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fitGlyRke4.py experiments
Data loaded from file: ../../DCPYPS/dcpyps/samples/glydemo/keA.scn
Concentration of agonist = 300.000 microMolar
Resolution for HJC calculations = 40.0 microseconds
Critical gap length to define end of group (tcrit) = 0.600 milliseconds
(defined so that all openings in a group prob come from same channel)
Initial and final vectors for bursts calculated asin Colquhoun, Hawkes & Srodzinski, (1996, eqs 5.8, 5.11).
Number of resolved intervals = 11662
Number of resolved periods = 11088
Number of open periods = 5544
Mean and SD of open periods = 0.397568729 +/- 1.362546164 ms
Range of open periods from 0.040033814 ms to 83.755209722 ms
Number of shut intervals = 5544
Mean and SD of shut periods = 109.531529248 +/- 2942.205429077 ms
Range of shut periods from 0.040052371 ms to 204117.309570312 ms
Last shut period = 10.665501468 ms
Number of bursts = 4618
Average length = 0.504651324 ms
Range: 0.040 to 83.755 millisec
Average number of openings= 1.200519706
Data loaded from file: ../../DCPYPS/dcpyps/samples/glydemo/keB.scn
Concentration of agonist = 3000.000 microMolar
Resolution for HJC calculations = 40.0 microseconds
Critical gap length to define end of group (tcrit) = -70.000 milliseconds
(defined so that all openings in a group prob come from same channel)
Initial and final vectors for are calculated as for steady state openings and shuttings (this involves a slight approximation at start and end of bursts that are defined by shut times that have been set as bad).
Number of resolved intervals = 14296
Number of resolved periods = 12338
Number of open periods = 6169
Mean and SD of open periods = 0.568432008 +/- 0.781032231 ms
Range of open periods from 0.040003666 ms to 23.221036885 ms
Number of shut intervals = 6169
Mean and SD of shut periods = 3.801412648 +/- 35.561904311 ms
Range of shut periods from 0.040001163 ms to 2761.569499969 ms
Last shut period = 0.373572315 ms
Number of bursts = 3
Average length = 8038.560359078 ms
Range: 1572.336 to 17533.538 millisec
Average number of openings= 2056.333333333
Data loaded from file: ../../DCPYPS/dcpyps/samples/glydemo/keC.scn
Concentration of agonist = 30000.000 microMolar
Resolution for HJC calculations = 40.0 microseconds
Critical gap length to define end of group (tcrit) = -20.000 milliseconds
(defined so that all openings in a group prob come from same channel)
Initial and final vectors for are calculated as for steady state openings and shuttings (this involves a slight approximation at start and end of bursts that are defined by shut times that have been set as bad).
Number of resolved intervals = 7569
Number of resolved periods = 5810
Number of open periods = 2905
Mean and SD of open periods = 0.764939965 +/- 1.200268148 ms
Range of open periods from 0.040136722 ms to 20.713106598 ms
Number of shut intervals = 2905
Mean and SD of shut periods = 76.107278466 +/- 2832.809209824 ms
Range of shut periods from 0.037358772 ms to 109791.648864746 ms
Last shut period = 0.037358772 ms
Number of bursts = 5
Average length = 886.178571851 ms
Range: 0.222 to 2465.916 millisec
Average number of openings= 581.000000000
Data loaded from file: ../../DCPYPS/dcpyps/samples/glydemo/keD.scn
Concentration of agonist = 100000.000 microMolar
Resolution for HJC calculations = 40.0 microseconds
Critical gap length to define end of group (tcrit) = -20.000 milliseconds
(defined so that all openings in a group prob come from same channel)
Initial and final vectors for are calculated as for steady state openings and shuttings (this involves a slight approximation at start and end of bursts that are defined by shut times that have been set as bad).
Number of resolved intervals = 14723
Number of resolved periods = 12210
Number of open periods = 6105
Mean and SD of open periods = 0.888958726 +/- 1.245775257 ms
Range of open periods from 0.040174076 ms to 21.068737711 ms
Number of shut intervals = 6105
Mean and SD of shut periods = 5.588796455 +/- 134.609654546 ms
Range of shut periods from 0.037023197 ms to 7994.186401367 ms
Last shut period = 0.037023197 ms
Number of bursts = 25
Average length = 478.491306786 ms
Range: 0.073 to 3397.090 millisec
Average number of openings= 244.200000000
class dcpyps.Mechanism
Values of unit rates [1/sec]:
From A3F3O to A3F3 alpha3fff 164180.872344
From A3F3 to A3F3O beta3fff 879798.259388
From A3F2O to A3F2 alpha3ff 17631.1000954
From A3F2 to A3F2O beta3ff 75963.8340657
From A2F2O to A2F2 alpha2ff 18512.6542595
From A2F2 to A2F2O beta2ff 72165.6459847
From A3F1O to A3F1 alpha3f 19957.2751004
From A3F1 to A3F1O beta3f 302.572972131
From A2F1O to A2F1 alpha2f 20555.9927824
From A2F1 to A2F1O beta2f 293.495791624
From A1F1O to A1F1 alpha1f 21154.7104645
From A1F1 to A1F1O beta1f 284.418611117
From A3F3 to A3F2 gama3fff 11673.7928596
From A3F2 to A3F3 delta3fff 2585.56822991
From A3F2 to A2F2 3kff(-3) 26.209768672
From A2F2 to A3F2 kff(+3) 684.568191741
From A3F2 to A3F1 gama3ff 2862.00095617
From A3F1 to A3F2 delta3ff 1741.88100927
From A2F2 to A2F1 gama2ff 11625.274006
From A2F1 to A2F2 delta2ff 8662.55618102
From A3F1 to A2F1 3kf(-3) 1436109.06916
From A2F1 to A3F1 kf(+3) 45923513.6955
From A3F1 to A3R gama3f 2473.77597999
From A3R to A3F1 delta3f 769.546855601
From A2F1 to A1F1 2kf(-2) 957406.04611
From A1F1 to A2F1 2kf(+2) 91847027.3909
From A2F1 to A2R gama2f 0.0997096333233
From A2R to A2F1 delta2f 0.027994525861
From A1F1 to A1R gama1f 7438.33684661
From A1R to A1F1 delta1f 1884.83412534
From A3R to A2R 3k(-3) 1507.83869722
From A2R to A3R k(+3) 43517.4928712
From A2R to A1R 2k(-2) 1005.22579814
From A1R to A2R 2k(+2) 87034.9857424
From A1R to R k(-1) 502.612899072
From R to A1R 3k(+1) 130552.478614
Conductance of state A3F3O (pS) = 50
Conductance of state A3F2O (pS) = 50
Conductance of state A2F2O (pS) = 50
Conductance of state A3F1O (pS) = 50
Conductance of state A2F1O (pS) = 50
Conductance of state A1F1O (pS) = 50
Number of open states = 6
Number of short-lived shut states (within burst) = 9
Number of long-lived shut states (between bursts) = 1
Number of desensitised states = 0
Number of cycles = 3
Cycle 1 is formed of states: A3F2 A2F2 A2F1 A3F1
forward product = 2.437361683e+16
backward product = 2.437361683e+16
Cycle 2 is formed of states: A3F1 A2F1 A2R A3R
forward product = 4.795384982e+12
backward product = 4.795384982e+12
Cycle 3 is formed of states: A2F1 A1F1 A1R A2R
forward product = 1.735157837e+13
backward product = 1.735157837e+13
Starting likelihood = 232502.287977
iteration # 100; log-lik = 232928.154662
[ 1.41924696e+05 9.91282568e+05 1.97840130e+04 7.82168302e+04
1.71306492e+04 7.68160837e+04 1.91299496e+04 3.29285607e+02
2.03109769e+04 3.21385337e+02 1.77876364e+04 3.07427710e+02
9.53885963e+03 3.14538983e+03 2.66831193e+01 2.88401102e+03
1.83802336e+03 9.93511657e+03 9.46742351e+03 4.79548708e+07
2.69765023e+03 9.59381397e+05 9.69674010e-02 2.95029655e-02
7.21696699e+03 4.79948914e+04 4.64842402e+02]
iteration # 200; log-lik = 232979.192057
[ 1.39959379e+05 1.17018226e+06 2.16700680e+04 7.53653081e+04
1.71029252e+04 7.68171076e+04 1.71190644e+04 3.42107973e+02
1.98215160e+04 3.28061884e+02 1.57404148e+04 3.69429873e+02
9.05588107e+03 2.93348168e+03 2.47742706e+01 2.66183859e+03
1.80308002e+03 9.82741621e+03 9.20819434e+03 4.89168093e+07
2.87111595e+03 9.56960899e+05 9.77159540e-02 3.00259005e-02
7.78208260e+03 4.73797799e+04 4.85791261e+02]
iteration # 300; log-lik = 233002.232358
[ 1.47312423e+05 1.12864285e+06 2.11448124e+04 7.36694063e+04
1.69317461e+04 7.74711685e+04 1.62870400e+04 3.92236574e+02
1.86587447e+04 3.48193383e+02 1.38161174e+04 4.13244661e+02
8.41526537e+03 2.83569328e+03 2.60822758e+01 2.44770496e+03
1.67354724e+03 9.51977339e+03 9.21709747e+03 4.62329996e+07
3.12459255e+03 9.75174512e+05 9.66457332e-02 2.93387769e-02
6.59904934e+03 4.70727221e+04 4.82397914e+02]
iteration # 400; log-lik = 233018.988138
[ 1.48644223e+05 1.25062179e+06 1.96390849e+04 7.13821925e+04
1.66352826e+04 7.76746330e+04 1.79133107e+04 4.21464957e+02
1.82306857e+04 3.83449704e+02 1.45437964e+04 4.31136662e+02
8.25161166e+03 2.74034750e+03 2.59165616e+01 2.29627631e+03
1.45026493e+03 9.53446236e+03 9.40284474e+03 4.72968854e+07
2.94066199e+03 9.44090357e+05 9.68547856e-02 2.88592808e-02
6.40567244e+03 4.66407464e+04 4.79943892e+02]
iteration # 500; log-lik = 233039.395788
[ 1.43921724e+05 1.32994457e+06 2.02449694e+04 6.68117594e+04
1.62172011e+04 7.94934703e+04 2.26566069e+04 5.29347681e+02
1.56810436e+04 4.50922832e+02 1.37971980e+04 4.71660034e+02
7.79209469e+03 2.60040045e+03 2.58362305e+01 1.98649454e+03
1.14826360e+03 9.86977844e+03 9.57688621e+03 4.71647054e+07
2.65861372e+03 8.73934049e+05 9.79258969e-02 2.91987287e-02
6.89841492e+03 4.51984767e+04 4.86336071e+02]
iteration # 600; log-lik = 233048.465860
[ 1.46262468e+05 1.28118709e+06 1.98733456e+04 6.65369686e+04
1.60324841e+04 7.98636684e+04 2.37706804e+04 6.30085713e+02
1.37892065e+04 4.95990174e+02 1.39243349e+04 5.00884359e+02
7.72789676e+03 2.63733775e+03 2.52296415e+01 1.89120845e+03
1.00135478e+03 9.99077801e+03 9.63004704e+03 4.87800502e+07
2.43395436e+03 8.51913920e+05 9.89014118e-02 2.94707396e-02
7.67575311e+03 4.49023615e+04 4.86137282e+02]
iteration # 700; log-lik = 233057.149323
[ 1.49512317e+05 1.23011740e+06 2.13138860e+04 6.79315040e+04
1.58888665e+04 8.01013199e+04 2.19366699e+04 7.27702613e+02
1.24049779e+04 5.27515813e+02 1.38621949e+04 5.62421214e+02
7.66341611e+03 2.79009095e+03 2.41159390e+01 1.80736481e+03
9.26036363e+02 9.97574384e+03 9.65850089e+03 4.96878513e+07
2.25527758e+03 8.29899324e+05 9.99611919e-02 3.03854219e-02
8.09623091e+03 4.53338548e+04 4.91714514e+02]
iteration # 800; log-lik = 233060.654072
[ 1.51402885e+05 1.16800642e+06 2.21648039e+04 6.90068340e+04
1.59982553e+04 7.92887719e+04 2.03651434e+04 7.86071809e+02
1.17987841e+04 5.45788246e+02 1.37135087e+04 5.68461400e+02
7.84646994e+03 2.95600780e+03 2.33945732e+01 1.76938109e+03
9.25737084e+02 9.85673993e+03 9.43903120e+03 4.95216116e+07
2.29888914e+03 8.15096090e+05 1.00533576e-01 3.01991878e-02
8.28623854e+03 4.57863064e+04 4.95039580e+02]
iteration # 900; log-lik = 233062.450423
[ 1.48141874e+05 1.14140374e+06 2.23716677e+04 6.85527156e+04
1.58599708e+04 7.94239596e+04 2.15671211e+04 8.22338534e+02
1.10904760e+04 5.64504346e+02 1.39878590e+04 5.58343931e+02
7.85790191e+03 2.96424252e+03 2.37553581e+01 1.71113928e+03
9.07245431e+02 9.97564384e+03 9.45234039e+03 4.91590432e+07
2.25573386e+03 8.04936581e+05 1.00595126e-01 3.01130966e-02
8.37852225e+03 4.56664346e+04 4.91602787e+02]
iteration # 1000; log-lik = 233065.495431
[ 1.48804115e+05 1.07812110e+06 2.37091142e+04 6.88080258e+04
1.55781518e+04 7.93410420e+04 2.24777392e+04 9.35575705e+02
9.00960759e+03 6.37900169e+02 1.41156098e+04 5.59462899e+02
7.69678557e+03 3.11874688e+03 2.43908467e+01 1.57122986e+03
8.72350317e+02 1.00211476e+04 9.34231224e+03 4.64133282e+07
2.30456767e+03 7.63399960e+05 1.02357514e-01 3.02529138e-02
8.26298275e+03 4.58105792e+04 4.90138216e+02]
iteration # 1100; log-lik = 233070.110392
[ 1.46828452e+05 9.88461558e+05 2.47264040e+04 6.84627358e+04
1.51382532e+04 7.86007127e+04 2.36739665e+04 1.06013101e+03
6.15754895e+03 7.41703545e+02 1.48154493e+04 5.26033863e+02
7.44409643e+03 3.24714750e+03 2.62198276e+01 1.44435304e+03
8.90554632e+02 1.01414074e+04 9.39117570e+03 4.10152850e+07
2.63014887e+03 7.29553747e+05 1.04103859e-01 3.04145924e-02
7.80511749e+03 4.61691965e+04 4.94014435e+02]
iteration # 1200; log-lik = 233072.588350
[ 1.52109628e+05 9.70062495e+05 2.49902197e+04 6.83171048e+04
1.48738570e+04 7.78757571e+04 2.37557746e+04 1.14961403e+03
5.18320318e+03 8.23108752e+02 1.53445220e+04 5.20637322e+02
7.56306392e+03 3.44776661e+03 2.67748348e+01 1.36084107e+03
8.66139638e+02 1.02333363e+04 9.45962292e+03 3.90671057e+07
2.65025002e+03 7.08083409e+05 1.05247616e-01 3.05739238e-02
7.57159709e+03 4.63029302e+04 4.95595990e+02]
iteration # 1300; log-lik = 233075.301533
[ 1.66086080e+05 9.65310365e+05 2.54242231e+04 6.86107154e+04
1.49695403e+04 7.77883401e+04 2.23263610e+04 1.15480710e+03
5.27092594e+03 8.65080843e+02 1.52156919e+04 5.00137610e+02
7.31378999e+03 3.66634354e+03 2.76928269e+01 1.32122551e+03
8.67621608e+02 1.02774316e+04 9.42624621e+03 3.61871706e+07
2.70586045e+03 6.80767948e+05 1.05542569e-01 3.06555792e-02
7.31739795e+03 4.62567347e+04 4.95444934e+02]
iteration # 1400; log-lik = 233078.387294
[ 1.78712661e+05 9.58230317e+05 2.55523672e+04 6.83924684e+04
1.48196710e+04 7.74556422e+04 2.14015908e+04 1.25221797e+03
5.01657531e+03 9.58872219e+02 1.50399245e+04 4.90137925e+02
7.36835707e+03 3.95480647e+03 2.81543293e+01 1.22997990e+03
8.38564855e+02 1.02480296e+04 9.49433778e+03 3.40103824e+07
2.69876989e+03 6.55874822e+05 1.06207435e-01 3.05068201e-02
7.05400919e+03 4.62609229e+04 4.97293960e+02]
iteration # 1500; log-lik = 233088.714461
[ 2.34118220e+05 1.02717175e+06 2.61505498e+04 6.55074959e+04
1.45181772e+04 7.76493768e+04 2.25441698e+04 1.27879574e+03
5.29057185e+03 1.23831672e+03 1.51439906e+04 4.09877188e+02
7.04769672e+03 5.04597610e+03 3.23238689e+01 9.87999730e+02
7.54543076e+02 1.04613771e+04 9.62424563e+03 2.53503023e+07
2.78680516e+03 5.61209856e+05 1.06991720e-01 3.09720830e-02
6.31249593e+03 4.48073561e+04 4.88339586e+02]
iteration # 1600; log-lik = 233098.368190
[ 3.16342090e+05 1.23448529e+06 2.64614166e+04 6.06584389e+04
1.38487340e+04 7.72141824e+04 2.35193038e+04 1.31475945e+03
5.53047572e+03 1.66142106e+03 1.51645013e+04 3.72238947e+02
6.88366962e+03 6.50465218e+03 3.56972763e+01 7.52476142e+02
6.21342857e+02 1.05267358e+04 9.78474120e+03 1.88984120e+07
3.02419186e+03 4.68803907e+05 1.08103957e-01 3.16089483e-02
5.88398693e+03 4.31283721e+04 4.89108570e+02]
iteration # 1700; log-lik = 233102.354114
[ 3.38999208e+05 1.20973797e+06 2.54083467e+04 5.97522425e+04
1.36200097e+04 7.69786989e+04 2.32738837e+04 1.47292370e+03
5.64390939e+03 1.85005419e+03 1.49324400e+04 3.77483446e+02
6.37549371e+03 6.72056627e+03 3.69162444e+01 6.90971452e+02
5.48549774e+02 1.03739448e+04 9.82836187e+03 1.75478463e+07
3.23836427e+03 4.48322116e+05 1.08389909e-01 3.13877796e-02
5.75418581e+03 4.25887218e+04 4.87563870e+02]
iteration # 1800; log-lik = 233105.816071
[ 3.27545388e+05 1.20413284e+06 2.50498360e+04 5.92421713e+04
1.34450147e+04 7.62767011e+04 2.47483146e+04 1.48307980e+03
5.43776239e+03 1.90706579e+03 1.51734412e+04 3.82931873e+02
6.68477354e+03 6.88322197e+03 3.59378486e+01 6.87220876e+02
5.31767438e+02 1.02525134e+04 9.73948985e+03 1.74148697e+07
3.18233146e+03 4.46197126e+05 1.08762685e-01 3.11838802e-02
5.96710158e+03 4.28518018e+04 4.92404354e+02]
iteration # 1900; log-lik = 233109.352055
[ 3.72055646e+05 1.23049634e+06 2.43520934e+04 5.81383202e+04
1.30392391e+04 7.50453064e+04 2.56949364e+04 1.60899870e+03
4.80598341e+03 2.28426187e+03 1.51964469e+04 3.73944934e+02
6.47355845e+03 7.57759393e+03 3.64370038e+01 6.36508205e+02
4.76247391e+02 1.02379131e+04 9.71046685e+03 1.55652983e+07
3.33545935e+03 4.15913716e+05 1.09573328e-01 3.12469049e-02
5.91487711e+03 4.29991632e+04 5.00993501e+02]
iteration # 2000; log-lik = 233113.229377
[ 4.01167273e+05 1.34202268e+06 2.36280227e+04 5.72971136e+04
1.27631642e+04 7.45745153e+04 2.92913423e+04 1.57499587e+03
4.89096156e+03 2.52490376e+03 1.49494378e+04 3.83876153e+02
6.51309124e+03 7.60987621e+03 3.48358616e+01 6.30193092e+02
4.37802749e+02 1.01497442e+04 9.59179895e+03 1.49474303e+07
3.05643943e+03 3.81556624e+05 1.10162352e-01 3.18069100e-02
6.65850383e+03 4.31238267e+04 5.10967091e+02]
iteration # 2100; log-lik = 233117.241846
[ 4.66081812e+05 1.44558194e+06 2.37573938e+04 5.67169329e+04
1.23726761e+04 7.38022048e+04 3.19478062e+04 1.58474033e+03
4.88588309e+03 3.02004421e+03 1.47298592e+04 3.74484645e+02
6.29902431e+03 7.99507730e+03 3.51125437e+01 5.81843101e+02
3.90758208e+02 1.02393572e+04 9.52027316e+03 1.28899179e+07
2.99215445e+03 3.31829016e+05 1.11930443e-01 3.21319952e-02
6.77027633e+03 4.32785899e+04 5.21020981e+02]
iteration # 2200; log-lik = 233126.839909
[ 6.17793005e+05 1.69238755e+06 2.56289667e+04 5.76110854e+04
1.10517286e+04 7.23873220e+04 3.87620255e+04 1.68856986e+03
4.47673512e+03 4.62142497e+03 1.48213355e+04 3.94603541e+02
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iteration # 2300; log-lik = 233133.813281
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iteration # 2400; log-lik = 233135.695276
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iteration # 2500; log-lik = 233136.831060
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iteration # 2600; log-lik = 233138.456119
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iteration # 2700; log-lik = 233139.361638
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iteration # 2800; log-lik = 233139.839857
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iteration # 2900; log-lik = 233140.254281
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iteration # 3000; log-lik = 233141.048428
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iteration # 3100; log-lik = 233141.844952
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iteration # 3200; log-lik = 233142.643585
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iteration # 3300; log-lik = 233143.624095
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iteration # 3400; log-lik = 233144.116111
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iteration # 3500; log-lik = 233144.661394
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iteration # 3600; log-lik = 233144.849162
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iteration # 3700; log-lik = 233144.975757
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iteration # 3800; log-lik = 233145.024746
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iteration # 3900; log-lik = 233145.143485
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iteration # 4000; log-lik = 233145.329902
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iteration # 4100; log-lik = 233145.466481
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iteration # 4200; log-lik = 233145.579027
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iteration # 4300; log-lik = 233145.677676
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iteration # 4500; log-lik = 233145.828877
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iteration # 4600; log-lik = 233145.896551
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iteration # 4700; log-lik = 233146.032343
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iteration # 4800; log-lik = 233146.123677
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iteration # 4900; log-lik = 233146.188024
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iteration # 5000; log-lik = 233146.275565
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iteration # 5100; log-lik = 233146.404584
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iteration # 5200; log-lik = 233146.752625
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iteration # 5300; log-lik = 233147.214224
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iteration # 5400; log-lik = 233147.761666
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iteration # 5500; log-lik = 233148.024699
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iteration # 5600; log-lik = 233148.236252
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iteration # 5700; log-lik = 233148.411315
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iteration # 5800; log-lik = 233148.470665
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iteration # 5900; log-lik = 233148.491486
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iteration # 6000; log-lik = 233148.501947
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iteration # 6100; log-lik = 233148.508076
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iteration # 6200; log-lik = 233148.517431
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iteration # 6300; log-lik = 233148.540807
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iteration # 6400; log-lik = 233148.558988
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iteration # 6500; log-lik = 233148.585978
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iteration # 6600; log-lik = 233148.690998
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iteration # 6700; log-lik = 233148.800957
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iteration # 6800; log-lik = 233148.995978
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iteration # 6900; log-lik = 233149.085682
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iteration # 7000; log-lik = 233149.160933
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iteration # 7100; log-lik = 233149.196825
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iteration # 7200; log-lik = 233149.208088
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iteration # 7300; log-lik = 233149.219763
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iteration # 7400; log-lik = 233149.227441
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iteration # 7500; log-lik = 233149.235125
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iteration # 7600; log-lik = 233149.238833
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iteration # 8000; log-lik = 233149.244566
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iteration # 8100; log-lik = 233149.244889
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iteration # 8200; log-lik = 233149.246154
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iteration # 8300; log-lik = 233149.250288
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iteration # 8400; log-lik = 233149.255194
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iteration # 10000; log-lik = 233149.589964
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4.23090782e+03 5.74280113e+03 1.75974881e+04 4.90189965e+02
1.66420716e+05 6.03360043e+03 5.32934474e-01 5.19230525e+02
3.42121027e+02 1.41862155e+04 9.00500466e+03 1.80593933e+08
2.84761767e+03 3.97229424e+06 1.01116094e-01 2.72216394e-02
7.00123567e+03 5.61630467e+04 6.84785240e+02]
iteration # 20900; log-lik = 233154.190400
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6.31991979e+03 5.56462966e+04 3.60099197e+04 1.12410946e+03
4.22900936e+03 5.75202503e+03 1.75930343e+04 4.90684891e+02
1.65191279e+05 6.02603034e+03 5.36264365e-01 5.17640226e+02
3.41117079e+02 1.41812705e+04 9.00403426e+03 1.78868974e+08
2.85278774e+03 3.93364175e+06 1.01220889e-01 2.72239794e-02
7.00579419e+03 5.61741435e+04 6.84878418e+02]
iteration # 21000; log-lik = 233154.191898
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6.31730598e+03 5.56353724e+04 3.60635263e+04 1.12956096e+03
4.22888833e+03 5.74953433e+03 1.75809431e+04 4.90722181e+02
1.66083950e+05 6.03585707e+03 5.31458467e-01 5.17702789e+02
3.40990019e+02 1.41866731e+04 9.00831514e+03 1.79403046e+08
