hello_node.py

from __future__ import print_function

import node
from twisted.internet.task import deferLater


@node.main
def main(reactor):
    return deferLater(reactor, 3, print, 'Hello, World!')

node.py

import sys
import atexit

_main = lambda x: None


def main(f):
    global _main
    _main = f


def _do_react():
    from twisted.internet.task import react
    react(_main, sys.argv[1:])

atexit.register(_do_react)