dtd_creative_alkaptonuria_results_message.json

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present on the axillary and inguinal areas, face, palms or soles. In addition, blue-black discoloration can be apparent on skin overlying cartilage in which the pigment is deposited, such as the ears. This is a characteristic manifestation of alkaptonuria, which is an autosomal recessively inherited deficiency of homogentisic acid oxidase that results in accumulation of homogentisic acid in collagenous structures. The sclerae are also typically involved. [HPO:probinson, PMID:24447956, PMID:26929770]; Brown or blue-gray discoloration of the skin that can present on the axillary and inguinal areas, face, palms or soles. In addition, blue-black discoloration can be apparent on skin overlying cartilage in which the pigment is deposited, such as the ears. This is a characteristic manifestation of alkaptonuria, which is an autosomal recessively inherited deficiency of homogentisic acid oxidase that results in accumulation of homogentisic acid in collagenous structures. The sclerae are also typically involved.; Brown or blue-gray discoloration of the skin that can present on the axillary and inguinal areas, face, palms or soles. In addition, blue-black discoloration can be apparent on skin overlying cartilage in which the pigment is deposited, such as the ears. This is a characteristic manifestation of alkaptonuria, which is an autosomal recessively inherited deficiency of homogentisic acid oxidase that results in accumulation of homogentisic acid in collagenous structures. 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It results in the accumulation in the blood of homogentisic acid which is excreted in the urine. The presence of homogentisic acid in the urine causes its color to turn black. The excessive amount of homogentisic acid in the blood may cause damage to cartilage and heart valves, and may result in the formation of kidney stones.; An inborn error of amino acid metabolism resulting from a defect in the enzyme HOMOGENTISATE 1,2-DIOXYGENASE, an enzyme involved in the breakdown of PHENYLALANINE and TYROSINE. It is characterized by accumulation of HOMOGENTISIC ACID in the urine, OCHRONOSIS in various tissues, and ARTHRITIS.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:Disease", "biolink:PhenotypicFeature", "biolink:Pathway"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Ochronosis, hereditary", "alkaptonuria", "Alkaptonuria", "Alkaptonuria related phenotypic feature"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["DOID:9270", "UMLS:C2931645", "ORPHANET:56", "MESH:D000474", "MONDO:0008753", "SMPDB:SMP0120453", "UMLS:C0002066", "PathWhiz:PW000180", "PathWhiz:PW121704", "SMPDB:SMP0120674", "MESH:C537862", "NCIT:C84546", "OMIM:203500", "PathWhiz:PW121930", "SMPDB:SMP0000169"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:2935875", "PMID:1903356", "PMID:15164053", "PMID:15815621", "PMID:3443096", "PMID:8182053", "PMID:10652282", "PMID:8188240", "http://en.wikipedia.org/wiki/alkaptonuria", "PMID:2920825"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "DRUGBANK:DB08327": {"name": "Homogentisic acid", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/drugbank:DB08327", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/drugbank:DB08327", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Homogentisic acid, also known as melanic acid, is an intermediate in the breakdown or catabolism of tyrosine and phenylalanine. It is generated from the compound p-hydroxyphenylpyruvate through the enzyme p-hydroxyphenylpyruvate dehydrogenase. The resulting homogentisic acid is then broken down into 4-maleylacetoacetate via the enzyme homogentisate 1,2-dioxygenase. Homogentisic acid is also found in other organisms. For instance, it can found in Arbutus unedo (strawberry-tree) honey, in the bacterial plant pathogen Xanthomonas campestris as well as in the yeast Yarrowia lipolytica where it is associated with the production of brown pigments. Homogentisic acid can be oxidatively dimerized to form hipposudoric acid, one of the main constituents of the 'blood sweat' of hippopotamuses. When present in sufficiently high levels, homogentisic acid can function as an osteotoxin and a renal toxin. An osteotoxin is a substance that causes damage to bones and/or joints. A renal toxin causes damage to the kidneys. Chronically high levels of homogentisic acid are associated with alkaptonuria (OMIM: 203500), an inborn error of metabolism. Alkaptonuria is a rare inherited genetic disorder in which the body cannot process the amino acids phenylalanine and tyrosine. It is caused by a mutation in the enzyme homogentisate 1,2-dioxygenase (EC 1.13.11.5), which leads to an accumulation of homogentisic acid in the blood and tissues. Homogentisic acid and its oxidized form benzoquinone acetic acid are excreted in the urine, giving it an unusually dark color. The accumulating homogentisic acid (and benzoquinone acetic acid) causes damage to cartilage (ochronosis, leading to osteoarthritis) and heart valves as well as precipitating as kidney stones and stones in other organs. More specifically, homogentisic acid can be converted to benzoquinone acetic acid (BQA), and the resulting BQA can be readily converted to polymers that resemble the dark skin pigment melanin. These polymers are deposited in the collagen, a connective tissue protein, of particular tissues such as cartilage. This process is called ochronosis (as the tissue looks ochre); ochronotic tissue is stiffened and unusually brittle, impairing its normal function and causing damage. Homogentisic acid is the primary precursor of melanin synthesis in Vibrio cholerae.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:MolecularEntity", "biolink:SmallMolecule", "biolink:BiologicalEntity"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["HGTA [cytosol]", "Homogentisate", "homogentisic acid", "Homogentisic Acid", "homogentisate", "Homogentisic acid"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["CHEBI:44747", "KEGG.COMPOUND:C00544", "UMLS:C0019881", "REACT:R-ALL-30337", "UMLS:C0178680", "LOINC:MTHU011724", "HMDB:HMDB0000130", "LOINC:LP15642-9", "CHEBI:16169", "PathWhiz.Compound:84", "DRUGBANK:DB08327", "MESH:D006713"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:9529368", "PMID:2383921", "PMID:2026685", "PMID:9870204", "PMID:8188241", "PMID:15849984", "PMID:9214216", "PMID:12501223", "PMID:8000039", "PMID:1495952"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "UniProtKB:Q93099": {"name": "HGD", "categories": ["biolink:Gene", "biolink:Protein"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/uniprot:Q93099", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/uniprot:Q93099", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "-!- CATALYTIC ACTIVITY: Reaction=homogentisate + O2 = 4-maleylacetoacetate + H(+); Xref=Rhea:RHEA:15449, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16169, ChEBI:CHEBI:17105; EC=1.13.11.5; -!- COFACTOR: Name=Fe cation; Xref=ChEBI:CHEBI:24875; -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. -!- SUBUNIT: Homohexamer arranged as a dimer of trimers. {ECO:0000269|PubMed:10876237}. -!- INTERACTION: Q93099; Q93099: HGD; NbExp=4; IntAct=EBI-3907760, EBI-3907760; Q93099; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-3907760, EBI-741158; Q93099; P54274: TERF1; NbExp=2; IntAct=EBI-3907760, EBI-710997; -!- TISSUE SPECIFICITY: Highest expression in the prostate, small intestine, colon, kidney and liver. -!- DISEASE: Alkaptonuria (AKU) [MIM:203500]: An autosomal recessive error of metabolism characterized by an increase in the level of homogentisic acid. The clinical manifestations are urine that turns dark on standing and alkalinization, black ochronotic pigmentation of cartilage and collagenous tissues, and spine arthritis. {ECO:0000269|PubMed:10205262, ECO:0000269|PubMed:10340975, ECO:0000269|PubMed:10482952, ECO:0000269|PubMed:10594001, ECO:0000269|PubMed:19862842, ECO:0000269|PubMed:21437689, ECO:0000269|PubMed:23353776, ECO:0000269|PubMed:23430897, ECO:0000269|PubMed:25681086, ECO:0000269|PubMed:8782815, ECO:0000269|PubMed:9154114, ECO:0000269|PubMed:9529363, ECO:0000269|PubMed:9630082}. Note=The disease is caused by variants affecting the gene represented in this entry. -!- SIMILARITY: Belongs to the homogentisate dioxygenase family. {ECO:0000305}. 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[GOC:dos, GOC:mah, ISBN:0815316194]; A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.;  Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. ; A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.; A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.; A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.; A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.; UMLS Semantic Type: STY:T026", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:GrossAnatomicalStructure", "biolink:AnatomicalEntity", "biolink:CellularComponent"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Membranous layer", "membrane", "Membranes", "Tissue membrane", "membranous layer", "Membrane"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["MESH:D008566", "FMA:82500", "GO:0016020", "PSY:30560", "FMA:30322", "UBERON:0000158", "UMLS:C0596901", "UMLS:C0025255", "UMLS:C2338391", "NCIT:C12749"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["ISBN:0815316194"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "FMA:82768": {"name": "Tyrosine", "categories": ["biolink:BiologicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "http://purl.obolibrary.org/obo/FMA_82768", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "http://purl.obolibrary.org/obo/FMA_82768", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Tyrosine (Tyr) or L-tyrosine is an alpha-amino acid. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon).  Amino acids are organic compounds that contain amino (\u201a\u00c4\u00ecNH2) and carboxyl (\u201a\u00c4\u00ecCOOH) functional groups, along with a side chain (R group) specific to each amino acid. L-tyrosine is one of 20 proteinogenic amino acids, i.e., the amino acids used in the biosynthesis of proteins. Tyrosine is found in all organisms ranging from bacteria to plants to animals. It is classified as a non-polar, uncharged (at physiological pH) aromatic amino acid.  Tyrosine is a non-essential amino acid, meaning the body can synthesize it \u201a\u00c4\u00ec usually from phenylalanine. The conversion of phenylalanine to tyrosine is catalyzed by the enzyme phenylalanine hydroxylase, a monooxygenase. This enzyme catalyzes the reaction causing the addition of a hydroxyl group to the end of the 6-carbon aromatic ring of phenylalanine, such that it becomes tyrosine. Tyrosine is found in many high-protein food products such as chicken, turkey, fish, milk, yogurt, cottage cheese, cheese, peanuts, almonds, pumpkin seeds, sesame seeds, soy products, lima beans, avocados and bananas. Tyrosine is one of the few amino acids that readily passes the blood-brain barrier. Once in the brain, it is a precursor for the neurotransmitters dopamine, norepinephrine and epinephrine, better known as adrenalin. These neurotransmitters are an important part of the body's sympathetic nervous system, and their concentrations in the body and brain are directly dependent upon dietary tyrosine. Tyrosine is not found in large concentrations throughout the body, probably because it is rapidly metabolized. Folic acid, copper and vitamin C are cofactor nutrients of these reactions. Tyrosine is also the precursor for hormones, including thyroid hormones (diiodotyrosine), catecholestrogens and the major human pigment, melanin. Tyrosine is an important amino acid in many proteins, peptides and even enkephalins, the body's natural pain reliever. Valine and other branched amino acids, and possibly tryptophan and phenylalanine may reduce tyrosine absorption. A number of genetic errors of tyrosine metabolism have been identified, such as hawkinsinuria and tyrosinemia I. The most common feature of these diseases is the increased amount of tyrosine in the blood, which is marked by decreased motor activity, lethargy and poor feeding. Infection and intellectual deficits may occur. Vitamin C supplements can help reverse these disease symptoms. Some adults also develop elevated tyrosine in their blood. This typically indicates a need for more vitamin C. More tyrosine is needed under stress, and tyrosine supplements prevent the stress-induced depletion of norepinephrine and can help aleviate biochemical depression. However, tyrosine may not be good for treating psychosis. Many antipsychotic medications apparently function by inhibiting tyrosine metabolism. L-Dopa, which is directly used in Parkinson's, is made from tyrosine. Tyrosine, the nutrient, can be used as an adjunct in the treatment of Parkinson's. Peripheral metabolism of tyrosine necessitates large doses of tyrosine, however, compared to L-Dopa (http://www.dcnutrition.com). In addition to its role as a precursor for neurotransmitters, tyrosine plays an important role for the function of many proteins.  Within many proteins or enzymes, certain tyrosine residues can be tagged (at the hydroxyl group) with a phosphate group (phosphorylated) by specialized protein kinases. In its phosphorylated form, tyrosine is called phosphotyrosine. Tyrosine phosphorylation is considered to be one of the key steps in signal transduction and regulation of enzymatic activity.  Tyrosine (or its precursor phenylalanine) is also needed to synthesize the benzoquinone structure which forms part of coenzyme Q10.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:NamedThing", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:ChemicalEntity", "biolink:BiologicalEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["2-Amino-3-(4-hydroxy-phenyl)-propionic acid (DL)", "L-tyrosine zwitterion", "6-hydroxysandoricin", "Tyrosine (USP/INN)", "D-tyrosine zwitterion", "D-tyrosine", "D-Tyrosine", "L-Tyr [melanosome lumen]", "6-Hydroxysandoricin", "DL-Tyrosine", "tyrosine", "Tyrosine", "L-Tyrosine", "L-Tyr [mitochondrial matrix]", "L-Tyr [cytosol]", "L-Tyr [extracellular region]", "TYROSINE", "L-tyrosine", "(R)-2-amino-3-(4-hydroxyphenyl)propanoic acid"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["CHEMBL.COMPOUND:CHEMBL108615", "CHEBI:58570", "MESH:C069233", "VANDF:4018678", "KEGG.COMPOUND:C01536", "REACT:R-ALL-352030", "RXNORM:10962", "NDDF:003449", "REACT:R-ALL-379710", "KEGG.COMPOUND:C00082", "LOINC:LP15793-0", "CHEMBL.COMPOUND:CHEMBL925", "DRUGBANK:DB00135", "CHEBI:28479", "LOINC:LP32175-9", "FMA:82768", "KEGG.COMPOUND:C06420", "CHEBI:18186", "CHEBI:17895", "HMDB:HMDB0000158", "UMLS:C0646157", "KEGG.DRUG:D00022", "REACT:R-ALL-5668567", "CHEMBL.COMPOUND:CHEMBL1076637", "LOINC:MTHU004109", "HMDB:HMDB0037556", "UMLS:C1880236", "CHEBI:58315", "PSY:54590", "MESH:D014443", "HMDB:HMDB0250803", "UMLS:C0041485", "REACT:R-ALL-29506", "CHEBI:185400", "PathWhiz.Compound:103", "NCIT:C61997", "DRUGBANK:DB03839", "DrugCentral:2786", "NCIT:C915"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:19464888", "PMID:24125877", "PMID:8884658", "PMID:23294703", "PMID:6696735", "PMID:30048132", "PMID:12097436", "PMID:18294854", "PMID:11827462", "PMID:20176489"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "UBERON:0000178": {"name": "blood", "categories": ["biolink:AnatomicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "http://purl.obolibrary.org/obo/UBERON_0000178", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "http://purl.obolibrary.org/obo/UBERON_0000178", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "The body fluid that circulates in the vascular system (BLOOD VESSELS). Whole blood includes PLASMA and BLOOD CELLS.; Portion of body substance which has as its parts plasma and blood cells.; Your blood is made up of liquid and solids. The liquid part, called plasma, is made of water, salts, and protein. Over half of your blood is plasma. The solid part of your blood contains red blood cells, white blood cells, and platelets. Red blood cells (RBC) deliver oxygen from your lungs to your tissues and organs. White blood cells (WBC) fight infection and are part of your immune system. Platelets help blood to clot when you have a cut or wound. Bone marrow, the spongy material inside your bones, makes new blood cells. Blood cells constantly die and your body makes new ones. Red blood cells live about 120 days, and platelets live about 6 days. Some white blood cells live less than a day, but others live much longer. There are four blood types: A, B, AB, or O. Also, blood is either Rh-positive or Rh-negative. So if you have type A blood, it's either A positive or A negative. Which type you are is important if you need a blood transfusion. And your Rh factor could be important if you become pregnant - an incompatibility between your type and the baby's could create problems.  Blood tests such as blood count tests help doctors check for certain diseases and conditions. They also help check the function of your organs and show how well treatments are working. Problems with your blood may include bleeding disorders, excessive clotting and platelet disorders. If you lose too much blood, you may need a transfusion. NIH: National Heart, Lung, and Blood Institute; UMLS Semantic Type: STY:T031; UMLS Semantic Type: STY:T031", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:AnatomicalEntity"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Blood", "blood"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["PSY:06200", "MESH:D001769", "LOINC:LA17759-4", "CHEMBL.TARGET:CHEMBL613416", "LOINC:MTHU029981", "NCIT:C12434", "CHEMBL.TARGET:CHEMBL613408", "UMLS:C0005767", "CHEMBL.TARGET:CHEMBL613397", "CHEMBL.TARGET:CHEMBL613615", "LOINC:LP71680-0", "EHDAA2:0000176", "MESH:Q000097", "UBERON:0000178", "CHEMBL.TARGET:CHEMBL613561", "CHEMBL.TARGET:CHEMBL4296529", "CHEMBL.TARGET:CHEMBL613444"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["http://orcid.org/0000-0002-6601-2165", "http://en.wikipedia.org/wiki/blood", "https://github.com/obophenotype/uberon/issues/9"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "FMA:67243": {"name": "Epinephrine", "categories": ["biolink:BiologicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "http://purl.obolibrary.org/obo/FMA_67243", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "http://purl.obolibrary.org/obo/FMA_67243", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Epinephrine is a catecholamine, a sympathomimetic monoamine derived from the amino acids phenylalanine and tyrosine. It is the active sympathomimetic hormone secreted from the adrenal medulla in most species. It stimulates both the alpha- and beta- adrenergic systems, causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels. It is used in asthma and cardiac failure and to delay absorption of local anesthetics. Epinephrine also constricts arterioles in the skin and gut while dilating arterioles in leg muscles. It elevates the blood sugar level by increasing hydrolysis of glycogen to glucose in the liver, and at the same time begins the breakdown of lipids in adipocytes. Epinephrine has a suppressive effect on the immune system.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:BiologicalEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["DIPIVEFRIN", "Dipivefrin hydrochloride (JAN/USP)", "Erythromycin", "L-Adrenaline", "d Epifrin", "(-)-adrenaline", "PMS-Dipivefrin", "Dipivefrin hydrochloride", "Epinephrine Acetate", "Epinephrine hydrochloride (JAN)", "Dipivefrin", "ADR [cytosol]", "EPINEPHrine", "ADR [clathrin-coated endocytic vesicle membrane]", "(R)-adrenaline", "EPINEPHRINE", "Dipivefrin Hydrochloride", "dipivefrin tartrate (1:1), (+-)-(R-(R*,R*))-isomer", "EPINEPHRINE HYDROCHLORIDE", "Epinephrine", "dipivefrin propanoate, (+-)-isomer", "dipivefrin", "dipivefrin monophosphate, (+-)-isomer", "dipivefrine", "Propine", "L-ADRENALINE", "dipivefrin acetate, (+-)-isomer", "ADR [clathrin-sculpted monoamine transport vesicle lumen]", "epinephrine", "ADR [extracellular region]", "dipivefrin hydrochloride", "Dipivefrin (USAN)", "Epinephrine (USP/INN)", "(S)-adrenaline", "EPINEPHRINE BITARTRATE", "DIPIVEFRIN HYDROCHLORIDE", "(R)-adrenaline hydrochloride"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["MESH:D004837", "LOINC:MTHU002341", "PSY:17700", "LOINC:MTHU060431", "UMLS:C0138647", "CHEMBL.COMPOUND:CHEMBL679", "KEGG.COMPOUND:C00788", "ATC:C01CA24", "NCIT:C2292", "KEGG.COMPOUND:C06963", "KEGG.DRUG:D01017", "ATC:R01AA14", "DrugCentral:1028", "NDDF:001788", "KEGG.DRUG:D02349", "FMA:67243", "CHEBI:4646", "CHEMBL.COMPOUND:CHEMBL1256958", "CHEBI:28918", "UMLS:C1529988", "CHEBI:6213", "UMLS:C4255548", "UMLS:C0889647", "NCIT:C61729", "HMDB:HMDB0014344", "UMLS:C0889648", "CHEMBL.COMPOUND:CHEMBL1200833", "REACT:R-ALL-444148", "UMLS:C0521932", "CHEBI:40751", "CHEBI:4647", "RXNORM:3992", "VANDF:4019152", "ATC:S01EA01", "UMLS:C0014563", "CHEMBL.COMPOUND:CHEMBL42280", "HMDB:HMDB0014592", "ATC:S01EA02", "DRUGBANK:DB00449", "ATC:R03AA01", "MESH:C015173", "ATC:A01AD01", "RXNORM:23410", "UMLS:C0889645", "VANDF:4019728", "REACT:R-ALL-390625", "KEGG.DRUG:D00996", "REACT:R-ALL-209794", "PathWhiz.Compound:48", "ATC:B02BC09", "UMLS:C0889649", "VANDF:4018034", "UMLS:C0700488", "CHEMBL.COMPOUND:CHEMBL1201262", "KEGG.DRUG:D00095", "DRUGBANK:DB00668", "REACT:R-ALL-549254", "LOINC:LP15027-3", "UMLS:C1529985", "HMDB:HMDB0000068", "REACT:R-ALL-8869056", "NCIT:C47495", "DrugCentral:922", "RXNORM:203156", "UMLS:C0058415", "CHEMBL.COMPOUND:CHEMBL3183376"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:2845082", "PMID:8254623", "PMID:23294703", "PMID:18294854", "PMID:9182127", "PMID:22096083", "PMID:16799554", "PMID:7154001", "PMID:2836587", "PMID:18930395"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "FMA:61799": {"name": "Norepinephrine", "categories": ["biolink:BiologicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "http://purl.obolibrary.org/obo/FMA_61799", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "http://purl.obolibrary.org/obo/FMA_61799", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "A synthetic phenylethylamine that mimics the sympathomimetic actions of the endogenous norepinephrine. Norepinephrine acts directly on the alpha- and beta-adrenergic receptors. Clinically, norepinephrine is used as a peripheral vasoconstrictor that causes constriction of arterial and venous beds via its alpha-adrenergic action. It is also used as a potent inotropic and chronotropic stimulator of the heart mediated through its beta-1 adrenergic action. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C62098\" active clinical trials using this agent. (\"http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C62098\" NCI Thesaurus); A synthetic phenylethylamine that mimics the sympathomimetic actions of the endogenous norepinephrine. Norepinephrine acts directly on the alpha- and beta-adrenergic receptors. Clinically, norepinephrine is used as a peripheral vasoconstrictor that causes constriction of arterial and venous beds via its alpha-adrenergic action. It is also used as a potent inotropic and chronotropic stimulator of the heart mediated through its beta-1 adrenergic action.; Precursor of epinephrine that is secreted by the ADRENAL MEDULLA and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers, and of the diffuse projection system in the brain that arises from the LOCUS CERULEUS. It is also found in plants and is used pharmacologically as a sympathomimetic.; UMLS Semantic Type: STY:T121; UMLS Semantic Type: STY:T109", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:BiologicalEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Noradrenaline tartrate renaudin", "norepinephrine bitartrate", "L-Noradrenaline", "Norepinephrine Hydrochloride, (+,-)-Isomer", "NAd [cytosol]", "NAd [clathrin-sculpted monoamine transport vesicle lumen]", "Norepinephrine bitartrate", "Noradrenaline (JP18)", "NOREPINEPHRINE BITARTRATE", "Norepinephrine Hydrochloride, (+)-Isomer", "Norepinephrine, (+,-)-Isomer", "Norepinephrine Bitartrate", "Arterenol", "NAd [clathrin-sculpted glutamate transport vesicle lumen]", "Norepinephrine d-Tartrate (1:1)", "Norepinephrine, (+)-Isomer", "NAd [secretory granule lumen]", "Norepinephrine Hydrochloride", "L(-)-Norepinephrine bitartrate", "NAd [clathrin-coated endocytic vesicle membrane]", "NAd [extracellular region]", "Norepinephrine l-Tartrate (1:1), Monohydrate, (+)-Isomer", "Norepinephrine l-Tartrate, (+)-Isomer", "Norepinephrine l-Tartrate (1:2)", "Norepinephrine", "(R)-noradrenaline", "norepinephrine", "Levophed", "Norepinephrine l-Tartrate (1:1), (+,-)-Isomer", "Norepinephrine l-Tartrate (1:1), Monohydrate", "Levonor", "NOREPINEPHRINE"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["CHEBI:18357", "CHEMBL.COMPOUND:CHEMBL2062274", "REACT:R-ALL-8869062", "ATC:C01CA03", "UMLS:C0028351", "UMLS:C0887101", "UMLS:C0887097", "UMLS:C0917761", "CHEMBL.COMPOUND:CHEMBL1434513", "PSY:34410", "FMA:61799", "REACT:R-ALL-351597", "MESH:D009638", "RXNORM:7512", "REACT:R-ALL-372509", "KEGG.COMPOUND:C00547", "REACT:R-ALL-209789", "UMLS:C0028333", "REACT:R-ALL-374935", "DrugCentral:1960", "UMLS:C0887103", "UMLS:C0702008", "LOINC:MTHU003447", "UMLS:C0772489", "CHEMBL.COMPOUND:CHEMBL1437", "CHEMBL.COMPOUND:CHEMBL1356607", "UMLS:C0887102", "UMLS:C0887096", "NCIT:C48646", "KEGG.DRUG:D00076", "VANDF:4018242", "LOINC:LP15271-7", "HMDB:HMDB0000216", "DRUGBANK:DB00368", "UMLS:C0887100", "UMLS:C0205860", "UMLS:C1450037", "RXNORM:7508", "UMLS:C0917760", "PDQ:CDR0000691834", "UMLS:C0887099", "UMLS:C0733815", "NDDF:004718", "PathWhiz.Compound:142", "RXNORM:227559", "UMLS:C0887098", "REACT:R-ALL-444150", "VANDF:4019859"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:15166677", "PMID:2845082", "PMID:8254623", "PMID:191614", "PMID:8884658", "PMID:10454528", "PMID:21129985", "PMID:22626821", "PMID:16799554", "PMID:7154001"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "FMA:67238": {"name": "Dopamine", "categories": ["biolink:BiologicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "http://purl.obolibrary.org/obo/FMA_67238", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "http://purl.obolibrary.org/obo/FMA_67238", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Dopamine is a member of the catecholamine family of neurotransmitters in the brain and is a precursor to epinephrine (adrenaline) and norepinephrine (noradrenaline). Dopamine is synthesized in the body (mainly by nervous tissue and adrenal glands) first by the hydration of the amino acid tyrosine to DOPA by tyrosine hydroxylase and then by the decarboxylation of DOPA by aromatic-L-amino-acid decarboxylase. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (dopamine receptors) mediates its action, which plays a major role in reward-motivated behaviour. Dopamine has many other functions outside the brain. In blood vessels, dopamine inhibits norepinephrine release and acts as a vasodilator (at normal concentrations); in the kidneys, it increases sodium excretion and urine output; in the pancreas, it reduces insulin production; in the digestive system, it reduces gastrointestinal motility and protects intestinal mucosa; and in the immune system, it reduces the activity of lymphocytes. Parkinson's disease, a degenerative condition causing tremor and motor impairment, is caused by a loss of dopamine-secreting neurons in an area of the midbrain called the substantia nigra. There is evidence that schizophrenia involves altered levels of dopamine activity, and most antipsychotic drugs used to treat this are dopamine antagonists, which reduce dopamine activity. Attention deficit hyperactivity disorder, bipolar disorder, and addiction are also characterized by defects in dopamine production or metabolism. It has been suggested that animals derived their dopamine-synthesizing machinery from bacteria via horizontal gene transfer that may have occurred relatively late in evolutionary time. This is perhaps a result of the symbiotic incorporation of bacteria into eukaryotic cells that gave rise to mitochondria. Dopamine is elevated in the urine of people who consume bananas. When present in sufficiently high levels, dopamine can be a neurotoxin and a metabotoxin. A neurotoxin is a compound that disrupts or attacks neural tissue. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Chronically high levels of dopamine are associated with neuroblastoma, Costello syndrome, leukemia, phaeochromocytoma, aromatic L-amino acid decarboxylase deficiency, and Menkes disease (MNK). High levels of dopamine can lead to hyperactivity, insomnia, agitation and anxiety, depression, delusions, excessive salivation, nausea, and digestive problems. A study has shown that urinary dopamine is produced by Bacillus and Serratia (PMID: 24621061)", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:Drug", "biolink:NamedThing", "biolink:MolecularEntity", "biolink:BiologicalEntity", "biolink:NucleicAcidEntity"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Doparkine", "L-Dopa [cytosol]", "Dopamine", "Doprin", "Dopastral", "DA [clathrin-sculpted monoamine transport vesicle lumen]", "LEVODOPA", "Dopaflex", "dA [mitochondrial matrix]", "Parda", "DOPAMINE HYDROCHLORIDE", "Dihydroxyphenylalanine", "L-dopa zwitterion", "Cidandopa", "DA [extracellular region]", "dA [cytosol]", "DEOXYADENOSINE", "Docarpamine", "L-Dopa", "MELEVODOPA", "dA [extracellular region]", "Levodopa", "Levopa", "DOPAMINE", "Melevodopa", "Docarpamine (JAN/INN)", "Eldopal", "DL-Dopa", "Dopaidan", "Eurodopa", "3,4-Dihydroxy-L-phenylalanine", "DOCARPAMINE", "Maipedopa", "DA [cytosol]", "L-dopa", "Deadopa", "Deoxyadenosine", "2'-deoxyadenosine", "dopamine", "docarpamine", "Veldopa", "2'-deoxyformycin A", "2-amino-3-(3,4-dihydroxyphenyl)propanoic acid", "levodopa methyl ester", "Laradopa", "Larodopa", "melevodopa", "Eldopatec", "Dopar", "Ledopa", "DOPamine", "Bendopa", "Doparl", "L-Dopa [melanosome lumen]", "dopa", "Melevodopa (INN)", "deoxyadenosine [cytoplasm]", "Dopamine hydrochloride", "Dopal", "Eldopar", "levodopa", "L-Dopa [extracellular region]", "Dopamine hydrochloride (JP18/USP)", "Dopamine (INN)", "Dopalina", "Dopa, DL-", "Dopasol", "Dopaston"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["CHEMBL.COMPOUND:CHEMBL2106351", "PSY:14950", "DRUGBANK:DB13313", "RXNORM:6375", "LOINC:MTHU015998", "REACT:R-ALL-159362", "FMA:67238", "CHEMBL.COMPOUND:CHEMBL351042", "LOINC:LP15543-9", "REACT:R-ALL-380873", "MESH:C052143", "UMLS:C1517852", "CHEMBL.COMPOUND:CHEMBL1557", "MESH:D004295", "DrugCentral:1673", "REACT:R-ALL-83919", "UMLS:C1517855", "NCIT:C81078", "UMLS:C1517864", "KEGG.DRUG:D07304", "UMLS:C1517857", "DrugCentral:947", "UMLS:C1449995", "DrugCentral:938", "UMLS:C1517862", "HMDB:HMDB0000181", "MESH:C045970", "CHEBI:18243", "REACT:R-ALL-5668568", "NCIT:C1503", "REACT:R-ALL-83925", "CHEBI:31513", "ATC:C01CA04", "REACT:R-ALL-351601", "MESH:C035420", "KEGG.COMPOUND:C00355", "UMLS:C1517849", "ATC:N04BA01", "VANDF:4019733", "CHEBI:17256", "CHEMBL.COMPOUND:CHEMBL1328898", "NDDF:001639", "CHEMBL.COMPOUND:CHEMBL1009", "UMLS:C0013030", "DRUGBANK:DB01235", "HMDB:HMDB0000073", "NCIT:C62025", "MESH:D004298", "UMLS:C1517863", "MESH:D007980", "MESH:C058118", "UMLS:C1517851", "CHEBI:49168", "PathWhiz.Compound:52", "UMLS:C0045183", "VANDF:4017790", "UMLS:C0624727", "HMDB:HMDB0000101", "UMLS:C1517865", "UMLS:C1517853", "KEGG.DRUG:D00633", "LOINC:MTHU062948", "UMLS:C1517861", "REACT:R-ALL-1131748", "LOINC:LA16923-7", "LOINC:LP32555-2", "NCIT:C611", "UMLS:C0720022", "UMLS:C1517859", "CHEMBL.COMPOUND:CHEMBL59", "UMLS:C0699991", "UMLS:C1517856", "DRUGBANK:DB00988", "PathWhiz.Compound:117", "UMLS:C1517850", "REACT:R-ALL-209849", "CHEBI:134880", "DrugCentral:1567", "UMLS:C1517858", "UMLS:C1517847", "KEGG.DRUG:D07870", "LOINC:MTHU047917", "REACT:R-ALL-109731", "PDQ:CDR0000042622", "KEGG.COMPOUND:C03758", "CHEBI:15765", "KEGG.DRUG:D01903", "KEGG.COMPOUND:C00559", "UMLS:C1517845", "CHEBI:57504", "UMLS:C0023570", "UMLS:C1517848", "RXNORM:3628", "REACT:R-ALL-8851314", "LOINC:LP16328-4", "PathWhiz.Compound:68", "HMDB:HMDB0000609", "UMLS:C1517860", "LOINC:LP99925-7", "UMLS:C1517846", "PSY:28290", "UMLS:C1517854", "UMLS:C0700880", "CHEBI:4698", "CHEMBL.TARGET:CHEMBL2364177", "CHEMBL.COMPOUND:CHEMBL449329"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:23294703", "PMID:29091437", "PMID:7069713", "PMID:10454528", "PMID:1973733", "PMID:25656088", "PMID:16799554", "PMID:2552117", "PMID:14561867", "PMID:18834111"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL1697783": {"name": "METHYLPREDNISOLONE SULEPTANATE", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL1697783", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL1697783", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "The acetate salt of a synthetic glucocorticoid receptor agonist with immunosuppressive and antiinflammatory effects. Methylprednisolone acetate is converted into active prednisolone in the body, which activates glucocorticoid receptor mediated gene expression. This includes inducing synthesis of anti-inflammatory protein IkappaB-alpha and inhibiting synthesis of nuclear factor kappaB (NF-kappaB). As a result, proinflammatory cytokine production such as IL-1, IL-2 and IL-6 is down-regulated and cytotoxic T-lymphocyte activation is inhibited. Therefore, an overall reduction in chronic inflammation and autoimmune reactions may be achieved. