Installing cx_Oracle for Python/ Mac OSX Portions taken from http://www.cs.utexas.edu/~mitra/csSpring2011/cs327/cx_mac.html (in case that link ever dies.) Assume you've got homebrew installed. Download the following files from Oracle instantclient-basic-$VERSION-macosx-x64.zip instantclient-sdk-$VERSION-macosx-x64.zip