2.85586636e+03 3.94784956e+06 1.01152756e-01 2.71983756e-02
7.00370114e+03 5.62252497e+04 6.85494049e+02]
iteration # 21100; log-lik = 233154.192787
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6.32231979e+03 5.56606823e+04 3.61376954e+04 1.13326624e+03
4.22920866e+03 5.75031557e+03 1.75795334e+04 4.90358969e+02
1.65458958e+05 6.03825006e+03 5.34328541e-01 5.18268416e+02
3.41392547e+02 1.41816428e+04 9.00828987e+03 1.77991447e+08
2.85836669e+03 3.91816001e+06 1.01242304e-01 2.72165141e-02
7.00301895e+03 5.62053063e+04 6.85271077e+02]
iteration # 21200; log-lik = 233154.193257
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6.32533972e+03 5.56837982e+04 3.62224238e+04 1.13644451e+03
4.22883093e+03 5.75248522e+03 1.75782706e+04 4.90599608e+02
1.64960552e+05 6.04384737e+03 5.37809594e-01 5.18270213e+02
3.41244518e+02 1.41800358e+04 9.01113206e+03 1.76331393e+08
2.85875830e+03 3.88104942e+06 1.01341704e-01 2.72323844e-02
7.00698573e+03 5.62314454e+04 6.85598777e+02]
iteration # 21300; log-lik = 233154.193544
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4.22997842e+03 5.75118122e+03 1.75693869e+04 4.90605923e+02
1.64639648e+05 6.04585995e+03 5.39394910e-01 5.18510980e+02
3.41302007e+02 1.41798748e+04 9.01410046e+03 1.75526319e+08
2.85909907e+03 3.86341208e+06 1.01386750e-01 2.72424333e-02
7.00814904e+03 5.62169980e+04 6.85430929e+02]
iteration # 21400; log-lik = 233154.193849
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6.33318310e+03 5.57282816e+04 3.62884198e+04 1.13969384e+03
4.23008269e+03 5.74934821e+03 1.75634182e+04 4.90416320e+02
1.64164863e+05 6.04757620e+03 5.42486215e-01 5.19245913e+02
3.41624998e+02 1.41759961e+04 9.01334432e+03 1.74622141e+08
2.85946035e+03 3.84397955e+06 1.01447161e-01 2.72594938e-02
7.00722152e+03 5.61981946e+04 6.85166293e+02]
iteration # 21500; log-lik = 233154.194223
[ 2.52957460e+05 2.97707328e+07 2.79949195e+04 6.28596129e+04
6.33819569e+03 5.57537258e+04 3.62842711e+04 1.13789966e+03
4.23128002e+03 5.74762964e+03 1.75641012e+04 4.90448994e+02
1.63694767e+05 6.04964732e+03 5.47698490e-01 5.19814010e+02
3.41733144e+02 1.41723651e+04 9.01321428e+03 1.73380952e+08
2.85865218e+03 3.81478857e+06 1.01546861e-01 2.72856769e-02
7.00990758e+03 5.61732614e+04 6.84780077e+02]
iteration # 21600; log-lik = 233154.194499
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6.33701929e+03 5.57471990e+04 3.62333541e+04 1.13606120e+03
4.23052757e+03 5.74743629e+03 1.75605685e+04 4.90543557e+02
1.63985436e+05 6.04838710e+03 5.46775539e-01 5.20039771e+02
3.41607215e+02 1.41719062e+04 9.01186637e+03 1.73930308e+08
2.85806900e+03 3.82604636e+06 1.01524423e-01 2.72819275e-02
7.01034311e+03 5.61772454e+04 6.84806427e+02]
iteration # 21700; log-lik = 233154.194626
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6.33716961e+03 5.57438416e+04 3.61852185e+04 1.13455100e+03
4.23027793e+03 5.74703716e+03 1.75647518e+04 4.90660508e+02
1.64127400e+05 6.04777599e+03 5.47338219e-01 5.20296455e+02
3.41648505e+02 1.41712799e+04 9.01188276e+03 1.73874504e+08
2.85804446e+03 3.82417748e+06 1.01538950e-01 2.72836930e-02
7.01096690e+03 5.61936721e+04 6.84977128e+02]
iteration # 21800; log-lik = 233154.194912
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6.33530367e+03 5.57358968e+04 3.62137760e+04 1.13485380e+03
4.23166470e+03 5.74345779e+03 1.75606658e+04 4.90584358e+02
1.64736234e+05 6.04984009e+03 5.43634440e-01 5.20725663e+02
3.41489975e+02 1.41761977e+04 9.01450440e+03 1.74753347e+08
2.85655710e+03 3.84323646e+06 1.01468593e-01 2.72740777e-02
7.01043426e+03 5.62124243e+04 6.85304074e+02]
iteration # 21900; log-lik = 233154.195091
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6.33591875e+03 5.57386780e+04 3.62226406e+04 1.13574316e+03
4.23154057e+03 5.74466838e+03 1.75640740e+04 4.90406224e+02
1.64455470e+05 6.04858377e+03 5.43674436e-01 5.20849783e+02
3.41364341e+02 1.41745166e+04 9.01343119e+03 1.74688662e+08
2.85689103e+03 3.84258798e+06 1.01464100e-01 2.72736056e-02
7.00832585e+03 5.62250514e+04 6.85512297e+02]
iteration # 22000; log-lik = 233154.195156
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6.33677107e+03 5.57444522e+04 3.62227133e+04 1.13498551e+03
4.23211786e+03 5.74458394e+03 1.75654315e+04 4.90453484e+02
1.64338060e+05 6.04771707e+03 5.44733344e-01 5.20931847e+02
3.41365908e+02 1.41743054e+04 9.01421539e+03 1.74443476e+08
2.85678752e+03 3.83724139e+06 1.01482946e-01 2.72802119e-02
7.00818280e+03 5.62139828e+04 6.85433160e+02]
iteration # 22100; log-lik = 233154.195238
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6.33633673e+03 5.57442312e+04 3.62319759e+04 1.13492075e+03
4.23329089e+03 5.74414366e+03 1.75666259e+04 4.90359806e+02
1.64553327e+05 6.04742070e+03 5.43845341e-01 5.20855758e+02
3.41282598e+02 1.41776595e+04 9.01719413e+03 1.74514005e+08
2.85763247e+03 3.83962577e+06 1.01479848e-01 2.72774813e-02
7.00647126e+03 5.62067067e+04 6.85370223e+02]
iteration # 22200; log-lik = 233154.195255
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6.33528376e+03 5.57372917e+04 3.62175095e+04 1.13431387e+03
4.23353638e+03 5.74293103e+03 1.75668659e+04 4.90354150e+02
1.64822436e+05 6.04674161e+03 5.42587634e-01 5.20940570e+02
3.41310474e+02 1.41798925e+04 9.01764743e+03 1.74894883e+08
2.85728955e+03 3.84789672e+06 1.01457316e-01 2.72729678e-02
7.00568683e+03 5.62122534e+04 6.85431261e+02]
iteration # 22300; log-lik = 233154.195260
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6.33574824e+03 5.57398627e+04 3.62139347e+04 1.13431055e+03
4.23359500e+03 5.74277964e+03 1.75675784e+04 4.90347170e+02
1.64730609e+05 6.04689125e+03 5.43202910e-01 5.21018933e+02
3.41350435e+02 1.41794441e+04 9.01722122e+03 1.74743364e+08
2.85745407e+03 3.84449495e+06 1.01468356e-01 2.72757983e-02
7.00518487e+03 5.62122200e+04 6.85413298e+02]
iteration # 22400; log-lik = 233154.195262
[ 2.53052397e+05 2.99893756e+07 2.79865707e+04 6.28722465e+04
6.33567901e+03 5.57396254e+04 3.62148966e+04 1.13425792e+03
4.23357620e+03 5.74306793e+03 1.75680263e+04 4.90369317e+02
1.64727866e+05 6.04715016e+03 5.43360392e-01 5.20994336e+02
3.41342599e+02 1.41794239e+04 9.01713808e+03 1.74691945e+08
2.85743397e+03 3.84320962e+06 1.01472799e-01 2.72765677e-02
7.00536783e+03 5.62133283e+04 6.85423384e+02]
iteration # 22500; log-lik = 233154.195263
[ 2.53054526e+05 2.99924775e+07 2.79864418e+04 6.28715898e+04
6.33546577e+03 5.57387722e+04 3.62158220e+04 1.13426137e+03
4.23356066e+03 5.74323487e+03 1.75680287e+04 4.90370285e+02
1.64748611e+05 6.04739576e+03 5.43294478e-01 5.20998319e+02
3.41342446e+02 1.41796374e+04 9.01713688e+03 1.74686127e+08
2.85746991e+03 3.84304839e+06 1.01473011e-01 2.72764603e-02
7.00530224e+03 5.62164249e+04 6.85457021e+02]
iteration # 22600; log-lik = 233154.195264
[ 2.53049229e+05 3.00052359e+07 2.79869213e+04 6.28715053e+04
6.33513334e+03 5.57367816e+04 3.62117894e+04 1.13409782e+03
4.23355462e+03 5.74324907e+03 1.75681190e+04 4.90364949e+02
1.64818956e+05 6.04738796e+03 5.43021557e-01 5.20984046e+02
3.41347206e+02 1.41800725e+04 9.01739402e+03 1.74754096e+08
2.85756023e+03 3.84460562e+06 1.01469166e-01 2.72751323e-02
7.00516197e+03 5.62177251e+04 6.85473059e+02]
iteration # 22700; log-lik = 233154.195264
[ 2.53049108e+05 3.00109849e+07 2.79868616e+04 6.28715148e+04
6.33488279e+03 5.57355889e+04 3.62105536e+04 1.13408309e+03
4.23351444e+03 5.74329597e+03 1.75678706e+04 4.90359491e+02
1.64849161e+05 6.04732239e+03 5.42811958e-01 5.20982794e+02
3.41350504e+02 1.41803057e+04 9.01733657e+03 1.74810634e+08
2.85757304e+03 3.84590781e+06 1.01465257e-01 2.72741657e-02
7.00501149e+03 5.62188945e+04 6.85488511e+02]
iteration # 22800; log-lik = 233154.195265
[ 2.53042157e+05 3.00148795e+07 2.79866707e+04 6.28713985e+04
6.33478111e+03 5.57347148e+04 3.62111598e+04 1.13414655e+03
4.23349806e+03 5.74323406e+03 1.75675986e+04 4.90359901e+02
1.64872887e+05 6.04733495e+03 5.42614022e-01 5.20990598e+02
3.41351931e+02 1.41803894e+04 9.01739553e+03 1.74855406e+08
2.85756312e+03 3.84692844e+06 1.01461387e-01 2.72734287e-02
7.00502933e+03 5.62200237e+04 6.85511130e+02]
iteration # 22900; log-lik = 233154.195265
[ 2.53050231e+05 3.00121750e+07 2.79865864e+04 6.28712280e+04
6.33483220e+03 5.57349930e+04 3.62111483e+04 1.13413710e+03
4.23352324e+03 5.74334531e+03 1.75676321e+04 4.90357659e+02
1.64852182e+05 6.04729524e+03 5.42730200e-01 5.20999476e+02
3.41364335e+02 1.41803411e+04 9.01737140e+03 1.74813889e+08
2.85758850e+03 3.84599631e+06 1.01464001e-01 2.72739820e-02
7.00509332e+03 5.62205885e+04 6.85518108e+02]
iteration # 23000; log-lik = 233154.195266
[ 2.53046366e+05 3.00109868e+07 2.79865036e+04 6.28714038e+04
6.33491455e+03 5.57351126e+04 3.62112140e+04 1.13412490e+03
4.23356600e+03 5.74315965e+03 1.75671555e+04 4.90351760e+02
1.64848697e+05 6.04727557e+03 5.42755763e-01 5.21027383e+02
3.41387677e+02 1.41802996e+04 9.01737551e+03 1.74804760e+08
2.85758159e+03 3.84576610e+06 1.01464342e-01 2.72742187e-02
7.00512549e+03 5.62204813e+04 6.85514848e+02]
iteration # 23100; log-lik = 233154.195266
[ 2.53049647e+05 3.00132476e+07 2.79866150e+04 6.28714776e+04
6.33483985e+03 5.57347253e+04 3.62110230e+04 1.13407508e+03
4.23359569e+03 5.74317455e+03 1.75671276e+04 4.90349825e+02
1.64859429e+05 6.04727310e+03 5.42716950e-01 5.21025427e+02
3.41385183e+02 1.41803799e+04 9.01738740e+03 1.74815078e+08
2.85757530e+03 3.84597009e+06 1.01463837e-01 2.72740563e-02
7.00509412e+03 5.62208944e+04 6.85518137e+02]
Optimization terminated successfully.
Current function value: -233154.195266
Iterations: 23165
Function evaluations: 28234
HJCFIT Fitting finished: 2016/02/11 11:39:11
CPU time in simplex= 2825.896872
Wallclock time in simplex= 2833.0548491477966
result=
final_simplex: (array([[ 12.44136064, 17.21711875, 10.23948459, 11.04884815,
8.75382305, 10.92835974, 10.49713103, 7.03360302,
8.3508114 , 8.65576619, 9.77378307, 6.19511159,
12.01279089, 8.70735769, -0.61117834, 6.25578846,
5.83300202, 9.55961217, 9.10690823, 18.97925377,
7.95772877, 15.1625547 , -2.28805903, -3.60182306,
8.85438668, 10.93704228, 6.53017519],
[ 12.44135748, 17.21709378, 10.23948313, 11.04884665,
8.75382514, 10.9283601 , 10.49713739, 7.03361079,
8.3508121 , 8.65576531, 9.77377938, 6.19510695,
12.0127695 , 8.70735967, -0.61116094, 6.25579308,
5.83300699, 9.55960981, 9.10690544, 18.97924569,
7.9577278 , 15.16254657, -2.28805956, -3.6018222 ,
8.85438257, 10.93704158, 6.53017461],
[ 12.44135392, 17.21709139, 10.23948269, 11.04884794,
8.75382599, 10.92836169, 10.49712334, 7.03359637,
8.35080984, 8.65576673, 9.77378482, 6.1951138 ,
12.01277372, 8.70735872, -0.61111866, 6.25579666,
5.83300647, 9.55961029, 9.1069054 , 18.97921475,
7.95772928, 15.1625144 , -2.28805304, -3.60181764,
8.85438328, 10.93704179, 6.53017348],
[ 12.44135811, 17.21707397, 10.23948123, 11.04884733,
8.75382704, 10.92836173, 10.4971383 , 7.03362021,
8.35080573, 8.65576609, 9.77377903, 6.19511229,
12.01275049, 8.70735964, -0.61113886, 6.25579637,
5.83300787, 9.55960817, 9.10690364, 18.97922346,
7.95772741, 15.16252367, -2.28805706, -3.60181964,
8.85438578, 10.93704423, 6.53017818],
[ 12.44135217, 17.21711131, 10.23948423, 11.04884731,
8.75382089, 10.92835927, 10.49713001, 7.03360448,
8.3508087 , 8.65577269, 9.77378525, 6.1951149 ,
12.01279564, 8.70736169, -0.61115656, 6.25579061,
5.83300638, 9.55961258, 9.10690611, 18.97922736,
7.95772921, 15.16252662, -2.28805423, -3.60182005,
8.85438618, 10.93704485, 6.5301773 ],
[ 12.44135536, 17.21709873, 10.23948172, 11.04884809,
8.7538267 , 10.92836166, 10.49712767, 7.03358936,
8.35081104, 8.65576679, 9.77378285, 6.19511628,
12.01277664, 8.70735812, -0.61111 , 6.25579761,
5.83301022, 9.55961015, 9.10690866, 18.97919419,
7.95772904, 15.16249268, -2.28805084, -3.60181608,
8.85438823, 10.9370424 , 6.53017536],
[ 12.44135702, 17.2170898 , 10.23948239, 11.0488476 ,
8.75382431, 10.92836088, 10.49713145, 7.03360987,
8.35080841, 8.6557707 , 9.77378262, 6.1951156 ,
12.01276621, 8.70735754, -0.61113651, 6.25579064,
5.83300583, 9.5596101 , 9.10690504, 18.97921887,
7.95772953, 15.16251944, -2.28805474, -3.60181938,
8.85438592, 10.93704286, 6.53017632],
[ 12.44134974, 17.21716117, 10.23948331, 11.04884811,
8.75381472, 10.92835443, 10.49712621, 7.03359348,
8.35080938, 8.65576665, 9.77378198, 6.19511284,
12.01284652, 8.70735866, -0.6112537 , 6.25578908,
5.83300624, 9.55961521, 9.10690717, 18.97931853,
7.95772785, 15.16261864, -2.28806561, -3.60182886,
8.85438501, 10.93704623, 6.53017912],
[ 12.44135149, 17.2171479 , 10.23948298, 11.04884743,
8.75381875, 10.92835683, 10.49711496, 7.03359385,
8.35080838, 8.65576705, 9.77377962, 6.19511056,
12.01282435, 8.70735506, -0.61122782, 6.25579228,
5.83300543, 9.55961289, 9.10690702, 18.97931173,
7.95772822, 15.16261407, -2.28806498, -3.6018283 ,
8.8543846 , 10.9370423 , 6.53017579],
[ 12.44134999, 17.21709154, 10.23948222, 11.04884829,
8.75382766, 10.92836227, 10.49713011, 7.03360657,
8.35081045, 8.65576632, 9.77378181, 6.19511166,
12.01277633, 8.70735836, -0.61112994, 6.25579814,
5.83301344, 9.55960984, 9.10690791, 18.97921049,
7.95772971, 15.16251142, -2.28805319, -3.60181804,
8.85438842, 10.93703926, 6.53017185],
[ 12.44135083, 17.21711494, 10.2394818 , 11.04884778,
8.75382213, 10.92835903, 10.49712864, 7.03360052,
8.35080884, 8.65576681, 9.77378103, 6.19511334,
12.01279883, 8.7073588 , -0.61117319, 6.25579784,
5.83301081, 9.55961173, 9.10690592, 18.97924856,
7.95772875, 15.16254895, -2.28805769, -3.60182144,
8.85438624, 10.93704425, 6.5301774 ],
[ 12.44135859, 17.2171202 , 10.23948298, 11.04884902,
8.75382112, 10.92835923, 10.49713144, 7.03359689,
8.35080901, 8.65577078, 9.77378239, 6.19511423,
12.01279573, 8.70735488, -0.61116919, 6.25578974,
5.83300481, 9.55961238, 9.10690731, 18.97923862,
7.95773098, 15.16253749, -2.28805603, -3.60182198,
8.85438851, 10.93704403, 6.53017691],
[ 12.44135174, 17.21711827, 10.239482 , 11.04884752,
8.75382369, 10.92836047, 10.49712774, 7.03359989,
8.35080912, 8.65576379, 9.77377917, 6.19511424,
12.01279978, 8.70735783, -0.61117149, 6.25579267,
5.83300477, 9.55961211, 9.10690868, 18.97925402,
7.95772946, 15.16255417, -2.28805851, -3.60182266,
8.85438612, 10.93704085, 6.53017327],
[ 12.44135489, 17.21710113, 10.23948166, 11.04884702,
8.75382448, 10.92836133, 10.49713848, 7.03360495,
8.3508103 , 8.65576912, 9.77378199, 6.19511527,
12.01278067, 8.70735975, -0.61114114, 6.25579434,
5.83300491, 9.55961157, 9.1069076 , 18.97921558,
7.95772623, 15.16251539, -2.28805419, -3.60181821,
8.85438801, 10.93704266, 6.53017615],
[ 12.44135308, 17.21712081, 10.23948179, 11.04884816,
8.75382302, 10.92835946, 10.4971227 , 7.03359507,
8.3508084 , 8.65576503, 9.77377918, 6.195116 ,
12.01280136, 8.70735776, -0.61117105, 6.25579672,
5.83300723, 9.55961132, 9.10690721, 18.97925332,
7.95772812, 15.16255188, -2.28805807, -3.60182197,
8.85438833, 10.93704397, 6.53017653],
[ 12.44135215, 17.21715054, 10.23948297, 11.0488471 ,
8.75381735, 10.92835775, 10.49711882, 7.03358023,
8.35081084, 8.65577206, 9.77378229, 6.19511599,
12.01283492, 8.70735959, -0.61118489, 6.25579015,
5.83300784, 9.55961557, 9.10690847, 18.9792589 ,
7.95772695, 15.16255579, -2.28805611, -3.60182242,
8.85439059, 10.93704197, 6.53017403],
[ 12.4413553 , 17.21710837, 10.23948268, 11.0488472 ,
8.75382142, 10.92835934, 10.49713101, 7.03360792,
8.35080803, 8.65577037, 9.773781 , 6.1951124 ,
12.01278917, 8.70736043, -0.61116976, 6.2557915 ,
5.83300675, 9.5596113 , 9.10690517, 18.97924508,
7.95772823, 15.1625461 , -2.28805777, -3.60182231,
8.854386 , 10.93704466, 6.53017685],
[ 12.4413448 , 17.21712016, 10.2394825 , 11.04884759,
8.75382109, 10.92835845, 10.49712173, 7.03359642,
8.35080762, 8.65577101, 9.77378375, 6.19511981,
12.0128102 , 8.70735773, -0.61116941, 6.25579109,
5.83300516, 9.55961137, 9.10690584, 18.979253 ,
7.95772622, 15.1625506 , -2.28805655, -3.60182185,
8.85439062, 10.93704312, 6.53017626],
[ 12.4413594 , 17.21706934, 10.23948205, 11.04884774,
8.7538273 , 10.92836294, 10.49713591, 7.03360874,
8.35080803, 8.65576985, 9.77377868, 6.19511411,
12.01274408, 8.70735687, -0.61110445, 6.25579677,
5.83300725, 9.55960783, 9.10690257, 18.97919877,
7.95772745, 15.16249636, -2.28805245, -3.60181604,
8.85438813, 10.93704137, 6.53017371],
[ 12.4413517 , 17.21709495, 10.23948372, 11.04884866,
8.75382572, 10.92836087, 10.49713033, 7.03359869,
8.35080973, 8.65576502, 9.77378132, 6.19511436,
12.0127776 , 8.70735645, -0.6111335 , 6.25579731,
5.83301355, 9.55961032, 9.10690614, 18.97921796,
7.95772846, 15.16251666, -2.28805391, -3.60181813,
8.85438733, 10.93704173, 6.53017402],
[ 12.44135478, 17.21710643, 10.2394824 , 11.04884755,
8.75382362, 10.92836049, 10.49712724, 7.03358971,
8.35080906, 8.65576931, 9.77378292, 6.19511459,
12.01278548, 8.70735839, -0.61113124, 6.25579219,
5.83300809, 9.55961118, 9.10690672, 18.97921712,
7.95773084, 15.16251901, -2.28805325, -3.60181876,
8.85438568, 10.93704099, 6.53017362],
[ 12.44135686, 17.21708879, 10.23948295, 11.04884774,
8.75382435, 10.92836099, 10.49713932, 7.03361167,
8.3508084 , 8.6557678 , 9.77378274, 6.1951139 ,
12.01276477, 8.70735827, -0.61114576, 6.25578838,
5.83300206, 9.55960917, 9.10690417, 18.97922978,
7.95772966, 15.16252961, -2.28805643, -3.6018205 ,
8.85438703, 10.93704245, 6.53017507],
[ 12.44135648, 17.21710252, 10.23948215, 11.04884553,
8.75382307, 10.92836038, 10.49713028, 7.03360479,
8.35080849, 8.65576869, 9.77378088, 6.1951148 ,
12.01278154, 8.70736273, -0.61114583, 6.25578884,
5.83300492, 9.55961182, 9.10690635, 18.97922689,
7.95773076, 15.16252741, -2.2880558 , -3.6018205 ,
8.85438528, 10.93704266, 6.53017551],
[ 12.44134983, 17.2170834 , 10.23948089, 11.04884701,
8.75382668, 10.92836192, 10.49712984, 7.03360731,
8.3508078 , 8.655769 , 9.7737816 , 6.19511444,
12.01277009, 8.70736155, -0.61111773, 6.25579755,
5.83301183, 9.55960953, 9.10690544, 18.97920354,
7.95772923, 15.16250466, -2.28805233, -3.60181703,
8.85438653, 10.93704086, 6.53017412],
[ 12.44135264, 17.21710385, 10.23948186, 11.04884645,
8.75382244, 10.92835879, 10.49712877, 7.03360142,
8.35080765, 8.65577037, 9.77378512, 6.19511325,
12.01278577, 8.70736035, -0.61115139, 6.25579308,
5.83301156, 9.5596107 , 9.1069056 , 18.97922637,
7.95773038, 15.16252714, -2.2880558 , -3.6018204 ,
8.85438733, 10.93704628, 6.5301792 ],
[ 12.44134657, 17.21709879, 10.2394815 , 11.04884855,
8.75382549, 10.92836053, 10.49713325, 7.03361049,
8.3508097 , 8.65576237, 9.77377822, 6.19511211,
12.01278669, 8.70735809, -0.61115807, 6.25580319,
5.83302033, 9.5596112 , 9.10690759, 18.97922701,
7.95772935, 15.16252807, -2.28805602, -3.60181987,
8.85438544, 10.93704351, 6.53017639],
[ 12.44134979, 17.21709371, 10.23948269, 11.04884733,
8.75382541, 10.92836151, 10.49713553, 7.03361042,
8.35080869, 8.65576934, 9.7737828 , 6.19511359,
12.0127782 , 8.70735986, -0.61114094, 6.25579486,
5.83300502, 9.55961026, 9.10690677, 18.97921982,
7.95772946, 15.16252128, -2.2880544 , -3.60181876,
8.85438479, 10.93704111, 6.530175 ],
[ 12.44135579, 17.21709085, 10.23948277, 11.04884736,
8.75382549, 10.92836162, 10.49712955, 7.03360033,
8.35080913, 8.65576941, 9.77378357, 6.19511326,
12.01277048, 8.70736004, -0.61112046, 6.25579397,
5.83301009, 9.55961008, 9.10690547, 18.97920778,
7.95772949, 15.16250776, -2.28805262, -3.60181705,
8.85438779, 10.93704051, 6.53017287]]), array([-233154.19526622, -233154.1952662 , -233154.1952662 ,
-233154.1952662 , -233154.1952662 , -233154.19526619,
-233154.19526619, -233154.19526619, -233154.19526618,
-233154.19526618, -233154.19526618, -233154.19526618,
-233154.19526618, -233154.19526617, -233154.19526617,
-233154.19526617, -233154.19526617, -233154.19526616,
-233154.19526616, -233154.19526616, -233154.19526616,
-233154.19526616, -233154.19526615, -233154.19526615,
-233154.19526614, -233154.19526614, -233154.19526614,
-233154.19526613]))
fun: -233154.19526622375
message: 'Optimization terminated successfully.'
nfev: 28234
nit: 23165
status: 0
success: True
x: array([ 12.44136064, 17.21711875, 10.23948459, 11.04884815,
8.75382305, 10.92835974, 10.49713103, 7.03360302,
8.3508114 , 8.65576619, 9.77378307, 6.19511159,
12.01279089, 8.70735769, -0.61117834, 6.25578846,
5.83300202, 9.55961217, 9.10690823, 18.97925377,
7.95772877, 15.1625547 , -2.28805903, -3.60182306,
8.85438668, 10.93704228, 6.53017519])
Final log-likelihood = 233154.195266
Number of iterations = 23165
Number of evaluations = 28234
Final rate constants:
class dcpyps.Mechanism
Values of unit rates [1/sec]:
From A3F3O to A3F3 alpha3fff 253054.622558
From A3F3 to A3F3O beta3fff 30012326.9388
From A3F2O to A3F2 alpha3ff 27986.6976893
From A3F2 to A3F2O beta3ff 62871.4945011
From A2F2O to A2F2 alpha2ff 6334.86033119
From A2F2 to A2F2O beta2ff 55734.7849606
From A3F1O to A3F1 alpha3f 36211.4638333
From A3F1 to A3F1O beta3f 1134.10948012
From A2F1O to A2F1 alpha2f 4233.61450596
From A2F1 to A2F1O beta2f 5743.16762327
From A1F1O to A1F1 alpha1f 17567.0992823
From A1F1 to A1F1O beta1f 490.346162057
From A3F3 to A3F2 gama3fff 164849.940257
From A3F2 to A3F3 delta3fff 6047.24269011
From A3F2 to A2F2 3kff(-3) 0.542710993044
From A2F2 to A3F2 kff(+3) 16.9450053348
From A3F2 to A3F1 gama3ff 521.020016436
From A3F1 to A3F2 delta3ff 341.381977735
From A2F2 to A2F1 gama2ff 14180.3456141
From A2F1 to A2F2 delta2ff 9017.37211441
From A3F1 to A2F1 3kf(-3) 5769060.54004
From A2F1 to A3F1 kf(+3) 174817611.294
From A3F1 to A3R gama3f 2857.57536123
From A3R to A3F1 delta3f 851.452655826
From A2F1 to A1F1 2kf(-2) 3846040.36003
From A1F1 to A2F1 2kf(+2) 349635222.587
From A2F1 to A2R gama2f 0.101463208104
From A2R to A2F1 delta2f 0.0272739550962
From A1F1 to A1R gama1f 7005.05060298
From A1R to A1F1 delta1f 1698.74240308
From A3R to A2R 3k(-3) 2056.55489459
From A2R to A3R k(+3) 56220.8116473
From A2R to A1R 2k(-2) 1371.03659639
From A1R to A2R 2k(+2) 112441.623295
From A1R to R k(-1) 685.518298197
From R to A1R 3k(+1) 168662.434942
Conductance of state A3F3O (pS) = 50
Conductance of state A3F2O (pS) = 50
Conductance of state A2F2O (pS) = 50
Conductance of state A3F1O (pS) = 50
Conductance of state A2F1O (pS) = 50
Conductance of state A1F1O (pS) = 50
Number of open states = 6
Number of short-lived shut states (within burst) = 9
Number of long-lived shut states (between bursts) = 1
Number of desensitised states = 0
Number of cycles = 3
Cycle 1 is formed of states: A3F2 A2F2 A2F1 A3F1
forward product = 4.592838838e+14
backward product = 4.592838838e+14
Cycle 2 is formed of states: A3F1 A2F1 A2R A3R
forward product = 2.802020459e+13
backward product = 2.802020459e+13
Cycle 3 is formed of states: A2F1 A1F1 A1R A2R
forward product = 8.262288248e+13
backward product = 8.262288248e+13
Data loaded from file: ../../DCPYPS/dcpyps/samples/glydemo/keA.scn
Concentration of agonist = 300.000 microMolar
Resolution for HJC calculations = 40.0 microseconds
Critical gap length to define end of group (tcrit) = 0.600 milliseconds
(defined so that all openings in a group prob come from same channel)
Initial and final vectors for bursts calculated asin Colquhoun, Hawkes & Srodzinski, (1996, eqs 5.8, 5.11).