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C48003\" active clinical trials using this agent. (\"http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C48003\" NCI Thesaurus); The acetate salt of a synthetic glucocorticoid receptor agonist with immunosuppressive and antiinflammatory effects. Methylprednisolone acetate is converted into active prednisolone in the body, which activates glucocorticoid receptor mediated gene expression. This includes inducing synthesis of anti-inflammatory protein IkappaB-alpha and inhibiting synthesis of nuclear factor kappaB (NF-kappaB). As a result, proinflammatory cytokine production such as IL-1, IL-2 and IL-6 is down-regulated and cytotoxic T-lymphocyte activation is inhibited. Therefore, an overall reduction in chronic inflammation and autoimmune reactions may be achieved.; Methylprednisolone derivative that is used as an anti-inflammatory agent for the treatment of ALLERGY and ALLERGIC RHINITIS; ASTHMA; and BURSITIS; and for the treatment of ADRENAL INSUFFICIENCY.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Methylprednisolone Aceponate", "SID26749858", "Methylprednisolone Suleptanate", "methylprednisolone suleptanate", "METHYLPREDNISOLONE ACETATE", "methylprednisolone acetate", "Methylprednisolone (JP18/USP/INN)", "Depo-Medrol", "Methylprednisolone", "METHYLPREDNISOLONE ACEPONATE", "Methylprednisolone aceponate (INN)", "Methylprednisolone suleptanate (USAN/INN)", "methylprednisolone", "6alpha-methylprednisolone", "Methylprednisolone Acetate, (11beta,16beta)-isomer", "methylprednisolone aceponate", "Methylprednisolone aceponate", "Methylprednisolone acetate (JAN/USP)", "Methylprednisolone acetate", "Pnu-67590a", "METHYLPREDNISOLONE", "METHYLPREDNISOLONE SULEPTANATE", "Methylprednisolone Acetate", "Advantan", "Acetic acid 2-(11,17-dihydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl ester", "methylprednisolone 21-suleptanic acid ester"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["RXNORM:6902", "DrugCentral:1768", "UMLS:C0630597", "CHEBI:6888", "NCIT:C90955", "CHEMBL.COMPOUND:CHEMBL66870", "KEGG.DRUG:D07203", "LOINC:LP18584-0", "UMLS:C0893911", "NCIT:C647", "UMLS:C0057476", "MESH:D000077555", "HMDB:HMDB0254660", "MESH:C078007", "CHEMBL.COMPOUND:CHEMBL1697783", "UMLS:C1527920", "NDDF:006227", "CHEMBL.COMPOUND:CHEMBL1200844", "ttd.target:Methylprednisolone_Acetate", "RXNORM:22584", "KEGG.DRUG:D00979", "DrugCentral:1769", "UMLS:C0025815", "HMDB:HMDB0254661", "CHEBI:6889", "NCIT:C77422", "CHEMBL.COMPOUND:CHEMBL650", "KEGG.COMPOUND:C08179", "ATC:D07AA01", "LOINC:MTHU004699", "RXNORM:62136", "ATC:D10AA02", "HMDB:HMDB0015094", "UMLS:C0174938", "UMLS:C0600901", "KEGG.DRUG:D00407", "VANDF:4018068", "NCIT:C48003", "CHEMBL.COMPOUND:CHEMBL1364144", "DRUGBANK:DB14643", "DRUGBANK:DB00959", "CHEBI:135762", "DrugCentral:1772", "PDQ:CDR0000041528", "RXNORM:155323", "KEGG.DRUG:D05002", "MESH:C052305", "VANDF:4018070", "CHEMBL.COMPOUND:CHEMBL1474440", "ATC:D07AC14", "UMLS:C0066429", "CHEBI:156480", "ATC:H02AB04", "CHEMBL.COMPOUND:CHEMBL1697782", "DrugCentral:1770", "MESH:D008775", "CHEMBL.COMPOUND:CHEMBL2106453", "CHEBI:135864"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:32181990", "PMID:455892", "PMID:23792784", "PMID:21458999", "PMID:12948019", "PMID:15646539", "PMID:13475063", "PMID:28435101", "PMID:17870541", "PMID:14661924"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "UniProtKB:P00439": {"name": "PAH", "categories": ["biolink:Gene", "biolink:Protein"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/uniprot:P00439", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/uniprot:P00439", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "A phenylalanine-4-hydroxylase that is encoded in the genome of Dictyostelium discoideum. // COMMENTS: Category=organism-gene.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:BiologicalEntity", "biolink:Gene", "biolink:Protein"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["phenylalanine-4-hydroxylase (Dictyostelium discoideum)", "PAH gene", "PAH", "phenylalanine-4-hydroxylase (human)", "Pah (rat)", "PAH S40L [cytosol]", "PAH (human)", "PAH [cytosol]", "Pah (mouse)", "phenylalanine-4-hydroxylase (mouse)"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["PR:P00439", "UMLS:C1418251", "REACT:R-HSA-71066", "OMIM:612349", "RGD:3248", "PR:Q54XS1", "REACT:R-HSA-5649486", "LOINC:LP63593-5", "HGNC:8582", "MGI:97473", "ENSEMBL:ENSG00000171759", "UniProtKB:P00439", "PR:P16331", "NCBIGene:5053"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["DOI:10.1002/(sici)1098-1004(1998)12:5<314::aid-humu4>3.0.co", "DOI:10.1016/j.ajhg.2008.05.013", "PMID:8364546", "PMID:9450897", "DOI:10.1056/nejmoa021654", "PMID:2840952", "PMID:10679941", "DOI:10.1007/bf00197152", "PMID:10694386", "PMID:1679029"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "UniProtKB:P04637": {"name": "TP53", "categories": ["biolink:Gene", "biolink:Protein"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/uniprot:P04637", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/uniprot:P04637", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Cellular tumor antigen p53 (393 aa, ~44 kDa) is encoded by the human TP53 gene. This protein plays a role in the regulation of both the cell cycle and apoptosis.; UMLS Semantic Type: STY:T123; UMLS Semantic Type: STY:T116", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:BiologicalEntity", "biolink:Gene", "biolink:Protein", "biolink:NamedThing"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["TP53 D281Efs*26 [nucleoplasm]", "TP53 P92Afs*57 [nucleoplasm]", "TP53 R290Kfs*53 [nucleoplasm]", "TP53 K319Rfs*26 [nucleoplasm]", "TP53 L93Cfs*30 [nucleoplasm]", "TP53 L43Cfs*9 [nucleoplasm]", "TP53 H115Ffs*33 [nucleoplasm]", "TP53 L264Sfs*8 [nucleoplasm]", "TP53 L145Afs*4 [nucleoplasm]", "p-T55-TP53 [nucleoplasm]", "TP53 H214Rfs*25 [nucleoplasm]", "TP53 L252Pfs*92 [nucleoplasm]", "TP53 T231Ffs*15 [nucleoplasm]", "TP53 D207Mfs*40 [nucleoplasm]", "TP53 R283Pfs*24 [nucleoplasm]", "TP53 V73Rfs*51 [nucleoplasm]", "TP53 E51Dfs*72 [nucleoplasm]", "TP53 V272Gfs*73 [nucleoplasm]", "TP53 W53Yfs*2 [nucleoplasm]", "TP53 E68* [nucleoplasm]", "TP53 G244Afs*3 [nucleoplasm]", "TP53 Q52Pfs*5 [nucleoplasm]", "TP53 L111Qfs*13 [nucleoplasm]", "TP53 C135Sfs*35 [nucleoplasm]", "TP53 V274Afs*33 [nucleoplasm]", "TP53 N210Kfs*6 [nucleoplasm]", "TP53 T150Afs*16 [nucleoplasm]", "TP53 S33Pfs*11 [nucleoplasm]", "TP53 L299Afs*6 [nucleoplasm]", "TP53 N239Wfs*4 [nucleoplasm]", "TP53 A276Lfs*29 [nucleoplasm]", "TP53 I232Sfs*15 [nucleoplasm]", "TP53 D208Efs*38 [nucleoplasm]", "TP53 L188Tfs*21 [nucleoplasm]", "TP53 Y205Ifs*42 [nucleoplasm]", "TP53 K139* [nucleoplasm]", "TP53 G334V [nucleoplasm]", "TP53 Q167Afs*13 [nucleoplasm]", "TP53 A74Sfs*71 [nucleoplasm]", "TP53 C242Afs*5 [nucleoplasm]", "TP53 H115Afs*34 [nucleoplasm]", "TP53 C124Lfs*25 [nucleoplasm]", "TP53 H168Rfs*4 [nucleoplasm]", "TP53 T155Hfs*26 [nucleoplasm]", "TP53 P152Lfs*29 [nucleoplasm]", "TP53 P190Lfs*53 [nucleoplasm]", "TP53 E56Rfs*6 [nucleoplasm]", "TP53 R249Sfs*96 [nucleoplasm]", "TP53 R110Qfs*15 [nucleoplasm]", "TP53 S95Ffs*53 [nucleoplasm]", "TP53 E224Gfs*4 [nucleoplasm]", "TP53 H296Tfs*49 [nucleoplasm]", "TP53 K292Rfs*13 [nucleoplasm]", "TP53 G244Rfs*19 [nucleoplasm]", "TP53 T256Hfs*89 [nucleoplasm]", "TP53 Y163Qfs*17 [nucleoplasm]", "TP53 N288Kfs*15 [nucleoplasm]", "TP53 S260Pfs*85 [nucleoplasm]", "TP53 M133Ifs*36 [nucleoplasm]", "TP53 P152Afs*28 [nucleoplasm]", "TP53 F270Lfs*72 [nucleoplasm]", "TP53 G325* [nucleoplasm]", "TP53 H233Vfs*8 [nucleoplasm]", "TP53 R174Mfs*68 [nucleoplasm]", "TP53 T170Lfs*2 [nucleoplasm]", "TP53 C242Hfs*18 [nucleoplasm]", "TP53 Q317Pfs*20 [nucleoplasm]", "TP53 G244Efs*17 [nucleoplasm]", "TP53 P60Vfs*64 [nucleoplasm]", "TP53 Q144Ffs*32 [nucleoplasm]", "TP53 E298Cfs*46 [nucleoplasm]", "TP53 P27Lfs*17 [nucleoplasm]", "TP53 A86Pfs*34 [nucleoplasm]", "TP53 S20Qfs*24 [nucleoplasm]", "TP53 R280Efs*26 [nucleoplasm]", "TP53 E51Pfs*59 [nucleoplasm]", "TP53 Q52* [nucleoplasm]", "TP53 S185Afs*62 [nucleoplasm]", "TP53 M66Nfs*83 [nucleoplasm]", "TP53 S315* [nucleoplasm]", "TP53 G187Vfs*60 [nucleoplasm]", "TP53 R249Kfs*15 [nucleoplasm]", "TP53 V122Afs*46 [nucleoplasm]", "TP53 G226Dfs*3 [nucleoplasm]", "TP53 I254Hfs*8 [nucleoplasm]", "TP53 L111Ifs*8 [nucleoplasm]", "TP53 C238* [nucleoplasm]", "TP53 E221* [nucleoplasm]", "TP53 G266* [nucleoplasm]", "TP53 R342P [nucleoplasm]", "TP53 V225Ffs*23 [nucleoplasm]", "TP53 I195Mfs*13 [nucleoplasm]", "TP53 P152Rfs*24 [nucleoplasm]", "TP53 R181Lfs*4 [nucleoplasm]", "TP53 R306Efs*39 [nucleoplasm]", "TP53 N210Hfs*5 [nucleoplasm]", "TP53 Y103Tfs*20 [nucleoplasm]", "TP53 Q167Nfs*4 [nucleoplasm]", "TP53 L323Wfs*22 [nucleoplasm]", "TP53 Q136Wfs*33 [nucleoplasm]", "TP53 R209Kfs*38 [nucleoplasm]", "TP53 A307Lfs*32 [nucleoplasm]", "TP53 T125Sfs*45 [nucleoplasm]", "TP53 S121Ifs*28 [nucleoplasm]", "TP53 S183Tfs*65 [nucleoplasm]", "TP53 A138Pfs*30 [nucleoplasm]", "TP53 P98Lfs*25 [nucleoplasm]", "TP53 W146Lfs*23 [nucleoplasm]", "TP53 D259Qfs*3 [nucleoplasm]", "TP53 A63Tfs*66 [nucleoplasm]", "TP53 P278Lfs*67 [nucleoplasm]", "TP53 Q38Sfs*4 [nucleoplasm]", "TP53 A138Pfs*32 [nucleoplasm]", "TP53 E294Vfs*12 [nucleoplasm]", "TP53 K292Lfs*54 [nucleoplasm]", "TP53 P87Lfs*59 [nucleoplasm]", "TP53 S215Ifs*33 [nucleoplasm]", "TP53 R209Hfs*5 [nucleoplasm]", "TP53 S313Afs*32 [nucleoplasm]", "TP53 D207Lfs*41 [nucleoplasm]", "TP53 A161Tfs*7 [nucleoplasm]", "TP53 L35Ffs*7 [nucleoplasm]", "TP53 G154Rfs*27 [nucleoplasm]", "TP53 (human)", "TP53 P177Tfs*69 [nucleoplasm]", "TP53 Q144Cfs*25 [nucleoplasm]", "TP53 S121Cfs*27 [nucleoplasm]", "TP53 R175Afs*6 [nucleoplasm]", "TP53 L130Dfs*16 [nucleoplasm]", "TP53 H178Pfs*70 [nucleoplasm]", "TP53 S313Lfs*45 [nucleoplasm]", "TP53 P295Lfs*50 [nucleoplasm]", "TP53 M133Pfs*13 [nucleoplasm]", "TP53 R249Tfs*14 [nucleoplasm]", "TP53 H179Lfs*68 [nucleoplasm]", "TP53 R158Afs*12 [nucleoplasm]", "TP53 R290Qfs*15 [nucleoplasm]", "TP53 A70Rfs*76 [nucleoplasm]", "TP53 Y234Lfs*4 [nucleoplasm]", "TP53 L206Wfs*41 [nucleoplasm]", "TP53 V218Sfs*26 [nucleoplasm]", "TP53 S127Ffs*36 [nucleoplasm]", "TP53 D324Afs*29 [nucleoplasm]", "TP53 I195Nfs*14 [nucleoplasm]", "TP53 W53Mfs*4 [nucleoplasm]", "TP53 I255Sfs*90 [nucleoplasm]", "TP53 G112Lfs*7 [nucleoplasm]", "TP53 G154Afs*16 [nucleoplasm]", "TP53 K120Qfs*29 [nucleoplasm]", "TP53 P191Lfs*53 [nucleoplasm]", "TP53 P85Hfs*37 [nucleoplasm]", "TP53 C238Vfs*9 [nucleoplasm]", "TP53 E68Rfs*81 [nucleoplasm]", "TP53 D186Mfs*61 [nucleoplasm]", "TP53 T304Yfs*2 [nucleoplasm]", "TP53 C124Afs*46 [nucleoplasm]", "TP53 E294Afs*11 [nucleoplasm]", "TP53 P278Sfs*28 [nucleoplasm]", "TP53 A129Pfs*41 [nucleoplasm]", "TP53 V73Lfs*43 [nucleoplasm]", "TP53 T155Pfs*25 [nucleoplasm]", "TP53 P142Gfs*24 [nucleoplasm]", "TP53 M133Ifs*12 [nucleoplasm]", "TP53 S33* [nucleoplasm]", "TP53 P80Rfs*41 [nucleoplasm]", "TP53 gene", "TP53 E204Wfs*44 [nucleoplasm]", "TP53 L348S [nucleoplasm]", "TP53 E294Gfs*12 [nucleoplasm]", "TP53 N263Tfs*7 [nucleoplasm]", "TP53 R209* [nucleoplasm]", "TP53 S106Rfs*16 [nucleoplasm]", "TP53 P75Lfs*74 [nucleoplasm]", "TP53 L130Tfs*39 [nucleoplasm]", "TP53 C229Yfs*10 [nucleoplasm]", "TP53 Y163Tfs*14 [nucleoplasm]", "TP53 L188Pfs*19 [nucleoplasm]", "TP53 N247Tfs*98 [nucleoplasm]", "TP53 C141Afs*29 [nucleoplasm]", "TP53 S99Pfs*24 [nucleoplasm]", "TP53 M237Cfs*10 [nucleoplasm]", "TP53 D57Tfs*72 [nucleoplasm]", "TP53 P60Qfs*63 [nucleoplasm]", "TP53 A84Vfs*65 [nucleoplasm]", "TP53 Y163Hfs*4 [nucleoplasm]", "TP53 C141Wfs*8 [nucleoplasm]", "TP53 S269Gfs*34 [nucleoplasm]", "TP53 I162Wfs*10 [nucleoplasm]", "TP53 C124* [nucleoplasm]", "TP53 S95Ifs*54 [nucleoplasm]", "TP53 R273Vfs*72 [nucleoplasm]", "TP53 P34Lfs*8 [nucleoplasm]", "TP53 S116Vfs*23 [nucleoplasm]", "TP53 T155Pfs*15 [nucleoplasm]", "TP53 T150Hfs*20 [nucleoplasm]", "TP53 P71Sfs*78 [nucleoplasm]", "TP53 E286* [nucleoplasm]", "TP53 C135Yfs*9 [nucleoplasm]", "TP53 Y103Rfs*19 [nucleoplasm]", "TP53 N268Qfs*3 [nucleoplasm]", "TP53 C275Lfs*70 [nucleoplasm]", "TP53 C229* [nucleoplasm]", "TP53 P75Lfs*48 [nucleoplasm]", "TP53 D228* [nucleoplasm]", "TP53 E286Sfs*17 [nucleoplasm]", "TP53 L93Pfs*59 [nucleoplasm]", "TP53 D208Efs*7 [nucleoplasm]", "TP53 A86Vfs*55 [nucleoplasm]", "TP53 D61* [nucleoplasm]", "TP53 H214Ifs*33 [nucleoplasm]", "TP53 C242Gfs*20 [nucleoplasm]", "TP53 K120Mfs*25 [nucleoplasm]", "TP53 N288Afs*55 [nucleoplasm]", "TP53 D57Sfs*86 [nucleoplasm]", "TP53 D207Ffs*3 [nucleoplasm]", "TP53 M44Tfs*75 [nucleoplasm]", "TP53 M246Ifs*92 [nucleoplasm]", "TP53 A347T [nucleoplasm]", "TP53 A88Sfs*61 [nucleoplasm]", "TP53 N311Kfs*34 [nucleoplasm]", "TP53 E204Tfs*39 [nucleoplasm]", "TP53 E286Hfs*22 [nucleoplasm]", "TP53 D207Efs*6 [nucleoplasm]", "TP53 R209Lfs*36 [nucleoplasm]", "TP53 P300Qfs*44 [nucleoplasm]", "TP53 S94Pfs*24 [nucleoplasm]", "TP53 Q144Hfs*4 [nucleoplasm]", "TP53 L265Pfs*5 [nucleoplasm]", "TP53 S261Tfs*2 [nucleoplasm]", "TP53 P36Afs*7 [nucleoplasm]", "TP53 N288Sfs*17 [nucleoplasm]", "TP53 P191Sfs*15 [nucleoplasm]", "TP53 T81Nfs*68 [nucleoplasm]", "TP53 M237* [nucleoplasm]", "TP53 H233Pfs*6 [nucleoplasm]", "TP53 L206* [nucleoplasm]", "TP53 D259Rfs*5 [nucleoplasm]", "TP53 R283Afs*62 [nucleoplasm]", "TP53 T230Pfs*17 [nucleoplasm]", "TP53 R213* [nucleoplasm]", "TP53 P82Afs*70 [nucleoplasm]", "TP53 S314Lfs*22 [nucleoplasm]", "p-S15,S20,S269,T284-TP53 [nucleoplasm]", "TP53 Q167* [nucleoplasm]", "TP53 C277* [nucleoplasm]", "TP53 gene [nucleoplasm]", "TP53 Y163* [nucleoplasm]", "TP53 L257Vfs*84 [nucleoplasm]", "TP53 Q144Pfs*5 [nucleoplasm]", "TP53 E221Gfs*26 [nucleoplasm]", "TP53 L330H [nucleoplasm]", "TP53 Y103Lfs*46 [nucleoplasm]", "TP53 N29Kfs*13 [nucleoplasm]", "TP53 A83Rfs*40 [nucleoplasm]", "TP53 R283Sfs*23 [nucleoplasm]", "TP53 Q144Afs*4 [nucleoplasm]", "TP53 F134Lfs*14 [nucleoplasm]", "TP53 D48* [nucleoplasm]", "TP53 Q38* [nucleoplasm]", "TP53 E271Gfs*74 [nucleoplasm]", "TP53 P82Rfs*41 [nucleoplasm]", "TP53 G302Hfs*2 [nucleoplasm]", "TP53 N310Qfs*27 [nucleoplasm]", "TP53 D184Efs*64 [nucleoplasm]", "TP53 H179Mfs*68 [nucleoplasm]", "TP53 R110Pfs*39 [nucleoplasm]", "TP53 P87Ifs*54 [nucleoplasm]", "TP53 E180Afs*65 [nucleoplasm]", "TP53 P190Sfs*12 [nucleoplasm]", "TP53 N288Qfs*15 [nucleoplasm]", "TP53 K139Nfs*9 [nucleoplasm]", "TP53 S185Rfs*23 [nucleoplasm]", "TP53 E271* [nucleoplasm]", "TP53 T118Qfs*5 [nucleoplasm]", "TP53 D324Rfs*13 [nucleoplasm]", "TP53 N268Tfs*77 [nucleoplasm]", "TP53 F109Sfs*14 [nucleoplasm]", "TP53 A83Gfs*66 [nucleoplasm]", "TP53 Q192Afs*16 [nucleoplasm]", "TP53 Q52Hfs*71 [nucleoplasm]", "TP53 R283Lfs*23 [nucleoplasm]", "TP53 C277Vfs*68 [nucleoplasm]", "TP53 Q165Hfs*5 [nucleoplasm]", "p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]", "TP53 L308Afs*6 [nucleoplasm]", "TP53 V157Rfs*24 [nucleoplasm]", "TP53 E51Gfs*6 [nucleoplasm]", "TP53 T211Ifs*4 [nucleoplasm]", "TP53 W146Pfs*19 [nucleoplasm]", "TP53 S46Vfs*6 [nucleoplasm]", "TP53 D148Gfs*2 [nucleoplasm]", "TP53 T140Pfs*30 [nucleoplasm]", "TP53 G334W [nucleoplasm]", "TP53 Y107Tfs*44 [nucleoplasm]", "TP53 A189Gfs*20 [nucleoplasm]", "TP53 Q104Pfs*45 [nucleoplasm]", "TP53 T155Afs*28 [nucleoplasm]", "TP53 T284Hfs*22 [nucleoplasm]", "TP53 A138Rfs*31 [nucleoplasm]", "TP53 S96Lfs*27 [nucleoplasm]", "TP53 H179Pfs*2 [nucleoplasm]", "TP53 E56Kfs*67 [nucleoplasm]", "TP53 E224Afs*2 [nucleoplasm]", "TP53 F341C [nucleoplasm]", "TP53 C124Wfs*25 [nucleoplasm]", "TP53 T170Sfs*8 [nucleoplasm]", "TP53 L252Pfs*12 [nucleoplasm]", "TP53 A69Cfs*79 [nucleoplasm]", "TP53 D49Efs*3 [nucleoplasm]", "TP53 T256Ifs*90 [nucleoplasm]", "TP53 N200Kfs*9 [nucleoplasm]", "TP53 T140Mfs*28 [nucleoplasm]", "TP53 D48Efs*75 [nucleoplasm]", "TP53 G154Vfs*18 [nucleoplasm]", "TP53 N239Kfs*25 [nucleoplasm]", "TP53 L43Afs*7 [nucleoplasm]", "TP53 Y220Hfs*5 [nucleoplasm]", "TP53 G108Afs*39 [nucleoplasm]", "TP53 G199Ifs*42 [nucleoplasm]", "TP53 S313Pfs*33 [nucleoplasm]", "TP53 T284Rfs*19 [nucleoplasm]", "TP53 M237Vfs*9 [nucleoplasm]", "TP53 T118Cfs*27 [nucleoplasm]", "TP53 G117Wfs*32 [nucleoplasm]", "TP53 R158Sfs*23 [nucleoplasm]", "TP53 G105Afs*18 [nucleoplasm]", "TP53 P316Sfs*21 [nucleoplasm]", "TP53 D207Gfs*8 [nucleoplasm]", "TP53 Q136Hfs*34 [nucleoplasm]", "TP53 H168Pfs*2 [nucleoplasm]", "TP53 F113Lfs*11 [nucleoplasm]", "p-S15,S20,S392-TP53 [nucleoplasm]", "TP53 V157Pfs*9 [nucleoplasm]", "TP53 Q100Sfs*54 [nucleoplasm]", "TP53 C238Hfs*21 [nucleoplasm]", "TP53 L26Qfs*13 [nucleoplasm]", "TP53 P72Rfs*76 [nucleoplasm]", "TP53 R174Kfs*24 [nucleoplasm]", "TP53 C275Lfs*67 [nucleoplasm]", "TP53 S95Lfs*28 [nucleoplasm]", "TP53 N268* [nucleoplasm]", "TP53 R290Afs*55 [nucleoplasm]", "TP53 V97Lfs*25 [nucleoplasm]", "TP53 R249Afs*14 [nucleoplasm]", "TP53 S37Cfs*79 [nucleoplasm]", "TP53 E171Mfs*61 [nucleoplasm]", "TP53 L93Afs*57 [nucleoplasm]", "TP53 K164* [nucleoplasm]", "TP53 P67Rfs*81 [nucleoplasm]", "TP53 P222Gfs*4 [nucleoplasm]", "TP53 S269Kfs*3 [nucleoplasm]", "TP53 E285* [nucleoplasm]", "TP53 I251Hfs*11 [nucleoplasm]", "TP53 P77Cfs*73 [nucleoplasm]", "TP53 K292Nfs*7 [nucleoplasm]", "TP53 Gene", "TP53 Q167Hfs*4 [nucleoplasm]", "TP53 P67Lfs*54 [nucleoplasm]", "TP53 C277Ffs*68 [nucleoplasm]", "TP53 S240Kfs*24 [nucleoplasm]", "TP53 L299Afs*7 [nucleoplasm]", "TP53 R306Afs*31 [nucleoplasm]", "TP53 T55Mfs*68 [nucleoplasm]", "TP53 V122Dfs*26 [nucleoplasm]", "TP53 K164Sfs*3 [nucleoplasm]", "TP53 P322Tfs*15 [nucleoplasm]", "TP53 L201Ffs*8 [nucleoplasm]", "TP53 Y107Vfs*13 [nucleoplasm]", "TP53 R283Hfs*22 [nucleoplasm]", "TP53 L130Sfs*40 [nucleoplasm]", "TP53 L14Sfs*15 [nucleoplasm]", "TP53 R267Gfs*78 [nucleoplasm]", "TP53 G302Vfs*44 [nucleoplasm]", "TP53 P222Sfs*26 [nucleoplasm]", "TP53 A159Pfs*11 [nucleoplasm]", "TP53 P322Hfs*23 [nucleoplasm]", "TP53 G262Lfs*2 [nucleoplasm]", "TP53 D148Efs*23 [nucleoplasm]", "TP53 L257Wfs*88 [nucleoplasm]", "TP53 A83Cfs*30 [nucleoplasm]", "TP53 S106Tfs*17 [nucleoplasm]", "TP53 C141Afs*5 [nucleoplasm]", "TP53 V173Rfs*23 [nucleoplasm]", "TP53 M66Sfs*57 [nucleoplasm]", "TP53 D57Vfs*64 [nucleoplasm]", "TP53 S106Vfs*15 [nucleoplasm]", "TP53 E298* [nucleoplasm]", "TP53 [nucleoplasm]", "TP53 D228Lfs*11 [nucleoplasm]", "TP53 E180* [nucleoplasm]", "TP53 L206Ffs*35 [nucleoplasm]", "TP53 Q317Sfs*28 [nucleoplasm]", "TP53 E198* [nucleoplasm]", "TP53 R290Lfs*50 [nucleoplasm]", "TP53 L308Sfs*30 [nucleoplasm]", "TP53 N131Cfs*27 [nucleoplasm]", "TP53 G244Afs*4 [nucleoplasm]", "TP53 R196Pfs*13 [nucleoplasm]", "TP53 I255Hfs*8 [nucleoplasm]", "TP53 A129Cfs*20 [nucleoplasm]", "TP53 V97Tfs*66 [nucleoplasm]", "TP53 A39Mfs*3 [nucleoplasm]", "TP53 K351R [nucleoplasm]", "TP53 R280Afs*62 [nucleoplasm]", "TP53 H168Tfs*69 [nucleoplasm]", "TP53 S33Vfs*6 [nucleoplasm]", "TP53 S269Cfs*32 [nucleoplasm]", "TP53 G244Tfs*19 [nucleoplasm]", "TP53 P153Sfs*28 [nucleoplasm]", "TP53 L35Cfs*9 [nucleoplasm]", "TP53 V97Sfs*26 [nucleoplasm]", "TP53 T211Lfs*36 [nucleoplasm]", "TP53 L111Ffs*40 [nucleoplasm]", "TP53 V143Lfs*28 [nucleoplasm]", "TP53 S149Yfs*31 [nucleoplasm]", "TP53 I195Sfs*52 [nucleoplasm]", "TP53 L188* [nucleoplasm]", "TP53 E204Gfs*46 [nucleoplasm]", "TP53 R209Kfs*6 [nucleoplasm]", "TP53 F270Vfs*72 [nucleoplasm]", "TP53 Q100* [nucleoplasm]", "TP53 R196Cfs*46 [nucleoplasm]", "TP53 K120Sfs*3 [nucleoplasm]", "TP53 N239Tfs*8 [nucleoplasm]", "TP53 I195Yfs*14 [nucleoplasm]", "TP53 K132Rfs*38 [nucleoplasm]", "TP53 G245Pfs*16 [nucleoplasm]", "TP53 A86Gfs*63 [nucleoplasm]", "TP53 N239Lfs*22 [nucleoplasm]", "TP53 Q192* [nucleoplasm]", "TP53 R158Pfs*12 [nucleoplasm]", "TP53 L344R [nucleoplasm]", "TP53 S227Lfs*20 [nucleoplasm]", "TP53 L114Cfs*30 [nucleoplasm]", "TP53 A84Pfs*35 [nucleoplasm]", "TP53 Y234Ifs*6 [nucleoplasm]", "TP53 R213Sfs*3 [nucleoplasm]", "TP53 L114* [nucleoplasm]", "TP53 R202Kfs*9 [nucleoplasm]", "TP53 P153Rfs*22 [nucleoplasm]", "TP53 G108Vfs*13 [nucleoplasm]", "TP53 V203Gfs*5 [nucleoplasm]", "TP53 K320Efs*17 [nucleoplasm]", "TP53 V157Sfs*13 [nucleoplasm]", "TP53 L114Cfs*9 [nucleoplasm]", "TP53 Q136Sfs*13 [nucleoplasm]", "TP53 R156Pfs*14 [nucleoplasm]", "TP53 P278Wfs*27 [nucleoplasm]", "TP53 A276Lfs*31 [nucleoplasm]", "TP53 A161Pfs*9 [nucleoplasm]", "TP53 Y220* [nucleoplasm]", "TP53 P77Sfs*71 [nucleoplasm]", "TP53 I251Tfs*94 [nucleoplasm]", "TP53 G293Efs*3 [nucleoplasm]", "TP53 L308Afs*28 [nucleoplasm]", "TP53 G226Pfs*17 [nucleoplasm]", "TP53 R213Vfs*32 [nucleoplasm]", "TP53 H214Tfs*2 [nucleoplasm]", "TP53 C141* [nucleoplasm]", "p-S315-TP53 [nucleoplasm]", "TP53 V143Rfs*6 [nucleoplasm]", "TP53 S94Ffs*28 [nucleoplasm]", "TP53 D41Gfs*2 [nucleoplasm]", "TP53 T284Rfs*21 [nucleoplasm]", "TP53 R175Pfs*72 [nucleoplasm]", "TP53 Q136Nfs*34 [nucleoplasm]", "TP53 S260Lfs*4 [nucleoplasm]", "TP53 S240Qfs*24 [nucleoplasm]", "TP53 T304Qfs*44 [nucleoplasm]", "TP53 V225Lfs*22 [nucleoplasm]", "TP53 S315Pfs*31 [nucleoplasm]", "TP53 I50Nfs*72 [nucleoplasm]", "TP53 S127Lfs*42 [nucleoplasm]", "TP53 P71Wfs*50 [nucleoplasm]", "TP53 F341V [nucleoplasm]", "TP53 G199Efs*48 [nucleoplasm]", "TP53 S90Lfs*59 [nucleoplasm]", "TP53 A86Cfs*63 [nucleoplasm]", "TP53 N131Tfs*39 [nucleoplasm]", "TP53 D259Afs*86 [nucleoplasm]", "TP53 P318Efs*16 [nucleoplasm]", "TP53 F270Lfs*2 [nucleoplasm]", "TP53 H168Rfs*3 [nucleoplasm]", "TP53 P36Wfs*4 [nucleoplasm]", "TP53 R175Lfs*5 [nucleoplasm]", "TP53 Y103Efs*23 [nucleoplasm]", "TP53 G154Wfs*10 [nucleoplasm]", "TP53 E68Gfs*80 [nucleoplasm]", "TP53 S149Pfs*21 [nucleoplasm]", "TP53 I50Mfs*73 [nucleoplasm]", "TP53 C176Afs*65 [nucleoplasm]", "TP53 S94Yfs*29 [nucleoplasm]", "TP53 D228Tfs*19 [nucleoplasm]", "TP53 Y163Lfs*18 [nucleoplasm]", "TP53 T123Hfs*24 [nucleoplasm]", "TP53 D208* [nucleoplasm]", "TP53 S183* [nucleoplasm]", "TP53 P128Tfs*21 [nucleoplasm]", "TP53 W146Ifs*22 [nucleoplasm]", "TP53 Q100Gfs*37 [nucleoplasm]", "TP53 R156Lfs*25 [nucleoplasm]", "TP53 K291* [nucleoplasm]", "TP53 W91Vfs*13 [nucleoplasm]", "TP53 S215Ifs*36 [nucleoplasm]", "TP53 R65* [nucleoplasm]", "TP53 S269Rfs*74 [nucleoplasm]", "TP53 H168Rfs*23 [nucleoplasm]", "TP53 Y220Mfs*27 [nucleoplasm]", "TP53 Y126Sfs*44 [nucleoplasm]", "TP53 P223Lfs*24 [nucleoplasm]", "TP53 H233Lfs*6 [nucleoplasm]", "TP53 V173Efs*7 [nucleoplasm]", "TP53 E258* [nucleoplasm]", "TP53 I50* [nucleoplasm]", "TP53 V157Afs*24 [nucleoplasm]", "TP53 P142Afs*7 [nucleoplasm]", "TP53 L264Yfs*81 [nucleoplasm]", "TP53 P222Rfs*25 [nucleoplasm]", "TP53 S227Hfs*9 [nucleoplasm]", "TP53 D281Efs*18 [nucleoplasm]", "TP53 K120Tfs*2 [nucleoplasm]", "TP53 N239Pfs*6 [nucleoplasm]", "TP53 Y126* [nucleoplasm]", "TP53 R248* [nucleoplasm]", "TP53 Q167Tfs*14 [nucleoplasm]", "TP53 P152Hfs*29 [nucleoplasm]", "TP53 E198Afs*7 [nucleoplasm]", "TP53 R174Sfs*73 [nucleoplasm]", "TP53 P77Qfs*46 [nucleoplasm]", "TP53 N288Ifs*57 [nucleoplasm]", "TP53 K164Nfs*6 [nucleoplasm]", "TP53 T125Afs*46 [nucleoplasm]", "TP53 C176Sfs*67 [nucleoplasm]", "TP53 P82Gfs*66 [nucleoplasm]", "TP53 D21Tfs*23 [nucleoplasm]", "TP53 G245Vfs*19 [nucleoplasm]", "TP53 C242Hfs*21 [nucleoplasm]", "TP53 V157Rfs*22 [nucleoplasm]", "TP53 V216Gfs*31 [nucleoplasm]", "TP53 Y205Tfs*37 [nucleoplasm]", "TP53 D184Efs*24 [nucleoplasm]", "TP53 L201Cfs*46 [nucleoplasm]", "TP53 K101Lfs*42 [nucleoplasm]", "TP53 H115Ifs*8 [nucleoplasm]", "TP53 G154Afs*14 [nucleoplasm]", "TP53 T304Lfs*41 [nucleoplasm]", "TP53 E298Tfs*48 [nucleoplasm]", "TP53 R280Sfs*66 [nucleoplasm]", "TP53 N239Afs*5 [nucleoplasm]", "TP53 L194Sfs*52 [nucleoplasm]", "cellular tumor antigen p53 (human)", "TP53 R248Qfs*15 [nucleoplasm]", "TP53 N239Kfs*22 [nucleoplasm]", "TP53 E204Wfs*41 [nucleoplasm]", "TP53 E221Sfs*26 [nucleoplasm]", "TP53 K24Nfs*20 [nucleoplasm]", "TP53 K305* [nucleoplasm]", "TP53 W23* [nucleoplasm]", "TP53 F341L [nucleoplasm]", "TP53 H168Qfs*2 [nucleoplasm]", "TP53 G245Afs*14 [nucleoplasm]", "TP53 K320Mfs*21 [nucleoplasm]", "TP53 H178Tfs*69 [nucleoplasm]", "TP53 Q52Lfs*68 [nucleoplasm]", "TP53 L32Cfs*12 [nucleoplasm]", "TP53 A276Vfs*68 [nucleoplasm]", "TP53 D48Gfs*4 [nucleoplasm]", "TP53 T253Hfs*11 [nucleoplasm]", "TP53 R267Tfs*5 [nucleoplasm]", "TP53 L93Rfs*30 [nucleoplasm]", "TP53 E285Rfs*54 [nucleoplasm]", "TP53 D281Afs*26 [nucleoplasm]", "TP53 P309Lfs*31 [nucleoplasm]", "TP53 R213Tfs*2 [nucleoplasm]", "TP53 P152Afs*14 [nucleoplasm]", "TP53 E56* [nucleoplasm]", "TP53 R248Gfs*97 [nucleoplasm]", "TP53 A119Qfs*5 [nucleoplasm]", "TP53 R337P [nucleoplasm]", "TP53 Q192Pfs*17 [nucleoplasm]", "TP53 R280Tfs*64 [nucleoplasm]", "TP53 R175Afs*72 [nucleoplasm]", "TP53 D41Mfs*3 [nucleoplasm]", "TP53 V73Rfs*76 [nucleoplasm]", "TP53 L299Cfs*46 [nucleoplasm]", "TP53 D184Vfs*63 [nucleoplasm]", "TP53 R290Gfs*12 [nucleoplasm]", "TP53 I195Cfs*46 [nucleoplasm]", "TP53 Y327* [nucleoplasm]", "TP53 S227* [nucleoplasm]", "TP53 E221Vfs*4 [nucleoplasm]", "TP53 T81Nfs*42 [nucleoplasm]", "TP53 D207Kfs*6 [nucleoplasm]", "TP53 S227Vfs*2 [nucleoplasm]", "TP53 N29Kfs*14 [nucleoplasm]", "TP53 Q317Rfs*28 [nucleoplasm]", "TP53 R196Sfs*12 [nucleoplasm]", "TP53 S149Ffs*32 [nucleoplasm]", "TP53 M133Nfs*34 [nucleoplasm]", "p-S37-TP53 [nucleoplasm]", "TP53 L130Pfs*19 [nucleoplasm]", "TP53 Q38Wfs*4 [nucleoplasm]", "TP53 S96Yfs*53 [nucleoplasm]", "TP53 C124Yfs*24 [nucleoplasm]", "TP53 Q144Afs*16 [nucleoplasm]", "TP53 Y220Rfs*25 [nucleoplasm]", "TP53 K351N [nucleoplasm]", "TP53 H178Pfs*3 [nucleoplasm]", "TP53 P71Gfs*75 [nucleoplasm]", "TP53 Q354* [nucleoplasm]", "TP53 [cytosol]", "TP53 C275Vfs*70 [nucleoplasm]", "TP53 Q167Sfs*3 [nucleoplasm]", "TP53 C277Lfs*67 [nucleoplasm]", "TP53 S96Ffs*53 [nucleoplasm]", "TP53 A74Gfs*75 [nucleoplasm]", "TP53 H168Rfs*5 [nucleoplasm]", "TP53 R283Kfs*59 [nucleoplasm]", "TP53 V274Cfs*32 [nucleoplasm]", "TP53 T55Pfs*52 [nucleoplasm]", "TP53 T231Nfs*9 [nucleoplasm]", "TP53 A69Lfs*54 [nucleoplasm]", "TP53 K139Afs*4 [nucleoplasm]", "TP53 L22Yfs*22 [nucleoplasm]", "TP53 R337L [nucleoplasm]", "TP53 S94Cfs*30 [nucleoplasm]", "TP53 G112Cfs*9 [nucleoplasm]", "Tp53 (rat)", "TP53 T123Ifs*47 [nucleoplasm]", "TP53 M66Ifs*76 [nucleoplasm]", "TP53 P153Sfs*13 [nucleoplasm]", "TP53 T155Hfs*21 [nucleoplasm]", "TP53 V147Lfs*23 [nucleoplasm]", "TP53 K321Nfs*24 [nucleoplasm]", "TP53 R209Sfs*5 [nucleoplasm]", "TP53 R181Pfs*66 [nucleoplasm]", "TP53 T155Pfs*23 [nucleoplasm]", "TP53 L111Rfs*37 [nucleoplasm]", "TP53 V143Cfs*27 [nucleoplasm]", "TP53 Q104* [nucleoplasm]", "TP53 P223Rfs*4 [nucleoplasm]", "TP53 R306Lfs*32 [nucleoplasm]", "TP53 L257Pfs*85 [nucleoplasm]", "TP53 L344P [nucleoplasm]", "TP53 I195Lfs*53 [nucleoplasm]", "TP53 V157Pfs*23 [nucleoplasm]", "TP53 G108Rfs*41 [nucleoplasm]", "TP53 S90Pfs*34 [nucleoplasm]", "TP53 Y234* [nucleoplasm]", "TP53 M133Cfs*37 [nucleoplasm]", "TP53 H214Qfs*7 [nucleoplasm]", "TP53 H193Qfs*48 [nucleoplasm]", "TP53 E271Gfs*73 [nucleoplasm]", "TP53 A63Lfs*60 [nucleoplasm]", "TP53 W91Cfs*52 [nucleoplasm]", "TP53 R196Efs*51 [nucleoplasm]", "TP53 K321Efs*16 [nucleoplasm]", "TP53 I195Sfs*12 [nucleoplasm]", "TP53 L130Pfs*39 [nucleoplasm]", "TP53 P85Lfs*59 [nucleoplasm]", "TP53 E171Lfs*2 [nucleoplasm]", "TP53 Q144Rfs*26 [nucleoplasm]", "TP53 K291Rfs*54 [nucleoplasm]", "TP53 P67Qfs*56 [nucleoplasm]", "TP53 P142Afs*5 [nucleoplasm]", "TP53 M44Sfs*79 [nucleoplasm]", "TP53 Q167Hfs*3 [nucleoplasm]", "TP53 K320* [nucleoplasm]", "TP53 Y234Sfs*15 [nucleoplasm]", "TP53 N268Kfs*4 [nucleoplasm]", "TP53 L26Pfs*11 [nucleoplasm]", "TP53 S149Pfs*17 [nucleoplasm]", "TP53 S149Afs*72 [nucleoplasm]", "TP53 L130Cfs*20 [nucleoplasm]", "TP53 G112Afs*11 [nucleoplasm]", "TP53 T18Hfs*26 [nucleoplasm]", "TP53 C176Mfs*68 [nucleoplasm]", "TP53 Y205Sfs*4 [nucleoplasm]", "TP53 P190Sfs*17 [nucleoplasm]", "TP53 G279* [nucleoplasm]", "TP53 Y234Qfs*5 [nucleoplasm]", "TP53 S269Lfs*75 [nucleoplasm]", "TP53 A74Pfs*49 [nucleoplasm]", "TP53 S95Hfs*29 [nucleoplasm]", "TP53 S185Tfs*62 [nucleoplasm]", "TP53 G302Afs*42 [nucleoplasm]", "TP53 R213Ffs*35 [nucleoplasm]", "TP53 N200Vfs*4 [nucleoplasm]", "TP53 G154Pfs*28 [nucleoplasm]", "TP53 T312Nfs*25 [nucleoplasm]", "TP53 T304Lfs*3 [nucleoplasm]", "TP53 D148Ifs*22 [nucleoplasm]", "TP53 A138Gfs*11 [nucleoplasm]", "TP53 T125Lfs*25 [nucleoplasm]", "TP53 Q136Pfs*13 [nucleoplasm]", "TP53 P128Tfs*12 [nucleoplasm]", "TP53 N288Kfs*18 [nucleoplasm]", "TP53 S240* [nucleoplasm]", "TP53 A307Gfs*30 [nucleoplasm]", "TP53 Q192Sfs*55 [nucleoplasm]", "TP53 M243* [nucleoplasm]", "TP53 V122Hfs*24 [nucleoplasm]", "TP53 N288Efs*14 [nucleoplasm]", "TP53 S315Lfs*30 [nucleoplasm]", "TP53 T123Rfs*48 [nucleoplasm]", "Ac-K120,p-S15,S20-TP53 [nucleoplasm]", "TP53 Q317Afs*19 [nucleoplasm]", "TP53 R248Pfs*16 [nucleoplasm]", "TP53 S96Cfs*52 [nucleoplasm]", "TP53 P316Afs*19 [nucleoplasm]", "TP53 H297Pfs*48 [nucleoplasm]", "TP53 T256Nfs*8 [nucleoplasm]", "TP53 S303Afs*42 [nucleoplasm]", "TP53 A86Pfs*33 [nucleoplasm]", "TP53 W91Cfs*32 [nucleoplasm]", "TP53 G266Efs*4 [nucleoplasm]", "TP53 Q136Pfs*30 [nucleoplasm]", "TP53 T304Ifs*41 [nucleoplasm]", "TP53 S240Vfs*7 [nucleoplasm]", "TP53 P278Lfs*28 [nucleoplasm]", "TP53 P13Lfs*2 [nucleoplasm]", "TP53 Q38Kfs*6 [nucleoplasm]", "TP53 C176* [nucleoplasm]", "TP53 Y205Ffs*8 [nucleoplasm]", "TP53 E287* [nucleoplasm]", "TP53 N310Kfs*27 [nucleoplasm]", "TP53 N268Pfs*45 [nucleoplasm]", "TP53 G59Vfs*64 [nucleoplasm]", "TP53 A189Pfs*19 [nucleoplasm]", "TP53 A189Cfs*20 [nucleoplasm]", "TP53 G112Lfs*36 [nucleoplasm]", "TP53 L330I [nucleoplasm]", "TP53 E287Sfs*17 [nucleoplasm]", "TP53 S94Hfs*29 [nucleoplasm]", "TP53 Q52Kfs*67 [nucleoplasm]", "TP53 T125Ifs*47 [nucleoplasm]", "TP53 E224Rfs*23 [nucleoplasm]", "TP53 Q144Afs*5 [nucleoplasm]", "TP53 I162Sfs*8 [nucleoplasm]", "TP53 V216Afs*28 [nucleoplasm]", "TP53 F109Tfs*16 [nucleoplasm]", "TP53 T253Nfs*11 [nucleoplasm]", "TP53 L257Hfs*89 [nucleoplasm]", "TP53 R196Ffs*8 [nucleoplasm]", "TP53 P82Hfs*42 [nucleoplasm]", "SUMO2,3-K386-TP53 [nucleoplasm]", "TP53 T256Hfs*8 [nucleoplasm]", "TP53 D42Qfs*5 [nucleoplasm]", "TP53 W146* [nucleoplasm]", "TP53 G279Pfs*69 [nucleoplasm]", "TP53 I195Wfs*50 [nucleoplasm]", "TP53 E198Ifs*47 [nucleoplasm]", "TP53 G279Efs*26 [nucleoplasm]", "TP53 R158Hfs*21 [nucleoplasm]", "TP53 M246Rfs*19 [nucleoplasm]", "TP53 R273Cfs*32 [nucleoplasm]", "TP53 R110Sfs*14 [nucleoplasm]", "TP53 H178Afs*65 [nucleoplasm]", "TP53 L130Pfs*41 [nucleoplasm]", "TP53 H179Qfs*64 [nucleoplasm]", "TP53 R209Ffs*35 [nucleoplasm]", "TP53 G59Qfs*84 [nucleoplasm]", "TP53 Y126Tfs*44 [nucleoplasm]", "TP53 W53* [nucleoplasm]", "TP53 G293* [nucleoplasm]", "TP53 N288Tfs*55 [nucleoplasm]", "TP53 G108Vfs*15 [nucleoplasm]", "TP53 R283Pfs*16 [nucleoplasm]", "TP53 S15Rfs*28 [nucleoplasm]", "TP53 E285Rfs*21 [nucleoplasm]", "TP53 T211Ifs*33 [nucleoplasm]", "TP53 M40Ifs*3 [nucleoplasm]", "TP53 L289Pfs*56 [nucleoplasm]", "TP53 C182Afs*66 [nucleoplasm]", "TP53 R280* [nucleoplasm]", "TP53 A86Gfs*32 [nucleoplasm]", "TP53 A307Sfs*30 [nucleoplasm]", "TP53 Y220Lfs*2 [nucleoplasm]", "TP53 P128Lfs*42 [nucleoplasm]", "TP53 T102Pfs*21 [nucleoplasm]", "TP53 E258Kfs*87 [nucleoplasm]", "TP53 H178Qfs*3 [nucleoplasm]", "TP53 P85Lfs*58 [nucleoplasm]", "TP53 W91Cfs*57 [nucleoplasm]", "TP53 N311Qfs*26 [nucleoplasm]", "TP53 P222Lfs*24 [nucleoplasm]", "TP53 Q5* [nucleoplasm]", "TP53 D208Ffs*42 [nucleoplasm]", "TP53 G262Wfs*80 [nucleoplasm]", "TP53 