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• Dosage

  • 2.5 µg = 100 I.U.
  • [[Tolerable Upper Intake Level]]
    • UK
      • https://www.gov.uk/government/publications/vitamin-d-supplements-how-to-take-them-safely/vitamin-d-supplements-how-to-take-them-safely
        • 100 micrograms (µg) equivalent to ^^4,000 international units^^) per day is considered safe.
    • US
      • 9+ years:100 µg/d (^^4000 IU/d^^)
  • Adverse Effects
    • Risk of Hypervitaminosis D
    • Data
      • A review of the growing risk of vitamin D toxicity from inappropriate practice
        • #Meta-analysis
        • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980613
          • Looks into formulation errors and manufacturing errors as primary issues
          • Inappropriate prescription of high doses up to 100,000 IU / day
      • Risk assessment for vitamin D
        • #Review
        • https://academic.oup.com/ajcn/article/85/1/6/4649294
          • ^^Newer clinical trial data are sufficient to show that vitamin D is not toxic at intakes much higher than previously considered unsafe.^^
          • Suggest [[Tolerable Upper Intake Level]] can be raised to 10K/day
      • Vitamin D Is Not as Toxic as Was Once Thought
        • #Editorial
        • https://www.mayoclinicproceedings.org/article/S0025-6196(15)00244-X/pdf
          • The evidence is clear that vitamin D ^^toxicity is one of the rarest medical conditions and is typically due to intentional or inadvertent intake of extremely high doses of vitamin D (usually in the range of >50,000-100,000 IU/d for months to years).^^