Eat my shorts, auto layout.

arrangeSubviews.m

#pragma mark - Rearrange the subviews

- (void)setFrame:(CGRect)frame {
	[super setFrame:frame];
	[self arrangeSubviews];
}

- (void)arrangeSubviews {

	// Cover image frame
	self.coverImageView.frame = CGRectMake( 15.0, 20.0, 100.0, 131.0 );

	// Determine the size for the labels
	CGFloat maxWidth = ( CGRectGetWidth( self.frame ) - 40.0 ) - CGRectGetWidth( self.coverImageView.frame );
	CGSize titleSize = [self.titleLabel sizeThatFits:CGSizeMake( maxWidth, 100.0 )];
	CGSize subtitleSize = [self.subtitleLabel sizeThatFits:CGSizeMake( maxWidth, 100.0 )];
	CGSize descriptionSize = [self.descriptionLabel sizeThatFits:CGSizeMake( maxWidth, 100.0 )];

	// We break after the colon if the title exceeds one line.
	if( titleSize.height > 20 ) {
		self.titleLabel.text = [self.titleLabel.text stringByReplacingOccurrencesOfString:@": " withString:@":\n"];
		titleSize = [self.titleLabel sizeThatFits:CGSizeMake( maxWidth, 100.0 )];
	}

	// Update the label frames
	CGFloat left = CGRectGetMaxX( self.coverImageView.frame ) + 10.0;
	CGFloat spacing = 3.0;
	self.titleLabel.frame = CGRectMake( left, 20.0, titleSize.width, titleSize.height );
	self.subtitleLabel.frame = CGRectMake( left, CGRectGetMaxY( self.titleLabel.frame ) + spacing, subtitleSize.width, subtitleSize.height );
	self.descriptionLabel.frame = CGRectMake( left, CGRectGetMaxY( self.subtitleLabel.frame ) + spacing, descriptionSize.width, descriptionSize.height );

	// Figure out the total height
	[super setFrame:CGRectWithHeight( self.frame, MAX( CGRectGetMaxY( self.coverImageView.frame ), CGRectGetMaxY( self.descriptionLabel.frame ) ) )];

	// Re-set the colours because sometimes the get confused.
	self.titleLabel.textColor = UIColor.coverHeaderTextColor;
	self.subtitleLabel.textColor = UIColor.coverHeaderTextColor;
	self.descriptionLabel.textColor = UIColor.coverHeaderTextColor;

}

The code above rearranges a set of views: a UIImageView and three UILabels to match the following layout. I've highlighted labels (yellow) and the superview (purple) for clarity.