Number of resolved intervals = 11662
Number of resolved periods = 11088
Number of open periods = 5544
Mean and SD of open periods = 0.397568729 +/- 1.362546164 ms
Range of open periods from 0.040033814 ms to 83.755209722 ms
Number of shut intervals = 5544
Mean and SD of shut periods = 109.531529248 +/- 2942.205429077 ms
Range of shut periods from 0.040052371 ms to 204117.309570312 ms
Last shut period = 10.665501468 ms
Number of bursts = 4618
Average length = 0.504651324 ms
Range: 0.040 to 83.755 millisec
Average number of openings= 1.200519706
Data loaded from file: ../../DCPYPS/dcpyps/samples/glydemo/keB.scn
Concentration of agonist = 3000.000 microMolar
Resolution for HJC calculations = 40.0 microseconds
Critical gap length to define end of group (tcrit) = -70.000 milliseconds
(defined so that all openings in a group prob come from same channel)
Initial and final vectors for are calculated as for steady state openings and shuttings (this involves a slight approximation at start and end of bursts that are defined by shut times that have been set as bad).
Number of resolved intervals = 14296
Number of resolved periods = 12338
Number of open periods = 6169
Mean and SD of open periods = 0.568432008 +/- 0.781032231 ms
Range of open periods from 0.040003666 ms to 23.221036885 ms
Number of shut intervals = 6169
Mean and SD of shut periods = 3.801412648 +/- 35.561904311 ms
Range of shut periods from 0.040001163 ms to 2761.569499969 ms
Last shut period = 0.373572315 ms
Number of bursts = 3
Average length = 8038.560359078 ms
Range: 1572.336 to 17533.538 millisec
Average number of openings= 2056.333333333
Data loaded from file: ../../DCPYPS/dcpyps/samples/glydemo/keC.scn
Concentration of agonist = 30000.000 microMolar
Resolution for HJC calculations = 40.0 microseconds
Critical gap length to define end of group (tcrit) = -20.000 milliseconds
(defined so that all openings in a group prob come from same channel)
Initial and final vectors for are calculated as for steady state openings and shuttings (this involves a slight approximation at start and end of bursts that are defined by shut times that have been set as bad).
Number of resolved intervals = 7569
Number of resolved periods = 5810
Number of open periods = 2905
Mean and SD of open periods = 0.764939965 +/- 1.200268148 ms
Range of open periods from 0.040136722 ms to 20.713106598 ms
Number of shut intervals = 2905
Mean and SD of shut periods = 76.107278466 +/- 2832.809209824 ms
Range of shut periods from 0.037358772 ms to 109791.648864746 ms
Last shut period = 0.037358772 ms
Number of bursts = 5
Average length = 886.178571851 ms
Range: 0.222 to 2465.916 millisec
Average number of openings= 581.000000000
Data loaded from file: ../../DCPYPS/dcpyps/samples/glydemo/keD.scn
Concentration of agonist = 100000.000 microMolar
Resolution for HJC calculations = 40.0 microseconds
Critical gap length to define end of group (tcrit) = -20.000 milliseconds
(defined so that all openings in a group prob come from same channel)
Initial and final vectors for are calculated as for steady state openings and shuttings (this involves a slight approximation at start and end of bursts that are defined by shut times that have been set as bad).
Number of resolved intervals = 14723
Number of resolved periods = 12210
Number of open periods = 6105
Mean and SD of open periods = 0.888958726 +/- 1.245775257 ms
Range of open periods from 0.040174076 ms to 21.068737711 ms
Number of shut intervals = 6105
Mean and SD of shut periods = 5.588796455 +/- 134.609654546 ms
Range of shut periods from 0.037023197 ms to 7994.186401367 ms
Last shut period = 0.037023197 ms
Number of bursts = 25
Average length = 478.491306786 ms
Range: 0.073 to 3397.090 millisec
Average number of openings= 244.200000000
class dcpyps.Mechanism
Values of unit rates [1/sec]:
From A3F3O to A3F3 alpha3fff 164180.872344
From A3F3 to A3F3O beta3fff 879798.259388
From A3F2O to A3F2 alpha3ff 17631.1000954
From A3F2 to A3F2O beta3ff 75963.8340657
From A2F2O to A2F2 alpha2ff 18512.6542595
From A2F2 to A2F2O beta2ff 72165.6459847
From A3F1O to A3F1 alpha3f 19957.2751004
From A3F1 to A3F1O beta3f 302.572972131
From A2F1O to A2F1 alpha2f 20555.9927824
From A2F1 to A2F1O beta2f 293.495791624
From A1F1O to A1F1 alpha1f 21154.7104645
From A1F1 to A1F1O beta1f 284.418611117
From A3F3 to A3F2 gama3fff 11673.7928596
From A3F2 to A3F3 delta3fff 2585.56822991
From A3F2 to A2F2 3kff(-3) 26.209768672
From A2F2 to A3F2 kff(+3) 684.568191741
From A3F2 to A3F1 gama3ff 2862.00095617
From A3F1 to A3F2 delta3ff 1741.88100927
From A2F2 to A2F1 gama2ff 11625.274006
From A2F1 to A2F2 delta2ff 8662.55618102
From A3F1 to A2F1 3kf(-3) 1436109.06916
From A2F1 to A3F1 kf(+3) 45923513.6955
From A3F1 to A3R gama3f 2473.77597999
From A3R to A3F1 delta3f 769.546855601
From A2F1 to A1F1 2kf(-2) 957406.04611
From A1F1 to A2F1 2kf(+2) 91847027.3909
From A2F1 to A2R gama2f 0.0997096333233
From A2R to A2F1 delta2f 0.027994525861
From A1F1 to A1R gama1f 7438.33684661
From A1R to A1F1 delta1f 1884.83412534
From A3R to A2R 3k(-3) 1507.83869722
From A2R to A3R k(+3) 43517.4928712
From A2R to A1R 2k(-2) 1005.22579814
From A1R to A2R 2k(+2) 87034.9857424
From A1R to R k(-1) 502.612899072
From R to A1R 3k(+1) 130552.478614
Conductance of state A3F3O (pS) = 50
Conductance of state A3F2O (pS) = 50
Conductance of state A2F2O (pS) = 50
Conductance of state A3F1O (pS) = 50
Conductance of state A2F1O (pS) = 50
Conductance of state A1F1O (pS) = 50
Number of open states = 6
Number of short-lived shut states (within burst) = 9
Number of long-lived shut states (between bursts) = 1
Number of desensitised states = 0
Number of cycles = 3
Cycle 1 is formed of states: A3F2 A2F2 A2F1 A3F1
forward product = 2.437361683e+16
backward product = 2.437361683e+16
Cycle 2 is formed of states: A3F1 A2F1 A2R A3R
forward product = 4.795384982e+12
backward product = 4.795384982e+12
Cycle 3 is formed of states: A2F1 A1F1 A1R A2R
forward product = 1.735157837e+13
backward product = 1.735157837e+13
Starting likelihood = 232502.287977
iteration # 100; log-lik = 232928.154662
[ 1.41924696e+05 9.91282568e+05 1.97840130e+04 7.82168302e+04
1.71306492e+04 7.68160837e+04 1.91299496e+04 3.29285607e+02
2.03109769e+04 3.21385337e+02 1.77876364e+04 3.07427710e+02
9.53885963e+03 3.14538983e+03 2.66831193e+01 2.88401102e+03
1.83802336e+03 9.93511657e+03 9.46742351e+03 4.79548708e+07
2.69765023e+03 9.59381397e+05 9.69674010e-02 2.95029655e-02
7.21696699e+03 4.79948914e+04 4.64842402e+02]
iteration # 200; log-lik = 232979.192057
[ 1.39959379e+05 1.17018226e+06 2.16700680e+04 7.53653081e+04
1.71029252e+04 7.68171076e+04 1.71190644e+04 3.42107973e+02
1.98215160e+04 3.28061884e+02 1.57404148e+04 3.69429873e+02
9.05588107e+03 2.93348168e+03 2.47742706e+01 2.66183859e+03
1.80308002e+03 9.82741621e+03 9.20819434e+03 4.89168093e+07
2.87111595e+03 9.56960899e+05 9.77159540e-02 3.00259005e-02
7.78208260e+03 4.73797799e+04 4.85791261e+02]
iteration # 300; log-lik = 233002.232358
[ 1.47312423e+05 1.12864285e+06 2.11448124e+04 7.36694063e+04
1.69317461e+04 7.74711685e+04 1.62870400e+04 3.92236574e+02
1.86587447e+04 3.48193383e+02 1.38161174e+04 4.13244661e+02
8.41526537e+03 2.83569328e+03 2.60822758e+01 2.44770496e+03
1.67354724e+03 9.51977339e+03 9.21709747e+03 4.62329996e+07
3.12459255e+03 9.75174512e+05 9.66457332e-02 2.93387769e-02
6.59904934e+03 4.70727221e+04 4.82397914e+02]
iteration # 400; log-lik = 233018.988138
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1.66352826e+04 7.76746330e+04 1.79133107e+04 4.21464957e+02
1.82306857e+04 3.83449704e+02 1.45437964e+04 4.31136662e+02
8.25161166e+03 2.74034750e+03 2.59165616e+01 2.29627631e+03
1.45026493e+03 9.53446236e+03 9.40284474e+03 4.72968854e+07
2.94066199e+03 9.44090357e+05 9.68547856e-02 2.88592808e-02
6.40567244e+03 4.66407464e+04 4.79943892e+02]
iteration # 500; log-lik = 233039.395788
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1.62172011e+04 7.94934703e+04 2.26566069e+04 5.29347681e+02
1.56810436e+04 4.50922832e+02 1.37971980e+04 4.71660034e+02
7.79209469e+03 2.60040045e+03 2.58362305e+01 1.98649454e+03
1.14826360e+03 9.86977844e+03 9.57688621e+03 4.71647054e+07
2.65861372e+03 8.73934049e+05 9.79258969e-02 2.91987287e-02
6.89841492e+03 4.51984767e+04 4.86336071e+02]
iteration # 600; log-lik = 233048.465860
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1.60324841e+04 7.98636684e+04 2.37706804e+04 6.30085713e+02
1.37892065e+04 4.95990174e+02 1.39243349e+04 5.00884359e+02
7.72789676e+03 2.63733775e+03 2.52296415e+01 1.89120845e+03
1.00135478e+03 9.99077801e+03 9.63004704e+03 4.87800502e+07
2.43395436e+03 8.51913920e+05 9.89014118e-02 2.94707396e-02
7.67575311e+03 4.49023615e+04 4.86137282e+02]
iteration # 700; log-lik = 233057.149323
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1.58888665e+04 8.01013199e+04 2.19366699e+04 7.27702613e+02
1.24049779e+04 5.27515813e+02 1.38621949e+04 5.62421214e+02
7.66341611e+03 2.79009095e+03 2.41159390e+01 1.80736481e+03
9.26036363e+02 9.97574384e+03 9.65850089e+03 4.96878513e+07
2.25527758e+03 8.29899324e+05 9.99611919e-02 3.03854219e-02
8.09623091e+03 4.53338548e+04 4.91714514e+02]
iteration # 800; log-lik = 233060.654072
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1.59982553e+04 7.92887719e+04 2.03651434e+04 7.86071809e+02
1.17987841e+04 5.45788246e+02 1.37135087e+04 5.68461400e+02
7.84646994e+03 2.95600780e+03 2.33945732e+01 1.76938109e+03
9.25737084e+02 9.85673993e+03 9.43903120e+03 4.95216116e+07
2.29888914e+03 8.15096090e+05 1.00533576e-01 3.01991878e-02
8.28623854e+03 4.57863064e+04 4.95039580e+02]
iteration # 900; log-lik = 233062.450423
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1.58599708e+04 7.94239596e+04 2.15671211e+04 8.22338534e+02
1.10904760e+04 5.64504346e+02 1.39878590e+04 5.58343931e+02
7.85790191e+03 2.96424252e+03 2.37553581e+01 1.71113928e+03
9.07245431e+02 9.97564384e+03 9.45234039e+03 4.91590432e+07
2.25573386e+03 8.04936581e+05 1.00595126e-01 3.01130966e-02
8.37852225e+03 4.56664346e+04 4.91602787e+02]
iteration # 1000; log-lik = 233065.495431
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1.55781518e+04 7.93410420e+04 2.24777392e+04 9.35575705e+02
9.00960759e+03 6.37900169e+02 1.41156098e+04 5.59462899e+02
7.69678557e+03 3.11874688e+03 2.43908467e+01 1.57122986e+03
8.72350317e+02 1.00211476e+04 9.34231224e+03 4.64133282e+07
2.30456767e+03 7.63399960e+05 1.02357514e-01 3.02529138e-02
8.26298275e+03 4.58105792e+04 4.90138216e+02]
iteration # 1100; log-lik = 233070.110392
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1.51382532e+04 7.86007127e+04 2.36739665e+04 1.06013101e+03
6.15754895e+03 7.41703545e+02 1.48154493e+04 5.26033863e+02
7.44409643e+03 3.24714750e+03 2.62198276e+01 1.44435304e+03
8.90554632e+02 1.01414074e+04 9.39117570e+03 4.10152850e+07
2.63014887e+03 7.29553747e+05 1.04103859e-01 3.04145924e-02
7.80511749e+03 4.61691965e+04 4.94014435e+02]
iteration # 1200; log-lik = 233072.588350
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1.48738570e+04 7.78757571e+04 2.37557746e+04 1.14961403e+03
5.18320318e+03 8.23108752e+02 1.53445220e+04 5.20637322e+02
7.56306392e+03 3.44776661e+03 2.67748348e+01 1.36084107e+03
8.66139638e+02 1.02333363e+04 9.45962292e+03 3.90671057e+07
2.65025002e+03 7.08083409e+05 1.05247616e-01 3.05739238e-02
7.57159709e+03 4.63029302e+04 4.95595990e+02]
iteration # 1300; log-lik = 233075.301533
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1.49695403e+04 7.77883401e+04 2.23263610e+04 1.15480710e+03
5.27092594e+03 8.65080843e+02 1.52156919e+04 5.00137610e+02
7.31378999e+03 3.66634354e+03 2.76928269e+01 1.32122551e+03
8.67621608e+02 1.02774316e+04 9.42624621e+03 3.61871706e+07
2.70586045e+03 6.80767948e+05 1.05542569e-01 3.06555792e-02
7.31739795e+03 4.62567347e+04 4.95444934e+02]
iteration # 1400; log-lik = 233078.387294
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1.48196710e+04 7.74556422e+04 2.14015908e+04 1.25221797e+03
5.01657531e+03 9.58872219e+02 1.50399245e+04 4.90137925e+02
7.36835707e+03 3.95480647e+03 2.81543293e+01 1.22997990e+03
8.38564855e+02 1.02480296e+04 9.49433778e+03 3.40103824e+07
2.69876989e+03 6.55874822e+05 1.06207435e-01 3.05068201e-02
7.05400919e+03 4.62609229e+04 4.97293960e+02]
iteration # 1500; log-lik = 233088.714461
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1.45181772e+04 7.76493768e+04 2.25441698e+04 1.27879574e+03
5.29057185e+03 1.23831672e+03 1.51439906e+04 4.09877188e+02
7.04769672e+03 5.04597610e+03 3.23238689e+01 9.87999730e+02
7.54543076e+02 1.04613771e+04 9.62424563e+03 2.53503023e+07
2.78680516e+03 5.61209856e+05 1.06991720e-01 3.09720830e-02
6.31249593e+03 4.48073561e+04 4.88339586e+02]
iteration # 1600; log-lik = 233098.368190
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1.38487340e+04 7.72141824e+04 2.35193038e+04 1.31475945e+03
5.53047572e+03 1.66142106e+03 1.51645013e+04 3.72238947e+02
6.88366962e+03 6.50465218e+03 3.56972763e+01 7.52476142e+02
6.21342857e+02 1.05267358e+04 9.78474120e+03 1.88984120e+07
3.02419186e+03 4.68803907e+05 1.08103957e-01 3.16089483e-02
5.88398693e+03 4.31283721e+04 4.89108570e+02]
iteration # 1700; log-lik = 233102.354114
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1.36200097e+04 7.69786989e+04 2.32738837e+04 1.47292370e+03
5.64390939e+03 1.85005419e+03 1.49324400e+04 3.77483446e+02
6.37549371e+03 6.72056627e+03 3.69162444e+01 6.90971452e+02
5.48549774e+02 1.03739448e+04 9.82836187e+03 1.75478463e+07
3.23836427e+03 4.48322116e+05 1.08389909e-01 3.13877796e-02
5.75418581e+03 4.25887218e+04 4.87563870e+02]
iteration # 1800; log-lik = 233105.816071
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1.34450147e+04 7.62767011e+04 2.47483146e+04 1.48307980e+03
5.43776239e+03 1.90706579e+03 1.51734412e+04 3.82931873e+02
6.68477354e+03 6.88322197e+03 3.59378486e+01 6.87220876e+02
5.31767438e+02 1.02525134e+04 9.73948985e+03 1.74148697e+07
3.18233146e+03 4.46197126e+05 1.08762685e-01 3.11838802e-02
5.96710158e+03 4.28518018e+04 4.92404354e+02]
iteration # 1900; log-lik = 233109.352055
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1.30392391e+04 7.50453064e+04 2.56949364e+04 1.60899870e+03
4.80598341e+03 2.28426187e+03 1.51964469e+04 3.73944934e+02
6.47355845e+03 7.57759393e+03 3.64370038e+01 6.36508205e+02
4.76247391e+02 1.02379131e+04 9.71046685e+03 1.55652983e+07
3.33545935e+03 4.15913716e+05 1.09573328e-01 3.12469049e-02
5.91487711e+03 4.29991632e+04 5.00993501e+02]
iteration # 2000; log-lik = 233113.229377
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1.27631642e+04 7.45745153e+04 2.92913423e+04 1.57499587e+03
4.89096156e+03 2.52490376e+03 1.49494378e+04 3.83876153e+02
6.51309124e+03 7.60987621e+03 3.48358616e+01 6.30193092e+02
4.37802749e+02 1.01497442e+04 9.59179895e+03 1.49474303e+07
3.05643943e+03 3.81556624e+05 1.10162352e-01 3.18069100e-02
6.65850383e+03 4.31238267e+04 5.10967091e+02]
iteration # 2100; log-lik = 233117.241846
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1.23726761e+04 7.38022048e+04 3.19478062e+04 1.58474033e+03
4.88588309e+03 3.02004421e+03 1.47298592e+04 3.74484645e+02
6.29902431e+03 7.99507730e+03 3.51125437e+01 5.81843101e+02
3.90758208e+02 1.02393572e+04 9.52027316e+03 1.28899179e+07
2.99215445e+03 3.31829016e+05 1.11930443e-01 3.21319952e-02
6.77027633e+03 4.32785899e+04 5.21020981e+02]
iteration # 2200; log-lik = 233126.839909
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1.10517286e+04 7.23873220e+04 3.87620255e+04 1.68856986e+03
4.47673512e+03 4.62142497e+03 1.48213355e+04 3.94603541e+02
5.24585075e+03 7.40986484e+03 3.83170238e+01 4.61246479e+02
3.16160989e+02 1.07575188e+04 9.23358700e+03 8.20549796e+06
3.08401270e+03 2.15224409e+05 1.21026742e-01 3.37090438e-02
6.89897984e+03 4.38436611e+04 5.42760027e+02]
iteration # 2300; log-lik = 233133.813281
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1.04119546e+04 7.19689849e+04 4.12608639e+04 1.67188787e+03
4.40632645e+03 5.15564014e+03 1.52157553e+04 4.18720485e+02
5.04388833e+03 6.35900617e+03 3.86109409e+01 4.48151705e+02
3.18779174e+02 1.11364254e+04 8.88612212e+03 7.17357938e+06
2.99780758e+03 1.73668515e+05 1.27790997e-01 3.47977383e-02
6.91991809e+03 4.49324716e+04 5.47048628e+02]
iteration # 2400; log-lik = 233135.695276
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1.03017903e+04 7.17088666e+04 4.09030956e+04 1.68210508e+03
4.49217036e+03 5.09906026e+03 1.59180318e+04 4.20867623e+02
5.19279095e+03 6.11192320e+03 3.79956414e+01 4.55760722e+02
3.27535733e+02 1.12652468e+04 8.78772951e+03 7.12399606e+06
3.06465909e+03 1.68659964e+05 1.29228945e-01 3.50539277e-02
6.87993873e+03 4.56365657e+04 5.44340698e+02]
iteration # 2500; log-lik = 233136.831060
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1.02587073e+04 7.15015048e+04 4.21094456e+04 1.71194405e+03
4.49820959e+03 5.07443729e+03 1.59975671e+04 4.33784403e+02
5.27336911e+03 5.79818002e+03 3.66870855e+01 4.65774375e+02
3.31670482e+02 1.12635311e+04 8.75616622e+03 7.17551325e+06
3.00966630e+03 1.66390794e+05 1.29812989e-01 3.52727612e-02
7.05211833e+03 4.62127425e+04 5.47813427e+02]
iteration # 2600; log-lik = 233138.456119
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4.48100000e+03 5.30344942e+03 1.61555290e+04 4.30528798e+02
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3.04933554e+03 1.61424968e+05 1.30475560e-01 3.54400916e-02
7.05933041e+03 4.70591985e+04 5.57877182e+02]
iteration # 2700; log-lik = 233139.361638
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3.37550471e+02 1.11225319e+04 8.73078449e+03 7.40636685e+06
3.03009877e+03 1.71064880e+05 1.29392669e-01 3.50983772e-02
7.08610721e+03 4.75259144e+04 5.63618571e+02]
iteration # 2800; log-lik = 233139.839857
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6.09094962e+03 5.72533158e+03 3.11148808e+01 4.77971558e+02
3.34993350e+02 1.11478219e+04 8.71523705e+03 7.25917662e+06
3.01938704e+03 1.67314586e+05 1.30170516e-01 3.52512845e-02
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iteration # 2900; log-lik = 233140.254281
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4.52363469e+03 5.34282713e+03 1.69026248e+04 4.45856631e+02
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3.28916023e+02 1.11165917e+04 8.68975726e+03 7.42645904e+06
3.01818840e+03 1.69496101e+05 1.30202227e-01 3.52635972e-02
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iteration # 3000; log-lik = 233141.048428
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4.43689490e+03 5.43200892e+03 1.69527174e+04 4.45453287e+02
6.97832397e+03 5.88532082e+03 2.78937726e+01 4.85433382e+02
3.31444960e+02 1.11862333e+04 8.62090817e+03 7.48831417e+06
3.01370396e+03 1.71943427e+05 1.30841848e-01 3.52649492e-02
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iteration # 3100; log-lik = 233141.844952
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3.25926484e+02 1.12233671e+04 8.53207549e+03 8.04063511e+06
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iteration # 3200; log-lik = 233142.643585
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3.25967345e+02 1.13100039e+04 8.46412438e+03 8.19068015e+06
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iteration # 3300; log-lik = 233143.624095
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iteration # 3400; log-lik = 233144.116111
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iteration # 3500; log-lik = 233144.661394
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iteration # 3600; log-lik = 233144.849162
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iteration # 3700; log-lik = 233144.975757
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iteration # 3800; log-lik = 233145.024746
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iteration # 3900; log-lik = 233145.143485
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iteration # 4000; log-lik = 233145.329902
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iteration # 4100; log-lik = 233145.466481
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iteration # 4200; log-lik = 233145.579027
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iteration # 4300; log-lik = 233145.677676
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iteration # 4400; log-lik = 233145.764848
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iteration # 4500; log-lik = 233145.828877
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iteration # 4600; log-lik = 233145.896551
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iteration # 4700; log-lik = 233146.032343
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iteration # 4800; log-lik = 233146.123677
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iteration # 4900; log-lik = 233146.188024
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iteration # 5000; log-lik = 233146.275565
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iteration # 5100; log-lik = 233146.404584
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iteration # 5200; log-lik = 233146.752625
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iteration # 5300; log-lik = 233147.214224
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iteration # 5400; log-lik = 233147.761666
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iteration # 5500; log-lik = 233148.024699
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iteration # 5600; log-lik = 233148.236252
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iteration # 5700; log-lik = 233148.411315
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iteration # 5800; log-lik = 233148.470665
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iteration # 5900; log-lik = 233148.491486
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iteration # 6000; log-lik = 233148.501947
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iteration # 6100; log-lik = 233148.508076
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iteration # 6200; log-lik = 233148.517431
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iteration # 6300; log-lik = 233148.540807
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iteration # 6400; log-lik = 233148.558988
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iteration # 6500; log-lik = 233148.585978
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iteration # 6600; log-lik = 233148.690998
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iteration # 6700; log-lik = 233148.800957
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iteration # 6800; log-lik = 233148.995978
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iteration # 7000; log-lik = 233149.160933
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iteration # 7600; log-lik = 233149.237222
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iteration # 7700; log-lik = 233149.240819
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iteration # 7900; log-lik = 233149.244472
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iteration # 8000; log-lik = 233149.245403
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iteration # 8100; log-lik = 233149.247221
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iteration # 8200; log-lik = 233149.249009
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iteration # 8300; log-lik = 233149.251940
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iteration # 8400; log-lik = 233149.255261
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iteration # 8500; log-lik = 233149.261308
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iteration # 8800; log-lik = 233149.311914
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iteration # 9000; log-lik = 233149.357663
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iteration # 9100; log-lik = 233149.387948
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iteration # 9300; log-lik = 233149.510779
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iteration # 9400; log-lik = 233149.562445
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iteration # 9600; log-lik = 233149.890752
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iteration # 10000; log-lik = 233150.232121
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iteration # 15800; log-lik = 233155.684687
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iteration # 18900; log-lik = 233161.550565
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iteration # 22000; log-lik = 233161.596377
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iteration # 25100; log-lik = 233161.616417
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[ 3.31350222e+05 2.59551902e+08 2.65984920e+04 6.23757914e+04
3.23964693e+03 2.84751472e+04 4.34040266e+04 1.54885939e+03
4.35397320e+03 5.38727306e+03 1.76852415e+04 4.90736657e+02
1.12954125e+06 6.42294839e+03 7.63051165e-02 6.39622363e+02
4.19846863e+02 1.79346443e+04 1.22803725e+04 5.16918076e+08
3.05377561e+03 1.15238691e+07 1.07898364e-01 2.79147999e-02
7.45116832e+03 5.19315271e+04 6.26454846e+02]
iteration # 43800; log-lik = 233166.270283
[ 3.31353705e+05 2.59539542e+08 2.65986574e+04 6.23759619e+04
3.23961405e+03 2.84746275e+04 4.34011469e+04 1.54888623e+03
4.35392072e+03 5.38720687e+03 1.76852508e+04 4.90734915e+02
1.12948415e+06 6.42299272e+03 7.63107098e-02 6.39641720e+02
4.19861548e+02 1.79346362e+04 1.22804768e+04 5.16895719e+08
3.05382520e+03 1.15235228e+07 1.07898681e-01 2.79147740e-02
7.45109454e+03 5.19307748e+04 6.26442971e+02]
iteration # 43900; log-lik = 233166.270284
[ 3.31376653e+05 2.59536629e+08 2.65986557e+04 6.23762790e+04
3.23957677e+03 2.84741664e+04 4.34000296e+04 1.54887605e+03
4.35393259e+03 5.38717001e+03 1.76854215e+04 4.90724569e+02
1.12939909e+06 6.42300053e+03 7.63120253e-02 6.39643266e+02
4.19870315e+02 1.79345333e+04 1.22805344e+04 5.16881313e+08
3.05392175e+03 1.15234276e+07 1.07898145e-01 2.79146825e-02
7.45089436e+03 5.19312860e+04 6.26447088e+02]
iteration # 44000; log-lik = 233166.270284
[ 3.31365398e+05 2.59570221e+08 2.65985344e+04 6.23759844e+04
3.23953839e+03 2.84737366e+04 4.33987364e+04 1.54879088e+03
4.35394339e+03 5.38711768e+03 1.76853171e+04 4.90721929e+02
1.12958632e+06 6.42307700e+03 7.62973351e-02 6.39639004e+02
4.19863737e+02 1.79345116e+04 1.22806122e+04 5.16987266e+08
3.05392707e+03 1.15258108e+07 1.07895527e-01 2.79140349e-02
7.45085576e+03 5.19316638e+04 6.26450912e+02]
iteration # 44100; log-lik = 233166.270284
[ 3.31352318e+05 2.59589848e+08 2.65985471e+04 6.23758341e+04
3.23953965e+03 2.84738628e+04 4.33984520e+04 1.54876645e+03
4.35392015e+03 5.38715909e+03 1.76852785e+04 4.90718955e+02
1.12972190e+06 6.42313494e+03 7.62853017e-02 6.39631964e+02
4.19855457e+02 1.79344495e+04 1.22804600e+04 5.17079934e+08
3.05389989e+03 1.15278863e+07 1.07893881e-01 2.79137243e-02
7.45083233e+03 5.19319172e+04 6.26455227e+02]
iteration # 44200; log-lik = 233166.270284
[ 3.31353395e+05 2.59593591e+08 2.65985891e+04 6.23758250e+04
3.23952701e+03 2.84737039e+04 4.33979590e+04 1.54876448e+03
4.35389086e+03 5.38714573e+03 1.76852673e+04 4.90714240e+02
1.12973524e+06 6.42312387e+03 7.62796858e-02 6.39626503e+02
4.19851495e+02 1.79343731e+04 1.22803843e+04 5.17135190e+08
3.05391248e+03 1.15291830e+07 1.07892367e-01 2.79134445e-02
7.45073390e+03 5.19319949e+04 6.26455676e+02]
Optimization terminated successfully.
