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@erickpeirson
Last active September 9, 2016 19:54
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xmlns:dcterms="http://purl.org/dc/terms/" xmlns:foaf="http://xmlns.com/foaf/0.1/"
xmlns:prsmstndrd="http://prismstandard.org/namespaces/1.2/basic#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns"
xmlns:ztr="http://www.zotero.org/namespaces/export#" xmlns="http://www.openarchives.org/OAI/2.0/"
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<responseDate>2016-09-09T19:41:07Z</responseDate>
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<header>
<identifier>2</identifier>
<datestamp>2016-09-09T19:40:26Z</datestamp>
<setSpec>1</setSpec>
</header>
<metadata>
<dcterms:provenance>
Added by erickpeirson on 2016-09-09 19:40:26.212995
</dcterms:provenance>
<dcterms:dateSubmitted>2014-10-30T18:04:59+00:00</dcterms:dateSubmitted>
<rdf:type>article</rdf:type>
<rdf:type>journalArticle</rdf:type>
<prsmstndrd:volume>4</prsmstndrd:volume>
<dc:title>
Perspectives on Zebrafish Models of Hallucinogenic Drugs and Related Psychotropic
Compounds
</dc:title>
<dc:description>PMID: 23883191 PMCID: PMC3750682</dc:description>
<dcterms:abstract>
, Among different classes of psychotropic drugs, hallucinogenic agents exert one
of the most prominent effects on human and animal behaviors,
markedly altering sensory, motor, affective, and cognitive responses.
The growing clinical and preclinical interest in psychedelic,
dissociative, and deliriant hallucinogens necessitates novel
translational, sensitive, and high-throughput in vivo models
and screens. Primate and rodent models have been traditionally
used to study cellular mechanisms and neural circuits of hallucinogenic
drugs’ action. The utility of zebrafish (Danio rerio) in neuroscience
research is rapidly growing due to their high physiological and
genetic homology to humans, ease of genetic manipulation, robust
behaviors, and cost effectiveness. Possessing a fully characterized
genome, both adult and larval zebrafish are currently widely
used for in vivo screening of various psychotropic compounds,
including hallucinogens and related drugs. Recognizing the growing
importance of hallucinogens in biological psychiatry, here we
discuss hallucinogenic-induced phenotypes in zebrafish and evaluate
their potential as efficient preclinical models of drug-induced
states in humans.
</dcterms:abstract>
<dcterms:creator>MIKHAYLOVA, ALINA</dcterms:creator>
<dcterms:creator>NEELKANTAN, NIKHIL</dcterms:creator>
<dcterms:creator>KALUEFF, ALLAN V</dcterms:creator>
<dcterms:creator>POUDEL, MANOJ K</dcterms:creator>
<dcterms:creator>ARNOLD, RAYMOND</dcterms:creator>
<dcterms:creator>KONDAVEETI, DIVYA</dcterms:creator>
<dcterms:creator>GJELOSHI, VISAR</dcterms:creator>
<dcterms:creator>STEWART, ADAM MICHAEL</dcterms:creator>
<dcterms:isPartOf>ACS Chemical Neuroscience</dcterms:isPartOf>
<dc:date>2013-07-24T00:00:00+00:00</dc:date>
<prsmstndrd:number>8</prsmstndrd:number>
<bib:pages>1137-1150</bib:pages>
<ztr:libraryCatalog>PubMed Central</ztr:libraryCatalog>
</metadata>
</record>
<record>
<header>
<identifier>4</identifier>
<datestamp>2016-09-09T19:40:28Z</datestamp>
<setSpec>1</setSpec>
</header>
<metadata>
<dcterms:provenance>
Added by erickpeirson on 2016-09-09 19:40:28.111509
</dcterms:provenance>
<dcterms:dateSubmitted>2014-10-30T18:04:59+00:00</dcterms:dateSubmitted>
<rdf:type>article</rdf:type>
<rdf:type>journalArticle</rdf:type>
<prsmstndrd:volume>9</prsmstndrd:volume>
<dc:title>Culturable Gut Microbiota Diversity in Zebrafish</dc:title>
<dc:description>PMID: 22428747 PMCID: PMC3308716</dc:description>
<dcterms:abstract>
The zebrafish (Danio rerio) is an increasingly used laboratory animal model in basic
biology and biomedicine, novel drug development, and toxicology.
The wide use has increased the demand for optimized husbandry
protocols to ensure animal health care and welfare. The knowledge
about the correlation between culturable zebrafish intestinal
microbiota and health in relation to environmental factors and
management procedures is very limited. A semi-quantitative level
of growth of individual types of bacteria was determined and
associated with sampling points. A total of 72 TAB line zebrafish
from four laboratories (Labs A–D) in the Zebrafish Network Norway
were used. Diagnostic was based on traditional bacterial culture
methods and biochemical characterization using commercial kits,
followed by 16S rDNA gene sequencing from pure subcultures. Also
selected Gram-negative isolates were analyzed for antibiotic
susceptibility to 8 different antibiotics. A total of 13 morphologically
different bacterial species were the most prevalent: Aeromonas
hydrophila, Aeromonas sobria, Vibrio parahaemolyticus, Photobacterium
damselae, Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas
luteola, Comamonas testosteroni, Ochrobactrum anthropi, Staphylococcus
cohnii, Staphylococcus epidermidis, Staphylococcus capitis, and
Staphylococcus warneri. Only Lab B had significantly higher levels
of total bacterial growth (OR=2.03), whereas numbers from Lab
C (OR=1.01) and Lab D (OR=1.12) were found to be similar to the
baseline Lab A. Sexually immature individuals had a significantly
higher level of harvested total bacterial growth than mature
fish (OR=0.82), no statistically significant differences were
found between male and female fish (OR=1.01), and the posterior
intestinal segment demonstrated a higher degree of culturable
bacteria than the anterior segment (OR=4.1). Multiple antibiotic
(>3) resistance was observed in 17% of the strains. We propose
that a rapid conventional diagnostic bacteriological assay on
the culturable microbiota profiles can be designed and used as
quality measure of the husbandry routines of a zebrafish facility
to ensure a bacterial standard safeguarding the zebrafish health
and welfare.
</dcterms:abstract>
<dcterms:creator>S?RUM, HENNING</dcterms:creator>
<dcterms:creator>CANTAS, LEON</dcterms:creator>
<dcterms:creator>ALESTROM, PETER</dcterms:creator>
<dcterms:creator>S?RBY, JAN ROGER TORP</dcterms:creator>
<dcterms:isPartOf>Zebrafish</dcterms:isPartOf>
<dc:date>2012-03-01T00:00:00+00:00</dc:date>
<prsmstndrd:number>1</prsmstndrd:number>
<bib:pages>26-37</bib:pages>
<ztr:libraryCatalog>PubMed Central</ztr:libraryCatalog>
</metadata>
</record>
...
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