An example of how to use npm as a build tool along with TypeScript

package.json

{
  "name": "playground",
  "version": "1.0.0",
  "main": "server/app.js",
  "private": true,
  "scripts": {
    "clean": "npm run clean:client && npm run clean:server",
    "clean:client": "rm -rf public/*.* && rm -rf public/**/*.* && rm -rf src/ts/*.js && rm -rf src/ts/**/*.js",
    "clean:server": "rm -rf server/*.{js,d.ts} && rm -rf server/**/*.{js,d.ts}",
    "compile": "npm run compile:client && npm run compile:sass && npm run compile:server && npm run compile:static",
    "compile:client": "tsc --project tsconfig.client.json && browserify src/ts/index.js -o public/bundle.js",
    "compile:sass": "node-sass src/scss/index.scss -o public",
    "compile:server": "tsc --project tsconfig.server.json",
    "compile:static": "for file in src/static/*; do cp \"$file\" \"public/${file/src\\/static\\/}\";done",
    "dev": "npm run compile && concurrently \"node server/app.js\" \"sleep 1 && npm run open\"",
    "open": "opn http://localhost:${PORT:-3000}/",
    "prestart": "npm run compile",
    "start": "node server/app.js"
  },
  "dependencies": {
    "@types/express": "^4.0.34",
    "@types/node": "^6.0.56",
    "browserify": "^13.3.0",
    "express": "^4.14.0",
    "node-sass": "^4.1.1",
    "typescript": "^2.1.4"
  },
  "devDependencies": {
    "concurrently": "^3.1.0",
    "opn-cli": "^3.1.0"
  }
}

tsconfig.client.json

{
  "compilerOptions": {
    "allowSyntheticDefaultImports": true,
    "declaration": false,
    "emitDecoratorMetadata": true,
    "experimentalDecorators": true,
    "lib": [
      "es2015",
      "dom"
    ],
    "module": "commonjs",
    "moduleResolution": "node",
    "target": "es5"
  },
  "include": [
    "src/**/*"
  ],
  "exclude": [
    "node_modules"
  ],
  "compileOnSave": false,
  "atom": {
    "rewriteTsconfig": false
  }
}

tsconfig.server.json

{
  "compilerOptions": {
    "allowSyntheticDefaultImports": true,
    "declaration": true,
    "emitDecoratorMetadata": true,
    "experimentalDecorators": true,
    "lib": [
      "es2015",
      "dom"
    ],
    "module": "commonjs",
    "moduleResolution": "node",
    "target": "es5"
  },
  "include": [
    "server/**/*"
  ],
  "exclude": [
    "node_modules"
  ],
  "compileOnSave": false,
  "atom": {
    "rewriteTsconfig": false
  }
}