Current function value: -233166.270284
Iterations: 44217
Function evaluations: 53527
HJCFIT Fitting finished: 2016/02/11 18:25:00
CPU time in simplex= 15126.733401
Wallclock time in simplex= 16448.24842786789
result=
final_simplex: (array([[ 12.71094139, 19.37463292, 10.18861095, 11.0409333 ,
8.08318318, 10.25673695, 10.67816552, 7.34521232,
8.37882443, 8.59177223, 9.78048392, 6.19586334,
13.93749875, 8.76766302, -2.57334938, 6.46088741,
6.0399021 , 9.79447483, 9.41575851, 20.06381404,
8.02417709, 16.26039119, -2.22662054, -3.57864628,
8.91606911, 10.85769009, 6.4400787 ],
[ 12.71094747, 19.37465845, 10.18860868, 11.04093206,
8.08317986, 10.25673106, 10.6781628 , 7.3452054 ,
8.37882895, 8.59176545, 9.78048741, 6.19585844,
13.937521 , 8.76766667, -2.57338701, 6.46088795,
6.03990144, 9.79447582, 9.41576365, 20.06384533,
8.02417673, 16.26042429, -2.22662656, -3.57865058,
8.91606419, 10.85769517, 6.44008328],
[ 12.71096174, 19.37462264, 10.18861023, 11.04093266,
8.08317973, 10.25673178, 10.6781636 , 7.34520299,
8.37882457, 8.59176909, 9.78048587, 6.19585874,
13.93747168, 8.76766707, -2.57333981, 6.46088835,
6.03990165, 9.79447348, 9.41575781, 20.06381573,
8.02417725, 16.26039498, -2.22662422, -3.57864777,
8.9160651 , 10.85769119, 6.44007994],
[ 12.71092893, 19.37467178, 10.18861301, 11.04093382,
8.08318007, 10.25673187, 10.67816224, 7.34520134,
8.37882584, 8.59176934, 9.7804863 , 6.19585906,
13.93755211, 8.76766336, -2.57342236, 6.4608822 ,
6.03989905, 9.79447387, 9.41575973, 20.06388275,
8.02418046, 16.26046319, -2.22662823, -3.57865338,
8.91606421, 10.85769346, 6.44008153],
[ 12.71094074, 19.37462785, 10.18861345, 11.04093306,
8.08318261, 10.25673627, 10.67816769, 7.34521278,
8.37882518, 8.59177097, 9.78048721, 6.19586196,
13.93749387, 8.76765986, -2.57334862, 6.46088442,
6.03990106, 9.79447444, 9.41575849, 20.06381489,
8.02417883, 16.26039203, -2.22662115, -3.57864682,
8.91606782, 10.85769035, 6.44007802],
[ 12.71093814, 19.37464292, 10.1886127 , 11.04093255,
8.08318227, 10.25673504, 10.67815718, 7.34520891,
8.37882483, 8.59177014, 9.7804873 , 6.19586188,
13.9375168 , 8.76766744, -2.57336054, 6.46088702,
6.03990299, 9.79447552, 9.41576093, 20.06381905,
8.02418104, 16.26039736, -2.22662165, -3.57864813,
8.91606605, 10.85769336, 6.44008057],
[ 12.71094519, 19.37463778, 10.18861326, 11.04093422,
8.08318109, 10.25673288, 10.67816468, 7.3452086 ,
8.37882606, 8.5917718 , 9.7804854 , 6.19586102,
13.93750109, 8.76766168, -2.57335402, 6.46088821,
6.03990791, 9.79447515, 9.41576129, 20.06380632,
8.02418136, 16.26038533, -2.22662074, -3.57864694,
8.91606643, 10.85769224, 6.4400804 ],
[ 12.71095853, 19.37461741, 10.18861061, 11.040932 ,
8.08318189, 10.25673576, 10.67816034, 7.3452046 ,
8.37882305, 8.59177269, 9.7804845 , 6.1958633 ,
13.9374693 , 8.76766825, -2.57332093, 6.46088761,
6.03989663, 9.79447406, 9.41575754, 20.06379437,
8.02417766, 16.26037285, -2.22662091, -3.57864645,
8.91606705, 10.85769135, 6.44008058],
[ 12.71096124, 19.37461485, 10.18861248, 11.04093331,
8.08318279, 10.25673663, 10.6781596 , 7.34520617,
8.37882545, 8.59177231, 9.78048705, 6.19586083,
13.93746165, 8.76766469, -2.57331051, 6.46088604,
6.0399 , 9.7944748 , 9.41575895, 20.0637801 ,
8.02418087, 16.26035974, -2.22661903, -3.57864545,
8.91606511, 10.85769066, 6.44007838],
[ 12.71093194, 19.37465252, 10.18861043, 11.04093239,
8.08317853, 10.25673134, 10.67816043, 7.34520143,
8.37882435, 8.59177217, 9.78048441, 6.19586523,
13.93753042, 8.76766615, -2.57337213, 6.46088802,
6.0399005 , 9.7944752 , 9.41576145, 20.063834 ,
8.0241781 , 16.26040973, -2.22662291, -3.57864974,
8.91607181, 10.8576899 , 6.44007799],
[ 12.71095305, 19.37463266, 10.18861131, 11.04093291,
8.08318147, 10.25673486, 10.67815963, 7.34520341,
8.37882717, 8.59176925, 9.78048616, 6.19586201,
13.93748922, 8.76766507, -2.57333335, 6.4608877 ,
6.03990528, 9.79447571, 9.41576155, 20.06379514,
8.02418023, 16.26037351, -2.22662005, -3.57864615,
8.91606623, 10.85769147, 6.44007947],
[ 12.71095799, 19.37461402, 10.18861063, 11.04093218,
8.08318094, 10.25673516, 10.67816743, 7.34521118,
8.37882468, 8.59177356, 9.78048666, 6.19586478,
13.93746496, 8.7676664 , -2.5733108 , 6.46088522,
6.03989718, 9.79447524, 9.41575923, 20.06377522,
8.02417877, 16.26035225, -2.22661844, -3.57864498,
8.91606859, 10.85769132, 6.44007954],
[ 12.71092724, 19.37465068, 10.18861056, 11.04093205,
8.08318187, 10.25673464, 10.67816731, 7.3452087 ,
8.37882774, 8.59177067, 9.78048726, 6.19586565,
13.93753317, 8.76766739, -2.57336261, 6.46088902,
6.03990319, 9.79447713, 9.41576324, 20.06380963,
8.02417733, 16.26038486, -2.22661977, -3.57864689,
8.91607114, 10.85769286, 6.44008054],
[ 12.71096336, 19.37460808, 10.18861394, 11.04093481,
8.08318177, 10.25673543, 10.67816043, 7.3452061 ,
8.37882312, 8.59177509, 9.78048645, 6.1958629 ,
13.93745413, 8.76766101, -2.57330641, 6.4608843 ,
6.03990277, 9.79447444, 9.4157572 , 20.06377826,
8.02417995, 16.26035617, -2.22661815, -3.57864478,
8.91606802, 10.85768855, 6.44007716],
[ 12.71094214, 19.37464069, 10.18861311, 11.04093265,
8.08318159, 10.25673467, 10.67816268, 7.34520992,
8.37882534, 8.59176864, 9.78048579, 6.19586286,
13.93750473, 8.76766204, -2.57335953, 6.46088425,
6.03990155, 9.79447528, 9.41576093, 20.06382269,
8.02417941, 16.26040082, -2.22662233, -3.57864827,
8.91606719, 10.85769143, 6.44007915],
[ 12.71094239, 19.37463456, 10.18861388, 11.04093352,
8.08318388, 10.25674065, 10.67816443, 7.34520268,
8.37882606, 8.59177631, 9.78048628, 6.19586495,
13.93750009, 8.76766396, -2.57333455, 6.46088523,
6.03989951, 9.79447522, 9.41575762, 20.06379674,
8.0241758 , 16.26037335, -2.22661728, -3.57864404,
8.91607151, 10.85768933, 6.44007832],
[ 12.7109667 , 19.37460148, 10.1886123 , 11.0409324 ,
8.0831833 , 10.25673626, 10.67816171, 7.3452066 ,
8.3788257 , 8.59176876, 9.78048488, 6.19586358,
13.93744355, 8.76766524, -2.57328235, 6.46088828,
6.03990278, 9.79447577, 9.41576101, 20.06375286,
8.02417794, 16.26033075, -2.22661689, -3.57864368,
8.91606856, 10.85768884, 6.44007694],
[ 12.71095332, 19.37461465, 10.18861071, 11.04093174,
8.08318316, 10.25673702, 10.67816131, 7.34519828,
8.37882571, 8.59177274, 9.7804855 , 6.19586413,
13.93746918, 8.76766552, -2.57330478, 6.46088692,
6.03990035, 9.79447478, 9.41575875, 20.06377886,
8.02417515, 16.26035443, -2.22661892, -3.5786455 ,
8.91607076, 10.85769009, 6.44007838],
[ 12.71094453, 19.37461847, 10.18861022, 11.04093301,
8.08318324, 10.25673729, 10.6781695 , 7.34521529,
8.37882668, 8.59177133, 9.78048633, 6.19586353,
13.93748299, 8.76766544, -2.57332298, 6.46089304,
6.03990463, 9.79447552, 9.415759 , 20.06378492,
8.02417514, 16.26036116, -2.22661772, -3.57864302,
8.91606946, 10.85768966, 6.44007816],
[ 12.71094706, 19.37461354, 10.18861156, 11.04093256,
8.0831821 , 10.25673598, 10.67816151, 7.34520476,
8.37882461, 8.59177191, 9.78048689, 6.19586661,
13.93747522, 8.76766458, -2.57331228, 6.46088838,
6.03990139, 9.7944751 , 9.41575846, 20.06378759,
8.02417383, 16.26036188, -2.22661912, -3.57864503,
8.91607075, 10.85768932, 6.44007724],
[ 12.71094259, 19.37463395, 10.18860958, 11.0409301 ,
8.08318179, 10.25673684, 10.67817203, 7.34521812,
8.37882677, 8.59177599, 9.78049025, 6.19586501,
13.93750149, 8.76767038, -2.57333946, 6.46087939,
6.03989546, 9.79447586, 9.41576063, 20.06378695,
8.02417981, 16.26036476, -2.2266186 , -3.57864583,
8.91606811, 10.85769614, 6.44008396],
[ 12.71095579, 19.37462062, 10.18861065, 11.04093277,
8.08318274, 10.25673576, 10.67816733, 7.34521114,
8.37882751, 8.59176826, 9.78048579, 6.1958641 ,
13.93747229, 8.76766425, -2.57331892, 6.46088846,
6.03990201, 9.7944754 , 9.41576177, 20.06377669,
8.02417919, 16.26035439, -2.22661892, -3.57864493,
8.91606712, 10.85769329, 6.44008121],
[ 12.71093702, 19.37462384, 10.18861 , 11.04093033,
8.08318225, 10.25673792, 10.6781636 , 7.34520581,
8.37882111, 8.59177622, 9.78048138, 6.19586822,
13.93749727, 8.76766833, -2.5733286 , 6.46088501,
6.0398947 , 9.79447489, 9.4157566 , 20.06380047,
8.02417565, 16.26037476, -2.22661974, -3.57864701,
8.91607045, 10.85769194, 6.44007974],
[ 12.7109458 , 19.37465228, 10.18861307, 11.0409329 ,
8.08318116, 10.25673409, 10.67815509, 7.34519422,
8.37882376, 8.59177288, 9.78048509, 6.19585627,
13.93751579, 8.76766465, -2.57338611, 6.46088349,
6.03990026, 9.79447326, 9.41575607, 20.06385924,
8.02418054, 16.26044104, -2.22662688, -3.57865153,
8.91606243, 10.85769314, 6.44008189],
[ 12.71094517, 19.37460796, 10.18861067, 11.04093348,
8.08318092, 10.25673427, 10.67816262, 7.34519957,
8.37882418, 8.59177552, 9.78048842, 6.19586934,
13.93747312, 8.76766602, -2.57328622, 6.46089001,
6.03990461, 9.79447548, 9.41576134, 20.0637468 ,
8.02418098, 16.26032368, -2.22661496, -3.57864335,
8.91607082, 10.85768924, 6.44007674],
[ 12.71094158, 19.37464209, 10.18860985, 11.04093102,
8.08318457, 10.25674041, 10.67817159, 7.34521347,
8.3788274 , 8.59177011, 9.78048349, 6.19586571,
13.93751148, 8.76766782, -2.57334726, 6.4608826 ,
6.03989507, 9.79447729, 9.41576107, 20.06380329,
8.02417846, 16.2603794 , -2.2266186 , -3.57864489,
8.91607078, 10.85768919, 6.44007816],
[ 12.71095048, 19.37463604, 10.18860893, 11.04093336,
8.08317695, 10.25672717, 10.67816345, 7.34519994,
8.37882794, 8.59176769, 9.78048552, 6.19586229,
13.93749683, 8.76766559, -2.57333245, 6.46089763,
6.03991137, 9.79447642, 9.41576603, 20.06378219,
8.02417995, 16.26035989, -2.22661952, -3.57864657,
8.91607108, 10.85769032, 6.44007822],
[ 12.71097159, 19.37461149, 10.1886122 , 11.04093321,
8.083185 , 10.25673928, 10.67816802, 7.34520964,
8.37882685, 8.59176995, 9.78048478, 6.1958608 ,
13.93744721, 8.76766309, -2.57329976, 6.46088705,
6.03990084, 9.79447563, 9.41575958, 20.06376005,
8.0241785 , 16.2603387 , -2.22661706, -3.57864307,
8.91606713, 10.85769316, 6.4400817 ]]), array([-233166.27028406, -233166.27028406, -233166.27028406,
-233166.27028406, -233166.27028406, -233166.27028406,
-233166.27028406, -233166.27028406, -233166.27028406,
-233166.27028406, -233166.27028406, -233166.27028406,
-233166.27028406, -233166.27028405, -233166.27028405,
-233166.27028405, -233166.27028405, -233166.27028405,
-233166.27028405, -233166.27028405, -233166.27028405,
-233166.27028405, -233166.27028405, -233166.27028405,
-233166.27028405, -233166.27028405, -233166.27028405,
-233166.27028405]))
fun: -233166.27028406371
message: 'Optimization terminated successfully.'
nfev: 53527
nit: 44217
status: 0
success: True
x: array([ 12.71094139, 19.37463292, 10.18861095, 11.0409333 ,
8.08318318, 10.25673695, 10.67816552, 7.34521232,
8.37882443, 8.59177223, 9.78048392, 6.19586334,
13.93749875, 8.76766302, -2.57334938, 6.46088741,
6.0399021 , 9.79447483, 9.41575851, 20.06381404,
8.02417709, 16.26039119, -2.22662054, -3.57864628,
8.91606911, 10.85769009, 6.4400787 ])
Final log-likelihood = 233166.270284
Number of iterations = 44217
Number of evaluations = 53527
Final rate constants:
class dcpyps.Mechanism
Values of unit rates [1/sec]:
From A3F3O to A3F3 alpha3fff 331353.608441
From A3F3 to A3F3O beta3fff 259594906.907
From A3F2O to A3F2 alpha3ff 26598.5224753
From A3F2 to A3F2O beta3ff 62375.8399441
From A2F2O to A2F2 alpha2ff 3239.52883837
From A2F2 to A2F2O beta2ff 28473.7231186
From A3F1O to A3F1 alpha3f 43397.8647155
From A3F1 to A3F1O beta3f 1548.76376331
From A2F1O to A2F1 alpha2f 4353.88763676
From A2F1 to A2F1O beta2f 5387.152506
From A1F1O to A1F1 alpha1f 17685.2090334
From A1F1 to A1F1O beta1f 490.714917428
From A3F3 to A3F2 gama3fff 1129740.75722
From A3F2 to A3F3 delta3fff 6423.14416508
From A3F2 to A2F2 3kff(-3) 0.0762796278287
From A2F2 to A3F2 kff(+3) 2.18658152254
From A3F2 to A3F1 gama3ff 639.628420502
From A3F1 to A3F2 delta3ff 419.851929815
From A2F2 to A2F1 gama2ff 17934.3801509
From A2F1 to A2F2 delta2ff 12280.3844806
From A3F1 to A2F1 3kf(-3) 17293759.8783
From A2F1 to A3F1 kf(+3) 517134752.989
From A3F1 to A3R gama3f 3053.90716676
From A3R to A3F1 delta3f 855.007294015
From A2F1 to A1F1 2kf(-2) 11529173.2522
From A1F1 to A2F1 2kf(+2) 1034269505.98
From A2F1 to A2R gama2f 0.107892432441
From A2R to A2F1 delta2f 0.0279134595726
From A1F1 to A1R gama1f 7450.74355523
From A1R to A1F1 delta1f 1781.2750726
From A3R to A2R 3k(-3) 1879.36830821
From A2R to A3R k(+3) 51931.9813146
From A2R to A1R 2k(-2) 1252.91220547
From A1R to A2R 2k(+2) 103863.962629
From A1R to R k(-1) 626.456102735
From R to A1R 3k(+1) 155795.943944
Conductance of state A3F3O (pS) = 50
Conductance of state A3F2O (pS) = 50
Conductance of state A2F2O (pS) = 50
Conductance of state A3F1O (pS) = 50
Conductance of state A2F1O (pS) = 50
Conductance of state A1F1O (pS) = 50
Number of open states = 6
Number of short-lived shut states (within burst) = 9
Number of long-lived shut states (between bursts) = 1
Number of desensitised states = 0
Number of cycles = 3
Cycle 1 is formed of states: A3F2 A2F2 A2F1 A3F1
forward product = 2.970262382e+14
backward product = 2.970262382e+14
Cycle 2 is formed of states: A3F1 A2F1 A2R A3R
forward product = 8.284858986e+13
backward product = 8.284858986e+13
Cycle 3 is formed of states: A2F1 A1F1 A1R A2R
forward product = 2.490441445e+14
backward product = 2.490441445e+14
Data loaded from file: ../../DCPYPS/dcpyps/samples/glydemo/keA.scn
Concentration of agonist = 300.000 microMolar
Resolution for HJC calculations = 40.0 microseconds
Critical gap length to define end of group (tcrit) = 0.600 milliseconds
(defined so that all openings in a group prob come from same channel)
Initial and final vectors for bursts calculated asin Colquhoun, Hawkes & Srodzinski, (1996, eqs 5.8, 5.11).
Number of resolved intervals = 11662
Number of resolved periods = 11088
Number of open periods = 5544
Mean and SD of open periods = 0.397568729 +/- 1.362546164 ms
Range of open periods from 0.040033814 ms to 83.755209722 ms
Number of shut intervals = 5544
Mean and SD of shut periods = 109.531529248 +/- 2942.205429077 ms
Range of shut periods from 0.040052371 ms to 204117.309570312 ms
Last shut period = 10.665501468 ms
Number of bursts = 4618
Average length = 0.504651324 ms
Range: 0.040 to 83.755 millisec
Average number of openings= 1.200519706
Data loaded from file: ../../DCPYPS/dcpyps/samples/glydemo/keB.scn
Concentration of agonist = 3000.000 microMolar
Resolution for HJC calculations = 40.0 microseconds
Critical gap length to define end of group (tcrit) = -70.000 milliseconds
(defined so that all openings in a group prob come from same channel)
Initial and final vectors for are calculated as for steady state openings and shuttings (this involves a slight approximation at start and end of bursts that are defined by shut times that have been set as bad).
Number of resolved intervals = 14296
Number of resolved periods = 12338
Number of open periods = 6169
Mean and SD of open periods = 0.568432008 +/- 0.781032231 ms
Range of open periods from 0.040003666 ms to 23.221036885 ms
Number of shut intervals = 6169
Mean and SD of shut periods = 3.801412648 +/- 35.561904311 ms
Range of shut periods from 0.040001163 ms to 2761.569499969 ms
Last shut period = 0.373572315 ms
Number of bursts = 3
Average length = 8038.560359078 ms
Range: 1572.336 to 17533.538 millisec
Average number of openings= 2056.333333333
Data loaded from file: ../../DCPYPS/dcpyps/samples/glydemo/keC.scn
Concentration of agonist = 30000.000 microMolar
Resolution for HJC calculations = 40.0 microseconds
Critical gap length to define end of group (tcrit) = -20.000 milliseconds
(defined so that all openings in a group prob come from same channel)
Initial and final vectors for are calculated as for steady state openings and shuttings (this involves a slight approximation at start and end of bursts that are defined by shut times that have been set as bad).
Number of resolved intervals = 7569
Number of resolved periods = 5810
Number of open periods = 2905
Mean and SD of open periods = 0.764939965 +/- 1.200268148 ms
Range of open periods from 0.040136722 ms to 20.713106598 ms
Number of shut intervals = 2905
Mean and SD of shut periods = 76.107278466 +/- 2832.809209824 ms
Range of shut periods from 0.037358772 ms to 109791.648864746 ms
Last shut period = 0.037358772 ms
Number of bursts = 5
Average length = 886.178571851 ms
Range: 0.222 to 2465.916 millisec
Average number of openings= 581.000000000
Data loaded from file: ../../DCPYPS/dcpyps/samples/glydemo/keD.scn
Concentration of agonist = 100000.000 microMolar
Resolution for HJC calculations = 40.0 microseconds
Critical gap length to define end of group (tcrit) = -20.000 milliseconds
(defined so that all openings in a group prob come from same channel)
Initial and final vectors for are calculated as for steady state openings and shuttings (this involves a slight approximation at start and end of bursts that are defined by shut times that have been set as bad).