T118Gfs*6 [nucleoplasm]", "TP53 M66Tfs*60 [nucleoplasm]", "TP53 Q165Sfs*5 [nucleoplasm]", "TP53 L130Qfs*17 [nucleoplasm]", "TP53 P152Rfs*27 [nucleoplasm]", "TP53 T253Qfs*3 [nucleoplasm]", "TP53 V203Wfs*44 [nucleoplasm]", "TP53 E287Kfs*53 [nucleoplasm]", "TP53 G266Dfs*79 [nucleoplasm]", "TP53 K291Tfs*48 [nucleoplasm]", "TP53 Q136* [nucleoplasm]", "TP53 K319Afs*19 [nucleoplasm]", "TP53 V274Ffs*71 [nucleoplasm]", "TP53 R196Ffs*35 [nucleoplasm]", "TP53 L35Ffs*8 [nucleoplasm]", "TP53 L330P [nucleoplasm]", "TP53 Q100Rfs*23 [nucleoplasm]", "TP53 E294* [nucleoplasm]", "TP53 Q52Nfs*71 [nucleoplasm]", "TP53 V73Wfs*50 [nucleoplasm]", "TP53", "TP53 R267Efs*65 [nucleoplasm]", "TP53 A161Hfs*19 [nucleoplasm]", "TP53 F109Lfs*36 [nucleoplasm]", "TP53 A84Gfs*65 [nucleoplasm]", "TP53 N235Tfs*12 [nucleoplasm]", "TP53 A88Gfs*44 [nucleoplasm]", "TP53 M243Wfs*4 [nucleoplasm]", "TP53 L45Pfs*5 [nucleoplasm]", "TP53 E298Gfs*43 [nucleoplasm]", "TP53 S261Vfs*84 [nucleoplasm]", "TP53 V218Gfs*30 [nucleoplasm]", "TP53 G279Efs*65 [nucleoplasm]", "TP53 M169Ifs*12 [nucleoplasm]", "TP53 C229Yfs*8 [nucleoplasm]", "TP53 S90Pfs*33 [nucleoplasm]", "TP53 K291Nfs*49 [nucleoplasm]", "TP53 A189Pfs*58 [nucleoplasm]", "cellular tumor antigen p53 (zebrafish)", "TP53 E285Rfs*60 [nucleoplasm]", "TP53 Q136Sfs*26 [nucleoplasm]", "TP53 R110Pfs*14 [nucleoplasm]", "p-S15,S33,S46-TP53 [nucleoplasm]", "TP53 P77Lfs*44 [nucleoplasm]", "TP53 A78Qfs*45 [nucleoplasm]", "TP53 S106Qfs*43 [nucleoplasm]", "TP53 R196* [nucleoplasm]", "TP53 R174Gfs*73 [nucleoplasm]", "TP53 E171Gfs*4 [nucleoplasm]", "TP53 P301Rfs*4 [nucleoplasm]", "TP53 R337S [nucleoplasm]", "TP53 R202Afs*7 [nucleoplasm]", "TP53 T140Cfs*6 [nucleoplasm]", "TP53 R249Gfs*96 [nucleoplasm]", "TP53 P151Tfs*30 [nucleoplasm]", "TP53 V272Afs*33 [nucleoplasm]", "PolyUb,p-S15,S20-TP53 [nucleoplasm]", "Me2-K373-TP53 [nucleoplasm]", "TP53 N263Tfs*5 [nucleoplasm]", "TP53 P47Gfs*4 [nucleoplasm]", "TP53 Y236Tfs*11 [nucleoplasm]", "TP53 L308Pfs*15 [nucleoplasm]", "TP53 C141Sfs*26 [nucleoplasm]", "TP53 A276Tfs*64 [nucleoplasm]", "TP53 E198Kfs*49 [nucleoplasm]", "TP53 E258Gfs*6 [nucleoplasm]", "TP53 V216Gfs*5 [nucleoplasm]", "TP53 A161Dfs*19 [nucleoplasm]", "TP53 P153Lfs*28 [nucleoplasm]", "TP53 K291Gfs*12 [nucleoplasm]", "TP53 A119Rfs*6 [nucleoplasm]", "TP53 V218Cfs*29 [nucleoplasm]", "TP53 C124Ffs*47 [nucleoplasm]", "TP53 R156Afs*14 [nucleoplasm]", "TP53 M44Afs*7 [nucleoplasm]", "TP53 C275Lfs*31 [nucleoplasm]", "TP53 I232Qfs*5 [nucleoplasm]", "TP53 E204* [nucleoplasm]", "TP53 S303Efs*3 [nucleoplasm]", "TP53 G154Pfs*25 [nucleoplasm]", "TP53 P75Yfs*68 [nucleoplasm]", "TP53 H297Sfs*10 [nucleoplasm]", "TP53 H178Pfs*2 [nucleoplasm]", "TP53 S215Cfs*29 [nucleoplasm]", "TP53 P128Qfs*17 [nucleoplasm]", "TP53 L114Ffs*33 [nucleoplasm]", "TP53 M243Hfs*18 [nucleoplasm]", "TP53 F109Gfs*37 [nucleoplasm]", "TP53 F19Ifs*10 [nucleoplasm]", "TP53 A39Qfs*5 [nucleoplasm]", "TP53 Q165Hfs*4 [nucleoplasm]", "TP53 C135Lfs*14 [nucleoplasm]", "TP53 I195Kfs*9 [nucleoplasm]", "TP53 A138Cfs*27 [nucleoplasm]", "TP53 P128Rfs*20 [nucleoplasm]", "TP53 M44Cfs*79 [nucleoplasm]", "TP53 V143Afs*21 [nucleoplasm]", "TP53 H115Qfs*4 [nucleoplasm]", "p-S15,S392-TP53 [nucleoplasm]", "TP53 S121Lfs*2 [nucleoplasm]", "TP53 T230Hfs*9 [nucleoplasm]", "TP53 D48Tfs*75 [nucleoplasm]", "TP53 A78Yfs*68 [nucleoplasm]", "TP53 K164Sfs*6 [nucleoplasm]", "TP53 S227Wfs*3 [nucleoplasm]", "Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]", "TP53 H214Qfs*2 [nucleoplasm]", "TP53 D228Vfs*18 [nucleoplasm]", "TP53 L43* [nucleoplasm]", "TP53 N235Lfs*4 [nucleoplasm]", "TP53 T284Ifs*57 [nucleoplasm]", "TP53 P191Yfs*14 [nucleoplasm]", "TP53 C229Vfs*18 [nucleoplasm]", "TP53 S46Pfs*77 [nucleoplasm]", "TP53 P301Qfs*44 [nucleoplasm]", "TP53 C182Afs*65 [nucleoplasm]", "TP53 L265Wfs*80 [nucleoplasm]", "TP53 R282Gfs*63 [nucleoplasm]", "TP53 V73Gfs*50 [nucleoplasm]", "TP53 T81Sfs*43 [nucleoplasm]", "TP53 D184Afs*62 [nucleoplasm]", "TP53 protein, human", "TP53 S315Wfs*22 [nucleoplasm]", "TP53 L93Vfs*55 [nucleoplasm]", "TP53 F341S [nucleoplasm]", "TP53 N311Tfs*34 [nucleoplasm]", "TP53 M160Wfs*10 [nucleoplasm]", "TP53 F54Sfs*69 [nucleoplasm]", "TP53 R110Vfs*13 [nucleoplasm]", "TP53 S99Rfs*23 [nucleoplasm]", "TP53 N263Tfs*8 [nucleoplasm]", "TP53 S314Rfs*25 [nucleoplasm]", "TP53 R65Qfs*84 [nucleoplasm]", "TP53 P58Rfs*6 [nucleoplasm]", "TP53 V173Afs*6 [nucleoplasm]", "TP53 T256Kfs*87 [nucleoplasm]", "TP53 D148Pfs*23 [nucleoplasm]", "TP53 L114Ffs*35 [nucleoplasm]", "TP53 H233Tfs*14 [nucleoplasm]", "TP53 T230Sfs*11 [nucleoplasm]", "TP53 S166Ifs*15 [nucleoplasm]", "TP53 A83Pfs*35 [nucleoplasm]", "TP53 K351E [nucleoplasm]", "TP53 E285Rfs*13 [nucleoplasm]", "TP53 L137Rfs*33 [nucleoplasm]", "TP53 K351* [nucleoplasm]", "TP53 A159Hfs*21 [nucleoplasm]", "TP53 P92Hfs*57 [nucleoplasm]", "MeK-370,p-S15,S20-TP53 [nucleoplasm]", "TP53 V218Gfs*4 [nucleoplasm]", "TP53 P47Rfs*76 [nucleoplasm]", "PolyUb-TP53 [nucleoplasm]", "TP53 V143Afs*4 [nucleoplasm]", "TP53 L111Nfs*14 [nucleoplasm]", "TP53 L289Sfs*56 [nucleoplasm]", "TP53 H115Lfs*8 [nucleoplasm]", "TP53 S183Rfs*2 [nucleoplasm]", "TP53 C176Afs*71 [nucleoplasm]", "TP53 R280Efs*65 [nucleoplasm]", "TP53 D228Tfs*12 [nucleoplasm]", "TP53 A83Pfs*39 [nucleoplasm]", "TP53 Y234Pfs*7 [nucleoplasm]", "TP53 T253Ifs*93 [nucleoplasm]", "TP53 D207Gfs*2 [nucleoplasm]", "TP53 N247Rfs*97 [nucleoplasm]", "TP53 E271Gfs*34 [nucleoplasm]", "TP53 G59Efs*58 [nucleoplasm]", "TP53 E62* [nucleoplasm]", "TP53 G154Afs*18 [nucleoplasm]", "TP53 E258Pfs*85 [nucleoplasm]", "TP53 N30Kfs*13 [nucleoplasm]", "TP53 T102Nfs*47 [nucleoplasm]", "cellular tumor antigen p53 (rat)", "TP53 H214Cfs*29 [nucleoplasm]", "TP53 Q144Hfs*26 [nucleoplasm]", "TP53 G226Afs*21 [nucleoplasm]", "TP53 P316Lfs*30 [nucleoplasm]", "TP53 D208Ffs*35 [nucleoplasm]", "TP53 K320Rfs*25 [nucleoplasm]", "TP53 R282Pfs*64 [nucleoplasm]", "TP53 Q165* [nucleoplasm]", "TP53 V173* [nucleoplasm]", "TP53 R273Lfs*33 [nucleoplasm]", "TP53 N288Kfs*59 [nucleoplasm]", "TP53 Q52Lfs*73 [nucleoplasm]", "TP53 V216Gfs*4 [nucleoplasm]", "TP53 Q104Rfs*19 [nucleoplasm]", "TP53 R110Lfs*13 [nucleoplasm]", "TP53 Y126Qfs*18 [nucleoplasm]", "TP53 P47Hfs*2 [nucleoplasm]", "TP53 T123Dfs*26 [nucleoplasm]", "TP53 L137Wfs*33 [nucleoplasm]", "TP53 S241Wfs*19 [nucleoplasm]", "TP53 N210Tfs*7 [nucleoplasm]", "TP53 S127Pfs*43 [nucleoplasm]", "TP53 D148Pfs*21 [nucleoplasm]", "TP53 H178Pfs*69 [nucleoplasm]", "TP53 C135Ffs*36 [nucleoplasm]", "TP53 P309Qfs*26 [nucleoplasm]", "TP53 P36Tfs*75 [nucleoplasm]", "TP53 A347D [nucleoplasm]", "TP53 T211Ffs*4 [nucleoplasm]", "TP53 M133Sfs*37 [nucleoplasm]", "TP53 P278Lfs*68 [nucleoplasm]", "TP53 F113Sfs*10 [nucleoplasm]", "TP53 Q104Afs*18 [nucleoplasm]", "TP53 R156Afs*12 [nucleoplasm]", "p-S15,S20,S46-TP53 [nucleoplasm]", "TP53 F109Sfs*38 [nucleoplasm]", "TP53 W53Gfs*70 [nucleoplasm]", "TP53 H179* [nucleoplasm]", "TP53 P152Rfs*18 [nucleoplasm]", "TP53 R273Cfs*73 [nucleoplasm]", "TP53 E298Dfs*7 [nucleoplasm]", "TP53 D57Kfs*67 [nucleoplasm]", "TP53 R290Sfs*56 [nucleoplasm]", "TP53 G199Rfs*10 [nucleoplasm]", "TP53 A189Dfs*14 [nucleoplasm]", "TP53 L330R [nucleoplasm]", "TP53 D281Pfs*24 [nucleoplasm]", "TP53 N210Kfs*37 [nucleoplasm]", "TP53 Q100Lfs*42 [nucleoplasm]", "TP53 V172Lfs*2 [nucleoplasm]", "TP53 A161Gfs*20 [nucleoplasm]", "TP53 L35* [nucleoplasm]", "TP53 Q144Gfs*2 [nucleoplasm]", "TP53 A74Qfs*45 [nucleoplasm]", "TP53 E56Vfs*73 [nucleoplasm]", "TP53 L188Pfs*58 [nucleoplasm]", "TP53 L201Ifs*47 [nucleoplasm]", "TP53 R156Sfs*8 [nucleoplasm]", "TP53 D186Wfs*22 [nucleoplasm]", "TP53 V143Gfs*2 [nucleoplasm]", "TP53 I251Sfs*94 [nucleoplasm]", "TP53 Y107Sfs*38 [nucleoplasm]", "TP53 P223Sfs*26 [nucleoplasm]", "TP53 G108Ffs*40 [nucleoplasm]", "TP53 P85Cfs*63 [nucleoplasm]", "TP53 D61Vfs*62 [nucleoplasm]", "TP53 L93Ffs*53 [nucleoplasm]", "TP53 A83Gfs*65 [nucleoplasm]", "TP53 L330F [nucleoplasm]", "TP53 A307Tfs*29 [nucleoplasm]", "TP53 R158Sfs*8 [nucleoplasm]", "TP53 E62Kfs*65 [nucleoplasm]", "TP53 E298Dfs*47 [nucleoplasm]", "TP53 A69Vfs*54 [nucleoplasm]", "TP53 K291Qfs*15 [nucleoplasm]", "TP53 C229Lfs*18 [nucleoplasm]", "TP53 D208Afs*39 [nucleoplasm]", "TP53 E285Gfs*20 [nucleoplasm]", "TP53 E298Sfs*47 [nucleoplasm]", "TP53 M237Vfs*2 [nucleoplasm]", "TP53 P316Lfs*21 [nucleoplasm]", "TP53 I254Tfs*7 [nucleoplasm]", "TP53 K292* [nucleoplasm]", "TP53 S94Ffs*55 [nucleoplasm]", "TP53 A88Vfs*55 [nucleoplasm]", "TP53 L194Hfs*14 [nucleoplasm]", "TP53 N210Tfs*37 [nucleoplasm]", "TP53 R110Wfs*12 [nucleoplasm]", "TP53 P153Afs*28 [nucleoplasm]", "TP53 T118Dfs*31 [nucleoplasm]", "TP53 A129Vfs*20 [nucleoplasm]", "TP53 L257Gfs*6 [nucleoplasm]", "TP53 R248Pfs*92 [nucleoplasm]", "TP53 N310Kfs*26 [nucleoplasm]", "TP53 M160Rfs*10 [nucleoplasm]", "TP53 T118Nfs*31 [nucleoplasm]", "TP53 T230Lfs*6 [nucleoplasm]", "TP53 S241Lfs*22 [nucleoplasm]", "Me-K382,p-S15,S20-TP53 [nucleoplasm]", "TP53 V122Cfs*27 [nucleoplasm]", "TP53 H214Lfs*33 [nucleoplasm]", "TP53 E204Sfs*43 [nucleoplasm]", "TP53 S261* [nucleoplasm]", "TP53 R65Tfs*84 [nucleoplasm]", "TP53 N29Tfs*15 [nucleoplasm]", "p-S15,S20-TP53 [nucleoplasm]", "TP53 S215Kfs*7 [nucleoplasm]", "TP53 W91Gfs*32 [nucleoplasm]", "TP53 D184Ifs*63 [nucleoplasm]", "TP53 K101* [nucleoplasm]", "TP53 E221Afs*2 [nucleoplasm]", "TP53 R273Ffs*71 [nucleoplasm]", "TP53 R273Lfs*72 [nucleoplasm]", "TP53 T150Nfs*20 [nucleoplasm]", "TP53 S215Vfs*32 [nucleoplasm]", "TP53 P92Vfs*55 [nucleoplasm]", "TP53 S99Ffs*55 [nucleoplasm]", "TP53 M169Dfs*11 [nucleoplasm]", "TP53 E224* [nucleoplasm]", "TP53 G302Rfs*4 [nucleoplasm]", "TP53 C242Tfs*98 [nucleoplasm]", "TP53 R337G [nucleoplasm]", "TP53 K139Dfs*9 [nucleoplasm]", "TP53 K164Sfs*5 [nucleoplasm]", "TP53 P190Lfs*57 [nucleoplasm]", "TP53 S215Wfs*31 [nucleoplasm]", "TP53 A307Rfs*39 [nucleoplasm]", "TP53 D184Rfs*2 [nucleoplasm]", "TP53 M133Dfs*16 [nucleoplasm]", "TP53 F113Qfs*5 [nucleoplasm]", "TP53 H214Gfs*5 [nucleoplasm]", "TP53 H115Cfs*27 [nucleoplasm]", "TP53 P152Tfs*30 [nucleoplasm]", "TP53 E180Sfs*67 [nucleoplasm]", "TP53 T253Sfs*91 [nucleoplasm]", "TP53 T256Nfs*89 [nucleoplasm]", "TP53 V73Afs*76 [nucleoplasm]", "TP53 P77Rfs*71 [nucleoplasm]", "TP53 R306* [nucleoplasm]", "TP53 M40Lfs*7 [nucleoplasm]", "TP53 T284Qfs*61 [nucleoplasm]", "TP53 H297Lfs*9 [nucleoplasm]", "TP53 R248Pfs*95 [nucleoplasm]", "TP53 H297Tfs*48 [nucleoplasm]", "TP53 V217Gfs*31 [nucleoplasm]", "TP53 Y103Gfs*44 [nucleoplasm]", "TP53 H296Rfs*8 [nucleoplasm]", "TP53 F212Sfs*3 [nucleoplasm]", "cellular tumor antigen p53 (chicken)", "TP53 L206Yfs*4 [nucleoplasm]", "TP53 C135Afs*35 [nucleoplasm]", "TP53 A86Lfs*59 [nucleoplasm]", "TP53 N288Rfs*13 [nucleoplasm]", "TP53 Q144Sfs*26 [nucleoplasm]", "TP53 A129Pfs*42 [nucleoplasm]", "TP53 C242* [nucleoplasm]", "TP53 Q317* [nucleoplasm]", "TP53 L188Wfs*59 [nucleoplasm]", "TP53 E198Gfs*11 [nucleoplasm]", "TP53 R174* [nucleoplasm]", "TP53 N131Pfs*19 [nucleoplasm]", "TP53 A88Pfs*35 [nucleoplasm]", "TP53 A119Sfs*3 [nucleoplasm]", "TP53 D324Vfs*21 [nucleoplasm]", "TP53 N239Kfs*15 [nucleoplasm]", "Me1-K372,p-S15,S20-TP53 [nucleoplasm]", "TP53 L201* [nucleoplasm]", "TP53 C275Gfs*20 [nucleoplasm]", "TP53 A69Gfs*80 [nucleoplasm]", "TP53 M246Afs*19 [nucleoplasm]", "TP53 T253Pfs*92 [nucleoplasm]", "TP53 I50Mfs*4 [nucleoplasm]", "TP53 E11* [nucleoplasm]", "TP53 Y103* [nucleoplasm]", "TP53 R337H [nucleoplasm]", "TP53 Y205Lfs*4 [nucleoplasm]", "TP53 E171Rfs*3 [nucleoplasm]", "TP53 K319Nfs*18 [nucleoplasm]", "TP53 W53Cfs*4 [nucleoplasm]", "TP53 S269Rfs*21 [nucleoplasm]", "TP53 P142Lfs*28 [nucleoplasm]", "TP53 P223* [nucleoplasm]", "TP53 Q317Hfs*28 [nucleoplasm]", "TP53 P191Lfs*56 [nucleoplasm]", "TP53 Y107* [nucleoplasm]", "TP53 P295Rfs*12 [nucleoplasm]", "TP53 G199* [nucleoplasm]", "TP53 L252Sfs*93 [nucleoplasm]", "TP53 M133Rfs*38 [nucleoplasm]", "TP53 R65Kfs*84 [nucleoplasm]", "TP53 Q16Rfs*28 [nucleoplasm]", "TP53 T312Pfs*20 [nucleoplasm]", "TP53 G245Afs*2 [nucleoplasm]", "TP53 V157Wfs*10 [nucleoplasm]", "TP53 Y103Lfs*42 [nucleoplasm]", "TP53 G334E [nucleoplasm]", "TP53 I255Nfs*9 [nucleoplasm]", "TP53 N131Kfs*39 [nucleoplasm]", "TP53 V272Cfs*73 [nucleoplasm]", "TP53 Y234Tfs*11 [nucleoplasm]", "TP53 W146Vfs*3 [nucleoplasm]", "TP53 L188Rfs*59 [nucleoplasm]", "TP53 P219Afs*3 [nucleoplasm]", "TP53 L299Hfs*2 [nucleoplasm]", "TP53 R156Pfs*25 [nucleoplasm]", "TP53 Y103Vfs*15 [nucleoplasm]", "TP53 P98Yfs*26 [nucleoplasm]", "TP53 N288Ifs*18 [nucleoplasm]", "TP53 R282Afs*23 [nucleoplasm]", "TP53 L257Hfs*9 [nucleoplasm]", "TP53 S215Mfs*32 [nucleoplasm]", "TP53 G117Dfs*26 [nucleoplasm]", "TP53 N263Ifs*82 [nucleoplasm]", "TP53 L257Rfs*6 [nucleoplasm]", "TP53 G187Afs*21 [nucleoplasm]", "TP53 G154Rfs*22 [nucleoplasm]", "TP53 Q167Lfs*2 [nucleoplasm]", "TP53 A76Vfs*55 [nucleoplasm]", "TP53 L265Tfs*7 [nucleoplasm]", "TP53 R156Lfs*18 [nucleoplasm]", "TP53 A74Gfs*50 [nucleoplasm]", "TP53 A76Hfs*47 [nucleoplasm]", "TP53 S215Cfs*6 [nucleoplasm]", "TP53 M237Sfs*10 [nucleoplasm]", "TP53 P151Rfs*27 [nucleoplasm]", "TP53 F113Pfs*37 [nucleoplasm]", "TP53 D207Afs*39 [nucleoplasm]", "TP53 I254Sfs*91 [nucleoplasm]", "TP53 N239* [nucleoplasm]", "TP53 A78Sfs*71 [nucleoplasm]", "TP53 K321* [nucleoplasm]", "TP53 R65Cfs*79 [nucleoplasm]", "TP53 Y163Tfs*7 [nucleoplasm]", "TP53 S94Ifs*54 [nucleoplasm]", "TP53 E294Sfs*51 [nucleoplasm]", "TP53 N268Efs*4 [nucleoplasm]", "TP53 P128Qfs*18 [nucleoplasm]", "TP53 P87Qfs*36 [nucleoplasm]", "TP53 L201Afs*7 [nucleoplasm]", "TP53 G293Rfs*13 [nucleoplasm]", "TP53 E171Gfs*9 [nucleoplasm]", "TP53 T81Pfs*49 [nucleoplasm]", "TP53 E286Kfs*59 [nucleoplasm]", "TP53 R337C [nucleoplasm]", "TP53 R283Sfs*56 [nucleoplasm]", "TP53 A83Cfs*63 [nucleoplasm]", "TP53 C182* [nucleoplasm]", "TP53 K319* [nucleoplasm]", "TP53 S215Mfs*27 [nucleoplasm]", "TP53 A84Pfs*39 [nucleoplasm]", "TP53 S33Ffs*10 [nucleoplasm]", "TP53 S116Afs*34 [nucleoplasm]", "TP53 Q16* [nucleoplasm]", "TP53 G279Sfs*68 [nucleoplasm]", "Ac-K382,p-S15,S20-TP53 [nucleoplasm]", "TP53 D281Tfs*64 [nucleoplasm]", "TP53 P191Sfs*18 [nucleoplasm]", "TP53 E171* [nucleoplasm]", "TP53 I195Tfs*52 [nucleoplasm]", "TP53 V218Wfs*30 [nucleoplasm]", "TP53 R213Dfs*34 [nucleoplasm]", "TP53 G154Afs*28 [nucleoplasm]", "TP53 M246Ifs*99 [nucleoplasm]", "TP53 G279Pfs*24 [nucleoplasm]", "TP53 V143Afs*5 [nucleoplasm]", "TP53 A347P [nucleoplasm]", "TP53 Q167Rfs*3 [nucleoplasm]", "TP53 M246* [nucleoplasm]", "TP53 P177Lfs*3 [nucleoplasm]", "Me2K-370,382-TP53 [nucleoplasm]", "TP53 T125Rfs*45 [nucleoplasm]", "TP53 M169Ifs*5 [nucleoplasm]", "TP53 M66Qfs*56 [nucleoplasm]", "TP53 D148Ffs*32 [nucleoplasm]", "TP53 Y107Tfs*16 [nucleoplasm]", "TP53 V143Afs*29 [nucleoplasm]", "TP53 I162Vfs*15 [nucleoplasm]", "TP53 P153Afs*16 [nucleoplasm]", "TP53 I162Tfs*8 [nucleoplasm]", "TP53 P301Lfs*41 [nucleoplasm]", "TP53 E51Nfs*72 [nucleoplasm]", "TP53 S240Ffs*23 [nucleoplasm]", "TP53 M133Lfs*42 [nucleoplasm]", "TP53 K291Sfs*51 [nucleoplasm]", "TP53 V225Wfs*3 [nucleoplasm]", "TP53 F54Lfs*69 [nucleoplasm]", "TP53 E68Rfs*55 [nucleoplasm]", "TP53 V173Tfs*69 [nucleoplasm]", "TP53 K132Cfs*37 [nucleoplasm]", "p-S15-TP53 [nucleoplasm]", "TP53 V217Gfs*30 [nucleoplasm]", "TP53 V157Hfs*21 [nucleoplasm]", "TP53 E198Wfs*44 [nucleoplasm]", "TP53 S95Gfs*37 [nucleoplasm]", "TP53 L299Rfs*46 [nucleoplasm]", "TP53 Q165Hfs*17 [nucleoplasm]", "TP53 C275* [nucleoplasm]", "TP53 E51* [nucleoplasm]", "TP53 T211Pfs*28 [nucleoplasm]", "TP53 V73Afs*51 [nucleoplasm]", "TP53 S149Hfs*31 [nucleoplasm]", "TP53 P72Lfs*48 [nucleoplasm]", "TP53 A189Vfs*53 [nucleoplasm]", "TP53 L264Hfs*81 [nucleoplasm]", "TP53 A129Rfs*38 [nucleoplasm]", "TP53 I251Pfs*12 [nucleoplasm]", "TP53 G199Ffs*8 [nucleoplasm]", "TP53 D259Tfs*86 [nucleoplasm]", "TP53 Y205* [nucleoplasm]", "TP53 E204Vfs*4 [nucleoplasm]", "TP53 T170Rfs*4 [nucleoplasm]", "TP53 L45Vfs*6 [nucleoplasm]", "TP53 P58Qfs*65 [nucleoplasm]", "TP53 K292Gfs*52 [nucleoplasm]", "TP53 P80Lfs*43 [nucleoplasm]", "TP53 N210Ffs*35 [nucleoplasm]", "TP53 R209Cfs*6 [nucleoplasm]", "TP53 V157Hfs*19 [nucleoplasm]", "TP53 L206Ffs*42 [nucleoplasm]", "TP53 T312Pfs*33 [nucleoplasm]", "TP53 S94* [nucleoplasm]", "TP53 I195Pfs*13 [nucleoplasm]", "TP53 V147Rfs*27 [nucleoplasm]", "TP53 R156Hfs*26 [nucleoplasm]", "TP53 L35Pfs*10 [nucleoplasm]", "TP53 C242Lfs*22 [nucleoplasm]", "TP53 N310Tfs*35 [nucleoplasm]", "TP53 S269Tfs*76 [nucleoplasm]", "TP53 G108Afs*34 [nucleoplasm]", "TP53 E221Gfs*25 [nucleoplasm]", "TP53 S166* [nucleoplasm]", "TP53 P85Lfs*38 [nucleoplasm]", "TP53 T140Dfs*9 [nucleoplasm]", "TP53 D148* [nucleoplasm]", "TP53 G262Vfs*83 [nucleoplasm]", "TP53 S260Qfs*3 [nucleoplasm]", "TP53 T102Pfs*45 [nucleoplasm]", "TP53 R282Pfs*24 [nucleoplasm]", "PolyUb-TP53 [cytosol]", "TP53 L32Pfs*11 [nucleoplasm]", "TP53 A88Gfs*32 [nucleoplasm]", "TP53 G245Efs*17 [nucleoplasm]", "TP53 S315Nfs*24 [nucleoplasm]", "TP53 T125Hfs*24 [nucleoplasm]", "TP53 Q165Afs*6 [nucleoplasm]", "TP53 K120* [nucleoplasm]", "TP53 P36Rfs*8 [nucleoplasm]", "TP53 M66Gfs*80 [nucleoplasm]", "TP53 K132* [nucleoplasm]", "TP53 R174Pfs*70 [nucleoplasm]", "TP53 G279Kfs*59 [nucleoplasm]", "TP53 R158Pfs*11 [nucleoplasm]", "TP53 S20* [nucleoplasm]", "TP53 S106Gfs*44 [nucleoplasm]", "TP53 N200Ifs*47 [nucleoplasm]", "TP53 S241Pfs*6 [nucleoplasm]", "TP53 D49Yfs*2 [nucleoplasm]", "TP53 Q144* [nucleoplasm]", "TP53 D186* [nucleoplasm]", "TP53 N311Kfs*26 [nucleoplasm]", "TP53 Y236* [nucleoplasm]", "Unfolded TP53 [cytosol]", "TP53 Q167Hfs*12 [nucleoplasm]", "TP53 L264Tfs*7 [nucleoplasm]", "TP53 A161Sfs*8 [nucleoplasm]", "TP53 L206Ffs*3 [nucleoplasm]", "TP53 P153Hfs*26 [nucleoplasm]", "TP53 R65Efs*58 [nucleoplasm]", "TP53 V225Gfs*20 [nucleoplasm]", "TP53 K139Rfs*31 [nucleoplasm]", "TP53 A78Gfs*73 [nucleoplasm]", "TP53 N30Tfs*14 [nucleoplasm]", "TP53 C135* [nucleoplasm]", "TP53 F338I [nucleoplasm]", "TP53 T231Pfs*16 [nucleoplasm]", "TP53 W91* [nucleoplasm]"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": 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These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon).  Amino acids are organic compounds that contain amino (\u201a\u00c4\u00ecNH2) and carboxyl (\u201a\u00c4\u00ecCOOH) functional groups, along with a side chain (R group) specific to each amino acid. L-phenylalanine is one of 20 proteinogenic amino acids, i.e., the amino acids used in the biosynthesis of proteins. Phenylalanine is found in all organisms ranging from bacteria to plants to animals.  It is classified as an aromatic, non-polar amino acid. In humans, phenylalanine is an essential amino acid and the precursor of the amino acid tyrosine. Like tyrosine, phenylalanine is also a precursor for catecholamines including tyramine, dopamine, epinephrine, and norepinephrine. Catecholamines are neurotransmitters that act as adrenalin-like substances. Interestingly, several psychotropic drugs (mescaline, morphine, codeine, and papaverine) also have phenylalanine as a constituent. Phenylalanine is highly concentrated in the human brain and plasma. Normal metabolism of phenylalanine requires biopterin, iron, niacin, vitamin B6, copper, and vitamin C. An average adult ingests 5 g of phenylalanine per day and may optimally need up to 8 g daily. Phenylalanine is highly concentrated in a number of high protein foods, such as meat, cottage cheese, and wheat germ. An additional dietary source of phenylalanine is artificial sweeteners containing aspartame (a methyl ester of the aspartic acid/phenylalanine dipeptide). As a general rule, aspartame should be avoided by phenylketonurics and pregnant women. When present in sufficiently high levels, phenylalanine can act as a neurotoxin and a metabotoxin. A neurotoxin is a compound that disrupts or attacks neural cells and neural tissue. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Chronically high levels of phenylalanine are associated with at least five inborn errors of metabolism, including Hartnup disorder, hyperphenylalaninemia due to guanosine triphosphate cyclohydrolase deficiency, phenylketonuria (PKU), tyrosinemia type 2 (or Richner-Hanhart syndrome), and tyrosinemia type III (TYRO3). Phenylketonurics have elevated serum plasma levels of phenylalanine up to 400 times normal. High plasma concentrations of phenylalanine influence the blood-brain barrier transport of large neutral amino acids. The high plasma phenylalanine concentrations increase phenylalanine entry into the brain and restrict the entry of other large neutral amino acids (PMID: 19191004). Phenylalanine has been found to interfere with different cerebral enzyme systems. Untreated phenylketonuria (PKU) can lead to intellectual disability, seizures, behavioural problems, and mental disorders. It may also result in a musty smell and lighter skin. Classic PKU dramatically affects myelination and white matter tracts in untreated infants; this may be one major cause of neurological disorders associated with phenylketonuria. Mild phenylketonuria can act as an unsuspected cause of hyperactivity, learning problems, and other developmental problems in children. It has been recently suggested that PKU may resemble amyloid diseases, such as Alzheimer's disease and Parkinson's disease, due to the formation of toxic amyloid-like assemblies of phenylalanine (PMID: 22706200). Phenylalanine also has some potential benefits. Phenylalanine can act as an effective pain reliever. Its use in premenstrual syndrome and Parkinson's may enhance the effects of acupuncture and electric transcutaneous nerve stimulation (TENS). Phenylalanine and tyrosine, like L-DOPA, produce a catecholamine-like effect. Phenylalanine is better absorbed than tyrosine and may cause fewer headaches. Low phenylalanine diets have been prescribed for certain cancers with mixed results. 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Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C642\" active clinical trials using this agent. (\"http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C642\" NCI Thesaurus); UMLS Semantic Type: STY:T121; UMLS Semantic Type: STY:T116; UMLS Semantic Type: STY:T109", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug", "biolink:NamedThing"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["methotrexate", "Methotrexate, (DL)-Isomer", "Methotrexate (JP18/USP/INN)", "Methotrexate hydrate", "Amethopterin", "METHOTREXATE SODIUM", "SID26749273", "Methotrexate Hydrate", "methotrexate polyglutamate", "methotrexate sodium", "Methotrexate, Dicesium Salt", "Methotrexate sodium", "Methotrexate", "Mexate", "2-[[[4-[(2,4-diamino-6-pteridinyl)methyl-methylamino]phenyl]-oxomethyl]amino]pentanedioic acid", "Methotrexate polyglutamate", "Methotrexate Sodium", "METHOTREXATE", "Methotrexate, (D)-Isomer", "methotrexate disodium"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["KEGG.DRUG:D00142", "CHEMBL.COMPOUND:CHEMBL426", "HMDB:HMDB0248287", "ATC:L04AX03", "ATC:L01BA01", "MESH:C014085", "UMLS:C0949357", "CHEMBL.COMPOUND:CHEMBL34259", "CHEBI:44185", "UMLS:C0025677", "UMLS:C0887180", "LOINC:MTHU005020", "CHEBI:183819", "CHEBI:50679", "RXNORM:6851", "UMLS:C0887181", "RXNORM:287734", "PathWhiz.Compound:9057", "UMLS:C0066146", "DRUGBANK:DB00563", "UMLS:C0949359", "NCIT:C642", "DrugCentral:1751", "HMDB:HMDB0014703", "LOINC:LP16198-1", "LOINC:LA14339-8", "MESH:D008727", "NDDF:002644", "CHEMBL.COMPOUND:CHEMBL3244648", "CHEMBL.TARGET:CHEMBL2364710", "VANDF:4017903", "NCIT:C1735", "CHEBI:93775", "PDQ:CDR0000041719", "ttd.target:Methotrexate_Sodium", "PathWhiz.ElementCollection:67", "KEGG.DRUG:D02115", "KEGG.COMPOUND:C01937", "UMLS:C0205839", "UMLS:C0949356", "VANDF:4019828"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:11856762", "PMID:850245", "PMID:19243173", "PMID:3100797", "PMID:22633692", "PMID:27210722", "PMID:28830032", "PMID:6694171", "PMID:24284432", "PMID:12682043"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL1683": {"name": "HYDROCORTISONE BUTYRATE", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL1683", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL1683", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Cortisol is the main glucocorticoid secreted by the adrenal cortex and it is involved in the stress response. Its synthetic counterpart hydrocortisone is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. Hydrocortisone is synthesized from pregnenolone and is used as an immunosuppressive drug given by injection in the treatment of severe allergic reactions such as anaphylaxis and angioedema, in place of prednisolone in patients who need steroid treatment but cannot take oral medication, and peri-operatively in patients on long-term steroid treatment to prevent an Addisonian crisis. Cortisol increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. The amount of cortisol present in the serum undergoes diurnal variation, with the highest levels present in the early morning and lower levels in the evening, several hours after the onset of sleep. Cortisol is found to be associated with ACTH deficiency and glucocorticoid deficiency, which are inborn errors of metabolism. Cortisol binds to the cytosolic glucocorticoid receptor. After binding the receptor, the newly formed receptor-ligand complex translocates itself into the cell nucleus where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA-bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes. The anti-inflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Specifically, glucocorticoids induce lipocortin-1 (annexin-1) synthesis, which then binds to cell membranes and prevents phospholipase A2 from coming into contact with its substrate arachidonic acid. This leads to diminished eicosanoid production. The cyclooxygenase (both COX-1 and COX-2) expression is also suppressed, potentiating the effect. In other words, the two main products of inflammation, prostaglandins and leukotrienes, are inhibited by the action of glucocorticoids. Glucocorticoids also stimulate the escape of lipocortin-1 into the extracellular space, where it binds to the leukocyte membrane receptors and inhibits various inflammatory events: epithelial adhesion, emigration, chemotaxis, phagocytosis, respiratory burst, and the release of various inflammatory mediators (lysosomal enzymes, cytokines, tissue plasminogen activator, chemokines, etc.) from neutrophils, macrophages, and mastocytes. Additionally, the immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug", "biolink:BiologicalEntity"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Kendall's compound F", "hydrocortisone", "Hydrocortisone Valerate", "hydrocortamate hydrochloride", "Hydrocortisone butyrate (JP18/USP)", "Hydrocortisone butyrate", "Reichstein's substance M", "Hydrocortamate Hydrochloride", "HYDROCORTAMATE HYDROCHLORIDE", "Hydrocortisone aceponate", "pentanoic acid [11-hydroxy-17-(2-hydroxy-1-oxoethyl)-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] ester", "Pentanoic acid 11-hydroxy-17-(2-hydroxy-acetyl)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester", "hydrocortisone-17-butyrate", "Hydrocortisone", "HYDROCORTISONE", "Hydrocortamate", "Locoid", "HYDROCORTISONE VALERATE", "Hydrocortisone valerate", "HYDROCORTISONE CYPIONATE", "cortisol 17-butyrate", "cortisol", "HYDROCORTISONE BUTYRATE", "Hydrocortisone Cypionate", "hydrocortamate", "HYDROCORTISONE ACEPONATE", "Hydrocortisone cypionate", "Hydrocortisone Aceponate", "hydrocortisone valerate", "CORT [nucleoplasm]", "Hydrocortisone Butyrate", "Hydrocortamate hydrochloride", "Westcort", "hydrocortisone cypionate", "CORT [mitochondrial matrix]", "hydrocortisone aceponate", "cortisol 17-valerate", "CORT [cytosol]", "HYDROCORTAMATE", "CORT [extracellular region]", "Cortisol", "Hydrocortisone valerate (USP)", "hydrocortisone butyrate", "Hydrocortisone aceponate (INN)"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["PathWhiz.Compound:45", "NCIT:C65864", "MESH:C007975", "RXNORM:27199", "UMLS:C0063079", "LOINC:MTHU035101", "LOINC:MTHU001562", "ATC:A07EA02", "UMLS:C0020268", "REACT:R-ALL-5618097", "UMLS:C4255948", "DrugCentral:1389", "DrugCentral:1388", "UMLS:C4255947", "LOINC:LP70288-3", "RXNORM:220938", "ATC:S02BA01", "VANDF:4017946", "NDDF:002147", "DRUGBANK:DB14538", "VANDF:4017941", "CHEMBL.COMPOUND:CHEMBL1549", "KEGG.COMPOUND:C08176", "UMLS:C0082944", "CHEBI:94344", "ATC:A01AC03", "DRUGBANK:DB14540", "HMDB:HMDB0014907", "VANDF:4017947", "UMLS:C0544368", "MESH:D006854", "NCIT:C48022", "LOINC:LP97871-5", "MESH:C038363", "UMLS:C1445700", "CHEMBL.COMPOUND:CHEMBL389621", "DRUGBANK:DB14541", "ATC:D07AB02", "CHEBI:5783", "NCIT:C2290", "ATC:D07AC16", "ATC:S01BA02", "CHEMBL.COMPOUND:CHEMBL1683", "MESH:C029109", "ATC:D07XA01", "UMLS:C0352536", "RXNORM:52147", "CHEBI:31674", "CHEBI:50865", "UMLS:C0126110", "CHEMBL.COMPOUND:CHEMBL1201263", "CHEBI:135746", "LOINC:LP14161-1", "CHEMBL.COMPOUND:CHEMBL67128", "RXNORM:103468", "ATC:D07AA02", "REACT:R-ALL-1449706", "DrugCentral:3959", "CHEBI:50851", "KEGG.COMPOUND:C00735", "CHEMBL.COMPOUND:CHEMBL1200635", "NDDF:002149", "PSY:23640", "CHEMBL.COMPOUND:CHEMBL2106309", "NCIT:C48024", "ATC:S01CB03", "NCIT:C65862", "NDDF:002150", "KEGG.DRUG:D06876", "NDDF:005250", "CHEBI:50854", "DrugCentral:4504", "REACT:R-ALL-193977", "CHEMBL.COMPOUND:CHEMBL1200562", "HMDB:HMDB0000063", "DrugCentral:1390", "DRUGBANK:DB00741", "KEGG.DRUG:D00976", "KEGG.DRUG:D01619", "NCIT:C90952", "PSY:12030", "DRUGBANK:DB00769", "KEGG.DRUG:D02288", "MESH:C063919", "RXNORM:41277", "NCIT:C65863", "DRUGBANK:DB14544", "REACT:R-ALL-194011", "VANDF:4017944", "RXNORM:163524", "CHEBI:17650", "RXNORM:5492", "UMLS:C0612688", "UMLS:C0724395", "NDDF:002153", "ATC:C05AA01", "ATC:H02AB09", "DrugCentral:1387"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:28810189", "PMID:24660966", "PMID:27484514", "PMID:25454267", "PMID:20159656", "PMID:23033255", "PMID:25282654", "PMID:722734", "PMID:14561088", "PMID:25156301"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL2104719": {"name": "PREDNIVAL", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL2104719", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL2104719", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Prednisolone is only found in individuals that have used or taken this drug. It is a glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states. [PubChem]Glucocorticoids such as Prednisolone can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The antiinflammatory actions of glucocorticoids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Prednisolone reduces inflammatory reaction by limiting the capillary dilatation and permeability of the vascular structures. These compounds restrict the accumulation of polymorphonuclear leukocytes and macrophages and reduce the release of vasoactive kinins. Recent research suggests that corticosteroids may inhibit the release of arachidonic acid from phospholipids, thereby reducing the formation of prostaglandins. Prednisolone is a glucocorticoid receptor agonist. On binding, the corticoreceptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing an increase or decrease in expression of specific target genes, including suppression of IL2 (interleukin 2) expression.