Full source solution for http://stackoverflow.com/questions/17180657/linq-to-entity-for-table-by-parametrs-in-dictionary

solution.cs

void Main()
{

  Dictionary<int,int> skillList = new Dictionary<int,int>();
   
  skillList.Add(1,1);
  skillList.Add(2,2);
  skillList.Add(3,1);
  skillList.Add(4,1);
   
  DataTable userSkills = new DataTable();
  userSkills.Columns.Add("UserSkillId", typeof(int));
  userSkills.Columns.Add("UserId", typeof(int));
  userSkills.Columns.Add("SkillId", typeof(int));
  userSkills.Columns.Add("SkillLevelId", typeof(int));

  userSkills.Rows.Add(1, 1, 1, 1);
  userSkills.Rows.Add(2, 1, 2, 2);
  userSkills.Rows.Add(3, 1, 3, 1);
  userSkills.Rows.Add(4, 1, 4, 1);
 
  userSkills.Rows.Add(5, 2, 1, 3);
  userSkills.Rows.Add(6, 2, 2, 3);
  userSkills.Rows.Add(7, 2, 3, 3);
  userSkills.Rows.Add(8, 2, 4, 3);

  userSkills.Rows.Add(9, 3, 1, 1);
  userSkills.Rows.Add(10, 3, 2, 2);
  userSkills.Rows.Add(11, 3, 3, 1);
  userSkills.Rows.Add(12, 3, 4, 1);
                                      
  var result = userSkills.AsEnumerable()
      .GroupBy(userRow => userRow.Field<int>("UserId"))
      .Where(userGroup => userGroup
                .Join(skillList,
                      user => new { sID = user.Field<int>("SkillId"), slID = user.Field<int>("SkillLevelId") },
                      skill => new { sID = skill.Key, slID = skill.Value },
                      (user, skill) => true).Count() == skillList.Count())
      .Select(match => new { userID = match.Key });
                                      
  result.Dump();
}

To test load full file in LinqPad, set to program and hit the run button.