Number of resolved intervals = 14723
Number of resolved periods = 12210
Number of open periods = 6105
Mean and SD of open periods = 0.888958726 +/- 1.245775257 ms
Range of open periods from 0.040174076 ms to 21.068737711 ms
Number of shut intervals = 6105
Mean and SD of shut periods = 5.588796455 +/- 134.609654546 ms
Range of shut periods from 0.037023197 ms to 7994.186401367 ms
Last shut period = 0.037023197 ms
Number of bursts = 25
Average length = 478.491306786 ms
Range: 0.073 to 3397.090 millisec
Average number of openings= 244.200000000
class dcpyps.Mechanism
Values of unit rates [1/sec]:
From A3F3O to A3F3 alpha3fff 164180.872344
From A3F3 to A3F3O beta3fff 879798.259388
From A3F2O to A3F2 alpha3ff 17631.1000954
From A3F2 to A3F2O beta3ff 75963.8340657
From A2F2O to A2F2 alpha2ff 18512.6542595
From A2F2 to A2F2O beta2ff 72165.6459847
From A3F1O to A3F1 alpha3f 19957.2751004
From A3F1 to A3F1O beta3f 302.572972131
From A2F1O to A2F1 alpha2f 20555.9927824
From A2F1 to A2F1O beta2f 293.495791624
From A1F1O to A1F1 alpha1f 21154.7104645
From A1F1 to A1F1O beta1f 284.418611117
From A3F3 to A3F2 gama3fff 11673.7928596
From A3F2 to A3F3 delta3fff 2585.56822991
From A3F2 to A2F2 3kff(-3) 26.209768672
From A2F2 to A3F2 kff(+3) 684.568191741
From A3F2 to A3F1 gama3ff 2862.00095617
From A3F1 to A3F2 delta3ff 1741.88100927
From A2F2 to A2F1 gama2ff 11625.274006
From A2F1 to A2F2 delta2ff 8662.55618102
From A3F1 to A2F1 3kf(-3) 1436109.06916
From A2F1 to A3F1 kf(+3) 45923513.6955
From A3F1 to A3R gama3f 2473.77597999
From A3R to A3F1 delta3f 769.546855601
From A2F1 to A1F1 2kf(-2) 957406.04611
From A1F1 to A2F1 2kf(+2) 91847027.3909
From A2F1 to A2R gama2f 0.0997096333233
From A2R to A2F1 delta2f 0.027994525861
From A1F1 to A1R gama1f 7438.33684661
From A1R to A1F1 delta1f 1884.83412534
From A3R to A2R 3k(-3) 1507.83869722
From A2R to A3R k(+3) 43517.4928712
From A2R to A1R 2k(-2) 1005.22579814
From A1R to A2R 2k(+2) 87034.9857424
From A1R to R k(-1) 502.612899072
From R to A1R 3k(+1) 130552.478614
Conductance of state A3F3O (pS) = 50
Conductance of state A3F2O (pS) = 50
Conductance of state A2F2O (pS) = 50
Conductance of state A3F1O (pS) = 50
Conductance of state A2F1O (pS) = 50
Conductance of state A1F1O (pS) = 50
Number of open states = 6
Number of short-lived shut states (within burst) = 9
Number of long-lived shut states (between bursts) = 1
Number of desensitised states = 0
Number of cycles = 3
Cycle 1 is formed of states: A3F2 A2F2 A2F1 A3F1
forward product = 2.437361683e+16
backward product = 2.437361683e+16
Cycle 2 is formed of states: A3F1 A2F1 A2R A3R
forward product = 4.795384982e+12
backward product = 4.795384982e+12
Cycle 3 is formed of states: A2F1 A1F1 A1R A2R
forward product = 1.735157837e+13
backward product = 1.735157837e+13
Starting likelihood = 232502.287977
iteration # 100; log-lik = 232928.154662
[ 1.41924696e+05 9.91282568e+05 1.97840130e+04 7.82168302e+04
1.71306492e+04 7.68160837e+04 1.91299496e+04 3.29285607e+02
2.03109769e+04 3.21385337e+02 1.77876364e+04 3.07427710e+02
9.53885963e+03 3.14538983e+03 2.66831193e+01 2.88401102e+03
1.83802336e+03 9.93511657e+03 9.46742351e+03 4.79548708e+07
2.69765023e+03 9.59381397e+05 9.69674010e-02 2.95029655e-02
7.21696699e+03 4.79948914e+04 4.64842402e+02]
iteration # 200; log-lik = 232979.192057
[ 1.39959379e+05 1.17018226e+06 2.16700680e+04 7.53653081e+04
1.71029252e+04 7.68171076e+04 1.71190644e+04 3.42107973e+02
1.98215160e+04 3.28061884e+02 1.57404148e+04 3.69429873e+02
9.05588107e+03 2.93348168e+03 2.47742706e+01 2.66183859e+03
1.80308002e+03 9.82741621e+03 9.20819434e+03 4.89168093e+07
2.87111595e+03 9.56960899e+05 9.77159540e-02 3.00259005e-02
7.78208260e+03 4.73797799e+04 4.85791261e+02]
iteration # 300; log-lik = 233002.232358
[ 1.47312423e+05 1.12864285e+06 2.11448124e+04 7.36694063e+04
1.69317461e+04 7.74711685e+04 1.62870400e+04 3.92236574e+02
1.86587447e+04 3.48193383e+02 1.38161174e+04 4.13244661e+02
8.41526537e+03 2.83569328e+03 2.60822758e+01 2.44770496e+03
1.67354724e+03 9.51977339e+03 9.21709747e+03 4.62329996e+07
3.12459255e+03 9.75174512e+05 9.66457332e-02 2.93387769e-02
6.59904934e+03 4.70727221e+04 4.82397914e+02]
iteration # 400; log-lik = 233018.988138
[ 1.48644223e+05 1.25062179e+06 1.96390849e+04 7.13821925e+04
1.66352826e+04 7.76746330e+04 1.79133107e+04 4.21464957e+02
1.82306857e+04 3.83449704e+02 1.45437964e+04 4.31136662e+02
8.25161166e+03 2.74034750e+03 2.59165616e+01 2.29627631e+03
1.45026493e+03 9.53446236e+03 9.40284474e+03 4.72968854e+07
2.94066199e+03 9.44090357e+05 9.68547856e-02 2.88592808e-02
6.40567244e+03 4.66407464e+04 4.79943892e+02]
iteration # 500; log-lik = 233039.395788
[ 1.43921724e+05 1.32994457e+06 2.02449694e+04 6.68117594e+04
1.62172011e+04 7.94934703e+04 2.26566069e+04 5.29347681e+02
1.56810436e+04 4.50922832e+02 1.37971980e+04 4.71660034e+02
7.79209469e+03 2.60040045e+03 2.58362305e+01 1.98649454e+03
1.14826360e+03 9.86977844e+03 9.57688621e+03 4.71647054e+07
2.65861372e+03 8.73934049e+05 9.79258969e-02 2.91987287e-02
6.89841492e+03 4.51984767e+04 4.86336071e+02]
iteration # 600; log-lik = 233048.465860
[ 1.46262468e+05 1.28118709e+06 1.98733456e+04 6.65369686e+04
1.60324841e+04 7.98636684e+04 2.37706804e+04 6.30085713e+02
1.37892065e+04 4.95990174e+02 1.39243349e+04 5.00884359e+02
7.72789676e+03 2.63733775e+03 2.52296415e+01 1.89120845e+03
1.00135478e+03 9.99077801e+03 9.63004704e+03 4.87800502e+07
2.43395436e+03 8.51913920e+05 9.89014118e-02 2.94707396e-02
7.67575311e+03 4.49023615e+04 4.86137282e+02]
iteration # 700; log-lik = 233057.149323
[ 1.49512317e+05 1.23011740e+06 2.13138860e+04 6.79315040e+04
1.58888665e+04 8.01013199e+04 2.19366699e+04 7.27702613e+02
1.24049779e+04 5.27515813e+02 1.38621949e+04 5.62421214e+02
7.66341611e+03 2.79009095e+03 2.41159390e+01 1.80736481e+03
9.26036363e+02 9.97574384e+03 9.65850089e+03 4.96878513e+07
2.25527758e+03 8.29899324e+05 9.99611919e-02 3.03854219e-02
8.09623091e+03 4.53338548e+04 4.91714514e+02]
iteration # 800; log-lik = 233060.654072
[ 1.51402885e+05 1.16800642e+06 2.21648039e+04 6.90068340e+04
1.59982553e+04 7.92887719e+04 2.03651434e+04 7.86071809e+02
1.17987841e+04 5.45788246e+02 1.37135087e+04 5.68461400e+02
7.84646994e+03 2.95600780e+03 2.33945732e+01 1.76938109e+03
9.25737084e+02 9.85673993e+03 9.43903120e+03 4.95216116e+07
2.29888914e+03 8.15096090e+05 1.00533576e-01 3.01991878e-02
8.28623854e+03 4.57863064e+04 4.95039580e+02]
iteration # 900; log-lik = 233062.450423
[ 1.48141874e+05 1.14140374e+06 2.23716677e+04 6.85527156e+04
1.58599708e+04 7.94239596e+04 2.15671211e+04 8.22338534e+02
1.10904760e+04 5.64504346e+02 1.39878590e+04 5.58343931e+02
7.85790191e+03 2.96424252e+03 2.37553581e+01 1.71113928e+03
9.07245431e+02 9.97564384e+03 9.45234039e+03 4.91590432e+07
2.25573386e+03 8.04936581e+05 1.00595126e-01 3.01130966e-02
8.37852225e+03 4.56664346e+04 4.91602787e+02]
iteration # 1000; log-lik = 233065.495431
[ 1.48804115e+05 1.07812110e+06 2.37091142e+04 6.88080258e+04
1.55781518e+04 7.93410420e+04 2.24777392e+04 9.35575705e+02
9.00960759e+03 6.37900169e+02 1.41156098e+04 5.59462899e+02
7.69678557e+03 3.11874688e+03 2.43908467e+01 1.57122986e+03
8.72350317e+02 1.00211476e+04 9.34231224e+03 4.64133282e+07
2.30456767e+03 7.63399960e+05 1.02357514e-01 3.02529138e-02
8.26298275e+03 4.58105792e+04 4.90138216e+02]
iteration # 1100; log-lik = 233070.110392
[ 1.46828452e+05 9.88461558e+05 2.47264040e+04 6.84627358e+04
1.51382532e+04 7.86007127e+04 2.36739665e+04 1.06013101e+03
6.15754895e+03 7.41703545e+02 1.48154493e+04 5.26033863e+02
7.44409643e+03 3.24714750e+03 2.62198276e+01 1.44435304e+03
8.90554632e+02 1.01414074e+04 9.39117570e+03 4.10152850e+07
2.63014887e+03 7.29553747e+05 1.04103859e-01 3.04145924e-02
7.80511749e+03 4.61691965e+04 4.94014435e+02]
iteration # 1200; log-lik = 233072.588350
[ 1.52109628e+05 9.70062495e+05 2.49902197e+04 6.83171048e+04
1.48738570e+04 7.78757571e+04 2.37557746e+04 1.14961403e+03
5.18320318e+03 8.23108752e+02 1.53445220e+04 5.20637322e+02
7.56306392e+03 3.44776661e+03 2.67748348e+01 1.36084107e+03
8.66139638e+02 1.02333363e+04 9.45962292e+03 3.90671057e+07
2.65025002e+03 7.08083409e+05 1.05247616e-01 3.05739238e-02
7.57159709e+03 4.63029302e+04 4.95595990e+02]
iteration # 1300; log-lik = 233075.301533
[ 1.66086080e+05 9.65310365e+05 2.54242231e+04 6.86107154e+04
1.49695403e+04 7.77883401e+04 2.23263610e+04 1.15480710e+03
5.27092594e+03 8.65080843e+02 1.52156919e+04 5.00137610e+02
7.31378999e+03 3.66634354e+03 2.76928269e+01 1.32122551e+03
8.67621608e+02 1.02774316e+04 9.42624621e+03 3.61871706e+07
2.70586045e+03 6.80767948e+05 1.05542569e-01 3.06555792e-02
7.31739795e+03 4.62567347e+04 4.95444934e+02]
iteration # 1400; log-lik = 233078.387294
[ 1.78712661e+05 9.58230317e+05 2.55523672e+04 6.83924684e+04
1.48196710e+04 7.74556422e+04 2.14015908e+04 1.25221797e+03
5.01657531e+03 9.58872219e+02 1.50399245e+04 4.90137925e+02
7.36835707e+03 3.95480647e+03 2.81543293e+01 1.22997990e+03
8.38564855e+02 1.02480296e+04 9.49433778e+03 3.40103824e+07
2.69876989e+03 6.55874822e+05 1.06207435e-01 3.05068201e-02
7.05400919e+03 4.62609229e+04 4.97293960e+02]
iteration # 1500; log-lik = 233088.714461
[ 2.34118220e+05 1.02717175e+06 2.61505498e+04 6.55074959e+04
1.45181772e+04 7.76493768e+04 2.25441698e+04 1.27879574e+03
5.29057185e+03 1.23831672e+03 1.51439906e+04 4.09877188e+02
7.04769672e+03 5.04597610e+03 3.23238689e+01 9.87999730e+02
7.54543076e+02 1.04613771e+04 9.62424563e+03 2.53503023e+07
2.78680516e+03 5.61209856e+05 1.06991720e-01 3.09720830e-02
6.31249593e+03 4.48073561e+04 4.88339586e+02]
iteration # 1600; log-lik = 233098.368190
[ 3.16342090e+05 1.23448529e+06 2.64614166e+04 6.06584389e+04
1.38487340e+04 7.72141824e+04 2.35193038e+04 1.31475945e+03
5.53047572e+03 1.66142106e+03 1.51645013e+04 3.72238947e+02
6.88366962e+03 6.50465218e+03 3.56972763e+01 7.52476142e+02
6.21342857e+02 1.05267358e+04 9.78474120e+03 1.88984120e+07
3.02419186e+03 4.68803907e+05 1.08103957e-01 3.16089483e-02
5.88398693e+03 4.31283721e+04 4.89108570e+02]
iteration # 1700; log-lik = 233102.354114
[ 3.38999208e+05 1.20973797e+06 2.54083467e+04 5.97522425e+04
1.36200097e+04 7.69786989e+04 2.32738837e+04 1.47292370e+03
5.64390939e+03 1.85005419e+03 1.49324400e+04 3.77483446e+02
6.37549371e+03 6.72056627e+03 3.69162444e+01 6.90971452e+02
5.48549774e+02 1.03739448e+04 9.82836187e+03 1.75478463e+07
3.23836427e+03 4.48322116e+05 1.08389909e-01 3.13877796e-02
5.75418581e+03 4.25887218e+04 4.87563870e+02]
iteration # 1800; log-lik = 233105.816071
[ 3.27545388e+05 1.20413284e+06 2.50498360e+04 5.92421713e+04
1.34450147e+04 7.62767011e+04 2.47483146e+04 1.48307980e+03
5.43776239e+03 1.90706579e+03 1.51734412e+04 3.82931873e+02
6.68477354e+03 6.88322197e+03 3.59378486e+01 6.87220876e+02
5.31767438e+02 1.02525134e+04 9.73948985e+03 1.74148697e+07
3.18233146e+03 4.46197126e+05 1.08762685e-01 3.11838802e-02
5.96710158e+03 4.28518018e+04 4.92404354e+02]
iteration # 1900; log-lik = 233109.352055
[ 3.72055646e+05 1.23049634e+06 2.43520934e+04 5.81383202e+04
1.30392391e+04 7.50453064e+04 2.56949364e+04 1.60899870e+03
4.80598341e+03 2.28426187e+03 1.51964469e+04 3.73944934e+02
6.47355845e+03 7.57759393e+03 3.64370038e+01 6.36508205e+02
4.76247391e+02 1.02379131e+04 9.71046685e+03 1.55652983e+07
3.33545935e+03 4.15913716e+05 1.09573328e-01 3.12469049e-02
5.91487711e+03 4.29991632e+04 5.00993501e+02]
iteration # 2000; log-lik = 233113.229377
[ 4.01167273e+05 1.34202268e+06 2.36280227e+04 5.72971136e+04
1.27631642e+04 7.45745153e+04 2.92913423e+04 1.57499587e+03
4.89096156e+03 2.52490376e+03 1.49494378e+04 3.83876153e+02
6.51309124e+03 7.60987621e+03 3.48358616e+01 6.30193092e+02
4.37802749e+02 1.01497442e+04 9.59179895e+03 1.49474303e+07
3.05643943e+03 3.81556624e+05 1.10162352e-01 3.18069100e-02
6.65850383e+03 4.31238267e+04 5.10967091e+02]
iteration # 2100; log-lik = 233117.241846
[ 4.66081812e+05 1.44558194e+06 2.37573938e+04 5.67169329e+04
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iteration # 2200; log-lik = 233126.839909
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iteration # 2300; log-lik = 233133.813281
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iteration # 2400; log-lik = 233135.695276
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iteration # 2500; log-lik = 233136.831060
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iteration # 2600; log-lik = 233138.456119
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iteration # 2700; log-lik = 233139.361638
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iteration # 2800; log-lik = 233139.839857
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iteration # 2900; log-lik = 233140.254281
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iteration # 3000; log-lik = 233141.048428
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iteration # 3100; log-lik = 233141.844952
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iteration # 3200; log-lik = 233142.643585
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iteration # 3300; log-lik = 233143.624095
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iteration # 3400; log-lik = 233144.116111
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iteration # 3500; log-lik = 233144.661394
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iteration # 3600; log-lik = 233144.849162
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iteration # 3700; log-lik = 233144.975757
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iteration # 3800; log-lik = 233145.024746
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iteration # 3900; log-lik = 233145.143485
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iteration # 4000; log-lik = 233145.329902
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iteration # 4100; log-lik = 233145.466481
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iteration # 4200; log-lik = 233145.579027
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iteration # 4300; log-lik = 233145.677676
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iteration # 4400; log-lik = 233145.764848
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iteration # 4500; log-lik = 233145.828877
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iteration # 4600; log-lik = 233145.896551
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iteration # 4700; log-lik = 233146.032343
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iteration # 4800; log-lik = 233146.123677
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iteration # 4900; log-lik = 233146.188024
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iteration # 5000; log-lik = 233146.275565
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iteration # 5100; log-lik = 233146.404584
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iteration # 5200; log-lik = 233146.752625
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iteration # 5300; log-lik = 233147.214224
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iteration # 5400; log-lik = 233147.761666
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iteration # 5500; log-lik = 233148.024699
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iteration # 5600; log-lik = 233148.236252
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iteration # 5700; log-lik = 233148.411315
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iteration # 5800; log-lik = 233148.470665
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iteration # 5900; log-lik = 233148.491486
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iteration # 6000; log-lik = 233148.501947
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iteration # 6100; log-lik = 233148.508076
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iteration # 6200; log-lik = 233148.517431
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iteration # 6300; log-lik = 233148.540807
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iteration # 6400; log-lik = 233148.558988
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iteration # 6500; log-lik = 233148.585978
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iteration # 6600; log-lik = 233148.690998
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iteration # 6700; log-lik = 233148.800957
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iteration # 6800; log-lik = 233148.995978
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iteration # 6900; log-lik = 233149.085682
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iteration # 7000; log-lik = 233149.160933
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iteration # 7100; log-lik = 233149.196825
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iteration # 7200; log-lik = 233149.208088
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iteration # 7300; log-lik = 233149.219763
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iteration # 7400; log-lik = 233149.227441
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iteration # 7500; log-lik = 233149.235125
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iteration # 7600; log-lik = 233149.238833
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iteration # 7700; log-lik = 233149.241906
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iteration # 7800; log-lik = 233149.243300
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iteration # 7900; log-lik = 233149.244077
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iteration # 8000; log-lik = 233149.244566
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iteration # 8100; log-lik = 233149.244889
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iteration # 8200; log-lik = 233149.246154
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iteration # 8300; log-lik = 233149.250288
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iteration # 10000; log-lik = 233149.589964
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iteration # 17600; log-lik = 233153.308015
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iteration # 20700; log-lik = 233154.184559
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6.32245331e+03 5.56466961e+04 3.59306110e+04 1.12206937e+03
4.23179679e+03 5.73877626e+03 1.75770605e+04 4.90030914e+02
1.64639028e+05 6.02729735e+03 5.36285017e-01 5.19680787e+02
3.42493895e+02 1.41854960e+04 9.00167028e+03 1.79642193e+08
2.84293642e+03 3.95113598e+06 1.01110759e-01 2.72350164e-02
6.99790828e+03 5.62150408e+04 6.85338732e+02]
iteration # 20800; log-lik = 233154.187679
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6.31869679e+03 5.56230741e+04 3.58891028e+04 1.11992326e+03
4.23090782e+03 5.74280113e+03 1.75974881e+04 4.90189965e+02
1.66420716e+05 6.03360043e+03 5.32934474e-01 5.19230525e+02
3.42121027e+02 1.41862155e+04 9.00500466e+03 1.80593933e+08
2.84761767e+03 3.97229424e+06 1.01116094e-01 2.72216394e-02
7.00123567e+03 5.61630467e+04 6.84785240e+02]
iteration # 20900; log-lik = 233154.190400
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6.31991979e+03 5.56462966e+04 3.60099197e+04 1.12410946e+03
4.22900936e+03 5.75202503e+03 1.75930343e+04 4.90684891e+02
1.65191279e+05 6.02603034e+03 5.36264365e-01 5.17640226e+02
3.41117079e+02 1.41812705e+04 9.00403426e+03 1.78868974e+08
2.85278774e+03 3.93364175e+06 1.01220889e-01 2.72239794e-02
7.00579419e+03 5.61741435e+04 6.84878418e+02]
iteration # 21000; log-lik = 233154.191898
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6.31730598e+03 5.56353724e+04 3.60635263e+04 1.12956096e+03
4.22888833e+03 5.74953433e+03 1.75809431e+04 4.90722181e+02
1.66083950e+05 6.03585707e+03 5.31458467e-01 5.17702789e+02
3.40990019e+02 1.41866731e+04 9.00831514e+03 1.79403046e+08
2.85586636e+03 3.94784956e+06 1.01152756e-01 2.71983756e-02
7.00370114e+03 5.62252497e+04 6.85494049e+02]
iteration # 21100; log-lik = 233154.192787
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6.32231979e+03 5.56606823e+04 3.61376954e+04 1.13326624e+03
4.22920866e+03 5.75031557e+03 1.75795334e+04 4.90358969e+02
1.65458958e+05 6.03825006e+03 5.34328541e-01 5.18268416e+02
3.41392547e+02 1.41816428e+04 9.00828987e+03 1.77991447e+08
2.85836669e+03 3.91816001e+06 1.01242304e-01 2.72165141e-02
7.00301895e+03 5.62053063e+04 6.85271077e+02]
iteration # 21200; log-lik = 233154.193257
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6.32533972e+03 5.56837982e+04 3.62224238e+04 1.13644451e+03
4.22883093e+03 5.75248522e+03 1.75782706e+04 4.90599608e+02
1.64960552e+05 6.04384737e+03 5.37809594e-01 5.18270213e+02
3.41244518e+02 1.41800358e+04 9.01113206e+03 1.76331393e+08
2.85875830e+03 3.88104942e+06 1.01341704e-01 2.72323844e-02
7.00698573e+03 5.62314454e+04 6.85598777e+02]
iteration # 21300; log-lik = 233154.193544
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6.32868916e+03 5.57060572e+04 3.62703760e+04 1.13872969e+03
4.22997842e+03 5.75118122e+03 1.75693869e+04 4.90605923e+02
1.64639648e+05 6.04585995e+03 5.39394910e-01 5.18510980e+02
3.41302007e+02 1.41798748e+04 9.01410046e+03 1.75526319e+08
2.85909907e+03 3.86341208e+06 1.01386750e-01 2.72424333e-02
7.00814904e+03 5.62169980e+04 6.85430929e+02]
iteration # 21400; log-lik = 233154.193849
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6.33318310e+03 5.57282816e+04 3.62884198e+04 1.13969384e+03
4.23008269e+03 5.74934821e+03 1.75634182e+04 4.90416320e+02
1.64164863e+05 6.04757620e+03 5.42486215e-01 5.19245913e+02
3.41624998e+02 1.41759961e+04 9.01334432e+03 1.74622141e+08
2.85946035e+03 3.84397955e+06 1.01447161e-01 2.72594938e-02
7.00722152e+03 5.61981946e+04 6.85166293e+02]
iteration # 21500; log-lik = 233154.194223
[ 2.52957460e+05 2.97707328e+07 2.79949195e+04 6.28596129e+04
6.33819569e+03 5.57537258e+04 3.62842711e+04 1.13789966e+03
4.23128002e+03 5.74762964e+03 1.75641012e+04 4.90448994e+02
1.63694767e+05 6.04964732e+03 5.47698490e-01 5.19814010e+02
3.41733144e+02 1.41723651e+04 9.01321428e+03 1.73380952e+08
2.85865218e+03 3.81478857e+06 1.01546861e-01 2.72856769e-02
7.00990758e+03 5.61732614e+04 6.84780077e+02]
iteration # 21600; log-lik = 233154.194499
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6.33701929e+03 5.57471990e+04 3.62333541e+04 1.13606120e+03
4.23052757e+03 5.74743629e+03 1.75605685e+04 4.90543557e+02
1.63985436e+05 6.04838710e+03 5.46775539e-01 5.20039771e+02
3.41607215e+02 1.41719062e+04 9.01186637e+03 1.73930308e+08
2.85806900e+03 3.82604636e+06 1.01524423e-01 2.72819275e-02
7.01034311e+03 5.61772454e+04 6.84806427e+02]
iteration # 21700; log-lik = 233154.194626
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6.33716961e+03 5.57438416e+04 3.61852185e+04 1.13455100e+03
4.23027793e+03 5.74703716e+03 1.75647518e+04 4.90660508e+02
1.64127400e+05 6.04777599e+03 5.47338219e-01 5.20296455e+02
3.41648505e+02 1.41712799e+04 9.01188276e+03 1.73874504e+08
2.85804446e+03 3.82417748e+06 1.01538950e-01 2.72836930e-02
7.01096690e+03 5.61936721e+04 6.84977128e+02]
iteration # 21800; log-lik = 233154.194912
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6.33530367e+03 5.57358968e+04 3.62137760e+04 1.13485380e+03
4.23166470e+03 5.74345779e+03 1.75606658e+04 4.90584358e+02
1.64736234e+05 6.04984009e+03 5.43634440e-01 5.20725663e+02
3.41489975e+02 1.41761977e+04 9.01450440e+03 1.74753347e+08
2.85655710e+03 3.84323646e+06 1.01468593e-01 2.72740777e-02
7.01043426e+03 5.62124243e+04 6.85304074e+02]
iteration # 21900; log-lik = 233154.195091
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6.33591875e+03 5.57386780e+04 3.62226406e+04 1.13574316e+03
4.23154057e+03 5.74466838e+03 1.75640740e+04 4.90406224e+02
1.64455470e+05 6.04858377e+03 5.43674436e-01 5.20849783e+02
3.41364341e+02 1.41745166e+04 9.01343119e+03 1.74688662e+08
2.85689103e+03 3.84258798e+06 1.01464100e-01 2.72736056e-02
7.00832585e+03 5.62250514e+04 6.85512297e+02]
iteration # 22000; log-lik = 233154.195156
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6.33677107e+03 5.57444522e+04 3.62227133e+04 1.13498551e+03
4.23211786e+03 5.74458394e+03 1.75654315e+04 4.90453484e+02
1.64338060e+05 6.04771707e+03 5.44733344e-01 5.20931847e+02
3.41365908e+02 1.41743054e+04 9.01421539e+03 1.74443476e+08
2.85678752e+03 3.83724139e+06 1.01482946e-01 2.72802119e-02
7.00818280e+03 5.62139828e+04 6.85433160e+02]
iteration # 22100; log-lik = 233154.195238
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6.33633673e+03 5.57442312e+04 3.62319759e+04 1.13492075e+03
4.23329089e+03 5.74414366e+03 1.75666259e+04 4.90359806e+02
1.64553327e+05 6.04742070e+03 5.43845341e-01 5.20855758e+02
3.41282598e+02 1.41776595e+04 9.01719413e+03 1.74514005e+08
2.85763247e+03 3.83962577e+06 1.01479848e-01 2.72774813e-02
7.00647126e+03 5.62067067e+04 6.85370223e+02]
iteration # 22200; log-lik = 233154.195255
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6.33528376e+03 5.57372917e+04 3.62175095e+04 1.13431387e+03
4.23353638e+03 5.74293103e+03 1.75668659e+04 4.90354150e+02
1.64822436e+05 6.04674161e+03 5.42587634e-01 5.20940570e+02
3.41310474e+02 1.41798925e+04 9.01764743e+03 1.74894883e+08
2.85728955e+03 3.84789672e+06 1.01457316e-01 2.72729678e-02
7.00568683e+03 5.62122534e+04 6.85431261e+02]
iteration # 22300; log-lik = 233154.195260
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6.33574824e+03 5.57398627e+04 3.62139347e+04 1.13431055e+03
4.23359500e+03 5.74277964e+03 1.75675784e+04 4.90347170e+02
1.64730609e+05 6.04689125e+03 5.43202910e-01 5.21018933e+02
3.41350435e+02 1.41794441e+04 9.01722122e+03 1.74743364e+08
2.85745407e+03 3.84449495e+06 1.01468356e-01 2.72757983e-02
7.00518487e+03 5.62122200e+04 6.85413298e+02]
iteration # 22400; log-lik = 233154.195262
[ 2.53052397e+05 2.99893756e+07 2.79865707e+04 6.28722465e+04
6.33567901e+03 5.57396254e+04 3.62148966e+04 1.13425792e+03
4.23357620e+03 5.74306793e+03 1.75680263e+04 4.90369317e+02
1.64727866e+05 6.04715016e+03 5.43360392e-01 5.20994336e+02
3.41342599e+02 1.41794239e+04 9.01713808e+03 1.74691945e+08
2.85743397e+03 3.84320962e+06 1.01472799e-01 2.72765677e-02
7.00536783e+03 5.62133283e+04 6.85423384e+02]
iteration # 22500; log-lik = 233154.195263
[ 2.53054526e+05 2.99924775e+07 2.79864418e+04 6.28715898e+04
6.33546577e+03 5.57387722e+04 3.62158220e+04 1.13426137e+03
4.23356066e+03 5.74323487e+03 1.75680287e+04 4.90370285e+02
1.64748611e+05 6.04739576e+03 5.43294478e-01 5.20998319e+02
3.41342446e+02 1.41796374e+04 9.01713688e+03 1.74686127e+08
2.85746991e+03 3.84304839e+06 1.01473011e-01 2.72764603e-02
7.00530224e+03 5.62164249e+04 6.85457021e+02]
iteration # 22600; log-lik = 233154.195264
[ 2.53049229e+05 3.00052359e+07 2.79869213e+04 6.28715053e+04
6.33513334e+03 5.57367816e+04 3.62117894e+04 1.13409782e+03
4.23355462e+03 5.74324907e+03 1.75681190e+04 4.90364949e+02
1.64818956e+05 6.04738796e+03 5.43021557e-01 5.20984046e+02
3.41347206e+02 1.41800725e+04 9.01739402e+03 1.74754096e+08
2.85756023e+03 3.84460562e+06 1.01469166e-01 2.72751323e-02
7.00516197e+03 5.62177251e+04 6.85473059e+02]
iteration # 22700; log-lik = 233154.195264
[ 2.53049108e+05 3.00109849e+07 2.79868616e+04 6.28715148e+04
6.33488279e+03 5.57355889e+04 3.62105536e+04 1.13408309e+03
4.23351444e+03 5.74329597e+03 1.75678706e+04 4.90359491e+02
1.64849161e+05 6.04732239e+03 5.42811958e-01 5.20982794e+02
3.41350504e+02 1.41803057e+04 9.01733657e+03 1.74810634e+08
2.85757304e+03 3.84590781e+06 1.01465257e-01 2.72741657e-02
7.00501149e+03 5.62188945e+04 6.85488511e+02]
iteration # 22800; log-lik = 233154.195265
[ 2.53042157e+05 3.00148795e+07 2.79866707e+04 6.28713985e+04
6.33478111e+03 5.57347148e+04 3.62111598e+04 1.13414655e+03
4.23349806e+03 5.74323406e+03 1.75675986e+04 4.90359901e+02
1.64872887e+05 6.04733495e+03 5.42614022e-01 5.20990598e+02
3.41351931e+02 1.41803894e+04 9.01739553e+03 1.74855406e+08
2.85756312e+03 3.84692844e+06 1.01461387e-01 2.72734287e-02
7.00502933e+03 5.62200237e+04 6.85511130e+02]
iteration # 22900; log-lik = 233154.195265
[ 2.53050231e+05 3.00121750e+07 2.79865864e+04 6.28712280e+04
6.33483220e+03 5.57349930e+04 3.62111483e+04 1.13413710e+03
4.23352324e+03 5.74334531e+03 1.75676321e+04 4.90357659e+02
1.64852182e+05 6.04729524e+03 5.42730200e-01 5.20999476e+02
3.41364335e+02 1.41803411e+04 9.01737140e+03 1.74813889e+08
2.85758850e+03 3.84599631e+06 1.01464001e-01 2.72739820e-02
7.00509332e+03 5.62205885e+04 6.85518108e+02]
iteration # 23000; log-lik = 233154.195266
[ 2.53046366e+05 3.00109868e+07 2.79865036e+04 6.28714038e+04
6.33491455e+03 5.57351126e+04 3.62112140e+04 1.13412490e+03
4.23356600e+03 5.74315965e+03 1.75671555e+04 4.90351760e+02
1.64848697e+05 6.04727557e+03 5.42755763e-01 5.21027383e+02
3.41387677e+02 1.41802996e+04 9.01737551e+03 1.74804760e+08
2.85758159e+03 3.84576610e+06 1.01464342e-01 2.72742187e-02
7.00512549e+03 5.62204813e+04 6.85514848e+02]
iteration # 23100; log-lik = 233154.195266
[ 2.53049647e+05 3.00132476e+07 2.79866150e+04 6.28714776e+04
6.33483985e+03 5.57347253e+04 3.62110230e+04 1.13407508e+03
4.23359569e+03 5.74317455e+03 1.75671276e+04 4.90349825e+02
1.64859429e+05 6.04727310e+03 5.42716950e-01 5.21025427e+02
3.41385183e+02 1.41803799e+04 9.01738740e+03 1.74815078e+08
2.85757530e+03 3.84597009e+06 1.01463837e-01 2.72740563e-02
7.00509412e+03 5.62208944e+04 6.85518137e+02]
Optimization terminated successfully.