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Prednisolone valerate acetate", "PREDNIVAL", "Prednisolone Steaglate", "prednisolone sodium metasulphobenzoate", "Pediapred", "prednisolone valerate acetate", "acepreval", "Prednisolone 21-Phosphate", "prednisoLONE", "Prednisolone sodium metazoate (USAN)", "Prednisolone", "prednisolamate", "Pentanoic acid 11-hydroxy-17-(2-hydroxy-acetyl)-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester", "PREDNISOLONE PHOSPHORIC ACID", "prednisolone 21-stearoylglycolate", "prednisolone phosphate", "Prednisolone Valerate Acetate", "prednisolone steaglate", "PREDNISOLAMATE", "Prednisolone sodium phosphate (JP18/USP)", "PREDNISOLONE", "prednival", "Prednisolone Sodium Phosphate", "Prednisolone steaglate (BAN)", "PREDNISOLONE SODIUM PHOSPHATE", "Prednisolone valerate acetate (JAN)", "Sintisone", "Prednival", "Predsol", "Prednisolone phosphate", "Prednisolone metasulfobenzoate", "PREDNISOLONE VALERATE ACETATE", "PREDNISOLONE STEAGLATE", "Prednisolone sodium phosphate", "prednisolone", "prednisolone sodium phosphate", "Pentanoic acid 17-(2-acetoxy-acetyl)-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester", "PREDNISOLONE METAZOATE", "Prednival (USAN)", "prednisolone 21-3-sulfobenzoate", "PREDNISOLONE SODIUM METAZOATE", "prednisolone sulfobenzoate"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["UMLS:C0142354", "VANDF:4017988", "DrugCentral:2252", "NCIT:C66462", "ATC:S01BA04", "KEGG.DRUG:D05603", "ATC:A07EA01", "KEGG.DRUG:D00981", "DrugCentral:2250", "CHEBI:135823", "MESH:C003312", "UMLS:C0138273", "UMLS:C0889299", "UMLS:C0071838", "RXNORM:8638", "CHEMBL.COMPOUND:CHEMBL66657", "UMLS:C0071842", "CHEBI:135763", "UMLS:C2825346", "LOINC:LP18169-0", "MESH:C009022", "CHEBI:135723", "UMLS:C2698873", "MESH:C023724", "KEGG.DRUG:D03301", "CHEMBL.COMPOUND:CHEMBL1201014", "VANDF:4017987", "DrugCentral:4451", "MESH:D011239", "RXNORM:219136", "UMLS:C1882444", "DrugCentral:3488", "CHEMBL.COMPOUND:CHEMBL2105774", "NDDF:002157", "CHEBI:145705", "RXNORM:34374", "CHEBI:8379", "PDQ:CDR0000043296", "ATC:S03BA02", "NCIT:C769", "UMLS:C0138279", "ATC:R01AD02", "CHEBI:8378", "CHEBI:135871", "ATC:C05AA04", "CHEBI:135785", "CHEMBL.COMPOUND:CHEMBL2104719", "ATC:H02AB06", "UMLS:C0032950", "HMDB:HMDB0256750", "UMLS:C0050414", "NCIT:C61904", "KEGG.DRUG:D08415", "LOINC:MTHU062945", "CHEMBL.COMPOUND:CHEMBL131", "MESH:C013218", "UMLS:C1882445", "CHEMBL.COMPOUND:CHEMBL2111103", "HMDB:HMDB0014998", "DRUGBANK:DB14631", "KEGG.DRUG:D08413", "PSY:39980", "CHEMBL.COMPOUND:CHEMBL2107364", "CHEMBL.COMPOUND:CHEMBL1697848", "DrugCentral:2245", "NDDF:002155", "CHEMBL.COMPOUND:CHEMBL68462", "NCIT:C80246", "ATC:D07XA02", "RXNORM:268872", "CHEMBL.COMPOUND:CHEMBL2106961", "NCIT:C80823", "HMDB:HMDB0256747", "RXNORM:55062", "CHEMBL.COMPOUND:CHEMBL1201231", "UMLS:C0722520", "PathWhiz.Compound:9315", "ATC:S01CB02", "DRUGBANK:DB00860", "ATC:S02BA03", "KEGG.COMPOUND:C07369", "ATC:D07AA03", "NCIT:C1402", "DrugCentral:3820", "DrugCentral:2249"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:27109867", "PMID:21316964", "PMID:23033255", "PMID:3965714", "PMID:12672239", "PMID:20399648", "PMID:21073190", "PMID:16996736", "PMID:20427184", "PMID:660591"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "UniProtKB:P02818": {"name": "BGLAP", "categories": ["biolink:Gene", "biolink:Protein"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/uniprot:P02818", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/uniprot:P02818", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "A protein that is a translation product of the human BGLAP gene or a 1:1 ortholog thereof. // COMMENTS: Category=gene.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:BiologicalEntity", "biolink:Gene", "biolink:Protein", "biolink:NamedThing"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["BGLAP(24-100) [endoplasmic reticulum lumen]", "osteocalcin", "BGLAP(24-51) [Golgi lumen]", "3xCbxE-BGLAP(24-100) [endoplasmic reticulum lumen]", "BGLAP Gene", "Bglap (rat)", "Bglap (mouse)", "3xCbxE-BGLAP(24-100) [Golgi lumen]", "osteocalcin (human)", "osteocalcin (mouse)", "BGLAP", "Osteocalcin", "osteocalcin (rat)", "BGLAP gene", "3xCbxE-BGLAP(52-100) [Golgi lumen]", "BGLAP gene [nucleoplasm]", "BGLAP (human)"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["UniProtKB:P02818", "REACT:R-HSA-6807212", "REACT:R-HSA-6807218", "REACT:R-HSA-6807225", "ENSEMBL:ENSG00000242252", "HGNC:1043", "PR:P04640", "REACT:R-HSA-6807227", "PR:000030444", "NCBIGene:632", "MGI:88156", "MESH:D015675", "REACT:R-HSA-6807222", "LOINC:MTHU004757", "UMLS:C0029419", "NCIT:C104592", "UMLS:C1412791", "OMIM:112260", "REACT:R-HSA-8877914", "NCIT:C104590", "PR:P86546", "PR:P02818", "RGD:2206", "LOINC:LP15759-1"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:2336375", "DOI:10.1093/nar/18.7.1909", "PMID:16710414", "DOI:10.1101/gr.2596504", "PMID:3019668", "DOI:10.1002/j.1460-2075.1986.tb04440.x", "PMID:15489334", "DOI:10.1038/nature04727", "PMID:6967872"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "MONDO:0024647": {"name": "urolithiasis", "categories": ["biolink:DiseaseOrPhenotypicFeature", "biolink:Disease", "biolink:PhenotypicFeature"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "http://purl.obolibrary.org/obo/MONDO_0024647", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "http://purl.obolibrary.org/obo/MONDO_0024647", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Stone(s) within the urinary tract.; Formation of stones in any part of the URINARY TRACT, usually in the KIDNEY; URINARY BLADDER; or the URETER.; UMLS Semantic Type: STY:T047", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:Disease", "biolink:NamedThing"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Urolithiasis", "urolithiasis"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["UMLS:C0451641", "OMIM:MTHU014570", "DOID:0080653", "NCIT:C114688", "MESH:D052878", "MONDO:0024647"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["https://www.ncbi.nlm.nih.gov/pmc/articles/pmc3126068/"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "UniProtKB:P46531": {"name": "NOTCH1", "categories": ["biolink:Gene", "biolink:Protein"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/uniprot:P46531", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/uniprot:P46531", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "-!- FUNCTION: Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). {ECO:0000269|PubMed:20616313}. -!- SUBUNIT: Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1 (PubMed:11101851, PubMed:12370315). The NOTCH1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ (PubMed:10713164). The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Forms a trimeric complex with FBXW7 and SGK1. Interacts with HIF1AN. HIF1AN negatively regulates the function of notch intracellular domain (NICD), accelerating myogenic differentiation (PubMed:17573339). Interacts (via NICD) with SNAI1 (via zinc fingers); the interaction induces SNAI1 degradation via MDM2-mediated ubiquitination and inhibits SNAI1-induced cell invasion. Interacts (via NICD) with MDM2A. Interacts (via NICD) with BCL6; the interaction decreases MAML1 recruitment by NOTCH1 NICD on target genes DNA and inhibits NOTCH1 transcractivation activity. Interacts with THBS4 (By similarity). Interacts (via the EGF-like repeat region) with CCN3 (via CTCK domain) (PubMed:12050162). Interacts (via EGF-like domains) with DLL4 (via N-terminal DSL and MNNL domains) (By similarity). Interacts with ZMIZ1. Interacts (via NICD domain) with MEGF10 (via the cytoplasmic domain). Interacts with DLL1 and JAG1 (By similarity). Interacts (via NICD domain) with PRAG1 (By similarity). Forms a complex with PRAG1, N1ICD and MAML1, in a MAML1-dependent manner (By similarity). Interacts (via transmembrane region) with PSEN1; the interaction is direct (PubMed:30598546). {ECO:0000250|UniProtKB:Q01705, ECO:0000250|UniProtKB:Q07008, ECO:0000269|PubMed:10713164, ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:12050162, ECO:0000269|PubMed:12370315, ECO:0000269|PubMed:17573339, ECO:0000269|PubMed:26522984, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:9590294}. -!- INTERACTION: P46531; Q13315: ATM; NbExp=8; IntAct=EBI-636374, EBI-495465; P46531; Q969H0: FBXW7; NbExp=10; IntAct=EBI-636374, EBI-359574; P46531; Q16665: HIF1A; NbExp=2; IntAct=EBI-636374, EBI-447269; P46531; P78504: JAG1; NbExp=6; IntAct=EBI-636374, EBI-2847071; P46531; O60341: KDM1A; NbExp=8; IntAct=EBI-636374, EBI-710124; P46531; Q8N423: LILRB2; NbExp=8; IntAct=EBI-636374, EBI-2816428; P46531; Q92585: MAML1; NbExp=14; IntAct=EBI-636374, EBI-908250; P46531; P19838: NFKB1; NbExp=2; IntAct=EBI-636374, EBI-300010; P46531; P46531: NOTCH1; NbExp=6; IntAct=EBI-636374, EBI-636374; P46531; Q13526: PIN1; NbExp=9; IntAct=EBI-636374, EBI-714158; P46531; Q06330: RBPJ; NbExp=12; IntAct=EBI-636374, EBI-632552; P46531; Q06330-6: RBPJ; NbExp=6; IntAct=EBI-636374, EBI-12599287; P46531; Q13573: SNW1; NbExp=3; IntAct=EBI-636374, EBI-632715; P46531; P98170: XIAP; NbExp=4; IntAct=EBI-636374, EBI-517127; -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q01705}; Single-pass type I membrane protein {ECO:0000305|PubMed:30598546}. -!- SUBCELLULAR LOCATION: [Notch 1 intracellular domain]: Nucleus {ECO:0000250|UniProtKB:Q01705}. Note=Following proteolytical processing NICD is translocated to the nucleus. Nuclear location may require MEGF10. {ECO:0000250|UniProtKB:Q01705}. -!- TISSUE SPECIFICITY: In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues. -!- DOMAIN: Interaction with PSEN1 causes partial unwinding of the transmembrane helix, facilitating access to the scissile peptide bond. {ECO:0000269|PubMed:30598546}. -!- PTM: Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form (By similarity). Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by ADAM17 to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT) (PubMed:24226769). Following endocytosis, this fragment is then cleaved by one of the catalytic subunits of gamma-secretase (PSEN1 or PSEN2), to release a Notch-derived peptide containing the intracellular domain (NICD) from the membrane (PubMed:30598546). {ECO:0000250|UniProtKB:Q01705, ECO:0000269|PubMed:24226769, ECO:0000269|PubMed:30598546}. -!- PTM: Phosphorylated. {ECO:0000250}. -!- PTM: O-glycosylated on the EGF-like domains (PubMed:24226769). O-glucosylated at Ser-435 by KDELC1 and KDELC2 (PubMed:30127001). Contains both O-linked fucose and O-linked glucose in the EGF-like domains 11, 12 and 13, which are interacting with the residues on DLL4 (By similarity). O-linked glycosylation by GALNT11 is involved in determination of left/right symmetry: glycosylation promotes activation of NOTCH1, possibly by promoting cleavage by ADAM17, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) (PubMed:24226769). MFNG-, RFNG- and LFNG-mediated modification of O-fucose residues at specific EGF-like domains results in inhibition of its activation by JAG1 and enhancement of its activation by DLL1 via an increased binding to DLL1 (By similarity). {ECO:0000250|UniProtKB:Q01705, ECO:0000250|UniProtKB:Q07008, ECO:0000269|PubMed:24226769, ECO:0000269|PubMed:30127001}. -!- PTM: Ubiquitinated. Undergoes 'Lys-29'-linked polyubiquitination by ITCH; promotes the lysosomal degradation of non-activated internalized NOTCH1 (PubMed:18628966, PubMed:23886940). Monoubiquitination at Lys-1759 is required for activation by gamma-secretase cleavage, it promotes interaction with AAK1, which stabilizes it. Deubiquitination by EIF3F is necessary for nuclear import of activated Notch (PubMed:24226769). {ECO:0000269|PubMed:18628966, ECO:0000269|PubMed:23886940, ECO:0000269|PubMed:24226769}. -!- PTM: Hydroxylated at Asn-1955 by HIF1AN. Hydroxylated at Asn-2022 by HIF1AN (By similarity). Hydroxylation reduces affinity for HI1AN and may thus indirectly modulate negative regulation of NICD (By similarity). {ECO:0000250}. -!- DISEASE: Aortic valve disease 1 (AOVD1) [MIM:109730]: A common defect in the aortic valve in which two rather than three leaflets are present. It is often associated with aortic valve calcification, stenosis and insufficiency. In extreme cases, the blood flow may be so restricted that the left ventricle fails to grow, resulting in hypoplastic left heart syndrome. {ECO:0000269|PubMed:16025100}. Note=The disease is caused by variants affecting the gene represented in this entry. -!- DISEASE: Adams-Oliver syndrome 5 (AOS5) [MIM:616028]: A form of Adams-Oliver syndrome, a disorder characterized by the congenital absence of skin (aplasia cutis congenita) in combination with transverse limb defects. Aplasia cutis congenita can be located anywhere on the body, but in the vast majority of the cases, it is present on the posterior parietal region where it is often associated with an underlying defect of the parietal bones. Limb abnormalities are typically limb truncation defects affecting the distal phalanges or entire digits (true ectrodactyly). Only rarely, metatarsals/metacarpals or more proximal limb structures are also affected. Apart from transverse limb defects, syndactyly, most commonly of second and third toes, can also be observed. The clinical features are highly variable and can also include cardiovascular malformations, brain abnormalities and vascular defects such as cutis marmorata and dilated scalp veins. {ECO:0000269|PubMed:25132448}. Note=The disease is caused by variants affecting the gene represented in this entry. -!- SIMILARITY: Belongs to the NOTCH family. {ECO:0000305}. -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL=\"http://atlasgeneticsoncology.org/Genes/NOTCH1ID30ch9q34.html\"; ; Short=Notch 1; Short=hN1; Short=NEXT; Short=NICDEvidence Codes from Name:  ", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:BiologicalEntity", "biolink:Gene", "biolink:Protein", "biolink:Polypeptide"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["NOTCH1 I1680N Transmembrane Fragment [plasma membrane]", "NOTCH1(1665-2555) [plasma membrane]", "NICD1 Q2395* [cytosol]", "NICD1 Q2395* [nucleoplasm]", "neurogenic locus notch homolog protein 1 (mouse)", "NEXT1 P2474Afs*4 [plasma membrane]", "NOTCH1 L1600P Extracellular Fragment [extracellular region]", "NOTCH1 I1680N S2 cleavage fragment [extracellular region]", "NOTCH1 P2514Rfs*4 Transmembrane Fragment [plasma membrane]", "NEXT1 Q2395* [plasma membrane]", "p-NICD1 Q2395* [nucleoplasm]", "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) extracellular fragment [extracellular region]", "NOTCH1 V1576E Extracellular Fragment [extracellular region]", "NOTCH1 L1593P Extracellular Fragment [extracellular region]", "NOTCH1(1665-2555) [Golgi membrane]", "Glc,Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane]", "19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) [extracellular region]", "NEXT1 P2514Rfs*4 [plasma membrane]", "NOTCH1 Q2395* Transmembrane Fragment [plasma membrane]", "NICD1 P2514Rfs*4 [cytosol]", "NOTCH1 P2474Afs*4 Transmembrane Fragment [plasma membrane]", "NOTCH1 Q2440* Transmembrane Fragment [plasma membrane]", "17xFucT-14xGlcS-2xFucS-NOTCH1(19-1664) [Golgi membrane]", "Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane]", "NOTCH1 I1616N Extracellular Fragment [extracellular region]", "Glc,GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane]", "Pre-NOTCH1 [endoplasmic reticulum membrane]", "NOTCH1(1665-1720) [extracellular region]", "NOTCH1 I1718T Transmembrane Fragment [plasma membrane]", "NOTCH1 F1592S Extracellular Fragment [extracellular region]", "NOTCH1 (human)", "17xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [Golgi membrane]", "NEXT1 Q2440* [plasma membrane]", "Notch1 (mouse)", "FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [Golgi membrane]", "p-NICD1 Q2440* [nucleoplasm]", "NOTCH1 L1678P Transmembrane Fragment [plasma membrane]", "NOTCH1 L1574Q Extracellular Fragment [extracellular region]", "NOTCH1 Gene", "NOTCH1 I1616T Extracellular Fragment [extracellular region]", "NOTCH1 V1676D Transmembrane Fragment [plasma membrane]", "NICD1 P2514Rfs*4 [nucleoplasm]", "NICD1 P2474Afs*4 [cytosol]", "neurogenic locus notch homolog protein 1 (rat)", "NICD1 P2474Afs*4 [nucleoplasm]", "NOTCH1 A1701P S2 cleavage fragment [plasma membrane]", "NOTCH1 L1678P S2 cleavage fragment [extracellular region]", "17xFucT-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane]", "NOTCH1 I1718T S2 cleavage fragment [extracellular region]", "19xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane]", "NOTCH1 A1701P Transmembrane Fragment [plasma membrane]", "NOTCH1(1721-1753) [plasma membrane]", "NICD1 Q2440* [nucleoplasm]", "NEXT1 [plasma membrane]", "NOTCH1 protein, human", "NOTCH1 gene", "NOTCH1 gene [nucleoplasm]", "NOTCH1 L1574P Extracellular Fragment [extracellular region]", "NICD1 [nucleoplasm]", "neurogenic locus notch homolog protein 1 (human)", "NOTCH1 V1676D S2 cleavage fragment [extracellular region]", "NICD1 Q2440* [cytosol]", "Notch1 (rat)", "NOTCH1 R1598P Extracellular Fragment [extracellular region]", "p-NICD1 P2514Rfs*4 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"PR:Q01705", "REACT:R-HSA-2902208", "REACT:R-HSA-1485602", "REACT:R-HSA-157024", "REACT:R-HSA-1485582", "REACT:R-HSA-1467425", "REACT:R-HSA-1911512"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["DOI:10.1038/nature03940", "DOI:10.1186/1741-7007-9-83", "DOI:10.1128/mcb.00360-10", "PMID:15164053", "DOI:10.1186/s12859-014-0440-9", "PMID:30598546", "PMID:21245387", "PMID:28439555", "PMID:15472075", "DOI:10.1016/j.cell.2005.12.037"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL2108305": {"name": "INSULIN TREGOPIL", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL2108305", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL2108305", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "INSULIN TREGOPIL; MAX_FDA_APPROVAL_PHASE: 2", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:NamedThing", "biolink:ChemicalEntity", "biolink:SmallMolecule"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["INSULIN TREGOPIL", "Insulin tregopil"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["UMLS:C4550894", "DRUGBANK:DB11568", "CHEMBL.COMPOUND:CHEMBL2108305"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL25": {"name": "ASPIRIN", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL25", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL25", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Aspirin is only found in individuals who have consumed this drug. Aspirin or acetylsalicylic acid (acetosal) is a drug in the family of salicylates, often used as an analgesic (against minor pains and aches), antipyretic (against fever), and anti-inflammatory. It has also an anticoagulant effect and is used in long-term low-doses to prevent heart attacks and cancer. It was isolated from meadowsweet (Filipendula ulmaria, formerly classified as Spiraea ulmaria) by German researchers in 1839. While their extract was somewhat effective, it also caused digestive problems such as irritated stomach and diarrhoea, and even death when consumed in high doses. In 1853, a French chemist named Charles Frederic Gerhardt neutralized salicylic acid by buffering it with sodium (sodium salicylate) and acetyl chloride, creating acetosalicylic anhydride. Gerhardt's product worked, but he had no desire to market it and abandoned his discovery. In 1897, researcher Arthur Eichengrun and Felix Hoffmann, a research assistant at Friedrich Bayer & Co. in Germany, derivatized one of the hydroxyl functional groups in salicylic acid with an acetyl group (forming the acetyl ester), which greatly reduced the negative effects. This was the first synthetic drug, not a copy of something that existed in nature, and the start of the pharmaceuticals industry. The name 'aspirin' is composed of a- (from the acetyl group) -spir- (from the plant genus Spiraea) and -in (a common ending for drugs at the time). It has also been stated that the name originated by another means. As referring to AcetylSalicylic and 'pir' in reference to one of the scientists who was able to isolate it in crystalline form, Raffaele Piria. Finally 'in' due to the same reasons as stated above. Salicylic acid (which is a naturally occurring substance found in many plants) can be acetylated using acetic anhydride, yielding aspirin and acetic acid as a byproduct. It is a common experiment performed in organic chemistry labs, and generally tends to produce low yields due to the relative difficulty of its extraction from an aqueous state. The trick to getting the reaction to work is to acidify with phosphoric acid and heat the reagents under reflux with a boiling water bath for between 40 minutes and an hour. Aspirin acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5).", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Acetylsalicylic acid", "Acetyl salicylate", "Polopiryna", "Acetysal", "aspirin", "Aspirin", "acetylsalicylic acid", "acetyl salicylate", "Aspirin (JP18/USP)", "ASPIRIN"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["PathWhiz.Compound:1251", "RXNORM:1191", "VANDF:4017536", "CHEMBL.COMPOUND:CHEMBL25", "UMLS:C0699271", "NCIT:C287", "PSY:04050", "RXNORM:91101", "UMLS:C0304348", "NDDF:001587", "HMDB:HMDB0001879", "MESH:D001241", "UMLS:C0004057", "UMLS:C0699278", "LOINC:LA26702-3", "KEGG.DRUG:D00109", "KEGG.COMPOUND:C01405", "CHEBI:15365", "DrugCentral:74", "DRUGBANK:DB00945"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:17451232", "PMID:24565904", "PMID:12193020", "PMID:22521372", "PMID:18835178", "PMID:17500510", "PMID:9597150", "PMID:21106454", "PMID:20576432", "PMID:17166724"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "UniProtKB:P12821": {"name": "ACE", "categories": ["biolink:Gene", "biolink:Protein"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/uniprot:P12821", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/uniprot:P12821", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Angiotensin-converting enzyme (1306 aa, ~150 kDa) is encoded by the human ACE gene. This protein plays a role in the hydrolysis of angiotensin I to form angiotensin II and the solubilization of glycophophoinositol-anchored proteins from the plasma membrane.; UMLS Semantic Type: STY:T123; UMLS Semantic Type: STY:T116", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:BiologicalEntity", "biolink:Gene", "biolink:Protein", "biolink:NamedThing", "biolink:Publication"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["angiotensin-converting enzyme (rat)", "Ace", "Ace (mouse)", "ACE (human)", "ACE protein, human", "Ace (rat)", "ACE(30-1306) [plasma membrane]", "angiotensin-converting enzyme (mouse)", "ACE", "ACE Gene", "ACE(30-1232) [extracellular region]", "acetylcholinesterase (fruit fly)", "ACE gene", "angiotensin-converting enzyme (human)"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["MESH:C488034", "RGD:2493", "HGNC:2707", "UMLS:C1413931", "UniProtKB:P12821", "LOINC:LP95187-8", "REACT:R-HSA-2065414", "NCBIGene:1636", "OMIM:106180", "REACT:R-HSA-508496", "PR:P07140", "LOINC:LP230189-5", "PR:P12821", "PR:P47820", "UMLS:C1452534", "ENSEMBL:ENSG00000159640", "NCIT:C91295", "MGI:87874", "PR:P09470"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["DOI:10.1006/bbrc.1998.8813", "PMID:16476442", "PMID:12459472", "DOI:10.1021/bi00243a012", "PMID:16625196", "PMID:15671045", "DOI:10.1212/01.wnl.0000098990.12845.da", "PMID:1649623", "DOI:10.1016/0014-5793(89)80897-x", "DOI:10.1038/nature01370"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEBI:26338": {"name": "prostaglandins E", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "http://purl.obolibrary.org/obo/CHEBI_26338", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "http://purl.obolibrary.org/obo/CHEBI_26338", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "A family comprised of three naturally occurring prostaglandins that are involved in the regulation of many biological functions including vasodilation, inflammation and smooth muscle cell contractility.; (11 alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three of the six naturally occurring prostaglandins. They are considered primary in that no one is derived from another in living organisms. Originally isolated from sheep seminal fluid and vesicles, they are found in many organs and tissues and play a major role in mediating various physiological activities.; UMLS Semantic Type: STY:T123; UMLS Semantic Type: STY:T109", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:MolecularEntity"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Prostaglandins E", "prostaglandins E"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["CHEBI:26338", "MESH:D011458", "UMLS:C0033559"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL1139": {"name": "EPOPROSTENOL", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL1139", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL1139", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Prostaglandin I2 or prostacyclin (or PGI2) is a member of the family of lipid molecules known as eicosanoids. It is produced in endothelial cells from prostaglandin H2 (PGH2) by the action of the enzyme prostacyclin synthase. It is a powerful vasodilator and inhibits platelet aggregation. Prostaglandin I2 is the main prostaglandin synthesized by the blood vessel wall. This suggests that it may play an important role in limiting platelet-mediated thrombosis. In particular, prostacyclin (PGI2) chiefly prevents formation of the platelet plug involved in primary hemostasis (a part of blood clot formation). The sodium salt (known as epoprostenol) has been used to treat primary pulmonary hypertension. Prostacyclin (PGI2) is released by healthy endothelial cells and performs its function through a paracrine signaling cascade that involves G protein-coupled receptors on nearby platelets and endothelial cells. The platelet Gs protein-coupled receptor (prostacyclin receptor) is activated when it binds to PGI2. This activation, in turn, signals adenylyl cyclase to produce cAMP. cAMP goes on to inhibit any undue platelet activation (in order to promote circulation) and also counteracts any increase in cytosolic calcium levels which would result from thromboxane A2 (TXA2) binding (leading to platelet activation and subsequent coagulation). PGI2 also binds to endothelial prostacyclin receptors and in the same manner raise cAMP levels in the cytosol. This cAMP then goes on to activate protein kinase A (PKA). PKA then continues the cascade by inhibiting myosin light-chain kinase which leads to smooth muscle relaxation and vasodilation. Notably, PGI2 and TXA2 work as antagonists. PGI2 is stable in basic buffers (pH=8), but it is rapidly hydrolyzed to 6-keto PGF1alpha in neutral or acidic solutions. The half-life is short both in vivo and in vitro, ranging from 30 seconds to a few minutes. PGI2 is administered by continuous infusion in humans for the treatment of idiopathic pulmonary hypertension.Prostaglandins are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs) and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes) and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent, able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signaling pathways.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug", "biolink:BiologicalEntity"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Prostaglandin I2", "EPOPROSTENOL", "Epoprostenol", "Epoprostenol (USAN/INN)", "Veletri", "epoprostenol sodium", "PGI2 [endoplasmic reticulum lumen]", "Epoprostenol Sodium", "epoprostenol", "prostaglandin I2(1-)", "PGI2 [extracellular region]", "prostaglandin I2", "Epoprostenol sodium (JAN/USAN)", "Epoprostenol sodium", "EPOPROSTENOL SODIUM"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["CHEBI:15552", "KEGG.COMPOUND:C01312", "CHEMBL.COMPOUND:CHEMBL962", "ATC:B01AC09", "VANDF:4020958", "DrugCentral:1034", "CHEMBL.COMPOUND:CHEMBL1139", "HMDB:HMDB0001335", "DRUGBANK:DB01240", "CHEBI:57403", "CHEBI:31548", "REACT:R-ALL-391926", "KEGG.DRUG:D00106", "UMLS:C0354594", "NDDF:003963", "MESH:D011464", "UMLS:C0033567", "RXNORM:104463", "UMLS:C1174787", "NCIT:C47514", "NCIT:C61748", "RXNORM:1009213", "VANDF:4024020", "PathWhiz.Compound:1028", "RXNORM:8814", "KEGG.DRUG:D01337", "REACT:R-ALL-31593"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:11126272", "PMID:2666669", "PMID:7504734", "PMID:10806831", "PMID:7035669", "PMID:6854582", "PMID:11258611", "PMID:22194678", "PMID:11980586", "PMID:10784307"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL1200896": {"name": "DINOPROST TROMETHAMINE", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL1200896", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL1200896", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Prostaglandin F2a (PGF2) is one of the earliest discovered and most common prostaglandins. It is actively biosynthesized in various organs of mammals and exhibits a variety of biological activities, including contraction of pulmonary arteries. It is used in medicine to induce labor and as an abortifacient. PGF2a binds to the Prostaglandin F2 receptor (PTGFR) which is a member of the G-protein coupled receptor family. PGF2-alpha mediates luteolysis. Luteolysis is the structural and functional degradation of the corpus luteum (CL) that occurs at the end of the luteal phase of both the estrous and menstrual cycles in the absence of pregnancy. PGF2 may also be involved in modulating intraocular pressure and smooth muscle contraction in the uterus and gastrointestinal tract sphincters. PGF2 is mainly synthesized directly from PGH2 by PGH2 9,11-endoperoxide reductase. A small amount of PGF2 is also produced from PGE2 by PGE2 9-ketoreductase. A PGF2 epimer has been reported to exhibit various biological activities, and its levels are increased in bronchoalveolar lavage fluid, plasma, and urine in patients with mastocytosis and bronchial asthma. PGF2 is synthesized from PGD2 by PGD2 11-ketoreductase. (PMID: 16475787). Prostaglandins are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent, able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signalling pathways.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug", "biolink:BiologicalEntity"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Dinoprost tromethamine", "Estrofan", "5-trans-PGF2alpha", "prostaglandin F2beta, (5Z,8beta,9beta,11alpha,12alpha,13E,15S)-isomer", "SID26754610", "prostaglandin F2beta", "dinoprost", "SID26754822", "Prostaglandin F2alpha", "PGF2a [cytosol]", "Enzaprost F", "prostaglandin F2beta, (5Z,9beta,11beta,13E,15S)-isomer", "Prostaglandin F2a", "Minprostin F2 Alpha", "Prostaglandin F2beta", "Prostaglandin F2b", "prostaglandin F2beta, (5Z,9beta,11beta,13E,15R)-isomer", "DINOPROST TROMETHAMINE", "PGF2a [extracellular region]", "Dinoprost tromethamine (JAN/USP)", "prostaglandin F2alpha", "dinoprost tromethamine", "Lutalyse", "Dinoprost Tromethamine", "Dinoprost", "DINOPROST"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["DrugCentral:912", "CHEBI:31502", "RXNORM:3477", "UMLS:C0701180", "KEGG.COMPOUND:C02314", "UMLS:C0970461", "HMDB:HMDB0001483", "PathWhiz.Compound:889", "PDQ:CDR0000039277", "NCIT:C152070", "NCIT:C65413", "CHEBI:15553", "CHEMBL.COMPOUND:CHEMBL815", "REACT:R-ALL-391928", "REACT:R-ALL-879657", "RXNORM:23321", "CHEMBL.COMPOUND:CHEMBL1903583", "CHEBI:28922", "UMLS:C0012471", "UMLS:C0950286", "MESH:C037027", "CHEMBL.COMPOUND:CHEMBL1200896", "UMLS:C0955936", "CHEBI:187232", "UMLS:C0072285", "UMLS:C0699143", "MESH:C010714", "NCIT:C1074", "ttd.target:Dinoprost_Tromethamine", "NDDF:003958", "DRUGBANK:DB12789", "UMLS:C0699144", "RXNORM:1312472", "CHEMBL.COMPOUND:CHEMBL1894513", "NDDF:001308", "UMLS:C0058310", "KEGG.DRUG:D01352", "UMLS:C0955937", "REACT:R-ALL-879535", "DRUGBANK:DB01160", "MESH:D015237", "HMDB:HMDB0001139", "KEGG.COMPOUND:C00639", "VANDF:4018089", "KEGG.COMPOUND:C12786", "ATC:G02AD01"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:1061097", "PMID:23062825", "PMID:15357985", "PMID:23317571", "PMID:15100168", "PMID:650661", "PMID:12650826", "PMID:2982905", "PMID:14631946", "PMID:10715159"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL165001": {"name": "7-[5-Hydroxy-2-(3-hydroxy-oct-1-enyl)-3-oxo-cyclopentyl]-hept-5-enoic acid", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL165001", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL165001", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Prostaglandin D2 (or PGD2) is a prostaglandin that is actively produced in various organs such as the brain, spleen, thymus, bone marrow, uterus, ovary, oviduct, testis, prostate and epididymis, and is involved in many physiological events. PGD2 binds to the prostaglandin D2 receptor (PTGDR) which is a G-protein-coupled receptor. Its activity is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+. PGD2 promotes sleep; regulates body temperature, olfactory function, hormone release, and nociception in the central nervous system; prevents platelet aggregation; and induces vasodilation and bronchoconstriction. PGD2 is also released from mast cells as an allergic and inflammatory mediator. Prostaglandin H2 is an unstable intermediate formed from PGG2 by the action of cyclooxygenase (COX) in the arachidonate cascade. In mammalian systems, it is efficiently converted into more stable arachidonate metabolites, such as PGD2, PGE2, PGF2a by the action of three groups of enzymes, PGD synthases (PGDS), PGE synthases and PGF synthases, respectively. PGDS catalyzes the isomerization of PGH2 to PGD2. Two types of PGD2 synthase are known. Lipocalin-type PGD synthase is present in cerebrospinal fluid, seminal plasma and may play an important role in male reproduction. Another PGD synthase, hematopoietic PGD synthase is present in the spleen, fallopian tube, endometrial gland cells, extravillous trophoblasts and villous trophoblasts, and perhaps plays an important role in female reproduction. Recent studies demonstrate that PGD2 is probably involved in multiple aspects of inflammation through its dual receptor systems, DP and CRTH2. (PMID: 12148545)Prostaglandins are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs) and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes) and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent, able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signaling pathways.