Karabiner-Elements Rules

⌘-enter to send in Apple Mail.json

{
    "description": "⌘-enter to send in Apple Mail",
    "manipulators": [
        {
            "conditions": [
                {
                    "bundle_identifiers": [
                        "com.apple.mail"
                    ],
                    "description": "Only for Apple Mail",
                    "type": "frontmost_application_if"
                }
            ],
            "from": {
                "key_code": "return_or_enter",
                "modifiers": {
                    "mandatory": [
                        "command"
                    ]
                }
            },
            "to": [
                {
                    "key_code": "d",
                    "modifiers": [
                        "shift",
                        "command"
                    ]
                }
            ],
            "type": "basic"
        }
    ]
}

⌘-number to switch profile in Safari.json

{
    "description": "⌘-number to switch profile in Safari",
    "manipulators": [
        {
            "conditions": [
                {
                    "bundle_identifiers": [
                        "com.apple.Safari"
                    ],
                    "description": "Only for Safari",
                    "type": "frontmost_application_if"
                }
            ],
            "from": {
                "key_code": "0",
                "modifiers": {
                    "mandatory": [
                        "command"
                    ]
                }
            },
            "to": [
                {
                    "key_code": "0",
                    "modifiers": [
                        "shift",
                        "option",
                        "command"
                    ]
                }
            ],
            "type": "basic"
        },
        {
            "conditions": [
                {
                    "bundle_identifiers": [
                        "com.apple.Safari"
                    ],
                    "description": "Only for Safari",
                    "type": "frontmost_application_if"
                }
            ],
            "from": {
                "key_code": "1",
                "modifiers": {
                    "mandatory": [
                        "command"
                    ]
                }
            },
            "to": [
                {
                    "key_code": "1",
                    "modifiers": [
                        "shift",
                        "option",
                        "command"
                    ]
                }
            ],
            "type": "basic"
        },
        {
            "conditions": [
                {
                    "bundle_identifiers": [
                        "com.apple.Safari"
                    ],
                    "description": "Only for Safari",
                    "type": "frontmost_application_if"
                }
            ],
            "from": {
                "key_code": "2",
                "modifiers": {
                    "mandatory": [
                        "command"
                    ]
                }
            },
            "to": [
                {
                    "key_code": "2",
                    "modifiers": [
                        "shift",
                        "option",
                        "command"
                    ]
                }
            ],
            "type": "basic"
        },
        {
            "conditions": [
                {
                    "bundle_identifiers": [
                        "com.apple.Safari"
                    ],
                    "description": "Only for Safari",
                    "type": "frontmost_application_if"
                }
            ],
            "from": {
                "key_code": "3",
                "modifiers": {
                    "mandatory": [
                        "command"
                    ]
                }
            },
            "to": [
                {
                    "key_code": "3",
                    "modifiers": [
                        "shift",
                        "option",
                        "command"
                    ]
                }
            ],
            "type": "basic"
        },
        {
            "conditions": [
                {
                    "bundle_identifiers": [
                        "com.apple.Safari"
                    ],
                    "description": "Only for Safari",
                    "type": "frontmost_application_if"
                }
            ],
            "from": {
                "key_code": "4",
                "modifiers": {
                    "mandatory": [
                        "command"
                    ]
                }
            },
            "to": [
                {
                    "key_code": "4",
                    "modifiers": [
                        "shift",
                        "option",
                        "command"
                    ]
                }
            ],
            "type": "basic"
        },
        {
            "conditions": [
                {
                    "bundle_identifiers": [
                        "com.apple.Safari"
                    ],
                    "description": "Only for Safari",
                    "type": "frontmost_application_if"
                }
            ],
            "from": {
                "key_code": "5",
                "modifiers": {
                    "mandatory": [
                        "command"
                    ]
                }
            },
            "to": [
                {
                    "key_code": "5",
                    "modifiers": [
                        "shift",
                        "option",
                        "command"
                    ]
                }
            ],
            "type": "basic"
        },
        {
            "conditions": [
                {
                    "bundle_identifiers": [
                        "com.apple.Safari"
                    ],
                    "description": "Only for Safari",
                    "type": "frontmost_application_if"
                }
            ],
            "from": {
                "key_code": "6",
                "modifiers": {
                    "mandatory": [
                        "command"
                    ]
                }
            },
            "to": [
                {
                    "key_code": "6",
                    "modifiers": [
                        "shift",
                        "option",
                        "command"
                    ]
                }
            ],
            "type": "basic"
        },
        {
            "conditions": [
                {
                    "bundle_identifiers": [
                        "com.apple.Safari"
                    ],
                    "description": "Only for Safari",
                    "type": "frontmost_application_if"
                }
            ],
            "from": {
                "key_code": "7",
                "modifiers": {
                    "mandatory": [
                        "command"
                    ]
                }
            },
            "to": [
                {
                    "key_code": "7",
                    "modifiers": [
                        "shift",
                        "option",
                        "command"
                    ]
                }
            ],
            "type": "basic"
        },
        {
            "conditions": [
                {
                    "bundle_identifiers": [
                        "com.apple.Safari"
                    ],
                    "description": "Only for Safari",
                    "type": "frontmost_application_if"
                }
            ],
            "from": {
                "key_code": "8",
                "modifiers": {
                    "mandatory": [
                        "command"
                    ]
                }
            },
            "to": [
                {
                    "key_code": "8",
                    "modifiers": [
                        "shift",
                        "option",
                        "command"
                    ]
                }
            ],
            "type": "basic"
        },
        {
            "conditions": [
                {
                    "bundle_identifiers": [
                        "com.apple.Safari"
                    ],
                    "description": "Only for Safari",
                    "type": "frontmost_application_if"
                }
            ],
            "from": {
                "key_code": "9",
                "modifiers": {
                    "mandatory": [
                        "command"
                    ]
                }
            },
            "to": [
                {
                    "key_code": "9",
                    "modifiers": [
                        "shift",
                        "option",
                        "command"
                    ]
                }
            ],
            "type": "basic"
        }
    ]
}

⌘-r to refresh in Apple Mail.json

{
    "description": "⌘-r to refresh in Apple Mail",
    "manipulators": [
        {
            "conditions": [
                {
                    "bundle_identifiers": [
                        "com.apple.mail"
                    ],
                    "description": "Only for Apple Mail",
                    "type": "frontmost_application_if"
                }
            ],
            "from": {
                "key_code": "r",
                "modifiers": {
                    "mandatory": [
                        "command"
                    ]
                }
            },
            "to": [
                {
                    "key_code": "n",
                    "modifiers": [
                        "shift",
                        "command"
                    ]
                }
            ],
            "type": "basic"
        }
    ]
}