Current function value: -233154.195266
Iterations: 23165
Function evaluations: 28234
HJCFIT Fitting finished: 2016/02/11 13:45:58
CPU time in simplex= 2876.252112
Wallclock time in simplex= 2887.1952929496765
result=
final_simplex: (array([[ 12.44136064, 17.21711875, 10.23948459, 11.04884815,
8.75382305, 10.92835974, 10.49713103, 7.03360302,
8.3508114 , 8.65576619, 9.77378307, 6.19511159,
12.01279089, 8.70735769, -0.61117834, 6.25578846,
5.83300202, 9.55961217, 9.10690823, 18.97925377,
7.95772877, 15.1625547 , -2.28805903, -3.60182306,
8.85438668, 10.93704228, 6.53017519],
[ 12.44135748, 17.21709378, 10.23948313, 11.04884665,
8.75382514, 10.9283601 , 10.49713739, 7.03361079,
8.3508121 , 8.65576531, 9.77377938, 6.19510695,
12.0127695 , 8.70735967, -0.61116094, 6.25579308,
5.83300699, 9.55960981, 9.10690544, 18.97924569,
7.9577278 , 15.16254657, -2.28805956, -3.6018222 ,
8.85438257, 10.93704158, 6.53017461],
[ 12.44135392, 17.21709139, 10.23948269, 11.04884794,
8.75382599, 10.92836169, 10.49712334, 7.03359637,
8.35080984, 8.65576673, 9.77378482, 6.1951138 ,
12.01277372, 8.70735872, -0.61111866, 6.25579666,
5.83300647, 9.55961029, 9.1069054 , 18.97921475,
7.95772928, 15.1625144 , -2.28805304, -3.60181764,
8.85438328, 10.93704179, 6.53017348],
[ 12.44135811, 17.21707397, 10.23948123, 11.04884733,
8.75382704, 10.92836173, 10.4971383 , 7.03362021,
8.35080573, 8.65576609, 9.77377903, 6.19511229,
12.01275049, 8.70735964, -0.61113886, 6.25579637,
5.83300787, 9.55960817, 9.10690364, 18.97922346,
7.95772741, 15.16252367, -2.28805706, -3.60181964,
8.85438578, 10.93704423, 6.53017818],
[ 12.44135217, 17.21711131, 10.23948423, 11.04884731,
8.75382089, 10.92835927, 10.49713001, 7.03360448,
8.3508087 , 8.65577269, 9.77378525, 6.1951149 ,
12.01279564, 8.70736169, -0.61115656, 6.25579061,
5.83300638, 9.55961258, 9.10690611, 18.97922736,
7.95772921, 15.16252662, -2.28805423, -3.60182005,
8.85438618, 10.93704485, 6.5301773 ],
[ 12.44135536, 17.21709873, 10.23948172, 11.04884809,
8.7538267 , 10.92836166, 10.49712767, 7.03358936,
8.35081104, 8.65576679, 9.77378285, 6.19511628,
12.01277664, 8.70735812, -0.61111 , 6.25579761,
5.83301022, 9.55961015, 9.10690866, 18.97919419,
7.95772904, 15.16249268, -2.28805084, -3.60181608,
8.85438823, 10.9370424 , 6.53017536],
[ 12.44135702, 17.2170898 , 10.23948239, 11.0488476 ,
8.75382431, 10.92836088, 10.49713145, 7.03360987,
8.35080841, 8.6557707 , 9.77378262, 6.1951156 ,
12.01276621, 8.70735754, -0.61113651, 6.25579064,
5.83300583, 9.5596101 , 9.10690504, 18.97921887,
7.95772953, 15.16251944, -2.28805474, -3.60181938,
8.85438592, 10.93704286, 6.53017632],
[ 12.44134974, 17.21716117, 10.23948331, 11.04884811,
8.75381472, 10.92835443, 10.49712621, 7.03359348,
8.35080938, 8.65576665, 9.77378198, 6.19511284,
12.01284652, 8.70735866, -0.6112537 , 6.25578908,
5.83300624, 9.55961521, 9.10690717, 18.97931853,
7.95772785, 15.16261864, -2.28806561, -3.60182886,
8.85438501, 10.93704623, 6.53017912],
[ 12.44135149, 17.2171479 , 10.23948298, 11.04884743,
8.75381875, 10.92835683, 10.49711496, 7.03359385,
8.35080838, 8.65576705, 9.77377962, 6.19511056,
12.01282435, 8.70735506, -0.61122782, 6.25579228,
5.83300543, 9.55961289, 9.10690702, 18.97931173,
7.95772822, 15.16261407, -2.28806498, -3.6018283 ,
8.8543846 , 10.9370423 , 6.53017579],
[ 12.44134999, 17.21709154, 10.23948222, 11.04884829,
8.75382766, 10.92836227, 10.49713011, 7.03360657,
8.35081045, 8.65576632, 9.77378181, 6.19511166,
12.01277633, 8.70735836, -0.61112994, 6.25579814,
5.83301344, 9.55960984, 9.10690791, 18.97921049,
7.95772971, 15.16251142, -2.28805319, -3.60181804,
8.85438842, 10.93703926, 6.53017185],
[ 12.44135083, 17.21711494, 10.2394818 , 11.04884778,
8.75382213, 10.92835903, 10.49712864, 7.03360052,
8.35080884, 8.65576681, 9.77378103, 6.19511334,
12.01279883, 8.7073588 , -0.61117319, 6.25579784,
5.83301081, 9.55961173, 9.10690592, 18.97924856,
7.95772875, 15.16254895, -2.28805769, -3.60182144,
8.85438624, 10.93704425, 6.5301774 ],
[ 12.44135859, 17.2171202 , 10.23948298, 11.04884902,
8.75382112, 10.92835923, 10.49713144, 7.03359689,
8.35080901, 8.65577078, 9.77378239, 6.19511423,
12.01279573, 8.70735488, -0.61116919, 6.25578974,
5.83300481, 9.55961238, 9.10690731, 18.97923862,
7.95773098, 15.16253749, -2.28805603, -3.60182198,
8.85438851, 10.93704403, 6.53017691],
[ 12.44135174, 17.21711827, 10.239482 , 11.04884752,
8.75382369, 10.92836047, 10.49712774, 7.03359989,
8.35080912, 8.65576379, 9.77377917, 6.19511424,
12.01279978, 8.70735783, -0.61117149, 6.25579267,
5.83300477, 9.55961211, 9.10690868, 18.97925402,
7.95772946, 15.16255417, -2.28805851, -3.60182266,
8.85438612, 10.93704085, 6.53017327],
[ 12.44135489, 17.21710113, 10.23948166, 11.04884702,
8.75382448, 10.92836133, 10.49713848, 7.03360495,
8.3508103 , 8.65576912, 9.77378199, 6.19511527,
12.01278067, 8.70735975, -0.61114114, 6.25579434,
5.83300491, 9.55961157, 9.1069076 , 18.97921558,
7.95772623, 15.16251539, -2.28805419, -3.60181821,
8.85438801, 10.93704266, 6.53017615],
[ 12.44135308, 17.21712081, 10.23948179, 11.04884816,
8.75382302, 10.92835946, 10.4971227 , 7.03359507,
8.3508084 , 8.65576503, 9.77377918, 6.195116 ,
12.01280136, 8.70735776, -0.61117105, 6.25579672,
5.83300723, 9.55961132, 9.10690721, 18.97925332,
7.95772812, 15.16255188, -2.28805807, -3.60182197,
8.85438833, 10.93704397, 6.53017653],
[ 12.44135215, 17.21715054, 10.23948297, 11.0488471 ,
8.75381735, 10.92835775, 10.49711882, 7.03358023,
8.35081084, 8.65577206, 9.77378229, 6.19511599,
12.01283492, 8.70735959, -0.61118489, 6.25579015,
5.83300784, 9.55961557, 9.10690847, 18.9792589 ,
7.95772695, 15.16255579, -2.28805611, -3.60182242,
8.85439059, 10.93704197, 6.53017403],
[ 12.4413553 , 17.21710837, 10.23948268, 11.0488472 ,
8.75382142, 10.92835934, 10.49713101, 7.03360792,
8.35080803, 8.65577037, 9.773781 , 6.1951124 ,
12.01278917, 8.70736043, -0.61116976, 6.2557915 ,
5.83300675, 9.5596113 , 9.10690517, 18.97924508,
7.95772823, 15.1625461 , -2.28805777, -3.60182231,
8.854386 , 10.93704466, 6.53017685],
[ 12.4413448 , 17.21712016, 10.2394825 , 11.04884759,
8.75382109, 10.92835845, 10.49712173, 7.03359642,
8.35080762, 8.65577101, 9.77378375, 6.19511981,
12.0128102 , 8.70735773, -0.61116941, 6.25579109,
5.83300516, 9.55961137, 9.10690584, 18.979253 ,
7.95772622, 15.1625506 , -2.28805655, -3.60182185,
8.85439062, 10.93704312, 6.53017626],
[ 12.4413594 , 17.21706934, 10.23948205, 11.04884774,
8.7538273 , 10.92836294, 10.49713591, 7.03360874,
8.35080803, 8.65576985, 9.77377868, 6.19511411,
12.01274408, 8.70735687, -0.61110445, 6.25579677,
5.83300725, 9.55960783, 9.10690257, 18.97919877,
7.95772745, 15.16249636, -2.28805245, -3.60181604,
8.85438813, 10.93704137, 6.53017371],
[ 12.4413517 , 17.21709495, 10.23948372, 11.04884866,
8.75382572, 10.92836087, 10.49713033, 7.03359869,
8.35080973, 8.65576502, 9.77378132, 6.19511436,
12.0127776 , 8.70735645, -0.6111335 , 6.25579731,
5.83301355, 9.55961032, 9.10690614, 18.97921796,
7.95772846, 15.16251666, -2.28805391, -3.60181813,
8.85438733, 10.93704173, 6.53017402],
[ 12.44135478, 17.21710643, 10.2394824 , 11.04884755,
8.75382362, 10.92836049, 10.49712724, 7.03358971,
8.35080906, 8.65576931, 9.77378292, 6.19511459,
12.01278548, 8.70735839, -0.61113124, 6.25579219,
5.83300809, 9.55961118, 9.10690672, 18.97921712,
7.95773084, 15.16251901, -2.28805325, -3.60181876,
8.85438568, 10.93704099, 6.53017362],
[ 12.44135686, 17.21708879, 10.23948295, 11.04884774,
8.75382435, 10.92836099, 10.49713932, 7.03361167,
8.3508084 , 8.6557678 , 9.77378274, 6.1951139 ,
12.01276477, 8.70735827, -0.61114576, 6.25578838,
5.83300206, 9.55960917, 9.10690417, 18.97922978,
7.95772966, 15.16252961, -2.28805643, -3.6018205 ,
8.85438703, 10.93704245, 6.53017507],
[ 12.44135648, 17.21710252, 10.23948215, 11.04884553,
8.75382307, 10.92836038, 10.49713028, 7.03360479,
8.35080849, 8.65576869, 9.77378088, 6.1951148 ,
12.01278154, 8.70736273, -0.61114583, 6.25578884,
5.83300492, 9.55961182, 9.10690635, 18.97922689,
7.95773076, 15.16252741, -2.2880558 , -3.6018205 ,
8.85438528, 10.93704266, 6.53017551],
[ 12.44134983, 17.2170834 , 10.23948089, 11.04884701,
8.75382668, 10.92836192, 10.49712984, 7.03360731,
8.3508078 , 8.655769 , 9.7737816 , 6.19511444,
12.01277009, 8.70736155, -0.61111773, 6.25579755,
5.83301183, 9.55960953, 9.10690544, 18.97920354,
7.95772923, 15.16250466, -2.28805233, -3.60181703,
8.85438653, 10.93704086, 6.53017412],
[ 12.44135264, 17.21710385, 10.23948186, 11.04884645,
8.75382244, 10.92835879, 10.49712877, 7.03360142,
8.35080765, 8.65577037, 9.77378512, 6.19511325,
12.01278577, 8.70736035, -0.61115139, 6.25579308,
5.83301156, 9.5596107 , 9.1069056 , 18.97922637,
7.95773038, 15.16252714, -2.2880558 , -3.6018204 ,
8.85438733, 10.93704628, 6.5301792 ],
[ 12.44134657, 17.21709879, 10.2394815 , 11.04884855,
8.75382549, 10.92836053, 10.49713325, 7.03361049,
8.3508097 , 8.65576237, 9.77377822, 6.19511211,
12.01278669, 8.70735809, -0.61115807, 6.25580319,
5.83302033, 9.5596112 , 9.10690759, 18.97922701,
7.95772935, 15.16252807, -2.28805602, -3.60181987,
8.85438544, 10.93704351, 6.53017639],
[ 12.44134979, 17.21709371, 10.23948269, 11.04884733,
8.75382541, 10.92836151, 10.49713553, 7.03361042,
8.35080869, 8.65576934, 9.7737828 , 6.19511359,
12.0127782 , 8.70735986, -0.61114094, 6.25579486,
5.83300502, 9.55961026, 9.10690677, 18.97921982,
7.95772946, 15.16252128, -2.2880544 , -3.60181876,
8.85438479, 10.93704111, 6.530175 ],
[ 12.44135579, 17.21709085, 10.23948277, 11.04884736,
8.75382549, 10.92836162, 10.49712955, 7.03360033,
8.35080913, 8.65576941, 9.77378357, 6.19511326,
12.01277048, 8.70736004, -0.61112046, 6.25579397,
5.83301009, 9.55961008, 9.10690547, 18.97920778,
7.95772949, 15.16250776, -2.28805262, -3.60181705,
8.85438779, 10.93704051, 6.53017287]]), array([-233154.19526622, -233154.1952662 , -233154.1952662 ,
-233154.1952662 , -233154.1952662 , -233154.19526619,
-233154.19526619, -233154.19526619, -233154.19526618,
-233154.19526618, -233154.19526618, -233154.19526618,
-233154.19526618, -233154.19526617, -233154.19526617,
-233154.19526617, -233154.19526617, -233154.19526616,
-233154.19526616, -233154.19526616, -233154.19526616,
-233154.19526616, -233154.19526615, -233154.19526615,
-233154.19526614, -233154.19526614, -233154.19526614,
-233154.19526613]))
fun: -233154.19526622375
message: 'Optimization terminated successfully.'
nfev: 28234
nit: 23165
status: 0
success: True
x: array([ 12.44136064, 17.21711875, 10.23948459, 11.04884815,
8.75382305, 10.92835974, 10.49713103, 7.03360302,
8.3508114 , 8.65576619, 9.77378307, 6.19511159,
12.01279089, 8.70735769, -0.61117834, 6.25578846,
5.83300202, 9.55961217, 9.10690823, 18.97925377,
7.95772877, 15.1625547 , -2.28805903, -3.60182306,
8.85438668, 10.93704228, 6.53017519])
Final log-likelihood = 233154.195266
Number of iterations = 23165
Number of evaluations = 28234
Final rate constants:
class dcpyps.Mechanism
Values of unit rates [1/sec]:
From A3F3O to A3F3 alpha3fff 253054.622558
From A3F3 to A3F3O beta3fff 30012326.9388
From A3F2O to A3F2 alpha3ff 27986.6976893
From A3F2 to A3F2O beta3ff 62871.4945011
From A2F2O to A2F2 alpha2ff 6334.86033119
From A2F2 to A2F2O beta2ff 55734.7849606
From A3F1O to A3F1 alpha3f 36211.4638333
From A3F1 to A3F1O beta3f 1134.10948012
From A2F1O to A2F1 alpha2f 4233.61450596
From A2F1 to A2F1O beta2f 5743.16762327
From A1F1O to A1F1 alpha1f 17567.0992823
From A1F1 to A1F1O beta1f 490.346162057
From A3F3 to A3F2 gama3fff 164849.940257
From A3F2 to A3F3 delta3fff 6047.24269011
From A3F2 to A2F2 3kff(-3) 0.542710993044
From A2F2 to A3F2 kff(+3) 16.9450053348
From A3F2 to A3F1 gama3ff 521.020016436
From A3F1 to A3F2 delta3ff 341.381977735
From A2F2 to A2F1 gama2ff 14180.3456141
From A2F1 to A2F2 delta2ff 9017.37211441
From A3F1 to A2F1 3kf(-3) 5769060.54004
From A2F1 to A3F1 kf(+3) 174817611.294
From A3F1 to A3R gama3f 2857.57536123
From A3R to A3F1 delta3f 851.452655826
From A2F1 to A1F1 2kf(-2) 3846040.36003
From A1F1 to A2F1 2kf(+2) 349635222.587
From A2F1 to A2R gama2f 0.101463208104
From A2R to A2F1 delta2f 0.0272739550962
From A1F1 to A1R gama1f 7005.05060298
From A1R to A1F1 delta1f 1698.74240308
From A3R to A2R 3k(-3) 2056.55489459
From A2R to A3R k(+3) 56220.8116473
From A2R to A1R 2k(-2) 1371.03659639
From A1R to A2R 2k(+2) 112441.623295
From A1R to R k(-1) 685.518298197
From R to A1R 3k(+1) 168662.434942
Conductance of state A3F3O (pS) = 50
Conductance of state A3F2O (pS) = 50
Conductance of state A2F2O (pS) = 50
Conductance of state A3F1O (pS) = 50
Conductance of state A2F1O (pS) = 50
Conductance of state A1F1O (pS) = 50
Number of open states = 6
Number of short-lived shut states (within burst) = 9
Number of long-lived shut states (between bursts) = 1
Number of desensitised states = 0
Number of cycles = 3
Cycle 1 is formed of states: A3F2 A2F2 A2F1 A3F1
forward product = 4.592838838e+14
backward product = 4.592838838e+14
Cycle 2 is formed of states: A3F1 A2F1 A2R A3R
forward product = 2.802020459e+13
backward product = 2.802020459e+13
Cycle 3 is formed of states: A2F1 A1F1 A1R A2R
forward product = 8.262288248e+13
backward product = 8.262288248e+13
Data loaded from file: ../../DCPYPS/dcpyps/samples/glydemo/keA.scn
Concentration of agonist = 300.000 microMolar
Resolution for HJC calculations = 40.0 microseconds
Critical gap length to define end of group (tcrit) = 0.600 milliseconds
(defined so that all openings in a group prob come from same channel)
Initial and final vectors for bursts calculated asin Colquhoun, Hawkes & Srodzinski, (1996, eqs 5.8, 5.11).
Number of resolved intervals = 11662
Number of resolved periods = 11088
Number of open periods = 5544
Mean and SD of open periods = 0.397568729 +/- 1.362546164 ms
Range of open periods from 0.040033814 ms to 83.755209722 ms
Number of shut intervals = 5544
Mean and SD of shut periods = 109.531529248 +/- 2942.205429077 ms
Range of shut periods from 0.040052371 ms to 204117.309570312 ms
Last shut period = 10.665501468 ms
Number of bursts = 4618
Average length = 0.504651324 ms
Range: 0.040 to 83.755 millisec
Average number of openings= 1.200519706
Data loaded from file: ../../DCPYPS/dcpyps/samples/glydemo/keB.scn
Concentration of agonist = 3000.000 microMolar
Resolution for HJC calculations = 40.0 microseconds
Critical gap length to define end of group (tcrit) = -70.000 milliseconds
(defined so that all openings in a group prob come from same channel)
Initial and final vectors for are calculated as for steady state openings and shuttings (this involves a slight approximation at start and end of bursts that are defined by shut times that have been set as bad).
Number of resolved intervals = 14296
Number of resolved periods = 12338
Number of open periods = 6169
Mean and SD of open periods = 0.568432008 +/- 0.781032231 ms
Range of open periods from 0.040003666 ms to 23.221036885 ms
Number of shut intervals = 6169
Mean and SD of shut periods = 3.801412648 +/- 35.561904311 ms
Range of shut periods from 0.040001163 ms to 2761.569499969 ms
Last shut period = 0.373572315 ms
Number of bursts = 3
Average length = 8038.560359078 ms
Range: 1572.336 to 17533.538 millisec
Average number of openings= 2056.333333333
Data loaded from file: ../../DCPYPS/dcpyps/samples/glydemo/keC.scn
Concentration of agonist = 30000.000 microMolar
Resolution for HJC calculations = 40.0 microseconds
Critical gap length to define end of group (tcrit) = -20.000 milliseconds
(defined so that all openings in a group prob come from same channel)
Initial and final vectors for are calculated as for steady state openings and shuttings (this involves a slight approximation at start and end of bursts that are defined by shut times that have been set as bad).
Number of resolved intervals = 7569
Number of resolved periods = 5810
Number of open periods = 2905
Mean and SD of open periods = 0.764939965 +/- 1.200268148 ms
Range of open periods from 0.040136722 ms to 20.713106598 ms
Number of shut intervals = 2905
Mean and SD of shut periods = 76.107278466 +/- 2832.809209824 ms
Range of shut periods from 0.037358772 ms to 109791.648864746 ms
Last shut period = 0.037358772 ms
Number of bursts = 5
Average length = 886.178571851 ms
Range: 0.222 to 2465.916 millisec
Average number of openings= 581.000000000
Data loaded from file: ../../DCPYPS/dcpyps/samples/glydemo/keD.scn
Concentration of agonist = 100000.000 microMolar
Resolution for HJC calculations = 40.0 microseconds
Critical gap length to define end of group (tcrit) = -20.000 milliseconds
(defined so that all openings in a group prob come from same channel)
Initial and final vectors for are calculated as for steady state openings and shuttings (this involves a slight approximation at start and end of bursts that are defined by shut times that have been set as bad).