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:BiologicalEntity"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["PROSTAGLANDIN D2", "7-[5-Hydroxy-2-(3-hydroxy-oct-1-enyl)-3-oxo-cyclopentyl]-hept-5-enoic acid", "PGD2 [extracellular region]", "PGD2 [cytosol]", "Prostaglandin D2", "prostaglandin D2", "PGD2 [endoplasmic reticulum lumen]"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["DRUGBANK:DB02056", "MESH:D015230", "PathWhiz.Compound:1084", "REACT:R-ALL-2161634", "REACT:R-ALL-879629", "LOINC:MTHU003622", "KEGG.COMPOUND:C00696", "REACT:R-ALL-416911", "UMLS:C0033532", "LOINC:LP18190-6", "CHEMBL.COMPOUND:CHEMBL165001", "CHEBI:15555", "HMDB:HMDB0001403", "NCIT:C116013", "CHEMBL.COMPOUND:CHEMBL1235252"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:380688", "PMID:3462506", "PMID:23566516", "PMID:806102", "PMID:6854581", "PMID:3890960", "PMID:8182221", "PMID:14631946", "PMID:3002327", "PMID:6430299"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL495": {"name": "ALPROSTADIL", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL495", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL495", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Prostaglandin E1 (PGE1) is a potent endogenous vasodilator agent that increases peripheral blood flow. It inhibits platelet aggregation and has many other biological effects such as bronchodilation, mediation of inflammation, and various protective functions. The protective action of PGE1 has been shown on both experimental animal models of liver injury and patients with fulminant viral hepatitis. PGE1-treated cirrhotic rats had less hepatosplenomegaly, lower serum alanine aminotransferase levels and portal pressures, and higher arterial pressure than placebo-treated cirrhotic rats. There are several mechanisms of PGE1 hepatic cytoprotection: inhibiting T-cell mediated cytotoxicity, enhancing DNA synthesis of the injured liver after partial hepatectomy by stimulating cyclic AMP production, increasing ATP level in hepatic tissue to accelerate the recovery of mitochondrial respiratory function after reperfusion, and stabilizing membrane microviscosity. PGE1 is a prostanoid. The term prostanoid collectively describes prostaglandins, prostacyclins, and thromboxanes. Prostanoids are a subclass of the lipid mediator group known as eicosanoids. They are derived from C-20 polyunsaturated fatty acids, mainly dihomo-\u03b3-linolenic (20:3n-6), arachidonic (20:4n-6), and eicosapentaenoic (20:5n-3) acids, through the action of cyclooxygenases-1 and -2 (COX-1 and COX-2) (PMID: 11819590, 16986207). Prostaglandins are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent and are able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis through receptor-mediated G-protein linked signalling pathways.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug", "biolink:BiologicalEntity"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["ALPROSTADIL", "Alprostadil alfadex", "Alprostadil alfadex (JP18)", "7-[(1R,2R,3R)-3-hydroxy-2-[(3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]heptanoic acid", "alprostadil", "Alprostadil", "PGE1 [extracellular region]", "Prostaglandin E1", "prostaglandin E1", "Alprostadil (JP18/USP/INN)", "ALPROSTADIL ALFADEX", "PGE1 [cytosol]", "alprostadil alfadex"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["PDQ:CDR0000360459", "LOINC:MTHU003621", "VANDF:4018099", "ATC:C01EA01", "NDDF:000704", "KEGG.COMPOUND:C13548", "LOINC:LP15823-5", "RXNORM:598", "CHEMBL.COMPOUND:CHEMBL2108900", "ATC:G04BE01", "DrugCentral:138", "DrugCentral:3864", "REACT:R-ALL-879519", "MESH:D000527", "NCIT:C28816", "KEGG.DRUG:D00180", "CHEBI:15544", "CHEMBL.COMPOUND:CHEMBL495", "CHEBI:34532", "HMDB:HMDB0001442", "DRUGBANK:DB00770", "UMLS:C0002335", "CHEBI:92915", "REACT:R-ALL-879611", "KEGG.DRUG:D02705", "KEGG.COMPOUND:C04741"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:2909735", "PMID:29541361", "PMID:23062825", "PMID:11177444", "PMID:16986207", "PMID:9500712", "PMID:22931300", "PMID:9612114", "PMID:16701566", "PMID:9248778"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL548": {"name": "DINOPROSTONE", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL548", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL548", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "The naturally occurring prostaglandin E2 (PGE2) is known in medicine as dinoprostone, and it is the most common and most biologically active of the mammalian prostaglandins. It has important effects during labour and also stimulates osteoblasts to release factors which stimulate bone resorption by osteoclasts (a type of bone cell that removes bone tissue by removing the bone's mineralized matrix). PGE2 is also the prostaglandin that ultimately induces fever. PGE2 has been shown to increase vasodilation and cAMP production, enhance the effects of bradykinin and histamine, and induce uterine contractions and platelet aggregation. PGE2 is also responsible for maintaining the open passageway of the fetal ductus arteriosus, decreasing T-cell proliferation and lymphocyte migration, and activating the secretion of IL-1\u03b1 and IL-2. PGE2 exhibits both pro- and anti-inflammatory effects, particularly on dendritic cells (DC). Depending on the nature of maturation signals, PGE2 has different and sometimes opposite effects on DC biology. PGE2 exerts an inhibitory action, reducing the maturation of DC and their ability to present antigen. PGE2 has also been shown to stimulate DC and promote IL-12 production when given in combination with TNF-alpha. PGE2 is an environmentally bioactive substance. Its action is prolonged and sustained by other factors especially IL-10. It modulates the activities of professional DC by acting on their differentiation, maturation, and their ability to secrete cytokines. PGE2 is a potent inducer of IL-10 in bone marrow-derived DC (BM-DC). PGE2-induced IL-10 is a key regulator of the BM-DC pro-inflammatory phenotype (PMID: 16978535). Prostaglandins are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent and are able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis through receptor-mediated G-protein linked signalling pathways.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug", "biolink:BiologicalEntity"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Prepidil Gel", "DINOPROSTONE", "7-Hydroxy-D4-neuroprostane", "PGE2 [extracellular region]", "Prostenon", "dinoprostone", "4-Hydroxy-D4-neuroprostane", "4-hydroxy-D4-neuroprostane", "17-Hydroxy-E4-neuroprostane", "14-Hydroxy-E4-neuroprostane", "Dinoprostone (JAN/USP/INN)", "20-hydroxy-E4-neuroprostane", "Dinoprostone", "Prostaglandin E2", "7-hydroxy-D4-neuroprostane", "14-hydroxy-E4-neuroprostane", "PGE2 [cytosol]", "20-Hydroxy-E4-neuroprostane", "prostaglandin E2", "17-hydroxy-E4-neuroprostane"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["HMDB:HMDB0012777", "DRUGBANK:DB00917", "MESH:D015232", "HMDB:HMDB0012601", "UMLS:C0012472", "NDDF:001309", "CHEBI:174983", "LOINC:MTHU003620", "NCIT:C61727", "KEGG.DRUG:D00079", "UMLS:C0699577", "CHEBI:15551", "CHEBI:174978", "HMDB:HMDB0012855", "CHEBI:174985", "CHEBI:174980", "KEGG.COMPOUND:C00584", "RXNORM:3478", "DrugCentral:913", "CHEMBL.COMPOUND:CHEMBL548", "LOINC:LP15824-3", "NCIT:C112043", "REACT:R-ALL-265287", "HMDB:HMDB0012638", "VANDF:4018093", "ATC:G02AD02", "PathWhiz.Compound:949", "HMDB:HMDB0012580", "REACT:R-ALL-391930", "HMDB:HMDB0001220", "UMLS:C0699578", "CHEBI:174982", "UMLS:C3813211"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:10873595", "PMID:12643927", "PMID:19250823", "PMID:8523407", "PMID:23062825", "PMID:14499495", "PMID:2666669", "PMID:9650585", "PMID:24279689", "PMID:10101033"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "VANDF:4021850": {"name": "Prostaglandins", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "http://purl.bioontology.org/ontology/VANDF/4021850", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "http://purl.bioontology.org/ontology/VANDF/4021850", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Physiologically potent compounds of ubiquitous occurrence formed from essential fatty acids and affecting the nervous system, female reproductive organs, and metabolism.; A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.; UMLS Semantic Type: STY:T121; UMLS Semantic Type: STY:T125; UMLS Semantic Type: STY:T109", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:MolecularEntity"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["prostaglandin", "Prostaglandin", "Prostaglandins"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["NCIT:C782", "VANDF:4021850", "LOINC:LP15827-6", "CHEBI:26333", "UMLS:C0033554", "LOINC:MTHU007142", "PSY:41136", "LOINC:MTHU013657", "LOINC:LP19203-6", "MESH:D011453"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL14192": {"name": "BENZYLIMIDAZOLE", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL14192", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL14192", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "1-benzylimidazole, an N-imidazole derivative, has been shown to have strong cardiotonic activity.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["BENZYLIMIDAZOLE", "1-benzylimidazole", "1-Benzylimidazole"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["CHEMBL.COMPOUND:CHEMBL14192", "HMDB:HMDB0243836", "MESH:C017062", "UMLS:C0044305", "DRUGBANK:DB04581"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:16870430", "PMID:20121113", "PMID:20810286", "PMID:20547819", "PMID:18558667", "PMID:24900247", "PMID:19056282", "PMID:6142461", "PMID:1159635", "PMID:4020834"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL1213009": {"name": "OXAPROTILINE", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL1213009", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL1213009", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Oxaprotiline is a norepinephrine reuptake inhibitor of the tetracyclic antidepressant family that is related to maprotiline. This drug was never marketed. Oxaprotiline is a racemic mixture of the isomers levoprotiline and dextroprotiline. Levoprotiline is the R or levo isomer of oxaprotiline (CGP-12,103-A). Dextroprotiline is the S or dextro isomer of oxaprotiline (CGP-12,104-A). 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Gulose has been found to be a metabolite of Ketogulonicigenium (PMID: 15785002).", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:MolecularEntity", "biolink:SmallMolecule", "biolink:BiologicalEntity", "biolink:Gene", "biolink:Protein", "biolink:NamedThing", "biolink:Polypeptide", "biolink:Drug", "biolink:InformationContentEntity"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["GAL", "galanin peptides (human)", "Glucose", "L-gulose", "b-D-GALACTOSE", "Gal", "L-altrose", "beta-D-galactose", "galanin", "\u03b2-D-Galactose", "Glycoprotein-phospho-D-mannose", "mannose", "Gal 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"NDDF:012467", "OMIM:137035", "CHEBI:72452", "UMLS:C0115426", "NCIT:C148352", "ATC:V06DC01", "PathWhiz.Compound:40952", "HMDB:HMDB0037209", "UMLS:C0024742", "KEGG.COMPOUND:C01825", "PR:P22466", "CHEMBL.COMPOUND:CHEMBL506553", "CHEBI:28061", "CHEMBL.COMPOUND:CHEMBL103010", "VANDF:4019541", "CHEMBL.COMPOUND:CHEMBL98182", "REACT:R-ALL-912281", "CHEBI:155877", "CHEBI:28260", "CHEBI:17118", "CHEMBL.COMPOUND:CHEMBL1222250", "RXNORM:4626", "CHEMBL.COMPOUND:CHEMBL1233058", "CHEBI:37684", "CHEMBL.COMPOUND:CHEMBL195923", "NCIT:C148351", "PDQ:CDR0000751909", "LOINC:MTHU004836", "PSY:21160", "PathWhiz.Compound:14766", "MESH:D019004", "REACT:R-ALL-188995", "ATC:V04CE01", "UniProtKB:P22466", "UMLS:C0385079", "MESH:D005690", "NCIT:C42565", "PSY:20531", "NCBIGene:51083", "CHEMBL.COMPOUND:CHEMBL3186423", "CHEBI:37675", "CHEMBL.COMPOUND:CHEMBL501079", "KEGG.COMPOUND:C15901", "DRUGBANK:DB12907", "CHEBI:4167", "HMDB:HMDB0000122", "VANDF:4018618", "UMLS:C0016945", "REACT:R-ALL-1605637", "KEGG.COMPOUND:C00159", "KEGG.DRUG:D09924", "MESH:C040642", "LOINC:LP32694-9", "CHEBI:28729", "REACT:R-ALL-429635", "RGD:61954", "REACT:R-ALL-6799594", "KEGG.COMPOUND:C15923", "LOINC:MTHU001675", "CHEBI:37619", "LOINC:LP32534-7", "KEGG.COMPOUND:C00124", "LOINC:MTHU025422", "REACT:R-ALL-429579", "HMDB:HMDB0033704", "CHEMBL.COMPOUND:CHEMBL300520", "CHEMBL.COMPOUND:CHEMBL469448", "CHEBI:80161", "HMDB:HMDB0304632", "NCIT:C2831", "KEGG.COMPOUND:C00737", "HMDB:HMDB0000169", "KEGG.COMPOUND:C00031", "RXNORM:4850", "ENSEMBL:ENSG00000069482", "NCIT:C148347", "NCIT:C68483", "CHEBI:16362", "PathWhiz.Compound:57903", "FMA:82794", "RXNORM:6633", "HMDB:HMDB0003449", "KEGG.COMPOUND:C00936", "DRUGBANK:DB11735", "CHEBI:4139", "PR:000007806", "CHEBI:42905", "DrugCentral:1271", "PathWhiz.Compound:1894", "MGI:95637", "CHEBI:27667", "LOINC:LP14635-4", "PR:P10683", "REACT:R-ALL-964752", "ATC:B05CX01", "UMLS:C1414945", "CHEMBL.COMPOUND:CHEMBL365590", "MESH:C097323", "VANDF:4028638", "HGNC:4114", 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"CHEMBL.COMPOUND:CHEMBL2074932": {"name": "DEOXYGLUCOSE", "categories": ["biolink:BiologicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL2074932", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL2074932", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "UMLS Semantic Type: STY:T109; 2-deoxyglucose is predominantly used as a diagnostic agent in its radiolabelled form (fluorine-18 is used as the radiolabel). By using positron emission tomography (PET), radiolabelled 2-deoxyglucose can determine glucose metabolism, which is altered in diseases such as cardiovascular disease, tumors, and Alzheimer's disease. Therapeutically, 2-deoxyglucose is an investigational drug that is being studied as an anticancer and antiviral agent. Concerning the former, 2- deoxyglucose was used as an adjunct to chemotherapy and radiotherapy in the treatment of solid tumors (lung, breast, pancreas, head, neck, and gastric tumors). The exact mechanisms of action of 2-deoxyglucose is still being investigated, but it is known that in hypoxic cancer cells, 2-deoxyglucose is a glycolysis inhibitor that prevents ATP production and, ultimately, cell survival. With respect to antiviral therapy, 2-deoxyglucose was shown to be effective against herpes simplex virus by affecting the virus' ability to penetrate cells. As an experimental drug, 2-deoxyglucose was demonstrated to work as an anticonvulsant in temporal lobe epilepsy. In this condition, 2-deoxyglucose represses the expression of certain proteins that are at high levels after a seizure. Although there are several possible therapeutic indications for 2-deoxyglucose, presently there is no approved indication for 2-deoxyglucose as a therapeutic agent.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["2-DEOXYGLUCOSE", "2-deoxy-D-glucopyranose", "deoxyglucose", "Deoxyglucose", "2-deoxy-D-glucose", "2-Deoxyglucose", "(2R,4R,5S,6R)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,4,5-triol", "SID56323667", "(2S,4R,5S,6R)-6-(hydroxymethyl)oxane-2,4,5-triol", "2-Deoxy-D-glucose", "DEOXYGLUCOSE", "2-deoxyglucose"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["CHEBI:84755", "DRUGBANK:DB08831", "CHEBI:125684", "CHEMBL.COMPOUND:CHEMBL4303562", "PSY:13585", "RXNORM:1733674", "NCIT:C116618", "UMLS:C4049845", "PDQ:CDR0000409701", "CHEMBL.COMPOUND:CHEMBL1377788", "CHEBI:15866", "CHEMBL.COMPOUND:CHEMBL2208394", "HMDB:HMDB0062477", "NDDF:007522", "UMLS:C0011501", "MESH:D003847", "CHEMBL.COMPOUND:CHEMBL2074932", "PathWhiz.Compound:43028", "KEGG.COMPOUND:C00586", "CHEBI:23623"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:23228990", "PMID:17041593", "PMID:6293188", "PMID:11413487", "PMID:23245650", "PMID:28063798", "PMID:17374880", "PMID:20044567", "PMID:16902246", "PMID:28841379"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "FMA:83358": {"name": "Prolactin", "categories": ["biolink:BiologicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "http://purl.obolibrary.org/obo/FMA_83358", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "http://purl.obolibrary.org/obo/FMA_83358", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate.; UMLS Semantic Type: STY:T121; UMLS Semantic Type: STY:T125; UMLS Semantic Type: STY:T116", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:NamedThing", "biolink:Gene", "biolink:BiologicalEntity", "biolink:Protein", "biolink:Drug", "biolink:MolecularEntity", "biolink:SmallMolecule"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Prl (mouse)", "prolactin", "PRL gene", "PRL Gene", "prolactin (rat)", "PRL (chicken)", "PRL [endosome lumen]", "prolactin (chicken)", "Prl (rat)", "prolactin (human)", "PRL [extracellular region]", "Prolactin", "DNA replication licensing factor MCM7 (Arabidopsis thaliana)", "PRL", "PRL (human)"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["UMLS:C1418938", "CHEBI:81580", "UniProtKB:P01236", "OMIM:176760", "LOINC:LP70338-6", "RGD:3403", "PR:P14676", "PR:P01237", "PR:P01236", "NCIT:C778", "MESH:D011388", "NCBIGene:5617", "REACT:R-HSA-976984", "HGNC:9445", "REACT:R-HSA-8942967", "KEGG.COMPOUND:C18201", "UMLS:C0033371", "PR:000013246", "RXNORM:1426890", "ENSEMBL:ENSG00000172179", "LOINC:LP14688-3", "NCIT:C39655", "FMA:83358", "PSY:41020", "MGI:97762", "NCBIGene:396453", "PR:P43299", "LOINC:MTHU003168"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:1126929", "DOI:10.1002/j.1460-2075.1984.tb01824.x", "DOI:10.1016/s0022-2836(03)00367-x", "PMID:6146607", "DOI:10.1210/jc.2004-1600", "PMID:15687336", "PMID:15489334", "DOI:10.1016/j.jmb.2005.06.042", "DOI:10.1023/a:1005879103367", "DOI:10.1074/jbc.m704364200"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "FMA:83376": {"name": "Estrogen", "categories": ["biolink:BiologicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "http://purl.obolibrary.org/obo/FMA_83376", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "http://purl.obolibrary.org/obo/FMA_83376", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "A hormone that stimulates or controls the development and maintenance of female sex characteristics in mammals by binding to oestrogen receptors. The oestrogens are named for their importance in the oestrous cycle. The oestrogens that occur naturally in the body, notably estrone, estradiol, estriol, and estetrol are steroids. Other compounds with oestrogenic activity are produced by plants (phytoestrogens) and fungi (mycoestrogens); synthetic compounds with oestrogenic activity are known as xenoestrogens.; Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.; A hormone that stimulates or controls the development and maintenance of female sex characteristics in mammals by binding to oestrogen receptors. The oestrogens are named for their importance in the oestrous cycle. The oestrogens that occur naturally in the body, notably estrone, estradiol, estriol, and estetrol are steroids. Other compounds with oestrogenic activity are produced by plants (phytoestrogens) and fungi (mycoestrogens); synthetic compounds with oestrogenic activity are known as xenoestrogens.; A hormone that stimulates or controls the development and maintenance of female sex characteristics in mammals by binding to oestrogen receptors. The oestrogens are named for their importance in the oestrous cycle. The oestrogens that occur naturally in the body, notably estrone, estradiol, estriol, and estetrol are steroids. Other compounds with oestrogenic activity are produced by plants (phytoestrogens) and fungi (mycoestrogens); synthetic compounds with oestrogenic activity are known as xenoestrogens.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug", "biolink:NamedThing", "biolink:BiologicalEntity"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Apstil", "ESTG [nucleoplasm]", "Estrogens", "ESTG [extracellular region]", "fosfestrol", "Diethylstilbestrol diphosphate", "Estrogen", "SID144204556", "ESTROGEN", "diethylstilbestrol diphosphate", "Diethylstilbestrol (USP/INN)", "fosfestrol, sodium salt, (E)-isomer", "Diethylstilbestrol diphosphate (USP)", "Honvan", "Diethylstilbestrol", "Tampovagan", "fostestrolum", "Fosfestrol", "estrogens", "estrogen", "Kyorin", "DIETHYLSTILBESTROL DIPHOSPHATE", "ESTG [cytosol]", "Distilb\u00e8ne", "DIETHYLSTILBESTROL", "Agostilben", "diethylstilbestrol", "4-[4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["CHEBI:4531", "KEGG.DRUG:D00577", "MESH:D004967", "REACT:R-ALL-374146", "UMLS:C0888422", "UMLS:C0591106", "UMLS:C0678155", "ATC:L02AA01", "ATC:L02AA04", "CHEMBL.COMPOUND:CHEMBL2135534", "UMLS:C0124791", "UMLS:C1511924", "MESH:D004054", "VANDF:4021628", "UMLS:C0118174", "NCIT:C1105", "UMLS:C0012203", "MESH:C004955", "VANDF:4017427", "UMLS:C0699334", "UMLS:C0060692", "RXNORM:4100", "RXNORM:3390", "UMLS:C0014939", "REACT:R-ALL-1254400", "ATC:G03CC05", "HMDB:HMDB0014400", "CHEBI:50114", "KEGG.COMPOUND:C07620", "LOINC:LP14661-0", "ATC:G03CB02", "DrugCentral:3248", "CHEBI:41922", "CHEMBL.COMPOUND:CHEMBL592868", "VANDF:4018404", "NCIT:C433", "CHEMBL.COMPOUND:CHEMBL411", "KEGG.COMPOUND:C08145", "FMA:83376", "DRUGBANK:DB00255", "LOINC:MTHU003480", "RXNORM:25284", "VANDF:4017428", "DrugCentral:875", "PDQ:CDR0000039308", "CHEBI:4532", "LOINC:MTHU004623", "PDQ:CDR0000043081", "HMDB:HMDB0302859", "CHEMBL.COMPOUND:CHEMBL1200598", "NCIT:C2293", "KEGG.DRUG:D00946", "LOINC:LP18551-9", "UMLS:C0592160", "REACT:R-ALL-9027649", "CHEBI:92795", "PSY:18010"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:28993106", "PMID:16279782", "PMID:13104505", "PMID:12672229", "PMID:22652053", "PMID:1573630", "PMID:22931300", "PMID:15646539", "PMID:5549830", "PMID:23403082"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL2109588": {"name": "CA2", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL2109588", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL2109588", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "-!- FUNCTION: Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. {ECO:0000250, ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:11831900, ECO:0000269|PubMed:15990874}. -!- CATALYTIC ACTIVITY: Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:17544; EC=4.2.1.1; -!- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:11076507, ECO:0000269|PubMed:12499545, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:1433293, ECO:0000269|PubMed:1909891, ECO:0000269|PubMed:19583303, ECO:0000269|PubMed:3151019, ECO:0000269|PubMed:3151020, ECO:0000269|PubMed:7761440, ECO:0000269|PubMed:7803386, ECO:0000269|PubMed:7901850, ECO:0000269|PubMed:8218160, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:8331673, ECO:0000269|PubMed:8399159, ECO:0000269|PubMed:8431430, ECO:0000269|PubMed:8451242, ECO:0000269|PubMed:8482389, ECO:0000269|PubMed:8639494, ECO:0000269|PubMed:8987974, ECO:0000269|PubMed:9398308, ECO:0000269|PubMed:9865942}; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence={ECO:0000269|PubMed:19583303}; Note=Zinc. Can also use cobalt(II) with lower efficiency, but not copper(II), nickel(II) and manganese(II). {ECO:0000269|PubMed:19583303}; -!- ACTIVITY REGULATION: Activated by X-ray, histamine, L-adrenaline, L- and D-phenylalanine, L- and D-histidine, L-His-OMe and beta-Ala-His (carnosine). Competitively inhibited by saccharin, thioxolone, coumarins, 667-coumate, celecoxib (Celebrex), valdecoxib (Bextra), SC-125, SC-560, diclofenac, acetate, azide, bromide, sulfonamide derivatives such as acetazolamide (AZA), methazolamide (MZA), ethoxzolamide (EZA), dichlorophenamide (DCP), brinzolamide, dansylamide, thiabendazole-5-sulfonamide, trifluoromethane sulfonamide and N-hydroxysulfamide, fructose-based sugar sulfamate RWJ-37497, and Foscarnet (phosphonoformate trisodium salt). Repressed strongly by hydrogen sulfide(HS) and weakly by nitrate (NO(3)). Esterase activity weakly reduced by cyanamide. N-hydroxyurea interfers with zinc binding and inhibit activity. {ECO:0000269|PubMed:11802772, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:14736236, ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:16290146, ECO:0000269|PubMed:16686544, ECO:0000269|PubMed:16759856, ECO:0000269|PubMed:16807956, ECO:0000269|PubMed:17127057, ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17540563, ECO:0000269|PubMed:17588751, ECO:0000269|PubMed:17705204, ECO:0000269|PubMed:18024029, ECO:0000269|PubMed:18162396, ECO:0000269|PubMed:18266323, ECO:0000269|PubMed:18374572, ECO:0000269|PubMed:18481843, ECO:0000269|PubMed:18618712, ECO:0000269|PubMed:18640037, ECO:0000269|PubMed:1910042, ECO:0000269|PubMed:19170619, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230, ECO:0000269|PubMed:19520834, ECO:0000269|PubMed:19778001, ECO:0000269|PubMed:9265618}. -!- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=9.3 mM for CO(2) {ECO:0000269|PubMed:18618712, ECO:0000269|PubMed:7761440}; KM=11 mM for CO(2) {ECO:0000269|PubMed:1909891}; KM=8.2 mM for CO(2) {ECO:0000269|PubMed:9398308}; KM=82 mM for H(2)CO(3) {ECO:0000269|PubMed:8262987}; KM=2.9 mM for 4-nitrophenyl acetate {ECO:0000269|PubMed:10550681}; pH dependence: Optimum pH is 6-8. {ECO:0000269|PubMed:15667203, ECO:0000269|PubMed:17330962, ECO:0000269|PubMed:18942852, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:9398308}; -!- SUBUNIT: Interacts with SLC4A4. Interaction with SLC4A7 regulates SLC4A7 transporter activity. Interacts with SLC26A6 isoform 4 (via C-terminus cytoplasmic domain). {ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:11015219, ECO:0000269|PubMed:11076507, ECO:0000269|PubMed:11327835, ECO:0000269|PubMed:11572683, ECO:0000269|PubMed:11802772, ECO:0000269|PubMed:11818565, ECO:0000269|PubMed:11831900, ECO:0000269|PubMed:12056894, ECO:0000269|PubMed:12166932, ECO:0000269|PubMed:12499545, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:1433293, ECO:0000269|PubMed:14567693, ECO:0000269|PubMed:14736236, ECO:0000269|PubMed:14736710, ECO:0000269|PubMed:1474587, ECO:0000269|PubMed:15218065, ECO:0000269|PubMed:15299481, ECO:0000269|PubMed:15299482, ECO:0000269|PubMed:15453828, ECO:0000269|PubMed:15865431, ECO:0000269|PubMed:15990874, ECO:0000269|PubMed:16134940, ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:16290146, ECO:0000269|PubMed:16506782, ECO:0000269|PubMed:16686544, ECO:0000269|PubMed:16759856, ECO:0000269|PubMed:16787097, ECO:0000269|PubMed:16807956, ECO:0000269|PubMed:16820676, ECO:0000269|PubMed:16942027, ECO:0000269|PubMed:17000110, ECO:0000269|PubMed:17071654, ECO:0000269|PubMed:17125255, ECO:0000269|PubMed:17127057, ECO:0000269|PubMed:17181151, ECO:0000269|PubMed:17251017, ECO:0000269|PubMed:17346964, ECO:0000269|PubMed:17407288, ECO:0000269|PubMed:17540563, ECO:0000269|PubMed:17588751, ECO:0000269|PubMed:17705204, ECO:0000269|PubMed:18024029, ECO:0000269|PubMed:18161740, ECO:0000269|PubMed:18162396, ECO:0000269|PubMed:18260615, ECO:0000269|PubMed:18266323, ECO:0000269|PubMed:18359629, ECO:0000269|PubMed:18374572, ECO:0000269|PubMed:18461940, ECO:0000269|PubMed:18481843, ECO:0000269|PubMed:18640037, ECO:0000269|PubMed:18723489, ECO:0000269|PubMed:18768466, ECO:0000269|PubMed:1909891, ECO:0000269|PubMed:19115843, ECO:0000269|PubMed:19170619, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230, ECO:0000269|PubMed:1932029, ECO:0000269|PubMed:19520834, ECO:0000269|PubMed:19583303, ECO:0000269|PubMed:19731956, ECO:0000269|PubMed:19778001, ECO:0000269|PubMed:19827837, ECO:0000269|PubMed:3151019, ECO:0000269|PubMed:3151020, ECO:0000269|PubMed:7608893, ECO:0000269|PubMed:7696263, ECO:0000269|PubMed:7761440, ECO:0000269|PubMed:7803386, ECO:0000269|PubMed:7901850, ECO:0000269|PubMed:8070585, ECO:0000269|PubMed:8142888, ECO:0000269|PubMed:8218160, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:8331673, ECO:0000269|PubMed:8399159, ECO:0000269|PubMed:8431430, ECO:0000269|PubMed:8451242, ECO:0000269|PubMed:8482389, ECO:0000269|PubMed:8557623, ECO:0000269|PubMed:8639494, ECO:0000269|PubMed:8987974, ECO:0000269|PubMed:9265618, ECO:0000269|PubMed:9398308, ECO:0000269|PubMed:9541386, ECO:0000269|PubMed:9865942}. -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15990874}. Cell membrane {ECO:0000269|PubMed:15990874}. Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells. -!- DISEASE: Osteopetrosis, autosomal recessive 3 (OPTB3) [MIM:259730]: A rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. Osteopetrosis occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Recessive osteopetrosis commonly manifests in early infancy with macrocephaly, feeding difficulties, evolving blindness and deafness, bone marrow failure, severe anemia, and hepatosplenomegaly. Deafness and blindness are generally thought to represent effects of pressure on nerves. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation. {ECO:0000269|PubMed:15300855, ECO:0000269|PubMed:1542674, ECO:0000269|PubMed:1928091, ECO:0000269|PubMed:8834238, ECO:0000269|PubMed:9143915}. Note=The disease is caused by variants affecting the gene represented in this entry. -!- MISCELLANEOUS: Target of drugs used in treatments against glaucoma disorder and breast cancer. -!