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calculate coverage of features in a Feature RDD using binning
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def featureCoverage(reference: RDD[Feature],reads: RDD[AlignmentRecord],bins:Int): RDD[(String, Iterable[Double])] = { | |
val getBinsForward = for{ | |
feature <- reference | |
bin = bins | |
interval = ((((feature.getEnd.toDouble-feature.getStart.toDouble)/bin).toDouble).ceil).toInt | |
strand = feature.getFeatureType.toString | |
start = feature.getStart.toInt | |
end = feature.getEnd.toInt | |
refName = feature.getContig.getContigName.toString | |
identifier = feature.getFeatureId.toString | |
i <- 0 until bin if strand == "+" | |
newStart = start + i*interval | |
newEnd = (newStart + interval) | |
newFeature = Feature.newBuilder.setStart(newStart).setEnd(newEnd).setFeatureId(identifier+"."+i).build | |
binnedRefRegionForward = (ReferenceRegion(refName, newStart,newEnd),newFeature) | |
} yield binnedRefRegionForward | |
val getBinsReverse = for{ | |
feature <- reference | |
bin = bins | |
interval = ((((feature.getEnd.toDouble-feature.getStart.toDouble)/bin).toDouble).ceil).toInt | |
strand = feature.getFeatureType | |
start = feature.getStart.toInt | |
end = feature.getEnd.toInt | |
refName = feature.getContig.getContigName.toString | |
identifier = feature.getFeatureId.toString | |
i <- bin-1 to 0 by -1 if strand == "-" | |
newEnd = (end - i*interval) | |
newStart = newEnd - interval | |
newFeature = Feature.newBuilder.setStart(newStart).setEnd(newEnd).setFeatureId(identifier+"."+i).build | |
binnedRefRegionReverse = (ReferenceRegion(refName, newStart,newEnd),newFeature) | |
} yield binnedRefRegionReverse | |
val getBins = getBinsForward.union(getBinsReverse) | |
val rMap = reads.map(r => ReferenceRegion(r) -> r) | |
val r = BroadcastRegionJoin.partitionAndJoin(getBins, rMap) | |
val numReadsPerFeature = r.map(_._1 -> 1.toDouble).reduceByKey(_ + _) | |
val featureCov = for(cov <- numReadsPerFeature) yield ((cov._1.getFeatureId.split('.')(0),cov._1.getFeatureId.split('.')(1)),cov._2.toDouble) | |
val nullCov = for{ | |
availFeatures <- featureCov | |
i <- 0 until bins} yield ((availFeatures._1._1,i.toString),0.toDouble) | |
val allCov = featureCov.union(nullCov.reduceByKey(_+_)).reduceByKey(_+_) | |
val featureCovArray = allCov.sortBy(_._1).groupBy(_._1._1).mapValues(_.map(_._2)) | |
val emptyCov = for{i <- 1 to reference.count().toInt-featureCovArray.count().toInt} yield (java.util.UUID.randomUUID.toString,Iterable.fill(bins)(0.toDouble)) | |
featureCovArray.union(sc.parallelize(emptyCov)) | |
} |
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