Number of resolved intervals = 14723
Number of resolved periods = 12210
Number of open periods = 6105
Mean and SD of open periods = 0.888958726 +/- 1.245775257 ms
Range of open periods from 0.040174076 ms to 21.068737711 ms
Number of shut intervals = 6105
Mean and SD of shut periods = 5.588796455 +/- 134.609654546 ms
Range of shut periods from 0.037023197 ms to 7994.186401367 ms
Last shut period = 0.037023197 ms
Number of bursts = 25
Average length = 478.491306786 ms
Range: 0.073 to 3397.090 millisec
Average number of openings= 244.200000000
class dcpyps.Mechanism
Values of unit rates [1/sec]:
From A3F3O to A3F3 alpha3fff 164180.872344
From A3F3 to A3F3O beta3fff 879798.259388
From A3F2O to A3F2 alpha3ff 17631.1000954
From A3F2 to A3F2O beta3ff 75963.8340657
From A2F2O to A2F2 alpha2ff 18512.6542595
From A2F2 to A2F2O beta2ff 72165.6459847
From A3F1O to A3F1 alpha3f 19957.2751004
From A3F1 to A3F1O beta3f 302.572972131
From A2F1O to A2F1 alpha2f 20555.9927824
From A2F1 to A2F1O beta2f 293.495791624
From A1F1O to A1F1 alpha1f 21154.7104645
From A1F1 to A1F1O beta1f 284.418611117
From A3F3 to A3F2 gama3fff 11673.7928596
From A3F2 to A3F3 delta3fff 2585.56822991
From A3F2 to A2F2 3kff(-3) 26.209768672
From A2F2 to A3F2 kff(+3) 684.568191741
From A3F2 to A3F1 gama3ff 2862.00095617
From A3F1 to A3F2 delta3ff 1741.88100927
From A2F2 to A2F1 gama2ff 11625.274006
From A2F1 to A2F2 delta2ff 8662.55618102
From A3F1 to A2F1 3kf(-3) 1436109.06916
From A2F1 to A3F1 kf(+3) 45923513.6955
From A3F1 to A3R gama3f 2473.77597999
From A3R to A3F1 delta3f 769.546855601
From A2F1 to A1F1 2kf(-2) 957406.04611
From A1F1 to A2F1 2kf(+2) 91847027.3909
From A2F1 to A2R gama2f 0.0997096333233
From A2R to A2F1 delta2f 0.027994525861
From A1F1 to A1R gama1f 7438.33684661
From A1R to A1F1 delta1f 1884.83412534
From A3R to A2R 3k(-3) 1507.83869722
From A2R to A3R k(+3) 43517.4928712
From A2R to A1R 2k(-2) 1005.22579814
From A1R to A2R 2k(+2) 87034.9857424
From A1R to R k(-1) 502.612899072
From R to A1R 3k(+1) 130552.478614
Conductance of state A3F3O (pS) = 50
Conductance of state A3F2O (pS) = 50
Conductance of state A2F2O (pS) = 50
Conductance of state A3F1O (pS) = 50
Conductance of state A2F1O (pS) = 50
Conductance of state A1F1O (pS) = 50
Number of open states = 6
Number of short-lived shut states (within burst) = 9
Number of long-lived shut states (between bursts) = 1
Number of desensitised states = 0
Number of cycles = 3
Cycle 1 is formed of states: A3F2 A2F2 A2F1 A3F1
forward product = 2.437361683e+16
backward product = 2.437361683e+16
Cycle 2 is formed of states: A3F1 A2F1 A2R A3R
forward product = 4.795384982e+12
backward product = 4.795384982e+12
Cycle 3 is formed of states: A2F1 A1F1 A1R A2R
forward product = 1.735157837e+13
backward product = 1.735157837e+13
Starting likelihood = 232502.287977
iteration # 100; log-lik = 232928.154662
[ 1.41924696e+05 9.91282568e+05 1.97840130e+04 7.82168302e+04
1.71306492e+04 7.68160837e+04 1.91299496e+04 3.29285607e+02
2.03109769e+04 3.21385337e+02 1.77876364e+04 3.07427710e+02
9.53885963e+03 3.14538983e+03 2.66831193e+01 2.88401102e+03
1.83802336e+03 9.93511657e+03 9.46742351e+03 4.79548708e+07
2.69765023e+03 9.59381397e+05 9.69674010e-02 2.95029655e-02
7.21696699e+03 4.79948914e+04 4.64842402e+02]
iteration # 200; log-lik = 232979.192057
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1.71029252e+04 7.68171076e+04 1.71190644e+04 3.42107973e+02
1.98215160e+04 3.28061884e+02 1.57404148e+04 3.69429873e+02
9.05588107e+03 2.93348168e+03 2.47742706e+01 2.66183859e+03
1.80308002e+03 9.82741621e+03 9.20819434e+03 4.89168093e+07
2.87111595e+03 9.56960899e+05 9.77159540e-02 3.00259005e-02
7.78208260e+03 4.73797799e+04 4.85791261e+02]
iteration # 300; log-lik = 233002.232358
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1.86587447e+04 3.48193383e+02 1.38161174e+04 4.13244661e+02
8.41526537e+03 2.83569328e+03 2.60822758e+01 2.44770496e+03
1.67354724e+03 9.51977339e+03 9.21709747e+03 4.62329996e+07
3.12459255e+03 9.75174512e+05 9.66457332e-02 2.93387769e-02
6.59904934e+03 4.70727221e+04 4.82397914e+02]
iteration # 400; log-lik = 233018.988138
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1.82306857e+04 3.83449704e+02 1.45437964e+04 4.31136662e+02
8.25161166e+03 2.74034750e+03 2.59165616e+01 2.29627631e+03
1.45026493e+03 9.53446236e+03 9.40284474e+03 4.72968854e+07
2.94066199e+03 9.44090357e+05 9.68547856e-02 2.88592808e-02
6.40567244e+03 4.66407464e+04 4.79943892e+02]
iteration # 500; log-lik = 233039.395788
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1.56810436e+04 4.50922832e+02 1.37971980e+04 4.71660034e+02
7.79209469e+03 2.60040045e+03 2.58362305e+01 1.98649454e+03
1.14826360e+03 9.86977844e+03 9.57688621e+03 4.71647054e+07
2.65861372e+03 8.73934049e+05 9.79258969e-02 2.91987287e-02
6.89841492e+03 4.51984767e+04 4.86336071e+02]
iteration # 600; log-lik = 233048.465860
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1.37892065e+04 4.95990174e+02 1.39243349e+04 5.00884359e+02
7.72789676e+03 2.63733775e+03 2.52296415e+01 1.89120845e+03
1.00135478e+03 9.99077801e+03 9.63004704e+03 4.87800502e+07
2.43395436e+03 8.51913920e+05 9.89014118e-02 2.94707396e-02
7.67575311e+03 4.49023615e+04 4.86137282e+02]
iteration # 700; log-lik = 233057.149323
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1.24049779e+04 5.27515813e+02 1.38621949e+04 5.62421214e+02
7.66341611e+03 2.79009095e+03 2.41159390e+01 1.80736481e+03
9.26036363e+02 9.97574384e+03 9.65850089e+03 4.96878513e+07
2.25527758e+03 8.29899324e+05 9.99611919e-02 3.03854219e-02
8.09623091e+03 4.53338548e+04 4.91714514e+02]
iteration # 800; log-lik = 233060.654072
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1.17987841e+04 5.45788246e+02 1.37135087e+04 5.68461400e+02
7.84646994e+03 2.95600780e+03 2.33945732e+01 1.76938109e+03
9.25737084e+02 9.85673993e+03 9.43903120e+03 4.95216116e+07
2.29888914e+03 8.15096090e+05 1.00533576e-01 3.01991878e-02
8.28623854e+03 4.57863064e+04 4.95039580e+02]
iteration # 900; log-lik = 233062.450423
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1.10904760e+04 5.64504346e+02 1.39878590e+04 5.58343931e+02
7.85790191e+03 2.96424252e+03 2.37553581e+01 1.71113928e+03
9.07245431e+02 9.97564384e+03 9.45234039e+03 4.91590432e+07
2.25573386e+03 8.04936581e+05 1.00595126e-01 3.01130966e-02
8.37852225e+03 4.56664346e+04 4.91602787e+02]
iteration # 1000; log-lik = 233065.495431
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7.69678557e+03 3.11874688e+03 2.43908467e+01 1.57122986e+03
8.72350317e+02 1.00211476e+04 9.34231224e+03 4.64133282e+07
2.30456767e+03 7.63399960e+05 1.02357514e-01 3.02529138e-02
8.26298275e+03 4.58105792e+04 4.90138216e+02]
iteration # 1100; log-lik = 233070.110392
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6.15754895e+03 7.41703545e+02 1.48154493e+04 5.26033863e+02
7.44409643e+03 3.24714750e+03 2.62198276e+01 1.44435304e+03
8.90554632e+02 1.01414074e+04 9.39117570e+03 4.10152850e+07
2.63014887e+03 7.29553747e+05 1.04103859e-01 3.04145924e-02
7.80511749e+03 4.61691965e+04 4.94014435e+02]
iteration # 1200; log-lik = 233072.588350
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7.56306392e+03 3.44776661e+03 2.67748348e+01 1.36084107e+03
8.66139638e+02 1.02333363e+04 9.45962292e+03 3.90671057e+07
2.65025002e+03 7.08083409e+05 1.05247616e-01 3.05739238e-02
7.57159709e+03 4.63029302e+04 4.95595990e+02]
iteration # 1300; log-lik = 233075.301533
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2.70586045e+03 6.80767948e+05 1.05542569e-01 3.06555792e-02
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iteration # 1400; log-lik = 233078.387294
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7.36835707e+03 3.95480647e+03 2.81543293e+01 1.22997990e+03
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2.69876989e+03 6.55874822e+05 1.06207435e-01 3.05068201e-02
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iteration # 1500; log-lik = 233088.714461
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2.78680516e+03 5.61209856e+05 1.06991720e-01 3.09720830e-02
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iteration # 1600; log-lik = 233098.368190
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iteration # 1700; log-lik = 233102.354114
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iteration # 1800; log-lik = 233105.816071
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3.18233146e+03 4.46197126e+05 1.08762685e-01 3.11838802e-02
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iteration # 1900; log-lik = 233109.352055
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4.76247391e+02 1.02379131e+04 9.71046685e+03 1.55652983e+07
3.33545935e+03 4.15913716e+05 1.09573328e-01 3.12469049e-02
5.91487711e+03 4.29991632e+04 5.00993501e+02]
iteration # 2000; log-lik = 233113.229377
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4.37802749e+02 1.01497442e+04 9.59179895e+03 1.49474303e+07
3.05643943e+03 3.81556624e+05 1.10162352e-01 3.18069100e-02
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iteration # 2100; log-lik = 233117.241846
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iteration # 2200; log-lik = 233126.839909
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iteration # 2300; log-lik = 233133.813281
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iteration # 2400; log-lik = 233135.695276
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iteration # 2500; log-lik = 233136.831060
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iteration # 2600; log-lik = 233138.456119
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iteration # 2700; log-lik = 233139.361638
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iteration # 2800; log-lik = 233139.839857
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iteration # 2900; log-lik = 233140.254281
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iteration # 3000; log-lik = 233141.048428
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iteration # 3100; log-lik = 233141.844952
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iteration # 3200; log-lik = 233142.643585
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iteration # 3300; log-lik = 233143.624095
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iteration # 3400; log-lik = 233144.116111
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iteration # 3500; log-lik = 233144.661394
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iteration # 3600; log-lik = 233144.849162
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iteration # 3700; log-lik = 233144.975757
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iteration # 3800; log-lik = 233145.024746
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iteration # 3900; log-lik = 233145.143485
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iteration # 4000; log-lik = 233145.329902
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iteration # 4100; log-lik = 233145.466481
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iteration # 4200; log-lik = 233145.579027
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iteration # 4300; log-lik = 233145.677676
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iteration # 4400; log-lik = 233145.764848
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iteration # 4500; log-lik = 233145.828877
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iteration # 4600; log-lik = 233145.896551
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iteration # 4700; log-lik = 233146.032343
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iteration # 4800; log-lik = 233146.123677
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iteration # 4900; log-lik = 233146.188024
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iteration # 5000; log-lik = 233146.275565
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iteration # 5100; log-lik = 233146.404584
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iteration # 5200; log-lik = 233146.752625
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iteration # 5300; log-lik = 233147.214224
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iteration # 5400; log-lik = 233147.761666
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iteration # 5500; log-lik = 233148.024699
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iteration # 5600; log-lik = 233148.236252
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iteration # 5700; log-lik = 233148.411315
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iteration # 5800; log-lik = 233148.470665
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iteration # 5900; log-lik = 233148.491486
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iteration # 6000; log-lik = 233148.501947
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iteration # 6100; log-lik = 233148.508076
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iteration # 6200; log-lik = 233148.517431
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iteration # 6300; log-lik = 233148.540807
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iteration # 6400; log-lik = 233148.558988
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iteration # 6500; log-lik = 233148.585978
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iteration # 6600; log-lik = 233148.690998
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iteration # 6700; log-lik = 233148.800957
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iteration # 6800; log-lik = 233148.995978
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iteration # 6900; log-lik = 233149.085682
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iteration # 7000; log-lik = 233149.160933
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iteration # 7100; log-lik = 233149.196825
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iteration # 7200; log-lik = 233149.208746
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iteration # 7300; log-lik = 233149.222066
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iteration # 7400; log-lik = 233149.228201
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iteration # 7500; log-lik = 233149.234081
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iteration # 7600; log-lik = 233149.237222
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iteration # 7700; log-lik = 233149.240819
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iteration # 7800; log-lik = 233149.243068
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iteration # 7900; log-lik = 233149.244472
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iteration # 8000; log-lik = 233149.245403
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iteration # 8100; log-lik = 233149.247221
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iteration # 8200; log-lik = 233149.249009
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iteration # 8300; log-lik = 233149.251940
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iteration # 8400; log-lik = 233149.255261
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iteration # 8500; log-lik = 233149.261308
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iteration # 8600; log-lik = 233149.271785
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iteration # 8700; log-lik = 233149.286011
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iteration # 8800; log-lik = 233149.311914
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iteration # 8900; log-lik = 233149.345079
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iteration # 9000; log-lik = 233149.357663
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iteration # 9100; log-lik = 233149.387948
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iteration # 9200; log-lik = 233149.430120
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iteration # 9300; log-lik = 233149.510779
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iteration # 9400; log-lik = 233149.562445
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iteration # 9500; log-lik = 233149.683767
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iteration # 10000; log-lik = 233150.232121
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iteration # 10600; log-lik = 233152.002648
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iteration # 10800; log-lik = 233152.713850
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iteration # 12600; log-lik = 233154.047008
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iteration # 12700; log-lik = 233154.050457
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iteration # 12800; log-lik = 233154.054329
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iteration # 12900; log-lik = 233154.061395
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iteration # 13000; log-lik = 233154.063313
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iteration # 13100; log-lik = 233154.064845
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iteration # 13200; log-lik = 233154.066676
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iteration # 13300; log-lik = 233154.071675
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iteration # 13400; log-lik = 233154.087094
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iteration # 13500; log-lik = 233154.103573
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iteration # 13600; log-lik = 233154.118115
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iteration # 13700; log-lik = 233154.156010
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iteration # 13800; log-lik = 233154.219383
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iteration # 13900; log-lik = 233154.288467
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iteration # 14000; log-lik = 233154.376435
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iteration # 14100; log-lik = 233154.490891
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iteration # 14200; log-lik = 233154.665333
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iteration # 14300; log-lik = 233154.736406
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iteration # 14400; log-lik = 233154.806658
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iteration # 14500; log-lik = 233154.872731
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iteration # 14700; log-lik = 233155.045687
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iteration # 14800; log-lik = 233155.117095
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iteration # 15000; log-lik = 233155.209127
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iteration # 15700; log-lik = 233155.663502
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iteration # 21900; log-lik = 233161.536631
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iteration # 25000; log-lik = 233161.566211
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iteration # 25100; log-lik = 233161.568716
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iteration # 25600; log-lik = 233161.597844
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iteration # 28100; log-lik = 233163.965045
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[ 3.23796651e+05 1.33064419e+08 2.66131447e+04 6.23894390e+04
3.24008122e+03 2.84802880e+04 4.33044470e+04 1.54360304e+03
4.35429135e+03 5.38155025e+03 1.76743119e+04 4.89827285e+02
5.92922621e+05 6.41770647e+03 1.11032029e-01 6.38118205e+02
4.18945784e+02 1.79325216e+04 1.22721038e+04 4.23590673e+08
3.05312261e+03 9.45152661e+06 9.76906305e-02 2.52987089e-02
7.43993747e+03 5.19828986e+04 6.27154364e+02]
iteration # 34400; log-lik = 233166.235826
[ 3.23821958e+05 1.33061271e+08 2.66134140e+04 6.23896106e+04
3.24009813e+03 2.84804360e+04 4.33075196e+04 1.54370874e+03
4.35434534e+03 5.38143933e+03 1.76741740e+04 4.89814999e+02
5.92855236e+05 6.41763601e+03 1.11030681e-01 6.38099993e+02
4.18940957e+02 1.79325521e+04 1.22721282e+04 4.23591046e+08
3.05312275e+03 9.45165551e+06 9.76903733e-02 2.52988481e-02
7.43987095e+03 5.19823528e+04 6.27146572e+02]
iteration # 34500; log-lik = 233166.235826
[ 3.23819221e+05 1.33061997e+08 2.66133552e+04 6.23896474e+04
3.24005837e+03 2.84798382e+04 4.33081399e+04 1.54375072e+03
4.35433865e+03 5.38141754e+03 1.76740390e+04 4.89816115e+02
5.92872601e+05 6.41774262e+03 1.11024892e-01 6.38103827e+02
4.18947330e+02 1.79325445e+04 1.22722401e+04 4.23598898e+08
3.05313485e+03 9.45183455e+06 9.76898349e-02 2.52986951e-02
7.43996143e+03 5.19819623e+04 6.27143996e+02]
iteration # 34600; log-lik = 233166.235826
[ 3.23812507e+05 1.33072669e+08 2.66133416e+04 6.23895863e+04
3.24005705e+03 2.84799068e+04 4.33082389e+04 1.54375011e+03
4.35434737e+03 5.38142197e+03 1.76740339e+04 4.89812610e+02
5.92930932e+05 6.41773665e+03 1.11011463e-01 6.38096949e+02
4.18942381e+02 1.79325881e+04 1.22721875e+04 4.23655181e+08
3.05312014e+03 9.45309413e+06 9.76891816e-02 2.52986337e-02
7.43994391e+03 5.19816883e+04 6.27140084e+02]
Optimization terminated successfully.
Current function value: -233166.235826
Iterations: 34620
Function evaluations: 42029
HJCFIT Fitting finished: 2016/02/11 12:56:41
CPU time in simplex= 4080.174974
Wallclock time in simplex= 4082.1152200698853
result=
final_simplex: (array([[ 12.68788593, 18.70650742, 10.18916981, 11.04115229,
8.08335051, 10.25695938, 10.67609537, 7.34196578,
8.37893335, 8.59070079, 9.77984581, 6.1940216 ,
13.29296337, 8.76681865, -2.19825958, 6.45847678,
6.0377202 , 9.79437422, 9.41509141, 19.86456259,
8.02392032, 16.06198485, -2.32596976, -3.67700964,
8.91461925, 10.85864698, 6.44116964],
[ 12.68789239, 18.70651184, 10.18916925, 11.04115246,
8.08334836, 10.25695674, 10.67609691, 7.34196963,
8.37893486, 8.59069872, 9.7798461 , 6.19401887,
13.29296339, 8.76682175, -2.1982655 , 6.45848182,
6.03772546, 9.79437575, 9.41509381, 19.86455791,
8.02392114, 16.06198294, -2.32597024, -3.67700909,
8.91461609, 10.85864837, 6.44117121],
[ 12.68789062, 18.70648293, 10.18916878, 11.04115321,
8.08335024, 10.25695762, 10.67610218, 7.34197981,
8.37893269, 8.59069881, 9.77984855, 6.19401651,
13.29293525, 8.76681886, -2.19825065, 6.45848287,
6.03772801, 9.79437318, 9.41508928, 19.86455348,
8.02391974, 16.06197787, -2.32597076, -3.67700887,
8.91461334, 10.85864957, 6.4411724 ],
[ 12.68788828, 18.70648376, 10.18916986, 11.04115213,
8.08334984, 10.2569571 , 10.67609671, 7.34196661,
8.37893329, 8.59070048, 9.77984753, 6.19402023,
13.29293831, 8.76681951, -2.19823586, 6.45847811,
6.03772346, 9.79437379, 9.41509126, 19.8645455 ,
8.02392073, 16.06196922, -2.32597041, -3.67701005,
8.91461795, 10.85864479, 6.44116735],
[ 12.68790341, 18.70645888, 10.18917072, 11.04115372,
8.08335035, 10.25695842, 10.6760972 , 7.34196893,
8.37893288, 8.59070185, 9.77984827, 6.19402059,
13.29289878, 8.76681752, -2.19819659, 6.45847865,
6.03772601, 9.79437442, 9.41509004, 19.86450709,
8.0239209 , 16.06192856, -2.32596745, -3.67700768,
8.91461709, 10.85864636, 6.44116807],
[ 12.68789501, 18.70648695, 10.18916892, 11.0411526 ,
8.08335084, 10.25695882, 10.67608744, 7.34195428,
8.37893327, 8.59069944, 9.77984825, 6.19401844,
13.29293604, 8.76682027, -2.19823711, 6.45847951,
6.03772416, 9.79437273, 9.41508828, 19.86455716,
8.0239207 , 16.06198083, -2.32597186, -3.67701033,
8.91461465, 10.85864743, 6.44117016],
[ 12.68787966, 18.70648578, 10.18916866, 11.04115313,
8.08334958, 10.25695918, 10.67609559, 7.34196963,
8.37892908, 8.59070644, 9.77984565, 6.19402572,
13.29294899, 8.76681722, -2.19823874, 6.45848 ,
6.03772264, 9.79437332, 9.41508747, 19.86454898,
8.02391772, 16.06196933, -2.32596802, -3.67700836,
8.91462085, 10.85864628, 6.44116906],
[ 12.68789811, 18.70647987, 10.18916898, 11.0411523 ,
8.08335018, 10.25695854, 10.67609802, 7.34196998,
8.37893322, 8.59070082, 9.77984758, 6.19401973,
13.29292625, 8.76682116, -2.19822569, 6.45847955,
6.03772442, 9.79437423, 9.41509074, 19.86452935,
8.02392147, 16.06195298, -2.32596877, -3.67700809,
8.91461634, 10.85864776, 6.44117064],
[ 12.68789589, 18.70648884, 10.18916859, 11.04115284,
8.08334856, 10.25695574, 10.67608316, 7.34194837,
8.37893205, 8.59070007, 9.77984666, 6.19402335,
13.29293694, 8.7668207 , -2.19822262, 6.45848586,
6.03772778, 9.79437508, 9.41509301, 19.86453193,
8.02391973, 16.06195395, -2.32597036, -3.67700998,
8.91461994, 10.85864811, 6.44117061],
[ 12.68790772, 18.70645275, 10.18916847, 11.0411518 ,
8.08335179, 10.25696139, 10.67609479, 7.34196971,
8.37893192, 8.59070359, 9.77984789, 6.19402188,
13.29289175, 8.76682423, -2.19817565, 6.45848191,
6.03772432, 9.79437432, 9.41508946, 19.86448273,
8.02392025, 16.06190473, -2.32596485, -3.67700539,
8.91461776, 10.85864893, 6.44117148],
[ 12.68788517, 18.70648183, 10.18916722, 11.04115216,
8.08334954, 10.25695791, 10.67609536, 7.34197074,
8.37893237, 8.59070131, 9.77984704, 6.1940227 ,
13.29294241, 8.76682063, -2.19822639, 6.45848549,
6.03772959, 9.79437474, 9.41509095, 19.86452682,
8.02392031, 16.0619492 , -2.32596728, -3.67700747,
8.91461882, 10.85864794, 6.44117043],
[ 12.6878753 , 18.7064912 , 10.18916963, 11.04115177,
8.08335115, 10.25695959, 10.67609699, 7.34197273,
8.37893148, 8.5907029 , 9.7798483 , 6.19402105,
13.2929613 , 8.766823 , -2.19824385, 6.4584819 ,
6.0377283 , 9.7943736 , 9.41508945, 19.86454309,
8.02392133, 16.06196551, -2.32596733, -3.67700729,
8.91461737, 10.85864814, 6.44117054],
[ 12.68791902, 18.70644942, 10.1891677 , 11.04115269,
8.08334987, 10.25695745, 10.67610314, 7.34197931,
8.37893396, 8.59069768, 9.77984482, 6.19402014,
13.2928777 , 8.76682375, -2.19818185, 6.45848445,
6.03772829, 9.79437427, 9.4150928 , 19.86447859,
8.02392135, 16.06190291, -2.32596668, -3.67700625,
8.9146177 , 10.85864942, 6.44117225],
[ 12.68789164, 18.70647095, 10.18916899, 11.04115336,
8.08334687, 10.25695375, 10.67609657, 7.34197068,
8.37893037, 8.59070414, 9.77984657, 6.19402141,
13.29292486, 8.76682251, -2.19822515, 6.4584824 ,
6.03772712, 9.79437297, 9.41509107, 19.86452927,
8.02392214, 16.06195322, -2.32596998, -3.67701024,
8.91461696, 10.85864615, 6.44116941],
[ 12.68788627, 18.70650892, 10.18916795, 11.04115154,
8.08335042, 10.25695888, 10.67609123, 7.34195918,
8.37893394, 8.59069789, 9.77984559, 6.1940208 ,
13.29296581, 8.76682178, -2.19825749, 6.4584811 ,
6.03772195, 9.79437488, 9.41509223, 19.8645641 ,
8.02391989, 16.0619866 , -2.32597084, -3.6770101 ,
8.91461731, 10.8586473 , 6.44117024],
[ 12.68789514, 18.70647612, 10.18916909, 11.04115227,
8.0833505 , 10.25695844, 10.67609588, 7.34196639,
8.37893186, 8.59069957, 9.77984735, 6.19401941,
13.29292523, 8.76682044, -2.1982243 , 6.45848094,
6.0377276 , 9.79437373, 9.41508953, 19.86453477,
8.02392099, 16.06195787, -2.32596969, -3.67700831,
8.91461559, 10.85864782, 6.44117026],
[ 12.68788283, 18.70648905, 10.18916968, 11.04115263,
8.08334799, 10.25695541, 10.67609781, 7.34196342,
8.37893163, 8.59070285, 9.77984899, 6.19402194,
13.29294617, 8.76681636, -2.19824202, 6.45847912,
6.03772417, 9.7943746 , 9.41509181, 19.86454526,
8.02392217, 16.06196882, -2.32597044, -3.67701065,
8.91461659, 10.85864736, 6.4411698 ],
[ 12.68789815, 18.7064649 , 10.18916999, 11.04115226,
8.08334937, 10.25695776, 10.67610336, 7.34198283,
8.3789324 , 8.59070235, 9.7798475 , 6.19402228,
13.29291204, 8.76682092, -2.19821633, 6.45847858,
6.0377253 , 9.79437373, 9.41508911, 19.86451518,
8.02392071, 16.06193618, -2.32596748, -3.67700729,
8.91461846, 10.85864987, 6.44117237],
[ 12.68789172, 18.70644705, 10.18916736, 11.04115195,
8.08335202, 10.25696037, 10.6761055 , 7.34198003,
8.37893086, 8.59070389, 9.77984999, 6.1940218 ,
13.29289939, 8.76682111, -2.19818791, 6.45848407,
6.03772727, 9.79437417, 9.41508821, 19.86449632,
8.0239181 , 16.0619187 , -2.32596555, -3.67700471,
8.91461744, 10.85864587, 6.44116931],
[ 12.68789531, 18.70647579, 10.18916916, 11.04115148,
8.0833501 , 10.25695926, 10.67609716, 7.34195997,
8.37893265, 8.59070124, 9.77984543, 6.19402163,
13.29292331, 8.76682083, -2.19821849, 6.45847805,
6.0377183 , 9.79437365, 9.41508945, 19.86453644,
8.02391936, 16.06195904, -2.32597021, -3.67700933,
8.91461638, 10.85864528, 6.44116797],
[ 12.6878969 , 18.70647003, 10.18916952, 11.04115254,
8.08334923, 10.25695634, 10.67609523, 7.34196603,
8.37893292, 8.59070123, 9.77984773, 6.19402255,
13.29291808, 8.76682144, -2.19820643, 6.45848233,
6.03772799, 9.79437421, 9.41509332, 19.86450547,
8.02392238, 16.06192841, -2.32596758, -3.67700836,
8.91461911, 10.85864739, 6.44117063],
[ 12.68790294, 18.70645667, 10.18916887, 11.04115297,
8.08334836, 10.25695674, 10.67609677, 7.34196782,
8.37893169, 8.59070436, 9.77984882, 6.19402224,
13.29289828, 8.76681972, -2.1981907 , 6.45848351,
6.0377268 , 9.79437456, 9.4150911 , 19.86449651,
8.02391983, 16.06191876, -2.32596711, -3.67700727,
8.91461892, 10.85864688, 6.44116979],
[ 12.68789709, 18.70647865, 10.18916871, 11.04115187,
8.08335002, 10.25695905, 10.67609702, 7.34196722,
8.37893304, 8.59070354, 9.77984845, 6.19401928,
13.29292556, 8.76682136, -2.19822324, 6.4584787 ,
6.03772196, 9.79437358, 9.41508965, 19.86452942,
8.02392198, 16.06195309, -2.32596883, -3.67700836,
8.91461557, 10.85864814, 6.44117105],
[ 12.68790349, 18.70647791, 10.18916969, 11.04115334,
8.0833492 , 10.25695756, 10.67608591, 7.34195271,
8.37893261, 8.59070204, 9.77984849, 6.19402286,
13.29291651, 8.76681744, -2.19820721, 6.45848236,
6.03772629, 9.79437464, 9.41509219, 19.86451301,
8.02392171, 16.06193627, -2.32596868, -3.67700908,
8.914616 , 10.85865073, 6.44117335],
[ 12.68788785, 18.70649241, 10.18917131, 11.04115356,
8.08335084, 10.25695887, 10.67609014, 7.34196003,
8.37893368, 8.59069996, 9.77984824, 6.19402174,
13.29294868, 8.76681963, -2.19823062, 6.45848122,
6.03772777, 9.79437462, 9.41509281, 19.86453313,
8.02392152, 16.06195608, -2.3259675 , -3.67700814,
8.91461868, 10.8586458 , 6.44116812],
[ 12.68788048, 18.70650989, 10.18917036, 11.04115243,
8.08334765, 10.25695497, 10.67609721, 7.3419663 ,
8.37893424, 8.59070351, 9.77984765, 6.19402176,
13.29297426, 8.76682128, -2.19827031, 6.45847618,
6.0377241 , 9.79437411, 9.41509246, 19.86456461,
8.02392078, 16.06198813, -2.32597074, -3.6770109 ,
8.91461867, 10.85864769, 6.44117064],
[ 12.68789866, 18.70646916, 10.18916889, 11.04115151,
8.08335049, 10.25695907, 10.6760906 , 7.34196098,
8.37893202, 8.5907034 , 9.77984766, 6.19401996,
13.29291446, 8.76682217, -2.1982029 , 6.4584826 ,
6.03772958, 9.79437379, 9.41508918, 19.86451313,
8.02391946, 16.06193697, -2.32596799, -3.6770075 ,
8.91461546, 10.85864945, 6.44117214],
[ 12.68789596, 18.70646332, 10.18916949, 11.04115303,
8.08334953, 10.25695694, 10.6761028 , 7.34197631,
8.37893349, 8.5907012 , 9.779848 , 6.1940212 ,
13.29291213, 8.76682067, -2.19820932, 6.45848375,
6.03772757, 9.79437371, 9.41509202, 19.86450857,
8.0239201 , 16.06193161, -2.3259675 , -3.6770072 ,
8.9146183 , 10.8586464 , 6.44116982]]), array([-233166.23582622, -233166.23582621, -233166.23582621,
-233166.23582621, -233166.23582621, -233166.2358262 ,
-233166.2358262 , -233166.2358262 , -233166.2358262 ,
-233166.2358262 , -233166.2358262 , -233166.2358262 ,
-233166.23582619, -233166.23582619, -233166.23582619,
-233166.23582619, -233166.23582619, -233166.23582618,
-233166.23582618, -233166.23582618, -233166.23582618,
-233166.23582618, -233166.23582617, -233166.23582617,
-233166.23582616, -233166.23582616, -233166.23582616,
-233166.23582615]))
fun: -233166.2358262224
message: 'Optimization terminated successfully.'
