conversion.py

def ic50_in_nM_to_pic50(nM):
    try:
        return 9.0 - math.log10(float(nM))
    except Exception as e:
        return 0.0
           
def ic50_in_uM_to_pic50(uM):
    nM = uM * 1000
    return ic50_in_nM_to_pic50(nM)
    
def Ki_in_nM_to_pic50(nM):
    # correct according to Kalliokoski et al. using factor 2
    return ic50_in_nM_to_pic50(float(nM) * 2.0)
    
def Ki_in_uM_to_pic50(uM):
    nM = uM * 1000
    # correct according to Kalliokoski et al. using factor 2
    return ic50_in_nM_to_pic50(float(nM) * 2.0)
    
def pKi_to_pic50(pKi):
    # convert pKi to nM
    Ki_in_nM = 10.0**(9-float(pKi))
    # correct according to Kalliokoski et al. using factor 2
    return Ki_in_nM_to_pic50(Ki_in_nM * 2.0)