requirements.txt

twitter==1.10.0

Tweet.py

from twitter import *
from Tkinter import *

OAUTH_TOKEN = ""
OAUTH_SECRET = ""
CONSUMER_KEY = ""
CONSUMER_SECRET = ""

twitter = Twitter(
              auth=OAuth(OAUTH_TOKEN, OAUTH_SECRET,
	                       CONSUMER_KEY, CONSUMER_SECRET)
	           )

class App:

    def __init__(self, master):

        frame = Frame(master)
        frame.pack()

        self.button = Button(frame, text="QUIT", fg="red", command=frame.quit)
        self.button.pack(side=LEFT)

        self.Tweet = Button(frame, text="Tweet", command=self.tweet)
        self.Tweet.pack(side=LEFT)

    def tweet(self):
        twitter.statuses.update(status="Hey Guys, Good Times are coming to an end")

root = Tk()

app = App(root)

root.mainloop()