_CT, :tv_kf_DT, :tv_Kd_DT, :tv_mα, :tv_α₀, :σ), Tuple{Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, Uniform{Float64}, RealDomain{Float64, Int64, Float64}, RealDomain{TransformVariables.Infinity{false}, TransformVariables.Infinity{true}, Float64}, RealDomain{Float64, TransformVariables.Infinity{true}, Int64}}}}, var"#531#540", Pumas.TimeDispatcher{var"#532#541", var"#533#542"}, Nothing, var"#535#544", ODEProblem{Nothing, Tuple{Nothing, Nothing}, true, SciMLBase.NullParameters, ODEFunction{true, SciMLBase.FullSpecialize, ModelingToolkit.ODEFunctionClosure{var"#536#545", var"#537#546"}, LinearAlgebra.UniformScaling{Bool}, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Nothing, Vector{Symbol}, Symbol, Vector{Symbol}, typeof(SciMLBase.DEFAULT_OBSERVED), Nothing, Nothing}, Base.Pairs{Symbol, Union{}, Tuple{}, NamedTuple{(), Tuple{}}}, SciMLBase.StandardODEProblem}, var"#538#547", var"#539#548", ModelingToolkit.ODESystem}, NamedTuple{(:tv_kf_AT, :tv_Kd_AT, :tv_kf_BT, :tv_Kd_BT, :tv_kf_CT, :tv_Kd_CT, :tv_kf_DT, :tv_Kd_DT, :tv_mα, :tv_α₀, :σ), Tuple{Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Int64}}, Vector{Subject{NamedTuple{(:F_F0,), Tuple{Vector{Float64}}}, Pumas.ConstantCovar{NamedTuple{(:cov_f_frac, :cov_τ_f, :cov_τ_s, :cov_kon_DMn, :cov_koff_DMn, :cov_Kd_DMn, :cov_koff_PP, :cov_DMn_t, :cov_CaM_t, :cov_OGB5_t, :cov_Ca_free, :PCD), Tuple{Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Float64, Int64}}}, Nothing, Vector{Float64}}}, Vector{Vector{Float64}}, Vector{Vector{Float64}}, Vector{ForwardDiff.GradientConfig{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6, Vector{ForwardDiff.Dual{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6}}}}, Vector{DiffResults.MutableDiffResult{1, Float64, Tuple{Vector{Float64}}}}, NamedTuple{(:alg,), Tuple{Rodas5P{0, true, Nothing, typeof(OrdinaryDiffEq.DEFAULT_PRECS), Val{:forward}, true, nothing}}}}, Vector{Float64}, TransformVariables.TransformTuple{NamedTuple{(:tv_kf_AT, :tv_Kd_AT, :tv_kf_BT, :tv_Kd_BT, :tv_kf_CT, :tv_Kd_CT, :tv_kf_DT, :tv_Kd_DT, :tv_mα, :tv_α₀, :σ), Tuple{TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.ScaledShiftedLogistic{Float64}, TransformVariables.Identity, TransformVariables.ShiftedExp{true, Float64}}}}, Vector{Float64}}, typeof(+), Tuple{UnitRange{Int64}}, Tuple{Vector{Float64}, Vector{Float64}, DiffResults.MutableDiffResult{1, Float64, Tuple{Vector{Float64}}}, ForwardDiff.GradientConfig{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6, Vector{ForwardDiff.Dual{ForwardDiff.Tag{Pumas.Tag, Float64}, Float64, 6}}}}})()
        @ Pumas .\threadingconstructs.jl:404