- SIMILARITY: Belongs to the alpha-carbonic anhydrase family. {ECO:0000305}. ; Short=CAC; Short=CA-IIEvidence Codes from Name:  ", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:BiologicalEntity", "biolink:Gene", "biolink:Protein", "biolink:SmallMolecule"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["carbonic anhydrase 2 (chicken)", "CA2 [cytosol]", "beta carbonic anhydrase 2, chloroplastic (Arabidopsis thaliana)", "CA2 (human)", "carbonic anhydrase 2 (cow)", "CA2 (chicken)", "carbonic anhydrase 2 (human)", "CA2 (cow)", "CA2", "CA2 gene"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["NCBIGene:396257", "ENSEMBL:ENSG00000104267", "OMIM:611492", "PR:P42737", "NCBIGene:760", "PR:P07630", "REACT:R-HSA-1237012", "UMLS:C1413043", "PR:P00921", "CHEMBL.COMPOUND:CHEMBL2109588", "UniProtKB:P00918", "HGNC:1373", "PR:P00918", "NCBIGene:280740"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:15299482", "DOI:10.1016/j.bmcl.2009.01.038", "DOI:10.1038/sj.emboj.7600736", "DOI:10.1016/j.bmcl.2005.09.040", "PMID:17000110", "PMID:6817747", "DOI:10.1002/prot.340040406", "DOI:10.1016/0014-5793(94)00798-5", "DOI:10.1021/jm801386n", "PMID:16787097"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "VANDF:4021566": {"name": "Calcium channel blockers", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "http://purl.bioontology.org/ontology/VANDF/4021566", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "http://purl.bioontology.org/ontology/VANDF/4021566", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "A pharmaceutical agent that inhibits the movement of calcium across through calcium channels in the cell membrane, preventing or decreasing the amount of calcium able to enter the cell. These drugs are used for their chronotropic, antihypertensive and vasodilatory effects.; A class of drugs that act by selective inhibition of calcium influx through cellular membranes.; UMLS Semantic Type: STY:T121", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:Drug", "biolink:BiologicalEntity"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Calcium channel blockers", "calcium channel blocker", "Calcium Channel Blockers", "Calcium Channel Blocker"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["NCIT:C333", "UMLS:C0006684", "CHEBI:38215", "PSY:07250", "ATC:C08", "VANDF:4021566", "LOINC:LP31438-2", "MESH:D002121"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}]}, "CHEMBL.TARGET:CHEMBL2331074": {"name": "Adrenergic receptor", "categories": ["biolink:GeneFamily"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.target:CHEMBL2331074", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.target:CHEMBL2331074", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Class of neural receptors that are sensitive to the neurotransmitters epinephrine and norepinephrine.; A family of G protein-coupled receptors that bind catecholamines and play a role in the stimulation of the sympathetic nervous system.; Cell-surface proteins that bind epinephrine and/or norepinephrine with high affinity and trigger intracellular changes. The two major classes of adrenergic receptors, alpha and beta, were originally discriminated based on their cellular actions but now are distinguished by their relative affinity for characteristic synthetic ligands. Adrenergic receptors may also be classified according to the subtypes of G-proteins with which they bind; this scheme does not respect the alpha-beta distinction.; UMLS Semantic Type: STY:T192; UMLS Semantic Type: STY:T116", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:Polypeptide", "biolink:ProteinFamily", "biolink:GeneFamily"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Adrenergic Receptor", "Adrenergic receptor"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["UMLS:C0034783", "NCIT:C105824", "CHEMBL.TARGET:CHEMBL2331074"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}]}, "CHEBI:35530": {"name": "beta-adrenergic antagonist", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "http://purl.obolibrary.org/obo/CHEBI_35530", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "http://purl.obolibrary.org/obo/CHEBI_35530", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Natural or synthetic beta adrenergic antagonists selectively or non-selectively blocking or diminishing physiologic beta-adrenergic agonist actions on the sympathetic system. This group of antagonists are generally used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.; Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.; UMLS Semantic Type: STY:T121", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Beta-Adrenergic Antagonist", "beta-adrenergic antagonist", "Adrenergic beta-Antagonists"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["MESH:D000319", "UMLS:C0001645", "CHEBI:35530", "NCIT:C29576"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}]}, "CHEMBL.TARGET:CHEMBL376": {"name": "Rattus norvegicus", "categories": ["biolink:OrganismTaxon"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.target:CHEMBL376", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.target:CHEMBL376", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "The common rat, Rattus norvegicus, often used as an experimental organism.; The common name for the genus Rattus.; UMLS Semantic Type: STY:T015", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:OrganismTaxon"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Rattus norvegicus"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["UMLS:C0034693", "NCIT:C14266", "CHEMBL.TARGET:CHEMBL376", "NCBITaxon:10116"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL408403": {"name": "ANGIOTENSIN II", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL408403", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL408403", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Angiotensin II is a hormone that may act on the central nervous system to regulate renal sympathetic nerve activity, renal function, and, therefore, blood pressure. Angiotensin II is produced locally within the kidney and mediates tissue injury through a series of nonhemodynamic effects. angiotensin II is not only involved in the regulation of blood pressure, water and sodium homeostasis, and control of other neurohumoral systems, but also leads to excessive production of reactive oxygen species and to hypertrophy, proliferation, migration, and apoptosis of vascular cells. Angiotensin II is one of the main factors involved in hypertension-induced tissue damage. This peptide regulates the inflammatory process. Angiotensin II activates circulating cells, and participates in their adhesion to the activated endothelium and subsequent transmigration through the synthesis of adhesion molecules, chemokines and cytokines. Among the intracellular signals involved in angiotensin II-induced inflammation, the production of reactive oxygen species and the activation of nuclear factor-kappaB are the best known. Classical, well-defined actions of Angiotensin II in the brain include the regulation of hormone formation and release, the control of the central and peripheral sympathoadrenal systems, and the regulation of water and sodium intake. As a consequence of changes in the hormone, sympathetic and electrolyte systems, feedback mechanisms in turn modulate the activity of the brain Angiotensin II systems. There are two Angiotensin II systems in the brain. The discovery of brain Angiotensin II receptors located in neurons inside the blood brain barrier confirmed the existence of an endogenous brain Angiotensin II system, responding to Angiotensin II generated in and/or transported into the brain. In addition, Angiotensin II receptors in circumventricular organs and in cerebrovascular endothelial cells respond to circulating Angiotensin II of peripheral origin. Thus, the brain responds to both circulating and tissue Angiotensin II, and the two systems are integrated. (PMID: 17147923, 16672146, 16601568, 16481883, 16075377).", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:NamedThing", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:ChemicalEntity", "biolink:Drug", "biolink:Protein"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Angiotensin II", "Giapreza", "angiotensin II", "(3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[[(1S)-1-carboxy-2-phenylethyl]amino]-oxomethyl]-1-pyrrolidinyl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid", "Angiotensin II Acetate", "ANGIOTENSIN II ACETATE", "Angiotensin II (USAN)", "Angiotensin II (INN)", "Ile(5)-angiotensin II", "Ile(5)-angiotensin II dizwitterion", "ANGIOTENSIN II", "Angiotensin ii"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["CHEMBL.COMPOUND:CHEMBL3989932", "LOINC:LP15389-7", "CHEBI:58506", "CHEMBL.COMPOUND:CHEMBL408403", "UMLS:C4684910", "KEGG.DRUG:D00150", "KEGG.DRUG:D02014", "VANDF:4037288", "RXNORM:1999003", "ttd.target:ANGIOTENSIN_II", "CHEBI:2719", "MESH:D000804", "UMLS:C0003009", "KEGG.COMPOUND:C02135", "DRUGBANK:DB11842", "ATC:C01CX09", "HMDB:HMDB0001035", "NCIT:C142924", "LOINC:MTHU005163", "PathWhiz.Compound:816", "CHEBI:48432", "UMLS:C4551140", "PR:000036009", "DrugCentral:5272", "RXNORM:1999008", "MESH:C000627694", "CHEBI:131170"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:16220978", "PMID:18793332", "PMID:10579816", "PMID:8515427", "PMID:11960488", "PMID:15115399", "PMID:16680159", "PMID:16075377", "PMID:26824643", "PMID:25313325"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL2146121": {"name": "CALCIUM", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL2146121", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL2146121", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Calcium is essential for the normal growth and maintenance of bones and teeth, and calcium requirements must be met throughout life. Requirements are greatest during periods of growth, such as childhood, during pregnancy and when breast-feeding. Long-term calcium deficiency can lead to osteoporosis, in which the bone deteriorates and there is an increased risk of fractures. Adults need between 1,000 and 1,300 mg of calcium in their daily diet. Calcium is essential for living organisms, particularly in cell physiology, and is the most common metal in many animals. Physiologically, it exists as an ion in the body. Calcium combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Calcium is an important component of a healthy diet. A deficit can affect bone and tooth formation, while overretention can cause kidney stones. Vitamin D is needed to absorb calcium. Dairy products, such as milk and cheese, are a well-known source of calcium. However, some individuals are allergic to dairy products and even more people, particularly those of non-European descent, are lactose-intolerant, leaving them unable to consume dairy products. Fortunately, many other good sources of calcium exist. These include: seaweeds such as kelp, wakame and hijiki; nuts and seeds (like almonds and sesame); beans; amaranth; collard greens; okra; rutabaga; broccoli; kale; and fortified products such as orange juice and soy milk. Calcium has also been found to assist in the production of lymphatic fluids. Furthermore, calcium is found to be associated with primary hypomagnesemia, which is an inborn error of metabolism.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:MolecularEntity", "biolink:Drug", "biolink:SmallMolecule", "biolink:BiologicalEntity"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Ca2+ [platelet dense tubular network lumen]", "Ca2+ [endoplasmic reticulum lumen]", "Ca2+ [Golgi lumen]", "CALCIUM", "Ca2+ [nucleoplasm]", "Ca2+ [nuclear envelope]", "Calcium, Dietary", "calcium(0)", "Ca2+ [mitochondrial matrix]", "Ca2+ [extracellular region]", "Ca2+ [lysosomal lumen]", "Ca2+ [secretory granule lumen]", "calcium atom", "PC(DiMe(11,3)/DiMe(13,5))", "Ca2+ [mitochondrial inner membrane]", "Ca2+ [mitochondrial intermembrane space]", "calcium(2+)", "Ca2+ [platelet dense tubular network membrane]", "Ca2+ [endosome membrane]", "Ca2+ [platelet dense granule lumen]", "Calcium cation", "Ca2+ [endoplasmic reticulum membrane]", "Ca2+ [plasma membrane]", "Ca2+ [endocytic vesicle lumen]", "Calcium", "Ca2+ [sarcoplasmic reticulum lumen]", "Ca2+ [cytosol]", "calcium"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["REACT:R-ALL-5210949", "REACT:R-ALL-1500625", "REACT:R-ALL-114582", "ATC:A12AA", "NDDF:000771", "VANDF:4017652", "REACT:R-ALL-141090", "UMLS:C0006675", "PSY:07240", "REACT:R-ALL-1606834", "CHEMBL.COMPOUND:CHEMBL2146121", "REACT:R-ALL-8949220", "HMDB:HMDB0000464", "REACT:R-ALL-111875", "CHEBI:29320", "HMDB:HMDB0061392", "LOINC:LP15257-6", "CHEBI:22984", "REACT:R-ALL-29496", "REACT:R-ALL-74016", "REACT:R-ALL-216801", "MESH:D002118", "LOINC:LP70404-6", "NCIT:C331", "UMLS:C0006726", "LOINC:MTHU001930", "REACT:R-ALL-8851519", "CHEMBL.TARGET:CHEMBL2364030", "PathWhiz.Compound:353", "RXNORM:1895", "LOINC:LP32547-9", "CHEBI:29108", "KEGG.COMPOUND:C00076", "MESH:D002136", "REACT:R-ALL-2318767", "VANDF:4021884", "REACT:R-ALL-2855229", "REACT:R-ALL-1524102", "REACT:R-ALL-74112", "REACT:R-ALL-167012", "REACT:R-ALL-139827", "DRUGBANK:DB01373", "REACT:R-ALL-140648", "DRUGBANK:DB14577", "REACT:R-ALL-8949232"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:26306852", "PMID:16296395", "PMID:11683549", "PMID:11413487", "PMID:15860827", "PMID:22194678", "PMID:16718844", "PMID:17374880", "PMID:21475195", "PMID:15885294"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "MESH:D004364": {"name": "Pharmaceutical Preparations", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "http://id.nlm.nih.gov/mesh/D004364", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "http://id.nlm.nih.gov/mesh/D004364", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Conceptually broad term referring to any substance other than food administered for experimental or treatment purposes. Use specific drug classes or names if possible.; A drug product that contains one or more active and/or inactive ingredients; it is intended to treat, prevent or alleviate the symptoms of disease. This term does not refer to the individual ingredients that make up the product.; Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.; UMLS Semantic Type: STY:T121", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Pharmaceutical Preparations"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["UMLS:C0013227", "MESH:D004364"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}]}, "CHEMBL.TARGET:CHEMBL373": {"name": "Canis familiaris", "categories": ["biolink:OrganismTaxon"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.target:CHEMBL373", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.target:CHEMBL373", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "The domestic dog, Canis familiaris.; The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065); UMLS Semantic Type: STY:T015", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:OrganismTaxon"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Canis familiaris"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["CHEMBL.TARGET:CHEMBL373", "UMLS:C0012984"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}]}, "RXNORM:3264": {"name": "Dexamethasone", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "http://purl.bioontology.org/ontology/RXNORM/3264", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "http://purl.bioontology.org/ontology/RXNORM/3264", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "A synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C422\" active clinical trials using this agent. (\"http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C422\" NCI Thesaurus); UMLS Semantic Type: STY:T121; UMLS Semantic Type: STY:T109", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Dexamethasone", "dexamethasone"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["ATC:S01BA01", "LOINC:LP32530-5", "LOINC:MTHU004621", "ATC:D07AB19", "ATC:D07XB05", "LOINC:LP18549-3", "ATC:S01CB01", "RXNORM:3264", "ATC:S03BA01", "ATC:S02BA06", "PSY:13905", "ATC:D10AA03", "NCIT:C422", "ATC:A01AC02", "ATC:H02AB02", "VANDF:4017922", "PDQ:CDR0000039789", "ATC:R01AD03", "ATC:C05AA09"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL632": {"name": "BETAMETHASONE", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL632", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL632", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "A synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory activities. Betamethasone binds to specific intracellular glucocorticoid receptors and subsequently binds to DNA to modify gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited. As a result, there is an overall reduction in chronic inflammation and autoimmune reactions. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C303\" active clinical trials using this agent. (\"http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C303\" NCI Thesaurus); A synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory activities. Betamethasone binds to specific intracellular glucocorticoid receptors and subsequently binds to DNA to modify gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited. As a result, there is an overall reduction in chronic inflammation and autoimmune reactions.; A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724)", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Betamethasone benzoate (USP)", "betamethasone", "Betamethasone dipropionate (JP18/USP)", "Bentelan", "Celestone phosphate", "Betamethasone 17-benzoate", "betamethasone phosphate", "betamethasone acetate", "BETAMETHASONE", "BETAMETHASONE SODIUM PHOSPHATE", "BETAMETHASONE BENZOATE", "betamethasone 17-benzoate", "Betamethasone Valerate", "Betamethasone Acibutate", "Celestone", "Betamethasone sodium phosphate", "Betamethasone sodium phosphate (JP18/USP)", "Betamethasone Acetate", "BETAMETHASONE DIPROPIONATE", "BETAMETHASONE BUTYRATE PROPIONATE", "betamethasone-17,21-dipropionate", "betamethasone dipropionate", "Betamethasone Butyrate Propionate", "BETAMETHASONE VALERATE", "Betamethasone Benzoate", "BETAMETHASONE PHOSPHORIC ACID", "Betamethasone", "9-fluoro-11,17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one", "BETAMETHASONE ACETATE", "Betamethasone Sodium Phosphate", "Betnovate", "SID24820037", "BETAMETHASONE ACIBUTATE", "Betamethasone butyrate propionate (JAN)", "Betamethasone valerate", "Celeston", "Betamethasone phosphate", "betamethasone benzoate", "Betamethasone (JP18/USP/INN)", "maxacalcitol and betamethasone butyrate propionate", "Celestona", "Betamethasone acetate (JAN/USP)", "Betamethasone dipropionate", "Betamethasone Dipropionate", "Maxacalcitol and betamethasone butyrate propionate", "Betamethasone benzoate", "SID50105953", "betamethasone valerate", "betamethasone butyrate propionate", "betamethasone sodium phosphate", "Betamethasone acetate", "Antebate", "Cellestoderm", "Betamethasone valerate (JP18/USP)", "betamethasone disodium phosphate, (11beta)-isomer", "Betamethasone Dihydrogen Phosphate", "SID90341476", "betamethasone acibutate"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["UMLS:C0701247", "ATC:S02BA07", "NCIT:C65256", "CHEBI:31276", "HMDB:HMDB0249163", "VANDF:4018643", "MESH:C015706", "DrugCentral:349", "DrugCentral:354", "UMLS:C0750848", "ATC:R03BA04", "CHEBI:93851", "UMLS:C0701246", "UMLS:C0701244", "ATC:D07XC01", "NCIT:C47964", "CHEBI:135815", "MESH:C580789", "KEGG.DRUG:D01402", "KEGG.DRUG:D00972", 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"RXNORM:19254", "RXNORM:203220", "MESH:C028994", "UMLS:C3852611", "DrugCentral:353", "HMDB:HMDB0249158", "UMLS:C4549055", "CHEMBL.COMPOUND:CHEMBL1610678", "ATC:D07AC01", "UMLS:C3849371", "CHEBI:50894", "UMLS:C1110622", "CHEMBL.COMPOUND:CHEMBL1393513", "CHEBI:68603", "CHEBI:31275", "VANDF:4018641", "DrugCentral:4667", "CHEBI:135798", "MESH:D001623", "MESH:C587113", "DRUGBANK:DB00443", "CHEMBL.COMPOUND:CHEMBL632", "CHEMBL.COMPOUND:CHEMBL1200538", "UMLS:C0005313", "CHEBI:3077", "VANDF:4018645", "CHEBI:3078", "KEGG.DRUG:D02286", "KEGG.COMPOUND:C06848", "LOINC:LP35866-0", "DRUGBANK:DB14669", "RXNORM:1517", "KEGG.DRUG:D01357", "MESH:C011175", "NCIT:C78755", "UMLS:C0701245", "CHEMBL.COMPOUND:CHEMBL1697784", "DrugCentral:350", "UMLS:C0005310", "LOINC:MTHU017343", "CHEMBL.COMPOUND:CHEMBL1201207", "UMLS:C1135728"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:23213332", "PMID:25111439", "PMID:21247763", "PMID:15646539", "PMID:1875343", "PMID:14661924", "PMID:29571573", "PMID:31808984", "PMID:31643719", "PMID:20185316"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL40": {"name": "PHENOBARBITAL", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL40", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL40", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "A long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain. The activation effects of the phenobarbital-receptor-ionophore complex include increased frequency of chloride channel openings, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability. In addition, this agent inhibits glutamate induced depolarization. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C739\" active clinical trials using this agent. (\"http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C739\" NCI Thesaurus); A long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain. The activation effects of the phenobarbital-receptor-ionophore complex include increased frequency of chloride channel openings, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability. In addition, this agent inhibits glutamate induced depolarization.; A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.; UMLS Semantic Type: STY:T121; UMLS Semantic Type: STY:T109", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["phenobarbital", "PHENOBARBITAL", "Gardenal", "PHENobarbital", "Phenobarbital sodium", "Phenobarbital sodium (JAN/USP/INN)", "Phenobarbital", "phenobarbital sodium", "Phenobarbital (JP18/USP/INN)", "Phenobarbital Sodium", "PHENOBARBITAL SODIUM"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["VANDF:4017422", "CHEBI:8070", "RXNORM:82077", "LOINC:MTHU060452", "UMLS:C0699491", "UMLS:C0031412", "CHEMBL.COMPOUND:CHEMBL40", "HMDB:HMDB0015305", "CHEBI:8069", "MESH:D010634", "PDQ:CDR0000042405", "CHEMBL.COMPOUND:CHEMBL149972", "KEGG.DRUG:D00701", "VANDF:4017423", "LOINC:LP14729-5", "ATC:N03AA02", "NCIT:C76956", "RXNORM:8134", "DRUGBANK:DB01174", "UMLS:C0282303", "PSY:38160", "KEGG.COMPOUND:C07434", "DrugCentral:2134", "NCIT:C739", "NDDF:001407", "KEGG.DRUG:D00506", "LOINC:LA28622-1"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:8632764", "PMID:15324906", "PMID:14570762", "PMID:8691481", "PMID:21861463", "PMID:3016269", "PMID:1992141", "PMID:21862182", "PMID:8035421", "PMID:8627613"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL103": {"name": "PROGESTERONE", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL103", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL103", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "The major progestational steroid that is secreted primarily by the corpus luteum and the placenta. Progesterone acts on the uterus, the mammary glands and the brain. It is required in embryo implantation, pregnancy maintenance, and the development of mammary tissue for milk production. Progesterone, converted from pregnenolone, also serves as an intermediate in the biosynthesis of gonadal steroid hormones and adrenal corticosteroids. Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy (supports gestation) and embryogenesis of humans and other species. Progesterone belongs to a class of hormones called progestagens, and is the major naturally occurring human progestagen. During implantation and gestation, progesterone appears to decrease the maternal immune response to allow for the acceptance of the pregnancy. Progesterone decreases contractility of the uterine smooth muscle. The fetus metabolizes placental progesterone in the production of adrenal mineralo- and glucosteroids. A drop in progesterone levels is possibly one step that facilitates the onset of labor. In addition progesterone inhibits lactation during pregnancy. The fall in progesterone levels following delivery is one of the triggers for milk production. Progesterone is found to be associated with pregnene hydroxylation deficiency, which is an inborn error of metabolism.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug", "biolink:BiologicalEntity"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["P4 [cytosol]", "PROGESTERONE", "P4 [nucleoplasm]", "Progesterone, (9 beta,10 alpha)-Isomer", "Agolutin", "P4 [extracellular region]", "Progesterone (JP18/USP/INN)", "Progesterone", "Luteohormone", "Akrolutin", "dacuronium", "progesterone"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["LOINC:MTHU003615", "MESH:D011374", "ATC:G03DA04", "CHEMBL.COMPOUND:CHEMBL103", "UMLS:C4256087", "REACT:R-ALL-193055", "KEGG.DRUG:D00066", "NCIT:C2297", "PathWhiz.Compound:1216", "CHEBI:17026", "RXNORM:8727", "UMLS:C0886987", "UMLS:C0033308", "UMLS:C4256086", "DRUGBANK:DB00396", "NDDF:001290", "REACT:R-ALL-5618083", "UMLS:C1515388", "REACT:R-ALL-1449667", "LOINC:LP14041-5", "VANDF:4017453", "MESH:C003549", "KEGG.COMPOUND:C00410", "HMDB:HMDB0001830", "DrugCentral:2279", "PSY:40820"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:8709117", "PMID:11859003", "PMID:27484514", "PMID:24601604", "PMID:25454267", "PMID:11785684", "PMID:3040999", "PMID:21944856", "PMID:25282654", "PMID:29407958"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL1201583": {"name": "BEVACIZUMAB", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL1201583", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL1201583", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "A recombinant humanized monoclonal antibody directed against the vascular endothelial growth factor (VEGF), a pro-angiogenic cytokine. Bevacizumab binds to VEGF and inhibits VEGF receptor binding, thereby preventing the growth and maintenance of tumor blood vessels. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2039\" active clinical trials using this agent. (\"http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2039\" NCI Thesaurus); A recombinant humanized monoclonal antibody directed against the vascular endothelial growth factor (VEGF), a pro-angiogenic cytokine. Bevacizumab binds to VEGF and inhibits VEGF receptor binding, thereby preventing the growth and maintenance of tumor blood vessels.; An anti-VEGF humanized murine monoclonal antibody. It inhibits VEGF RECEPTORS and helps to prevent PATHOLOGIC ANGIOGENESIS.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:NamedThing", "biolink:Polypeptide", "biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:Drug", "biolink:MolecularEntity"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Bevacizumab Biosimilar LY01008", "BEVACIZUMAB", "Bevacizumab Biosimilar HLX04", "Bevacizumab (USAN)", "Bevacizumab Biosimilar BI 695502", "Bevacizumab Biosimilar CBT 124", "Avastin", "Bevacizumab Biosimilar FKB238", "Bevacizumab Biosimilar IBI305", "Bevacizumab", "Bevacizumab Biosimilar QL 1101", "bevacizumab", "Mvasi", "Bevacizumab Biosimilar BEVZ92", "Bevacizumab Biosimilar HD204", "Bevacizumab Biosimilar SCT501", "Bevacizumab Biosimilar MIL60"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["CHEMBL.COMPOUND:CHEMBL1201583", "UMLS:C4732963", "UMLS:C4331844", "RXNORM:253337", "RXNORM:337521", "KEGG.DRUG:D06409", "RXNORM:2046141", "PDQ:CDR0000043234", "UMLS:C1135130", "ATC:L01XC07", "UMLS:C4727810", "UMLS:C4764379", "MESH:D000068258", "NCIT:C2039", "VANDF:4021437", "UMLS:C4764381", "PathWhiz.ProteinComplex:726", "DrugCentral:4956", "NDDF:008586", "UMLS:C0796392", "DRUGBANK:DB00112", "UMLS:C4721851", "UMLS:C4764380", "UMLS:C4694346", "UMLS:C4727811", "UMLS:C3900212", "UMLS:C4331843", "UMLS:C4727812"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:28660302", "PMID:20688807", "PMID:29362402", "PMID:15338755", "PMID:23208836", "PMID:28056756", "PMID:23419196", "PMID:30030240", "PMID:17409907", "PMID:28801849"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "UniProtKB:P00533": {"name": "EGFR", "categories": ["biolink:Gene", "biolink:Protein"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/uniprot:P00533", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/uniprot:P00533", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "L858R, a substitution of leucine 858 with arginine, accounts for ~40% of EGFR mutations in the non-small-cell lung cancer. L858R, encoded by exon 21, localizes to the N-terminal portion of the activation loop (A loop) of the kinase domain of EGFR. By locking the EGFR in its active conformation, L858R mutation results in constitutive catalytic activity of EGFR which is ~50-fold higher than the activity of the wild-type enzyme (Yun et al. 2007). The L858R EGFR mutant is inhibited by binding of small EGFR-specific tyrosine kinase inhibitors from the 4-anilinoquinazoline group, erlotinib and gefitinib, as well as the pyrrolopyrimidine compound AEE788. Gefitinib is ~100-fold more potent against the L858R mutant than against the wild-type EGFR kinase (Yun et al. 2007). 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["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL3544996", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL3544996", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "UMLS Semantic Type: STY:T121; UMLS Semantic Type: STY:T129; UMLS Semantic Type: STY:T116; Idarucizumab is a humanized monoclonal antibody fragment (Fab) derived from an immunoglobulin G1 isotype molecule that binds to and inactivates the oral anticoagulant dabigatran, thereby reversing its anticoagulant effect. As a direct acting oral anticoagulant (DOAC), one of the risks associated with the use of dabigatran includes bleeding, espeically when given to patients at increased risk (elderly, chronic kidney disease, concomitant NSAID or warfarin use, etc).     Approved under the tradename Praxbind (FDA), idarucizumab is indicated for the emergency treatment of dabigatran-associated bleeding in life-threatening or surgically induced situations. Its use is associated with immediate, complete and sustained reversal of the anticoagulant effects of dabigatran.    Idarucizumab protein structure can be viewed below, with disulfide bridges at the following points: H22-H95, H149-H205, H225-L-219, L23-L93, L139-L199.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:NamedThing", "biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Praxbind", "Bi-655075", "idarucizumab", "IDARUCIZUMAB", "Idarucizumab (USAN/INN)", "Idarucizumab"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["MESH:C000594745", "VANDF:4034988", "UMLS:C4056952", "NCIT:C128646", "CHEMBL.COMPOUND:CHEMBL3544996", "KEGG.DRUG:D10741", "UMLS:C3885063", "DRUGBANK:DB09264", "RXNORM:1716196", "NDDF:016531", "DrugCentral:5055", "ATC:V03AB37", "RXNORM:1716191", "UMLS:C5226758"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:27388764", "PMID:27389324"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "DRUGBANK:DB11529": {"name": "Melengestrol", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/drugbank:DB11529", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/drugbank:DB11529", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "A progestogen-like compound used as a cattle feed additive for its growth promoting effects and suppression of estrus (heat) in heifers. Critics have claimed that hormones used as growth promotants in cattle may cause breast cancer. (NCI); A 6-methyl PROGESTERONE acetate with reported glucocorticoid activity and effect on ESTRUS.; UMLS Semantic Type: STY:T121; UMLS Semantic Type: STY:T125; UMLS Semantic Type: STY:T109", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:Drug", "biolink:SmallMolecule"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Melengestrol", "melengestrol"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["UMLS:C0376337", "NCIT:C1659", "DRUGBANK:DB11529", "HMDB:HMDB0254422", "RXNORM:1537799"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:5169599", "PMID:327640", "PMID:949121", "PMID:4495779", "PMID:1270378", "PMID:14192473", "PMID:5465999", "PMID:31557052", "PMID:1100303", "PMID:4781045"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL1350": {"name": "TILUDRONIC ACID", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL1350", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL1350", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Tiludronate is only found in individuals that have used or taken this drug. It is a bisphosphonate characterized by a (4-chlorophenylthio) group on the carbon atom of the basic P-C-P structure common to all bisphosphonates.The bisphosphonate group binds strongly to the bone mineral, hydroxyapatite. This explains the specific pharmacological action of these compounds on mineralized tissues, especially bone. <i>In vitro</i> studies indicate that tiludronate acts primarily on bone through a mechanism that involves inhibition of osteoclastic activity with a probable reduction in the enzymatic and transport processes that lead to resorption of the mineralized matrix. Bone resorption occurs following recruitment, activation, and polarization of osteoclasts. Tiludronate appears to inhibit osteoclasts by at least two mechanisms: disruption of the cytoskeletal ring structure, possibly by inhibition of protein-tyrosine-phosphatase, thus leading to detachment of osteoclasts from the bone surface and the inhibition of the osteoclastic proton pump.