gistfile1.rb

$ cat test.rb
require 'rubygems'
require 'bundler'

Bundler.setup
Bundler.require(:default)

puts ImageScience

$ ruby test.rb 
/Users/drew/.rvm/gems/ruby-1.9.2-p0/gems/RubyInline-3.8.6/lib/inline.rb:513:in `load': require on /Users/drew/.ruby_inline/Inline_ImageScience_cdab.bundle failed (LoadError)
        from /Users/drew/.rvm/gems/ruby-1.9.2-p0/gems/RubyInline-3.8.6/lib/inline.rb:829:in `inline'
        from /Users/drew/.rvm/gems/ruby-1.9.2-p0/bundler/gems/image_science-a6001f8/lib/image_science.rb:89:in `<class:ImageScience>'
        from /Users/drew/.rvm/gems/ruby-1.9.2-p0/bundler/gems/image_science-a6001f8/lib/image_science.rb:12:in `<top (required)>'
        from /Users/drew/.rvm/gems/ruby-1.9.2-p0/gems/bundler-1.0.0.rc.5/lib/bundler/runtime.rb:64:in `require'
        from /Users/drew/.rvm/gems/ruby-1.9.2-p0/gems/bundler-1.0.0.rc.5/lib/bundler/runtime.rb:64:in `block (2 levels) in require'
        from /Users/drew/.rvm/gems/ruby-1.9.2-p0/gems/bundler-1.0.0.rc.5/lib/bundler/runtime.rb:62:in `each'
        from /Users/drew/.rvm/gems/ruby-1.9.2-p0/gems/bundler-1.0.0.rc.5/lib/bundler/runtime.rb:62:in `block in require'
        from /Users/drew/.rvm/gems/ruby-1.9.2-p0/gems/bundler-1.0.0.rc.5/lib/bundler/runtime.rb:51:in `each'
        from /Users/drew/.rvm/gems/ruby-1.9.2-p0/gems/bundler-1.0.0.rc.5/lib/bundler/runtime.rb:51:in `require'
        from /Users/drew/.rvm/gems/ruby-1.9.2-p0/gems/bundler-1.0.0.rc.5/lib/bundler.rb:107:in `require'
        from test.rb:5:in `<main>'

In my Gemfile:

gem "RubyInline", :require => "inline"
gem "g1nn13-image_science", :require=>false