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["TILUDRONIC ACID", "tiludronic acid", "Tiludronic acid (INN)", "Tiludronate disodium (USAN)", "Tiludronic Acid", "tiludronate disodium", "Tiludronate disodium", "Tiludronic acid", "tiludronate", "Tiludronate", "TILUDRONATE DISODIUM", "Tiludronate Disodium"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["UMLS:C0286030", "NCIT:C61973", "RXNORM:57230", "UMLS:C0043611", "CHEMBL.COMPOUND:CHEMBL1350", "DRUGBANK:DB01133", "MESH:C058651", "KEGG.COMPOUND:C08141", "NCIT:C72091", "HMDB:HMDB0015265", "VANDF:4024072", "CHEBI:9598", "RXNORM:11476", "KEGG.DRUG:D02285", "DrugCentral:2666", "KEGG.DRUG:D08599", "NDDF:006071", "VANDF:4021043", "ATC:M05BA05", "CHEMBL.COMPOUND:CHEMBL1200448", "UMLS:C0145942", "RXNORM:83153"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:14529538", "PMID:26948801", "PMID:8554921", "PMID:22194678", "PMID:8573422", "PMID:24071448", "PMID:15646539", "PMID:15920768", "PMID:15743175", "PMID:16019946"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL126": {"name": "LINEZOLID", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL126", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL126", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Linezolid is only found in individuals that have used or taken this drug. It is a synthetic antibiotic, the first of the oxazolidinone class, used for the treatment of infections caused by multi-resistant bacteria including streptococcus and methicillin-resistant Staphylococcus aureus (MRSA). Linezolid is a synthetic antibacterial agent of the oxazolidinone class of antibiotics. It has in vitro activity against aerobic Gram positive bacteria, certain Gram negative bacteria and anaerobic microorganisms. It selectively inhibits bacterial protein synthesis through binding to sites on the bacterial ribosome and prevents the formation of a functional 70S-initiation complex. Specifically, linezolid binds to a site on the bacterial 23S ribosomal RNA of the 50S subunit and prevents the formation of a functional 70S initiation complex, which is an essential component of the bacterial translation process. The results of time-kill studies have shown linezolid to be bacteriostatic against enterococci and staphylococci. For streptococci, linezolid was found to be bactericidal for the majority of strains. Linezolid is also a reversible, nonselective inhibitor of monoamine oxidase. Therefore, linezolid has the potential for interaction with adrenergic and serotonergic agents.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["LINEZOLID", "SID29216113", "Linezolid (JAN/USAN/INN)", "N-[[(5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide", "U 100766", "Linezolid", "linezolid", "Zyvox"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["CHEMBL.COMPOUND:CHEMBL191283", "KEGG.COMPOUND:C08146", "PDQ:CDR0000735710", "CHEBI:63607", "UMLS:C0876226", "MESH:D000069349", "RXNORM:190376", "DrugCentral:1584", "ATC:J01XX08", "HMDB:HMDB0014739", "VANDF:4021218", "UMLS:C0386550", "RXNORM:261710", "CHEBI:181548", "LOINC:MTHU013614", "NCIT:C29158", "DRUGBANK:DB00601", "CHEMBL.COMPOUND:CHEMBL126", "KEGG.DRUG:D00947", "UMLS:C0663241", "LOINC:LP21256-0"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:26536532", "PMID:29957525", "PMID:19289527", "PMID:27612961", "PMID:19470504", "PMID:19047652", "PMID:19819597", "PMID:22779424", "PMID:19736016", "PMID:19581465"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL1075790": {"name": "PERUVOSIDE", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL1075790", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL1075790", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "PERUVOSIDE; 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Cicletanine exerts thiazide-like diuretic activity. In addition, this agent inhibits protein kinase C (PKC) and is able to reverse vasoconstriction through the inhibition of PKC-mediated inhibition of Na/K-ATPase phosphorylation.; UMLS Semantic Type: STY:T121; UMLS Semantic Type: STY:T109", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Cicletanine", "cicletanine", "Cicletanine (USAN/INN)", "Justar", "CICLETANINE"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["NDDF:004193", "NCIT:C77557", "CHEBI:135078", "MESH:C038068", "RXNORM:21914", "CHEMBL.COMPOUND:CHEMBL191886", "DrugCentral:634", "DRUGBANK:DB12766", "UMLS:C0056686", "UMLS:C1530417", "HMDB:HMDB0250233", "KEGG.DRUG:D03487", "ATC:C03BX03"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:15857133", "PMID:31557052"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL160": {"name": "CYCLOSPORINE", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL160", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL160", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "A natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C406\" active clinical trials using this agent. (\"http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C406\" NCI Thesaurus); A natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release. (NCI04); A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:NamedThing", "biolink:SmallMolecule", "biolink:Drug", "biolink:ChemicalEntity"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["CYCLOSPORINE", "cyclosporine", "27-400", "Ol 27-400", "ciclosporin", "Cyclosporine (USP)", "Sangcya", "cyclosporin A", "Cyclosporin A", "Neoral", "cycloSPORINE", "Cyclosporine", "SID26747463", "Sandimmune"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["RXNORM:202817", "NCIT:C406", "UMLS:C1522536", "DRUGBANK:DB00091", "CHEMBL.COMPOUND:CHEMBL160", "PathWhiz.Compound:97909", "UMLS:C0010592", "DrugCentral:760", "CHEMBL.COMPOUND:CHEMBL386389", "KEGG.COMPOUND:C05086", "HMDB:HMDB0250682", "RXNORM:202816", "UMLS:C0878526", "MESH:D016572", "NDDF:003420", "UMLS:C0699605", "LOINC:LA16776-9", "LOINC:MTHU062952", "PDQ:CDR0000039201", "KEGG.DRUG:D00184", "CHEBI:4031", "VANDF:4018761", "UMLS:C0723210", "RXNORM:3008", "LOINC:LP16098-3", "UMLS:C0699604"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:14604686", "PMID:19451286", "PMID:17418581", "PMID:7537331", "PMID:15916418", "PMID:11785684", "PMID:24992153", "PMID:26564266", "PMID:15546730", "PMID:9732409"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "UniProtKB:P07911": {"name": "UMOD", "categories": ["biolink:Gene", "biolink:Protein"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/uniprot:P07911", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/uniprot:P07911", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "A uromodulin that is encoded in the genome of human. // COMMENTS: Category=organism-gene.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:BiologicalEntity", "biolink:Gene", "biolink:Protein"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Umod (mouse)", "UMOD [Golgi lumen]", "uromodulin (rat)", "UMOD (human)", "UMOD gene", "UMOD", "Umod (rat)", "uromodulin (human)", "uromodulin (mouse)", "Sda-UMOD [Golgi lumen]"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["RGD:3940", "LOINC:LP101431-7", "REACT:R-HSA-8855962", "ENSEMBL:ENSG00000169344", "PR:Q91X17", "UniProtKB:P07911", "UMLS:C1421351", "REACT:R-HSA-8855988", "NCBIGene:7369", "MGI:102674", "PR:P07911", "OMIM:191845", "HGNC:12559", "PR:P27590"], "value_type_id": "metatype:Nodeidentifier", 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{"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Phospholipid-transporting ATPase IB (1148 aa, ~129 kDa) is encoded by the human ATP8A2 gene. 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UMLS Semantic Type: STY:T109; Esmirtazapine, known by the standardized identifier SCH 900265, was under development by Organon to treat insomnia and vasomotor symptoms associated with menopause. Esmirtazapine is the (S)-(+)-enantiomer of mirtazapine and possesses similar overall pharmacology. This includes inverse agonist activity of H1 and 5-HT2 receptors and antagonism of \u03b12-adrenergic receptors. 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Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.; UMLS Semantic Type: STY:T121", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Adrenergic Antagonists"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["UMLS:C0242889", "MESH:D018674"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}]}, "FMA:67245": {"name": "Serotonin", "categories": ["biolink:BiologicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "http://purl.obolibrary.org/obo/FMA_67245", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "http://purl.obolibrary.org/obo/FMA_67245", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Serotonin or 5-hydroxytryptamine (5-HT) is a molecule that belongs to the class of compounds known as indoleamines. An indoleamine consists of an indole ring that bears an amino group or an alkyl amino group attached to the indole ring. Serotonin has an aminoethyl at position 2 and a hydroxyl group at position 5 of the indole ring. Serotonin exists in all living organisms, ranging from bacteria to plants to humans. In mammals, serotonin functions as a monoamine neurotransmitter, a biochemical messenger and regulator. It is synthesized from the essential amino acid L-Tryptophan. Approximately 90% of the human body's total serotonin is located in the enterochromaffin cells in the GI tract, where it regulates intestinal movements. About 8% is found in platelets and 1\u201a\u00c4\u00ec2% in the CNS. Serotonin in the nervous system acts as a local transmitter at synapses, and as a paracrine or hormonal modulator of circuits upon diffusion, allowing a wide variety of \"state-dependent\" behavioral responses to different stimuli. Serotonin is widely distributed in the nervous system of vertebrates and invertebrates and some of its behavioral effects have been preserved along evolution. Such is the case of aggressive behavior and rhythmic motor patterns, including those responsible for feeding.  In vertebrates, which display a wider and much more sophisticated behavioral repertoire, serotonin also modulates sleep, the arousal state, sexual behavior, and others. Deficiencies of the serotonergic system causes disorders such as depression, obsessive-compulsive disorder, phobias, posttraumatic stress disorder, epilepsy, and generalized anxiety disorder. Serotonin has three different modes of action in the nervous system: as transmitter, acting locally at synaptic boutons; upon diffusion at a distance from its release sites, producing paracrine (also called volume) effects, and by circulating in the blood stream, producing hormonal effects. The three modes can affect a single neuronal circuit. (PMID: 16047543). Serotonin is also a microbial metabolite that can be found in the feces and urine of mammals. Urinary serotonin is produced by Candida, Streptococcus, Escherichia, and Enterococcus (PMID: 24621061). In plants, serotonin was first found and reported in a legume called Mucuna pruriens. The greatest concentration of serotonin in plants has been found in walnuts and hickory. In pineapples, banana, kiwi fruit, plums and tomatoes the concentration of serotonin is around 3 to 30 mg/kg.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:BiologicalEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["5HT [cytosol]", "5HT [clathrin-sculpted monoamine transport vesicle lumen]", "5HT [platelet dense granule lumen]", "serotonin", "Serotonin", "SEROTONIN", "5HT [extracellular region]"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["REACT:R-ALL-209914", "LOINC:LP14693-3", "REACT:R-ALL-380585", "REACT:R-ALL-30717", "CHEMBL.COMPOUND:CHEMBL39", "UMLS:C0036751", "FMA:67245", "PathWhiz.Compound:178", "RXNORM:1311214", "NCIT:C828", "MESH:D012701", "DRUGBANK:DB08839", "CHEBI:28790", "LOINC:MTHU005043", "REACT:R-ALL-114523", "HMDB:HMDB0000259", "NDDF:003368", "PSY:46740", "KEGG.COMPOUND:C00780"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:16366421", "PMID:19223092", "PMID:671450", "PMID:10367709", "PMID:23294703", "PMID:8884658", "PMID:16580588", "PMID:11055342", "PMID:18294854", "PMID:10454528"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL3707204": {"name": "(2-BENZHYDRYLOXYETHYL)DIETHYL-METHYLAMMONIUM IODIDE", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL3707204", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL3707204", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "(2-BENZHYDRYLOXYETHYL)DIETHYL-METHYLAMMONIUM; FULL_MW:298.45; MAX_FDA_APPROVAL_PHASE: 0", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:MolecularEntity", "biolink:SmallMolecule"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["(2-BENZHYDRYLOXYETHYL)DIETHYL-METHYLAMMONIUM", "(2-benzhydryloxyethyl)diethyl-methylammonium iodide", "Emetonium iodide", "(2-BENZHYDRYLOXYETHYL)DIETHYL-METHYLAMMONIUM IODIDE"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["DrugCentral:4327", "ATC:A03AB16", "DRUGBANK:DB13769", "CHEMBL.COMPOUND:CHEMBL3707205", "CHEBI:135943", "CHEMBL.COMPOUND:CHEMBL3707204", "UMLS:C3652946"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL730": {"name": "NITROGLYCERIN", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL730", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL730", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "An organic nitrate with vasodilator activity. 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FULL_MW:247.09; MAX_FDA_APPROVAL_PHASE: 0", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:Drug", "biolink:MolecularEntity", "biolink:SmallMolecule"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["guanoxabenz", "Guanoxabenz", "guanoxabenz hydrochloride", "GUANOXABENZ", "guanoxabenz monohydrochloride", "Guanoxabenz (USAN/INN)"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["UMLS:C0891639", "CHEMBL.COMPOUND:CHEMBL461343", "DrugCentral:1345", "UMLS:C0891638", "KEGG.DRUG:D04398", "MESH:C028782", "UMLS:C0061990", "ATC:C02CC07", "NCIT:C77298", "CHEBI:135006", "DRUGBANK:DB13410"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:19053771"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL1200862": {"name": "METYROSINE", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL1200862", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL1200862", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Metyrosine is only found in individuals that have used or taken this drug. It is an inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma. (Martindale, The Extra Pharmacopoeia, 30th ed)Metyrosine inhibits tyrosine hydroxylase, which catalyzes the first transformation in catecholamine biosynthesis, i.e., the conversion of tyrosine to dihydroxyphenylalanine (DOPA). Because the first step is also the rate-limiting step, blockade of tyrosine hydroxylase activity results in decreased endogenous levels of catecholamines and their synthesis. This consequently, depletes the levels of the catecholamines dopamine, adrenaline and noradrenaline in the body,usually measured as decreased urinary excretion of catecholamines and their metabolites. One main end result of the catecholamine depletion is a decrease in blood presure.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:NamedThing", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:ChemicalEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["RACEMETYROSINE", "Demser", "alpha-methyl-L-tyrosine", "L-588357-0", "alpha-Methyltyrosine", "metyrosine", "Metyrosine", "Racemetyrosine (USAN)", "METYROSINE", "Metyrosine (USP)", "Mk-781", "metirosine"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["CHEBI:6912", "UMLS:C0886584", "KEGG.COMPOUND:C07921", "KEGG.DRUG:D11606", "DRUGBANK:DB00765", "UMLS:C1524091", "MESH:D019805", "UMLS:C0591337", "PDQ:CDR0000039501", "KEGG.DRUG:D00762", "CHEMBL.COMPOUND:CHEMBL1330596", "NDDF:000666", "RXNORM:151594", "UMLS:C0051427", "UMLS:C1524090", "NCIT:C998", "DrugCentral:1792", "VANDF:4017952", "RXNORM:266604", "HMDB:HMDB0014903", "CHEMBL.COMPOUND:CHEMBL1200862"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:26948801", "PMID:21624500", "PMID:22931300", "PMID:23571415", "PMID:16472241", "PMID:17417631"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL1671": {"name": "PROPRANOLOL HYDROCHLORIDE", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL1671", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL1671", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Propranolol is a widely used non-cardioselective beta-adrenergic antagonist. Propranolol is used in the treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hypertensive emergencies, hyperthyroidism, migraine, pheochromocytoma, menopause, and anxiety. --PubChem; Propranolol is a highly lipophilic drug achieving high concentrations in the brain. The duration of action of a single oral dose is longer than the half-life indicates and may be up to 12 hours, if the single dose is high enough (e.g. 80 mg). Effective plasma concentrations are between 10-100 ng/mL. -- Wikipedia; It was the first successful beta blocker developed. Propranolol is commonly marketed by Wyeth under the trade name Inderal.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Dexpropranolol", "(R)-(+)-propranolol", "PROPRANOLOL HYDROCHLORIDE", "Anaprilin", "PROPRANOLOL", "propranolol", "R (+)-Propanolol", "Propranolol", "DEXPROPRANOLOL", "Propranolol hydrochloride (JP18/USP)", "propranolol hydrochloride", "Inderal", "Propranolol (INN)"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["DRUGBANK:DB00571", "DrugCentral:2303", "KEGG.DRUG:D00483", "UMLS:C0591636", "UMLS:C0700773", "UMLS:C0033497", "CHEMBL.COMPOUND:CHEMBL27", "DRUGBANK:DB03322", "ATC:C07AA05", "MESH:D011433", "KEGG.COMPOUND:C07407", "CHEBI:8499", "KEGG.COMPOUND:C11193", "CHEMBL.COMPOUND:CHEMBL275742", "HMDB:HMDB0001849", "RXNORM:151890", "UMLS:C0011792", "NCIT:C77944", "VANDF:4019916", "NCIT:C62073", "PSY:41100", "KEGG.DRUG:D08443", "RXNORM:8787", "LOINC:MTHU005037", "CHEBI:8736", "PathWhiz.Compound:1224", "CHEBI:8500", "CHEMBL.COMPOUND:CHEMBL1671", "LOINC:LP16266-6"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:3001305", "PMID:29459278", "PMID:16790553", "PMID:6146718", "PMID:29407977", "PMID:6115057", "PMID:18220330", "PMID:24332655", "PMID:24601604", "PMID:25149511"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL1091841": {"name": "NAFAMOSTAT MESYLATE", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL1091841", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL1091841", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "UMLS Semantic Type: STY:T121; UMLS Semantic Type: STY:T109; Nafamostat is a synthetic serine protease inhibitor that is commonly formulated with hydrochloric acid due to its basic properties. It has been used in trials studying the prevention of Liver Transplantation and Postreperfusion Syndrome. The use of nafamostat in Asian countries is approved as an anticoagulant therapy for patients undergoing continuous renal replacement therapy due to acute kidney injury.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Nafamostat mesylate (USAN)", "nafamostat", "nafamostat methanesulfonate", "Nafamostat (INN)", "Nafamostat", "NAFAMOSTAT", "Fut 175", "NAFAMOSTAT MESYLATE"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["DrugCentral:1867", "CHEBI:135466", "CHEMBL.COMPOUND:CHEMBL3989553", "UMLS:C0060891", "CHEMBL.COMPOUND:CHEMBL273264", "KEGG.DRUG:D01670", "KEGG.DRUG:D08240", "HMDB:HMDB0255419", "MESH:C032855", "NCIT:C96292", "CHEMBL.COMPOUND:CHEMBL1091841", "DRUGBANK:DB12598", "CHEBI:31890", "UMLS:C0207683"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:21786254", "PMID:25408834", "PMID:27610041", "PMID:28135089", "PMID:24985053", "PMID:10669559", "PMID:8012693", "PMID:9544206", "PMID:27668164", "PMID:14705184"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL134": {"name": "CLONIDINE", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL134", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL134", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Clonidine, an imidazoline-derivative hypotensive agent is a centrally-acting &alpha;<sub>2</sub>-adrenergic agonist. It crosses the blood-brain barrier and acts in the hypothalamus to induce a decrease in blood pressure. It may also be administered as an epidural infusion as an adjunct treatment in the management of severe cancer pain that is not relieved by opiate analgesics alone. Clonidine may be used for differential diagnosis of pheochromocytoma in hypertensive patients. Other uses for clonidine include prophylaxis of vascular migraine headaches, treatment of severe dysmenorrhea, management of vasomotor symptoms associated with menopause, rapid detoxification in the management of opiate withdrawal, treatment of alcohol withdrawal used in conjunction with benzodiazepines, management of nicotine dependence, topical use to reduce intraocular pressure in the treatment of open-angle and secondary glaucoma and hemorrhagic glaucoma associated with hypertension, and in the treatment of attention-deficit hyperactivity disorder (ADHD). Clonidine also exhibits some peripheral activity.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug", "biolink:BiologicalEntity"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["CLON [cytosol]", "cloNIDine", "Chlofazoline", "clonidine", "Gemiton", "M-5041t", "Clonidine hydrochloride", "CLONIDINE HYDROCHLORIDE", "CLON [extracellular region]", "Clonidine (JAN/USP/INN)", "clonidine (amino form)", "Clonidine hydrochloride (JP18/USP)", "Klofelin", "CLONIDINE", "Clonidine", "clonidine (imino form)"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["ATC:C02AC01", "NCIT:C380", "HMDB:HMDB0014714", "DRUGBANK:DB00575", "UMLS:C0392431", "UMLS:C4256018", "UMLS:C0009014", "REACT:R-ALL-549314", "UMLS:C0699878", "ATC:S01EA04", "CHEBI:46632", "LOINC:MTHU060427", "LOINC:LP14987-9", "CHEMBL.COMPOUND:CHEMBL1705", "REACT:R-ALL-549239", "CHEMBL.COMPOUND:CHEMBL134", "KEGG.DRUG:D00604", "DrugCentral:704", "UMLS:C0699875", "LOINC:LP32548-7", "PSY:09740", "MESH:D003000", "KEGG.DRUG:D00281", "NDDF:004495", "CHEBI:46631", "VANDF:4017850", "RXNORM:2599", "ATC:N02CX02", "CHEBI:3757", "CHEBI:3758"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:27484514", "PMID:10215651", "PMID:17691718", "PMID:25454267", "PMID:25282654", "PMID:29407958", "PMID:2879913", "PMID:25156301", "PMID:10454528", "PMID:27774136"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL2008565": {"name": "GUANAZODINE", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL2008565", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL2008565", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "GUANAZODINE; FULL_MW:184.29; MAX_FDA_APPROVAL_PHASE: 0", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Sanegit", "guanazodine", "Guanazodine", "Guanazodine (INN)", "GUANAZODINE"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["DRUGBANK:DB13604", "DrugCentral:3455", "MESH:C014017", "UMLS:C0141514", "NCIT:C83741", "KEGG.DRUG:D07169", "ATC:C02CC06", "UMLS:C0061940", "CHEBI:134828", "CHEMBL.COMPOUND:CHEMBL2008565"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL2051958": {"name": "GUANETHIDINE SULFATE", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL2051958", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL2051958", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "UMLS Semantic Type: STY:T121; UMLS Semantic Type: STY:T109; An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. [PubChem]", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Guanethidine sulfate (USAN)", "guanethidine monosulfate", "Guanethidine Sulfate", "guanethidine sulfate", "Guanethidine Sulfate (2:1), 14C-Labeled", "GUANETHIDINE", "GUANETHIDINE SULFATE", "Guanethidine", "GUANETHIDINE MONOSULFATE", "Ismelin", "Guanethidine (INN)", "guanethidine", "Guanethidine monosulfate (USP)", "Guanethidine Sulfate (1:2)"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["KEGG.COMPOUND:C07036", "NDDF:000639", "NCIT:C80000", "KEGG.DRUG:D04382", "KEGG.DRUG:D08030", "RXNORM:5036", "CHEMBL.COMPOUND:CHEMBL1345", "UMLS:C0936276", "CHEMBL.COMPOUND:CHEMBL765", "VANDF:4019770", "CHEBI:51017", "UMLS:C0701214", "UMLS:C0018318", "ATC:C02CC02", "CHEBI:51016", "NCIT:C65830", "UMLS:C0700538", "KEGG.DRUG:D02237", "RXNORM:203181", "NDDF:004524", "CHEBI:5557", "CHEMBL.COMPOUND:CHEMBL2051958", "DrugCentral:1342", "HMDB:HMDB0015301", "ATC:S01EX01", "UMLS:C0887236", "PSY:21930", "DRUGBANK:DB01170", "MESH:D006145"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:836492", "PMID:10447956", "PMID:11527735", "PMID:20185316", "PMID:7452699", "PMID:20843939", "PMID:22194678", "PMID:22961681", "PMID:3735318", "PMID:20020916"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL2110368": {"name": "BETHANIDINE SULFATE", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL2110368", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL2110368", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Bethanidine is only found in individuals that have used or taken this drug. It is a guanidinium antihypertensive agent that acts by blocking adrenergic transmission.Bethanidine, a guanidine derivative, is a peripherally acting antiadrenergic agent which primarily acts as an alpha2a adrenergic agonist. Bethanidine effectively decreases blood pressure by suppressing renin secretion or interfering with function of the sympathetic nervous system.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Bethanidine sulfate (JAN/USAN)", "BETHANIDINE", "BETHANIDINE SULFATE", "betanidine", "bethanidine sulfate", "Bethanidine Sulfate", "Bethanidine", "Batel", "bethanidine"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["UMLS:C0005324", "CHEMBL.COMPOUND:CHEMBL1201260", "RXNORM:1523", "CHEMBL.COMPOUND:CHEMBL2110368", "NDDF:003936", "DRUGBANK:DB00217", "KEGG.DRUG:D01603", "ATC:C02CC01", "NCIT:C81343", "CHEBI:31279", "DrugCentral:359", "NDDF:003935", "MESH:D001627", "CHEBI:37937", "HMDB:HMDB0014362", "UMLS:C1449783", "RXNORM:81966", "NCIT:C65260", "UMLS:C0282073"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:20020916"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL3184143": {"name": "GUANADREL SULFATE", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL3184143", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL3184143", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Guanadrel is a postganglionic sympathetic adrenergic antagonist that is administered orally to treat hypertension (high blood pressure). It was used in the form of its sulfate (trade name: Hylorel) but has been largely superseded by other antihypertensive agents due to its unpleasant side effect of orthostatic hypotension (i.e. dizziness when standing) (PMID: 6143629). Guanadrel both prevents noradrenaline (norepinephrine) release and depletes noradrenaline stores which effectively creates a peripheral sympathetic blockade. This serves to reduce vasoconstriction which subsequently lowers blood pressure (PMID: 3896742).", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["GUANADREL", "Guanadrel", "GUANADREL SULFATE", "guanadrel sulfate", "guanadrel", "Hylorel", "Guanadrel sulfate", "Guanadrel sulfate (USAN)", "Guanadrel (INN)", "Guanadrel Sulfate"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["CHEBI:5556", "DrugCentral:1339", "KEGG.DRUG:D08029", "UMLS:C0304525", "UMLS:C0720982", "CHEMBL.COMPOUND:CHEMBL1037", "VANDF:4019769", "MESH:C004945", "VANDF:4018079", "CHEBI:5555", "NCIT:C65827", "ttd.target:Guanadrel_Sulfate", "RXNORM:26296", "HMDB:HMDB0014371", "UMLS:C0061938", "DRUGBANK:DB00226", "KEGG.DRUG:D00607", "RXNORM:91239", "NDDF:000641", "CHEMBL.COMPOUND:CHEMBL3184143", "NCIT:C65828", "KEGG.COMPOUND:C07035"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:11527735", "PMID:3896742", "PMID:6143629", "PMID:16472241"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL76725": {"name": "GUANOXAN", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL76725", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL76725", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "A family of iminourea derivatives. The parent compound has been isolated from mushrooms, corn germ, rice hulls, mussels, earthworms, and turnip juice. Derivatives may have antiviral and antifungal properties.; UMLS Semantic Type: STY:T109", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["guanoxan", "Guanidines", "Guanoxan", "guanidines", "GUANOXAN SULFATE", "Guanoxan sulfate (USAN)", "GUANOXAN"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["CHEBI:24436", "ATC:C02CC03", "DrugCentral:1346", "UMLS:C0018320", "CHEBI:134871", "CHEMBL.COMPOUND:CHEMBL1742462", "DRUGBANK:DB13211", "MESH:C073344", "CHEMBL.COMPOUND:CHEMBL76725", "UMLS:C0650263", "KEGG.DRUG:D04399", "MESH:D006146"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:11527735", "PMID:19734051", "PMID:21112128", "PMID:20022146", "PMID:22096083", "PMID:21458999", "PMID:15646539"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL1200425": {"name": "PARGYLINE HYDROCHLORIDE", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL1200425", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL1200425", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Pargyline is only found in individuals that have used or taken this drug. It is a monoamine oxidase inhibitor with antihypertensive properties. [PubChem]MAOIs act by inhibiting the activity of monoamine oxidase, thus preventing the breakdown of monoamine neurotransmitters and thereby increasing their availability. There are two isoforms of monoamine oxidase, MAO-A and MAO-B. MAO-A preferentially deaminates serotonin, melatonin, epinephrine and norepinephrine. MAO-B preferentially deaminates phenylethylamine and trace amines. Pargyline functions by inhibiting the metabolism of catecholamines and tyramine within presynaptic nerve terminals. Catecholamines cause general physiological changes that prepare the body for physical activity (fight-or-flight response). Some typical effects are increases in heart rate, blood pressure, blood glucose levels, and a general reaction of the sympathetic nervous system.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Pargyline (INN)", "Pargyline Hydrochloride", "pargyline", "Pargyline", "PARGYLINE", "pargyline hydrochloride", "Pargyline hydrochloride", "Pargyline hydrochloride (USAN)", "1-[(1R)-2-[(4-chlorophenyl)methyl]-1-(hydroxymethyl)-7-methoxy-1'-spiro[3,9-dihydro-1H-pyrido[3,4-b]indole-4,4'-piperidine]yl]-1-butanone", "PARGYLINE HYDROCHLORIDE"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["CHEMBL.COMPOUND:CHEMBL673", "KEGG.DRUG:D08453", "DRUGBANK:DB01626", "NCIT:C66323", "KEGG.DRUG:D02564", "UMLS:C0282289", "LOINC:MTHU036237", "KEGG.COMPOUND:C07414", "LOINC:LP101037-2", "VANDF:4018734", "MESH:D010293", "VANDF:4019877", "UMLS:C0030557", "PSY:36700", "RXNORM:7930", "NDDF:004598", "ATC:C02KC01", "HMDB:HMDB0015563", "NCIT:C66322", "CHEBI:128477", "CHEMBL.COMPOUND:CHEMBL1200425", "CHEBI:7930", "RXNORM:82069", "DrugCentral:2065"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:24794105", "PMID:21965623", "PMID:18980841", "PMID:458796", "PMID:25600407", "PMID:650671", "PMID:23611731", "PMID:26432037", "PMID:3373495", "PMID:16137882"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL778": {"name": "DEXMEDETOMIDINE", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL778", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL778", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "A profound lethargy and characteristic lowering of the head with reduced sensitivity to environmental stimuli (sound, pain, etc.) are seen with detomidine. A short period of reduced coordination is characteristically followed by immobility and a firm stance with front legs spread. Following administration there is an initial increase in blood pressure, followed by bradycardia and second degree atrioventricular block (this is not pathologic in horses). The horse commonly sweats to excess, especially on the flanks and neck. Other side effects reported include pilo erection (hair standing erect), ataxia, salivation, slight muscle tremors, and (rarely) penile prolapse. An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine. [PubChem]; As detomidine is an arrhythmogenic agent, extreme care should be exercised in horses with cardiac disease, and in the concurrent administration of other arrhythmogenics. The concurrent use of potentiated sulfonamide antibiotics is considered particularly dangerous. Detomidine is a poor premedication when using Ketamine as an anesthetic in horses. Detomidine is a sedative with analgesic properties. 2-adrenergic agonists produce dose-dependent sedative and analgesic effects, mediatated by activation of catecholamine receptors, thus inducing a negative feedback response, reducing production of excitatory neurotransmitters. Due to inhibition of the sympathetic nervous system, detomidine also has cardiac and respiratory effects and an antidiuretic action. Detomidine is an imidazole derivative and I-adrenergic agonist, used as a large animal sedative, primarily used in horses. It is usually available as the salt detomidine hydrochloride. It is a prescription medication available to veterinarians sold under the trade name Dormosedan.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Dexmedetomidine", "DETOMIDINE", "Medetomidine Hydrochloride", "medetomidine hydrochloride", "MEDETOMIDINE", "Mpv-1440", "dexmedetomidine hydrochloride", "DEXMEDETOMIDINE", "dexmedetomidine", "Precedex", "MEDETOMIDINE HYDROCHLORIDE", "detomidine", "Dexmedetomidine (USAN/INN)", "medetomidine", "DEXMEDETOMIDINE HYDROCHLORIDE", "Dexmedetomidine Hydrochloride", "Dexmedetomidine hydrochloride (JAN/USP)", "Medetomidine", "Detomidine (INN)", "Medetomidine hydrochloride (USAN)", "levomedetomidine", "Detomidine", "Medetomidine (INN)"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["UMLS:C0752310", "PDQ:CDR0000632933", "HMDB:HMDB0014771", "HMDB:HMDB0254052", "RXNORM:228054", "RXNORM:29428", "CHEMBL.COMPOUND:CHEMBL2106195", "DRUGBANK:DB11556", "CHEBI:48555", "CHEBI:31472", "CHEMBL.COMPOUND:CHEMBL77921", "CHEBI:48556", "RXNORM:48937", "UMLS:C0876757", "ATC:N05CM18", "KEGG.COMPOUND:C07450", "CHEBI:4466", "CHEMBL.COMPOUND:CHEMBL2110829", "HMDB:HMDB0041872", "DrugCentral:1655", "KEGG.DRUG:D04883", "NCIT:C72738", "KEGG.DRUG:D01205", "MESH:D020926", "NCIT:C47479", "NCIT:C81368", "MESH:D020927", "MESH:C041255", "RXNORM:52016", "KEGG.DRUG:D00514", "CHEBI:48552", "DRUGBANK:DB00633", "DrugCentral:835", "UMLS:C0065852", "VANDF:4021214", "CHEMBL.COMPOUND:CHEMBL537161", "RXNORM:262138", "UMLS:C0113293", "UMLS:C0752311", "UMLS:C0125656", "KEGG.DRUG:D07795", "CHEMBL.COMPOUND:CHEMBL778", "KEGG.DRUG:D08165", "NCIT:C81367", "DRUGBANK:DB11428"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:8966714", "PMID:10753480", "PMID:8709134", "PMID:2309424", "PMID:10715142", "PMID:21129985", "PMID:17630725", "PMID:10602691", "PMID:9301663", "PMID:22194678"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL110": {"name": "BENZNIDAZOLE", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL110", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL110", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "UMLS Semantic Type: STY:T121; UMLS Semantic Type: STY:T109; Benznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017 [L939]. It is the first treatment made available in the United States for Chagas disease.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Ro 7-1051", "BENZNIDAZOLE", "Radanil", "Benznidazole (USAN/INN)", "2-nitroimidazole benznidazole", "benznidazole", "benzonidazole", "Benznidazole"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["NCIT:C1013", "UMLS:C0140794", "DrugCentral:322", "UMLS:C0053230", "ATC:P01CA02", "KEGG.DRUG:D02489", "CHEBI:133833", "UMLS:C0093512", "HMDB:HMDB0248997", "CHEMBL.COMPOUND:CHEMBL110", "PDQ:CDR0000040311", "MESH:C009999", "RXNORM:18994", "VANDF:4037055", "DRUGBANK:DB11989", "UMLS:C0139900"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:24929292", "PMID:21397502", "PMID:21229977", "PMID:12443785", "PMID:28881289", "PMID:27017556", "PMID:24630563", "PMID:10893302", "PMID:26072173", "PMID:18712933"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL1201071": {"name": "TETRACYCLINE PHOSPHATE COMPLEX", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL1201071", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL1201071", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "An alpha,beta-unsaturated ester resulting from the formal condensation of the alcoholic hydroxy group of 9-hydroxynonanoic acid with the carboxy group of (2E)-4-[(2S)-tetrahydro-2H-pyran-2-yl]-3-methylbut-2-enoic acid in which the tetrahydropyranyl ring is substituted at positions 3 and 4 by hydroxy groups and at position 5 by a {(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl}methyl group. Originally isolated from the Gram-negative bacterium Pseudomonas fluorescens, it is used as a topical antibiotic for the treatment of Gram-positive bacterial infections.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["tetracycline zwitterion", "Sustamycin", "Tetracycline hydrochloride", "tetracycline hydrochloride", "Tetracycline Hydrochloride", "Tetrabid", "Mupirocin (USP/INN)", "TETRACYCLINE HYDROCHLORIDE", "Hostacyclin", "tetracycline", "MUPIROCIN CALCIUM", "Tetracycline Phosphate Complex", "mupirocin calcium (anhydrous)", "Mupirocin calcium (USP)", "mupirocin calcium hydrate", "Tetracycline hydrochloride (JP18/USP)", "TETRACYCLINE", "TETRACYCLINE PHOSPHATE COMPLEX", "mupirocin", "Tetracycline", "SID26754295", "4-Epitetracycline", "Tetracycline (JAN/USP/INN)", "Mupirocin", "tetracycline phosphate complex", "MUPIROCIN", "SID26755325", "Achromycin V"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["KEGG.DRUG:D01076", "VANDF:4017625", "NCIT:C29271", "RXNORM:142446", "CHEMBL.COMPOUND:CHEMBL1440", "NCIT:C48020", "DrugCentral:2611", "KEGG.DRUG:D02195", "ATC:A01AB13", "RXNORM:2105975", "UMLS:C0546879", "UMLS:C0699126", "LOINC:LP17279-8", "HMDB:HMDB0014897", "UMLS:C0699125", "UMLS:C0521901", "CHEMBL.COMPOUND:CHEMBL2068726", "DRUGBANK:DB00759", "LOINC:LP16286-4", "NDDF:002802", "LOINC:MTHU009172", "ATC:D06AA04", "ATC:J01AA07", "UMLS:C0677059", "UMLS:C0085259", "CHEMBL.COMPOUND:CHEMBL454950", "PDQ:CDR0000042307", "DrugCentral:1857", "KEGG.DRUG:D02122", "KEGG.DRUG:D00201", "VANDF:4017626", "CHEBI:34858", "ATC:R01AX06", "CHEMBL.COMPOUND:CHEMBL3989715", "NCIT:C87225", "NCIT:C865", "CHEMBL.COMPOUND:CHEMBL1205019", "CHEMBL.COMPOUND:CHEMBL1201071", "LOINC:MTHU008490", "CHEBI:145818", "PathWhiz.Compound:9228", "HMDB:HMDB0014554", "ATC:D06AX09", "CHEBI:77932", "CHEMBL.COMPOUND:CHEMBL198", "UMLS:C0039644", "MESH:D016712", "NDDF:002738", "KEGG.COMPOUND:C06570", "NDDF:002740", "RXNORM:42372", "ATC:S02AA08", "CHEBI:7025", "ATC:S01AA09", "DRUGBANK:DB00410", "KEGG.COMPOUND:C11758", "UMLS:C0699127", "UMLS:C0000488", "MESH:D013752", "RXNORM:10395", "CHEBI:27902", "CHEMBL.COMPOUND:CHEMBL1485984", "CHEBI:35006", "VANDF:4019345", "ATC:S03AA02", "CHEMBL.COMPOUND:CHEMBL719"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:20498309", "PMID:21570162", "PMID:20038624", "PMID:20713660", "PMID:18606839", "PMID:19047652", "PMID:19620323", "PMID:29033234", "PMID:19433553", "PMID:14998336"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "UMLS:C0597357": {"name": "receptor", "categories": ["biolink:Polypeptide"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/umls:C0597357", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/umls:C0597357", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "A protein located on the cell surface, or in the cytoplasm, that binds to a specific signaling factor, such as a hormone, antigen, or neurotransmitter, causing a conformational and functional change in the receptor molecule. The ligand-bound receptor then alters its interaction with target molecules, which leads to changes in cellular physiology through modification of the activity of one or more signal transduction pathways.; UMLS Semantic Type: STY:T192; UMLS Semantic Type: STY:T116", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:NamedThing", "biolink:Polypeptide", "biolink:Protein"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Receptor", "receptor"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["UMLS:C0597357", "NCIT:C18106", "STY:T192", "LOINC:LP21071-3"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}]}, "FMA:84786": {"name": "Gamma-aminobutyric acid", "categories": ["biolink:BiologicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "http://purl.obolibrary.org/obo/FMA_84786", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "http://purl.obolibrary.org/obo/FMA_84786", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "gamma-Aminobutyric acid (GABA) is an inhibitory neurotransmitter found in the nervous systems of widely divergent species, including humans. It is the chief inhibitory neurotransmitter in the vertebrate central nervous system. In vertebrates, GABA acts at inhibitory synapses in the brain. It acts by binding to specific transmembrane receptors in the plasma membrane of both pre- and postsynaptic neurons. This binding causes the opening of ion channels to allow either the flow of negatively-charged chloride ions into the cell or positively-charged potassium ions out of the cell. This will typically result in a negative change in the transmembrane potential, usually causing hyperpolarization. Three general classes of GABA receptor are known (PMID: 10561820). These include GABA-A and GABA-C ionotropic receptors, which are ion channels themselves, and GABA-B metabotropic receptors, which are G protein-coupled receptors that open ion channels via intermediaries known as G proteins (PMID: 10561820). Activation of the GABA-B receptor by GABA causes neuronal membrane hyperpolarization and a resultant inhibition of neurotransmitter release. In addition to binding sites for GABA, the GABA-A receptor has binding sites for benzodiazepines, barbiturates, and neurosteroids. GABA-A receptors are coupled to chloride ion channels. Therefore, activation of the GABA-A receptor induces increased inward chloride ion flux, resulting in membrane hyperpolarization and neuronal inhibition (PMID: 10561820). After release into the synapse, free GABA that does not bind to either the GABA-A or GABA-B receptor complexes can be taken up by neurons and glial cells. Four different GABA membrane transporter proteins (GAT-1, GAT-2, GAT-3, and BGT-1), which differ in their distribution in the CNS, are believed to mediate the uptake of synaptic GABA into neurons and glial cells. The GABA-A receptor subtype regulates neuronal excitability and rapid changes in fear arousal, such as anxiety, panic, and the acute stress response (PMID: 10561820). Drugs that stimulate GABA-A receptors, such as the benzodiazepines and barbiturates, have anxiolytic and anti-seizure effects via GABA-A-mediated reduction of neuronal excitability, which effectively raises the seizure threshold. GABA-A antagonists produce convulsions in animals and there is decreased GABA-A receptor binding in a positron emission tomography (PET) study of patients with panic disorder. Neurons that produce GABA as their output are called GABAergic neurons and have chiefly inhibitory action at receptors in the vertebrate. Medium spiny neurons (MSNs) are a typical example of inhibitory CNS GABAergic cells. GABA has been shown to have excitatory roles in the vertebrate, most notably in the developing cortex. Organisms synthesize GABA from glutamate using the enzyme L-glutamic acid decarboxylase and pyridoxal phosphate as a cofactor (PMID: 12467378). It is worth noting that this involves converting the principal excitatory neurotransmitter (glutamate) into the principal inhibitory one (GABA). Drugs that act as agonists of GABA receptors (known as GABA analogs or GABAergic drugs), or increase the available amount of GABA typically have relaxing, anti-anxiety, and anti-convulsive effects. GABA is found to be deficient in cerebrospinal fluid and the brain in many studies of experimental and human epilepsy. Benzodiazepines (such as Valium) are useful in status epilepticus because they act on GABA receptors. GABA increases in the brain after administration of many seizure medications. Hence, GABA is clearly an antiepileptic nutrient. Inhibitors of GAM metabolism can also produce convulsions. Spasticity and involuntary movement syndromes, such as Parkinson's, Friedreich's ataxia, tardive dyskinesia, and Huntington's chorea, are all marked by low GABA when amino acid levels are studied. Trials of 2 to 3 g of GABA given orally have been effective in various epilepsy and spasticity syndromes. Agents that elevate GABA are also useful in lowering hypertension. Three grams orally have been effective in controlling blood pressure. GABA is decreased in various encephalopathies. GABA can reduce appetite and is decreased in hypoglycemics. GABA reduces blood sugar in diabetics. Chronic brain syndromes can also be marked by deficiencies of GABA. Vitamin B6, manganese, taurine, and lysine can increase both GABA synthesis and effects, while aspartic acid and glutamic acid probably inhibit GABA effects. Low plasma GABA has been reported in some depressed patients and may be a useful trait marker for mood disorders. GABA has an important role in embryonic development, especially facial development, as substantiated by the association of a cleft palate in transgenic mice deficient in GAD67 (glutamate decarboxylase). A recent Japanese population study reported linkage in patients with a nonsyndromic cleft lip with or without a cleft palate and specific GAD67 haplotypes (PMID: 23842532). Unusually high levels of GABA (especially in the brain) can be toxic and GABA can function as both a neurotoxin and a metabotoxin. A neurotoxin is a compound that damages the brain and/or nerve tissue. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Chronically high levels of GABA are associated with at least five inborn errors of metabolism, including D-2-hydroxyglutaric aciduria, 4-hydroxybutyric aciduria/succinic semialdehyde dehydrogenase deficiency, GABA-transaminase deficiency, homocarnosinosis, and hyper beta-alaninemia. Nearly all of these conditions are associated with seizures, hypotonia, intellectual deficits, macrocephaly, encephalopathy, and other serious neurological or neuromuscular problems. Increased levels of GABA seem to alter the function of the GABA-B receptor, which may play a role in the tonic-clonic seizures that are often seen in patients with the above disorders. GABA is also a microbial metabolite, urinary GABA is produced by Lactobacillus and Bifidobacterium (PMID: 24621061).", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:NamedThing", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:ChemicalEntity", "biolink:BiologicalEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["\u03b3-Aminobutyric acid", "gamma-aminobutyric acid", "GABA [synaptic vesicle]", "4-Aminobutanoate", "GABA [cytosol]", "gamma-aminobutyrate", "gamma-Aminobutyric acid", "Gamma-aminobutyric acid", "GAMMA-AMINOBUTYRIC ACID", "aminobutyric acid", "GABA [clathrin-sculpted gamma-aminobutyric acid transport vesicle lumen]", "Aminobutyrates", "gamma-Aminobutyric acid (JAN)", "gamma-Aminobutyric Acid", "GABA [extracellular region]", "gamma-aminobutyric acid zwitterion", "GABA [mitochondrial matrix]", "Gamma-Aminobutyric Acid"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["MESH:D000613", "KEGG.DRUG:D00058", "RXNORM:4617", "REACT:R-ALL-352003", "UMLS:C0016904", "FMA:84786", "REACT:R-ALL-916850", "UMLS:C1979618", "REACT:R-ALL-936479", "DRUGBANK:DB02530", "PathWhiz.Compound:71", "VANDF:4034308", "KEGG.COMPOUND:C00334", "NDDF:006466", "LOINC:LP31651-0", "NCIT:C80523", "CHEBI:16865", "CHEMBL.COMPOUND:CHEMBL96", "CHEBI:30566", "MESH:D005680", "REACT:R-ALL-428571", "DrugCentral:1262", "REACT:R-ALL-352011", "HMDB:HMDB0000112", "CHEBI:59888"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:2985785", "PMID:3625705", "PMID:18528996", "PMID:12097436", "PMID:11827462", "PMID:1485027", "PMID:15509161", "PMID:1619617", "PMID:15538143", "PMID:3001304"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "UMLS:C0027908": {"name": "Neurotransmitters", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/umls:C0027908", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/umls:C0027908", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Chemical substances, synthesized and released by nerve cells, or glandular hormones that excite or inhibit other nerve, muscle, or gland cells by producing a brief alteration in the postsynaptic membrane of the receiving cell. Use a more specific term if possible.; Endogenous signaling molecules that alter the behavior of neurons or effector cells. Neurotransmitter is used here in its most general sense, including not only messengers that act directly to regulate ion channels, but also those that act through second messenger systems, and those that act at a distance from their site of release. Included are neuromodulators, neuroregulators, neuromediators, and neurohumors, whether or not acting at synapses.; Endogenous signaling molecules secreted by neurons that alter the behavior of neurons or effector cells. Neurotransmitter is used here in its most general sense, including not only messengers that act directly to regulate ion channels, but also those that act through second messenger systems, and those that act at a distance from their site of release. Included are neuromodulators, neuroregulators, neuromediators, neurohormones, and neurohumors, whether or not acting at synapses.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Neurotransmitters"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["UMLS:C0027908", "PSY:33924"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}]}, "MESH:D004798": {"name": "Enzymes", "categories": ["biolink:Polypeptide"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "http://id.nlm.nih.gov/mesh/D004798", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "http://id.nlm.nih.gov/mesh/D004798", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Molecules that catalyze a chemical reaction. They are usually proteins, although catalytic RNA and DNA molecules have been identified.; Biological molecules that possess catalytic activity. They may occur naturally or be synthetically created. Enzymes are usually proteins, however CATALYTIC RNA and CATALYTIC DNA molecules have also been identified.; UMLS Semantic Type: STY:T126; UMLS Semantic Type: STY:T116", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:Polypeptide"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Enzymes"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["PSY:17630", "LOINC:LP21234-7", "LOINC:LP31392-1", "MESH:D004798", "UMLS:C0014442"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}]}, "FMA:61811": {"name": "Dopamine receptor", "categories": ["biolink:BiologicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "http://purl.obolibrary.org/obo/FMA_61811", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "http://purl.obolibrary.org/obo/FMA_61811", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "A rhodopsin-like G-protein coupled receptor that is a translation product of the human DRD1 to DRD5 genes, 1:1 orthologs thereof, or pro-orthologs thereof. // COMMENTS: Category=family. Pro-orthology refers to, in this case, after-speciation gene duplication in the non-human species (aka 1:many orthology).", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:Polypeptide", "biolink:BiologicalEntity", "biolink:Protein", "biolink:GeneFamily"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Dopamine Receptor", "dopamine receptor", "Dopamine receptor"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["CHEMBL.TARGET:CHEMBL2111359", "CHEMBL.TARGET:CHEMBL2096970", "PR:000044633", "UMLS:C0034798", "CHEMBL.TARGET:CHEMBL2093868", "NCIT:C17066", "FMA:61811", "CHEMBL.TARGET:CHEMBL2096905"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL1201580": {"name": "ADALIMUMAB", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL1201580", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL1201580", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "A recombinant, human IgG1 monoclonal antibody directed against tumor necrosis factor-alpha (TNF-alpha), with immunomodulating activity. Upon administration, adalimumab binds to TNF-alpha, thereby preventing its binding to the p55 and p75 TNF cell surface receptors and inhibiting TNF-mediated immune responses. TNF-alpha, a pro-inflammatory cytokine, is upregulated in various autoimmune diseases. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C65216\" active clinical trials using this agent. (\"http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C65216\" NCI Thesaurus); A recombinant, human IgG1 monoclonal antibody directed against tumor necrosis factor-alpha (TNF-alpha), with immunomodulating activity. Upon administration, adalimumab binds to TNF-alpha, thereby preventing its binding to the p55 and p75 TNF cell surface receptors and inhibiting TNF-mediated immune responses. TNF-alpha, a pro-inflammatory cytokine, is upregulated in various autoimmune diseases.; A humanized monoclonal antibody that binds specifically to TNF-ALPHA and blocks its interaction with endogenous TNF RECEPTORS to modulate INFLAMMATION. 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FULL_MW:165.16; MAX_FDA_APPROVAL_PHASE: 0", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:NucleicAcidEntity", "biolink:SmallMolecule"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["9-methylguanine", "9-Methylguanine"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["MESH:C116701", "UMLS:C0762193", "CHEMBL.COMPOUND:CHEMBL1230674", "DRUGBANK:DB02489"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:31484", "PMID:29220796"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "FMA:74644": {"name": "Melatonin", "categories": ["biolink:BiologicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "http://purl.obolibrary.org/obo/FMA_74644", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "http://purl.obolibrary.org/obo/FMA_74644", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B.Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. In mammals, melatonin is produced by the pineal gland. The pineal gland is small endocrine gland, about the size of a rice grain and shaped like a pine cone (hence the name), that is located in the center of the brain (rostro-dorsal to the superior colliculus) but outside the blood-brain barrier. The secretion of melatonin increases in darkness and decreases during exposure to light, thereby regulating the circadian rhythms of several biological functions, including the sleep-wake cycle. In particular, melatonin regulates the sleep-wake cycle by chemically causing drowsiness and. lowering the body temperature. Melatonin is also implicated in the regulation of mood,learning and memory, immune activity, dreaming, fertility and reproduction. Melatonin is also an effective antioxidant. Most of the actions of melatonin are mediated through the binding and activation of melatonin receptors. Individuals with autism spectrum disorders(ASD) may have lower than normal levels of melatonin. A 2008 study found that unaffected parents of individuals with ASD also have lower melatonin levels, and that the deficits. were associated with low activity of the ASMT gene, which encodes the last enzyme of melatonin synthesis. Reduced melatonin production has also been proposed as a likely factor in the significantly higher cancer rates in night workers.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:BiologicalEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["melatonin", "MELATONIN", "MLT [extracellular region]", "Melatonin (JAN)", "Melatonin", "MLT [cytosol]", "Circadin"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["MESH:D008550", "DrugCentral:1672", "KEGG.COMPOUND:C01598", "DRUGBANK:DB01065", "UMLS:C0025219", "LOINC:MTHU002350", "KEGG.DRUG:D08170", "PathWhiz.Compound:1074", "REACT:R-ALL-209934", "CHEBI:16796", "CHEMBL.COMPOUND:CHEMBL45", "FMA:74644", "NCIT:C2267", "HMDB:HMDB0001389", "REACT:R-ALL-419339", "RXNORM:6711", "PSY:30540", "ATC:N05CH01", "VANDF:4021324", "UMLS:C1710381", "LOINC:LP15036-4"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:27484514", "PMID:12643943", "PMID:30126274", "PMID:14980664", "PMID:21473625", "PMID:10224140", "PMID:12767050", "PMID:7773197", "PMID:8258829", "PMID:15566297"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "DRUGBANK:DB01978": {"name": "7,9-Dimethylguanine", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/drugbank:DB01978", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/drugbank:DB01978", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "UMLS Semantic Type: STY:T114", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:NucleicAcidEntity", "biolink:SmallMolecule"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["7,9-dimethylguanine", "7,9-Dimethylguanine"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["MESH:C061517", "UMLS:C0638477", "DRUGBANK:DB01978"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL1697788": {"name": "DEXAMETHASONE DIPROPIONATE", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL1697788", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL1697788", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Dexamethasone is only found in individuals that have used or taken this drug. It is an anti-inflammatory 9-fluoro-glucocorticoid. Dexamethasone is a glucocorticoid agonist. It is used for its antiinflammatory or immunosuppressive properties and ability to penetrate the CNS, dexamethasone is used alone to manage cerebral edema and with tobramycin to treat corticosteroid-responsive inflammatory ocular conditions. Dexamethasone can be used in the context of congenital adrenal hyperplasia, to prevent virilisation of a female fetus. Unbound dexamethasone crosses cell membranes and binds with high affinity to specific cytoplasmic glucocorticoid receptors. This complex binds to DNA elements (glucocorticoid response elements) which results in a modification of transcription and, hence, protein synthesis in order to achieve inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of dexamethasone are thought to involve phospholipase A<sub>2</sub> inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Dexamethasone has been shown to exhibit anesthetic, anti-microbial, appetite stimulant, muscle building and sedative functions (PMID 16571981, 19842390, 11563572, 20080405, 2898201). Its potency is about 20-30 times that of hydrocortisone and 4-5 times of prednisone.", "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": null, "attributes": null}, {"attribute_type_id": "biolink:category", "original_attribute_name": null, "value": ["biolink:ChemicalEntity", "biolink:SmallMolecule", "biolink:MolecularEntity", "biolink:Drug"], "value_type_id": "metatype:Uriorcurie", "attribute_source": null, "value_url": null, "description": "Categories of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:synonym", "original_attribute_name": null, "value": ["Dexamethasone Acefurate", "dexamethasone dipropionate", "Dexpak", "Dexamethasone acetate anhydrous", "Dexamethasone dipropionate (USAN)", "Dexamethasone Acetate", "Decaject-L.A.", "Dexamethasone 21-acetate", "DEXAMETHASONE ACETATE", "DEXAMETHASONE ACEFURATE", "Furan-2-carboxylic acid 17-(2-acetoxy-acetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester", "Decaspray", "dexamethasone acetate", "Maxidex", "Dexamethasone acetate (JAN/USP)", "Dexamethasone 17-propionate", "Hexadrol", "Dexamethasone Dipropionate", "Decameth", "Dexamethasone acetate", "Oradexon", "DEXAMETHASONE", "dexamethasone", "Dexamethasone Acetate Anhydrous", "Dexamethasone", "Decaject", "dexamethasone acefurate", "DEXAMETHASONE DIPROPIONATE", "Dexamethasone acefurate (USAN/INN)"], "value_type_id": "metatype:String", "attribute_source": null, "value_url": null, "description": "Names of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:xref", "original_attribute_name": null, "value": ["NCIT:C77413", "CHEMBL.COMPOUND:CHEMBL290547", "UMLS:C1720761", "KEGG.DRUG:D01632", "KEGG.COMPOUND:C15643", "UMLS:C0701254", "CHEBI:135819", "DrugCentral:824", "UMLS:C0701252", "CHEBI:135805", "NCIT:C77000", "NCIT:C1067", "KEGG.DRUG:D02591", "RXNORM:22690", "CHEMBL.COMPOUND:CHEMBL1651", "KEGG.DRUG:D02174", "UMLS:C0719687", "UMLS:C0719686", "CHEBI:31470", "CHEMBL.COMPOUND:CHEMBL1697788", "UMLS:C1658209", "UMLS:C0701250", "UMLS:C0057598", "CHEBI:41879", "KEGG.COMPOUND:C08174", "KEGG.DRUG:D07796", "MESH:C018038", "HMDB:HMDB0015364", "UMLS:C2699606", "VANDF:4017924", "DrugCentral:825", "HMDB:HMDB0242728", "RXNORM:203705", "UMLS:C0245678", "NDDF:002175", "UMLS:C0701260", "DRUGBANK:DB01234", "UMLS:C0011777", "DrugCentral:826", "NCIT:C77417", "UMLS:C1511840", "DRUGBANK:DB14649", "CHEBI:4463", "MESH:D003907", "MESH:C059542", "CHEMBL.COMPOUND:CHEMBL1530428", "DrugCentral:827", "CHEMBL.COMPOUND:CHEMBL384467", "CHEMBL.COMPOUND:CHEMBL1697787", "CHEMBL.COMPOUND:CHEMBL416603"], "value_type_id": "metatype:Nodeidentifier", "attribute_source": null, "value_url": null, "description": "Identifiers of all nodes in this synonym set in RTX-KG2.", "attributes": null}, {"attribute_type_id": "biolink:publications", "original_attribute_name": null, "value": ["PMID:20099827", "PMID:11557128", "PMID:23373965", "PMID:25338180", "PMID:21257309", "PMID:26116178", "PMID:20875743", "PMID:11785684", "PMID:21944856", "PMID:23033255"], "value_type_id": "biolink:Uriorcurie", "attribute_source": null, "value_url": null, "description": null, "attributes": null}]}, "CHEMBL.COMPOUND:CHEMBL85": {"name": "RISPERIDONE", "categories": ["biolink:ChemicalEntity"], "attributes": [{"attribute_type_id": "biolink:IriType", "original_attribute_name": null, "value": "https://identifiers.org/chembl.compound:CHEMBL85", "value_type_id": "metatype:Uri", "attribute_source": null, "value_url": "https://identifiers.org/chembl.compound:CHEMBL85", "description": null, "attributes": null}, {"attribute_type_id": "biolink:description", "original_attribute_name": null, "value": "Risperidone is an atypical antipsychotic medication approved in 1993. It is most often used to treat delusional psychosis (including schizophrenia), but risperidone (like other atypical antipsychotics) is also used to treat some forms of bipolar disorder, psychotic depression and Tourette syndrome. Generally lower doses are used for autistic spectrum disorders than are used for schizophrenia and other forms of psychosis; Risperidone is a very strong dopamine blocker (antagonist); Risperidone is a very strong dopamine blocker (antagonist); i.e., it inhibits functioning of postsynaptic dopamine receptors. An anxiolytic agent and a serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the benzodiazepines, but it has an efficacy comparable to diazepam; i.e., it inhibits functioning of postsynaptic dopamine receptors. Risperidone (Belivon, Rispen, Risperdal; in the United States) is an atypical antipsychotic medication. It was approved by the United States Food and Drug Administration (FDA) in 1993. It is most often used to treat delusional psychosis (including schizophrenia), but risperidone (like other atypical antipsychotics) is also used to treat some forms of bipolar disorder, psychotic depression and Tourette syndrome; risperidone has received approval from the Food and Drug Administration (FDA) for symptomatic treatment of irritability in autistic children and adolescents. 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In women, it is released mainly after distention of the cervix and vagina during labor, and after stimulation of the nipples, facilitating birth and breastfeeding, respectively. Oxytocin is released during orgasm in both sexes. In the brain, oxytocin is involved in social recognition and bonding, and might be involved in the formation of trust between people. -- Wikipedia; In the pituitary gland, oxytocin is packaged in large, dense-core vesicles, where it is bound to neurophysin as shown in the inset of the figure; neurophysin is a large peptide fragment of the giant precursor protein molecule from which oxytocin is derived by enzymatic cleavage. -- Wikipedia; Oxytocin is a peptide of nine amino acids (a nonapeptide). The sequence is cysteine - tyrosine - isoleucine - glutamine - asparagine - cysteine - proline - leucine - glycine (CYIQNCPLG). The cysteine residues form a sulfur bridge. Oxytocin has a molecular mass of 1007 daltons. One international unit (IU) of oxytocin is the equivalent of about 2 micrograms of pure peptide. -- Wikipedia; Oxytocin has peripheral (hormonal) actions, and also has actions in the brain. The actions of oxytocin are mediated by specific, high affinity oxytocin receptors. The oxytocin receptor is a G-protein-coupled receptor which requires Mg2+ and cholesterol. 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