nfev: 42029
nit: 34620
status: 0
success: True
x: array([ 12.68788593, 18.70650742, 10.18916981, 11.04115229,
8.08335051, 10.25695938, 10.67609537, 7.34196578,
8.37893335, 8.59070079, 9.77984581, 6.1940216 ,
13.29296337, 8.76681865, -2.19825958, 6.45847678,
6.0377202 , 9.79437422, 9.41509141, 19.86456259,
8.02392032, 16.06198485, -2.32596976, -3.67700964,
8.91461925, 10.85864698, 6.44116964])
Final log-likelihood = 233166.235826
Number of iterations = 34620
Number of evaluations = 42029
Final rate constants:
class dcpyps.Mechanism
Values of unit rates [1/sec]:
From A3F3O to A3F3 alpha3fff 323801.49264
From A3F3 to A3F3O beta3fff 133086176.511
From A3F2O to A3F2 alpha3ff 26613.3915667
From A3F2 to A3F2O beta3ff 62389.5010804
From A2F2O to A2F2 alpha2ff 3240.0709613
From A2F2 to A2F2O beta2ff 28480.0573515
From A3F1O to A3F1 alpha3f 43308.117803
From A3F1 to A3F1O beta3f 1543.74378808
From A2F1O to A2F1 alpha2f 4354.36187098
From A2F1 to A2F1O beta2f 5381.38358602
From A1F1O to A1F1 alpha1f 17673.9275542
From A1F1 to A1F1O beta1f 489.811978097
From A3F3 to A3F2 gama3fff 593008.117043
From A3F2 to A3F3 delta3fff 6417.72292858
From A3F2 to A2F2 3kff(-3) 0.110996170104
From A2F2 to A3F2 kff(+3) 3.18158427412
From A3F2 to A3F1 gama3ff 638.088368674
From A3F1 to A3F2 delta3ff 418.936852784
From A2F2 to A2F1 gama2ff 17932.575921
From A2F1 to A2F2 delta2ff 12272.1949429
From A3F1 to A2F1 3kf(-3) 14181515.6666
From A2F1 to A3F1 kf(+3) 423711173.011
From A3F1 to A3R gama3f 3053.1231249
From A3R to A3F1 delta3f 855.0226929
From A2F1 to A1F1 2kf(-2) 9454343.77772
From A1F1 to A2F1 2kf(+2) 847422346.022
From A2F1 to A2R gama2f 0.0976886635273
From A2R to A2F1 delta2f 0.0252985133918
From A1F1 to A1R gama1f 7439.94882271
From A1R to A1F1 delta1f 1781.71523088
From A3R to A2R 3k(-3) 1881.41969695
From A2R to A3R k(+3) 51981.6983189
From A2R to A1R 2k(-2) 1254.27979796
From A1R to A2R 2k(+2) 103963.396638
From A1R to R k(-1) 627.139898982
From R to A1R 3k(+1) 155945.094957
Conductance of state A3F3O (pS) = 50
Conductance of state A3F2O (pS) = 50
Conductance of state A2F2O (pS) = 50
Conductance of state A3F1O (pS) = 50
Conductance of state A2F1O (pS) = 50
Conductance of state A1F1O (pS) = 50
Number of open states = 6
Number of short-lived shut states (within burst) = 9
Number of long-lived shut states (between bursts) = 1
Number of desensitised states = 0
Number of cycles = 3
Cycle 1 is formed of states: A3F2 A2F2 A2F1 A3F1
forward product = 3.533207584e+14
backward product = 3.533207584e+14
Cycle 2 is formed of states: A3F1 A2F1 A2R A3R
forward product = 6.157365344e+13
backward product = 6.157365344e+13
Cycle 3 is formed of states: A2F1 A1F1 A1R A2R
forward product = 1.850021604e+14
backward product = 1.850021604e+14
This file has been truncated, but you can view the full file.
Data loaded from file: ../../DCPYPS/dcpyps/samples/glydemo/keA.scn
Concentration of agonist = 300.000 microMolar
Resolution for HJC calculations = 40.0 microseconds
Critical gap length to define end of group (tcrit) = 0.600 milliseconds
(defined so that all openings in a group prob come from same channel)
Initial and final vectors for bursts calculated asin Colquhoun, Hawkes & Srodzinski, (1996, eqs 5.8, 5.11).
Number of resolved intervals = 11662
Number of resolved periods = 11088
Number of open periods = 5544
Mean and SD of open periods = 0.397568729 +/- 1.362546164 ms
Range of open periods from 0.040033814 ms to 83.755209722 ms
Number of shut intervals = 5544
Mean and SD of shut periods = 109.531529248 +/- 2942.205429077 ms
Range of shut periods from 0.040052371 ms to 204117.309570312 ms
Last shut period = 10.665501468 ms
Number of bursts = 4618
Average length = 0.504651324 ms
Range: 0.040 to 83.755 millisec
Average number of openings= 1.200519706
Data loaded from file: ../../DCPYPS/dcpyps/samples/glydemo/keB.scn
Concentration of agonist = 3000.000 microMolar
Resolution for HJC calculations = 40.0 microseconds
Critical gap length to define end of group (tcrit) = -70.000 milliseconds
(defined so that all openings in a group prob come from same channel)
Initial and final vectors for are calculated as for steady state openings and shuttings (this involves a slight approximation at start and end of bursts that are defined by shut times that have been set as bad).
Number of resolved intervals = 14296
Number of resolved periods = 12338
Number of open periods = 6169
Mean and SD of open periods = 0.568432008 +/- 0.781032231 ms
Range of open periods from 0.040003666 ms to 23.221036885 ms
Number of shut intervals = 6169
Mean and SD of shut periods = 3.801412648 +/- 35.561904311 ms
Range of shut periods from 0.040001163 ms to 2761.569499969 ms
Last shut period = 0.373572315 ms
Number of bursts = 3
Average length = 8038.560359078 ms
Range: 1572.336 to 17533.538 millisec
Average number of openings= 2056.333333333
Data loaded from file: ../../DCPYPS/dcpyps/samples/glydemo/keC.scn
Concentration of agonist = 30000.000 microMolar
Resolution for HJC calculations = 40.0 microseconds
Critical gap length to define end of group (tcrit) = -20.000 milliseconds
(defined so that all openings in a group prob come from same channel)
Initial and final vectors for are calculated as for steady state openings and shuttings (this involves a slight approximation at start and end of bursts that are defined by shut times that have been set as bad).
Number of resolved intervals = 7569
Number of resolved periods = 5810
Number of open periods = 2905
Mean and SD of open periods = 0.764939965 +/- 1.200268148 ms
Range of open periods from 0.040136722 ms to 20.713106598 ms
Number of shut intervals = 2905
Mean and SD of shut periods = 76.107278466 +/- 2832.809209824 ms
Range of shut periods from 0.037358772 ms to 109791.648864746 ms
Last shut period = 0.037358772 ms
Number of bursts = 5
Average length = 886.178571851 ms
Range: 0.222 to 2465.916 millisec
Average number of openings= 581.000000000
Data loaded from file: ../../DCPYPS/dcpyps/samples/glydemo/keD.scn
Concentration of agonist = 100000.000 microMolar
Resolution for HJC calculations = 40.0 microseconds
Critical gap length to define end of group (tcrit) = -20.000 milliseconds
(defined so that all openings in a group prob come from same channel)
Initial and final vectors for are calculated as for steady state openings and shuttings (this involves a slight approximation at start and end of bursts that are defined by shut times that have been set as bad).
Number of resolved intervals = 14723
Number of resolved periods = 12210
Number of open periods = 6105
Mean and SD of open periods = 0.888958726 +/- 1.245775257 ms
Range of open periods from 0.040174076 ms to 21.068737711 ms
Number of shut intervals = 6105
Mean and SD of shut periods = 5.588796455 +/- 134.609654546 ms
Range of shut periods from 0.037023197 ms to 7994.186401367 ms
Last shut period = 0.037023197 ms
Number of bursts = 25
Average length = 478.491306786 ms
Range: 0.073 to 3397.090 millisec
Average number of openings= 244.200000000
class dcpyps.Mechanism
Values of unit rates [1/sec]:
From A3F3O to A3F3 alpha3fff 164180.872344
From A3F3 to A3F3O beta3fff 879798.259388
From A3F2O to A3F2 alpha3ff 17631.1000954
From A3F2 to A3F2O beta3ff 75963.8340657
From A2F2O to A2F2 alpha2ff 18512.6542595
From A2F2 to A2F2O beta2ff 72165.6459847
From A3F1O to A3F1 alpha3f 19957.2751004
From A3F1 to A3F1O beta3f 302.572972131
From A2F1O to A2F1 alpha2f 20555.9927824
From A2F1 to A2F1O beta2f 293.495791624
From A1F1O to A1F1 alpha1f 21154.7104645
From A1F1 to A1F1O beta1f 284.418611117
From A3F3 to A3F2 gama3fff 11673.7928596
From A3F2 to A3F3 delta3fff 2585.56822991
From A3F2 to A2F2 3kff(-3) 26.209768672
From A2F2 to A3F2 kff(+3) 684.568191741
From A3F2 to A3F1 gama3ff 2862.00095617
From A3F1 to A3F2 delta3ff 1741.88100927
From A2F2 to A2F1 gama2ff 11625.274006
From A2F1 to A2F2 delta2ff 8662.55618102
From A3F1 to A2F1 3kf(-3) 1436109.06916
From A2F1 to A3F1 kf(+3) 45923513.6955
From A3F1 to A3R gama3f 2473.77597999
From A3R to A3F1 delta3f 769.546855601
From A2F1 to A1F1 2kf(-2) 957406.04611
From A1F1 to A2F1 2kf(+2) 91847027.3909
From A2F1 to A2R gama2f 0.0997096333233
From A2R to A2F1 delta2f 0.027994525861
From A1F1 to A1R gama1f 7438.33684661
From A1R to A1F1 delta1f 1884.83412534
From A3R to A2R 3k(-3) 1507.83869722
From A2R to A3R k(+3) 43517.4928712
From A2R to A1R 2k(-2) 1005.22579814
From A1R to A2R 2k(+2) 87034.9857424
From A1R to R k(-1) 502.612899072
From R to A1R 3k(+1) 130552.478614
Conductance of state A3F3O (pS) = 50
Conductance of state A3F2O (pS) = 50
Conductance of state A2F2O (pS) = 50
Conductance of state A3F1O (pS) = 50
Conductance of state A2F1O (pS) = 50
Conductance of state A1F1O (pS) = 50
Number of open states = 6
Number of short-lived shut states (within burst) = 9
Number of long-lived shut states (between bursts) = 1
Number of desensitised states = 0
Number of cycles = 3
Cycle 1 is formed of states: A3F2 A2F2 A2F1 A3F1
forward product = 2.437361683e+16
backward product = 2.437361683e+16
Cycle 2 is formed of states: A3F1 A2F1 A2R A3R
forward product = 4.795384982e+12
backward product = 4.795384982e+12
Cycle 3 is formed of states: A2F1 A1F1 A1R A2R
forward product = 1.735157837e+13
backward product = 1.735157837e+13
Starting likelihood = 232502.287977
iteration # 100; log-lik = 232928.154662
[ 1.41924696e+05 9.91282568e+05 1.97840130e+04 7.82168302e+04
1.71306492e+04 7.68160837e+04 1.91299496e+04 3.29285607e+02
2.03109769e+04 3.21385337e+02 1.77876364e+04 3.07427710e+02
9.53885963e+03 3.14538983e+03 2.66831193e+01 2.88401102e+03
1.83802336e+03 9.93511657e+03 9.46742351e+03 4.79548708e+07
2.69765023e+03 9.59381397e+05 9.69674010e-02 2.95029655e-02
7.21696699e+03 4.79948914e+04 4.64842402e+02]
iteration # 200; log-lik = 232979.192057
[ 1.39959379e+05 1.17018226e+06 2.16700680e+04 7.53653081e+04
1.71029252e+04 7.68171076e+04 1.71190644e+04 3.42107973e+02
1.98215160e+04 3.28061884e+02 1.57404148e+04 3.69429873e+02
9.05588107e+03 2.93348168e+03 2.47742706e+01 2.66183859e+03
1.80308002e+03 9.82741621e+03 9.20819434e+03 4.89168093e+07
2.87111595e+03 9.56960899e+05 9.77159540e-02 3.00259005e-02
7.78208260e+03 4.73797799e+04 4.85791261e+02]
iteration # 300; log-lik = 233002.232358
[ 1.47312423e+05 1.12864285e+06 2.11448124e+04 7.36694063e+04
1.69317461e+04 7.74711685e+04 1.62870400e+04 3.92236574e+02
1.86587447e+04 3.48193383e+02 1.38161174e+04 4.13244661e+02
8.41526537e+03 2.83569328e+03 2.60822758e+01 2.44770496e+03
1.67354724e+03 9.51977339e+03 9.21709747e+03 4.62329996e+07
3.12459255e+03 9.75174512e+05 9.66457332e-02 2.93387769e-02
6.59904934e+03 4.70727221e+04 4.82397914e+02]
iteration # 400; log-lik = 233018.988138
[ 1.48644223e+05 1.25062179e+06 1.96390849e+04 7.13821925e+04
1.66352826e+04 7.76746330e+04 1.79133107e+04 4.21464957e+02
1.82306857e+04 3.83449704e+02 1.45437964e+04 4.31136662e+02
8.25161166e+03 2.74034750e+03 2.59165616e+01 2.29627631e+03
1.45026493e+03 9.53446236e+03 9.40284474e+03 4.72968854e+07
2.94066199e+03 9.44090357e+05 9.68547856e-02 2.88592808e-02
6.40567244e+03 4.66407464e+04 4.79943892e+02]
iteration # 500; log-lik = 233039.395788
[ 1.43921724e+05 1.32994457e+06 2.02449694e+04 6.68117594e+04
1.62172011e+04 7.94934703e+04 2.26566069e+04 5.29347681e+02
1.56810436e+04 4.50922832e+02 1.37971980e+04 4.71660034e+02
7.79209469e+03 2.60040045e+03 2.58362305e+01 1.98649454e+03
1.14826360e+03 9.86977844e+03 9.57688621e+03 4.71647054e+07
2.65861372e+03 8.73934049e+05 9.79258969e-02 2.91987287e-02
6.89841492e+03 4.51984767e+04 4.86336071e+02]
iteration # 600; log-lik = 233048.465860
[ 1.46262468e+05 1.28118709e+06 1.98733456e+04 6.65369686e+04
1.60324841e+04 7.98636684e+04 2.37706804e+04 6.30085713e+02
1.37892065e+04 4.95990174e+02 1.39243349e+04 5.00884359e+02
7.72789676e+03 2.63733775e+03 2.52296415e+01 1.89120845e+03
1.00135478e+03 9.99077801e+03 9.63004704e+03 4.87800502e+07
2.43395436e+03 8.51913920e+05 9.89014118e-02 2.94707396e-02
7.67575311e+03 4.49023615e+04 4.86137282e+02]
iteration # 700; log-lik = 233057.149323
[ 1.49512317e+05 1.23011740e+06 2.13138860e+04 6.79315040e+04
1.58888665e+04 8.01013199e+04 2.19366699e+04 7.27702613e+02
1.24049779e+04 5.27515813e+02 1.38621949e+04 5.62421214e+02
7.66341611e+03 2.79009095e+03 2.41159390e+01 1.80736481e+03
9.26036363e+02 9.97574384e+03 9.65850089e+03 4.96878513e+07
2.25527758e+03 8.29899324e+05 9.99611919e-02 3.03854219e-02
8.09623091e+03 4.53338548e+04 4.91714514e+02]
iteration # 800; log-lik = 233060.654072
[ 1.51402885e+05 1.16800642e+06 2.21648039e+04 6.90068340e+04
1.59982553e+04 7.92887719e+04 2.03651434e+04 7.86071809e+02
1.17987841e+04 5.45788246e+02 1.37135087e+04 5.68461400e+02
7.84646994e+03 2.95600780e+03 2.33945732e+01 1.76938109e+03
9.25737084e+02 9.85673993e+03 9.43903120e+03 4.95216116e+07
2.29888914e+03 8.15096090e+05 1.00533576e-01 3.01991878e-02
8.28623854e+03 4.57863064e+04 4.95039580e+02]
iteration # 900; log-lik = 233062.450423
[ 1.48141874e+05 1.14140374e+06 2.23716677e+04 6.85527156e+04
1.58599708e+04 7.94239596e+04 2.15671211e+04 8.22338534e+02
1.10904760e+04 5.64504346e+02 1.39878590e+04 5.58343931e+02
7.85790191e+03 2.96424252e+03 2.37553581e+01 1.71113928e+03
9.07245431e+02 9.97564384e+03 9.45234039e+03 4.91590432e+07
2.25573386e+03 8.04936581e+05 1.00595126e-01 3.01130966e-02
8.37852225e+03 4.56664346e+04 4.91602787e+02]
iteration # 1000; log-lik = 233065.495431
[ 1.48804115e+05 1.07812110e+06 2.37091142e+04 6.88080258e+04
1.55781518e+04 7.93410420e+04 2.24777392e+04 9.35575705e+02
9.00960759e+03 6.37900169e+02 1.41156098e+04 5.59462899e+02
7.69678557e+03 3.11874688e+03 2.43908467e+01 1.57122986e+03
8.72350317e+02 1.00211476e+04 9.34231224e+03 4.64133282e+07
2.30456767e+03 7.63399960e+05 1.02357514e-01 3.02529138e-02
8.26298275e+03 4.58105792e+04 4.90138216e+02]
iteration # 1100; log-lik = 233070.110392
[ 1.46828452e+05 9.88461558e+05 2.47264040e+04 6.84627358e+04
1.51382532e+04 7.86007127e+04 2.36739665e+04 1.06013101e+03
6.15754895e+03 7.41703545e+02 1.48154493e+04 5.26033863e+02
7.44409643e+03 3.24714750e+03 2.62198276e+01 1.44435304e+03
8.90554632e+02 1.01414074e+04 9.39117570e+03 4.10152850e+07
2.63014887e+03 7.29553747e+05 1.04103859e-01 3.04145924e-02
7.80511749e+03 4.61691965e+04 4.94014435e+02]
iteration # 1200; log-lik = 233072.588350
[ 1.52109628e+05 9.70062495e+05 2.49902197e+04 6.83171048e+04
1.48738570e+04 7.78757571e+04 2.37557746e+04 1.14961403e+03
5.18320318e+03 8.23108752e+02 1.53445220e+04 5.20637322e+02
7.56306392e+03 3.44776661e+03 2.67748348e+01 1.36084107e+03
8.66139638e+02 1.02333363e+04 9.45962292e+03 3.90671057e+07
2.65025002e+03 7.08083409e+05 1.05247616e-01 3.05739238e-02
7.57159709e+03 4.63029302e+04 4.95595990e+02]
iteration # 1300; log-lik = 233075.301533
[ 1.66086080e+05 9.65310365e+05 2.54242231e+04 6.86107154e+04
1.49695403e+04 7.77883401e+04 2.23263610e+04 1.15480710e+03
5.27092594e+03 8.65080843e+02 1.52156919e+04 5.00137610e+02
7.31378999e+03 3.66634354e+03 2.76928269e+01 1.32122551e+03
8.67621608e+02 1.02774316e+04 9.42624621e+03 3.61871706e+07
2.70586045e+03 6.80767948e+05 1.05542569e-01 3.06555792e-02
7.31739795e+03 4.62567347e+04 4.95444934e+02]
iteration # 1400; log-lik = 233078.387294
[ 1.78712661e+05 9.58230317e+05 2.55523672e+04 6.83924684e+04
1.48196710e+04 7.74556422e+04 2.14015908e+04 1.25221797e+03
5.01657531e+03 9.58872219e+02 1.50399245e+04 4.90137925e+02
7.36835707e+03 3.95480647e+03 2.81543293e+01 1.22997990e+03
8.38564855e+02 1.02480296e+04 9.49433778e+03 3.40103824e+07
2.69876989e+03 6.55874822e+05 1.06207435e-01 3.05068201e-02
7.05400919e+03 4.62609229e+04 4.97293960e+02]
iteration # 1500; log-lik = 233088.714461
[ 2.34118220e+05 1.02717175e+06 2.61505498e+04 6.55074959e+04
1.45181772e+04 7.76493768e+04 2.25441698e+04 1.27879574e+03
5.29057185e+03 1.23831672e+03 1.51439906e+04 4.09877188e+02
7.04769672e+03 5.04597610e+03 3.23238689e+01 9.87999730e+02
7.54543076e+02 1.04613771e+04 9.62424563e+03 2.53503023e+07
2.78680516e+03 5.61209856e+05 1.06991720e-01 3.09720830e-02
6.31249593e+03 4.48073561e+04 4.88339586e+02]
iteration # 1600; log-lik = 233098.368190
[ 3.16342090e+05 1.23448529e+06 2.64614166e+04 6.06584389e+04
1.38487340e+04 7.72141824e+04 2.35193038e+04 1.31475945e+03
5.53047572e+03 1.66142106e+03 1.51645013e+04 3.72238947e+02
6.88366962e+03 6.50465218e+03 3.56972763e+01 7.52476142e+02
6.21342857e+02 1.05267358e+04 9.78474120e+03 1.88984120e+07
3.02419186e+03 4.68803907e+05 1.08103957e-01 3.16089483e-02
5.88398693e+03 4.31283721e+04 4.89108570e+02]
iteration # 1700; log-lik = 233102.354114
[ 3.38999208e+05 1.20973797e+06 2.54083467e+04 5.97522425e+04
1.36200097e+04 7.69786989e+04 2.32738837e+04 1.47292370e+03
5.64390939e+03 1.85005419e+03 1.49324400e+04 3.77483446e+02
6.37549371e+03 6.72056627e+03 3.69162444e+01 6.90971452e+02
5.48549774e+02 1.03739448e+04 9.82836187e+03 1.75478463e+07
3.23836427e+03 4.48322116e+05 1.08389909e-01 3.13877796e-02
5.75418581e+03 4.25887218e+04 4.87563870e+02]
iteration # 1800; log-lik = 233105.816071
[ 3.27545388e+05 1.20413284e+06 2.50498360e+04 5.92421713e+04
1.34450147e+04 7.62767011e+04 2.47483146e+04 1.48307980e+03
5.43776239e+03 1.90706579e+03 1.51734412e+04 3.82931873e+02
6.68477354e+03 6.88322197e+03 3.59378486e+01 6.87220876e+02
5.31767438e+02 1.02525134e+04 9.73948985e+03 1.74148697e+07
3.18233146e+03 4.46197126e+05 1.08762685e-01 3.11838802e-02
5.96710158e+03 4.28518018e+04 4.92404354e+02]
iteration # 1900; log-lik = 233109.352055
[ 3.72055646e+05 1.23049634e+06 2.43520934e+04 5.81383202e+04
1.30392391e+04 7.50453064e+04 2.56949364e+04 1.60899870e+03
4.80598341e+03 2.28426187e+03 1.51964469e+04 3.73944934e+02
6.47355845e+03 7.57759393e+03 3.64370038e+01 6.36508205e+02
4.76247391e+02 1.02379131e+04 9.71046685e+03 1.55652983e+07
3.33545935e+03 4.15913716e+05 1.09573328e-01 3.12469049e-02
5.91487711e+03 4.29991632e+04 5.00993501e+02]
iteration # 2000; log-lik = 233113.229377
[ 4.01167273e+05 1.34202268e+06 2.36280227e+04 5.72971136e+04
1.27631642e+04 7.45745153e+04 2.92913423e+04 1.57499587e+03
4.89096156e+03 2.52490376e+03 1.49494378e+04 3.83876153e+02
6.51309124e+03 7.60987621e+03 3.48358616e+01 6.30193092e+02
4.37802749e+02 1.01497442e+04 9.59179895e+03 1.49474303e+07
3.05643943e+03 3.81556624e+05 1.10162352e-01 3.18069100e-02
6.65850383e+03 4.31238267e+04 5.10967091e+02]
iteration # 2100; log-lik = 233117.241846
[ 4.66081812e+05 1.44558194e+06 2.37573938e+04 5.67169329e+04
1.23726761e+04 7.38022048e+04 3.19478062e+04 1.58474033e+03
4.88588309e+03 3.02004421e+03 1.47298592e+04 3.74484645e+02
6.29902431e+03 7.99507730e+03 3.51125437e+01 5.81843101e+02
3.90758208e+02 1.02393572e+04 9.52027316e+03 1.28899179e+07
2.99215445e+03 3.31829016e+05 1.11930443e-01 3.21319952e-02
6.77027633e+03 4.32785899e+04 5.21020981e+02]
iteration # 2200; log-lik = 233126.839909
[ 6.17793005e+05 1.69238755e+06 2.56289667e+04 5.76110854e+04
1.10517286e+04 7.23873220e+04 3.87620255e+04 1.68856986e+03
4.47673512e+03 4.62142497e+03 1.48213355e+04 3.94603541e+02
5.24585075e+03 7.40986484e+03 3.83170238e+01 4.61246479e+02
3.16160989e+02 1.07575188e+04 9.23358700e+03 8.20549796e+06
3.08401270e+03 2.15224409e+05 1.21026742e-01 3.37090438e-02
6.89897984e+03 4.38436611e+04 5.42760027e+02]
iteration # 2300; log-lik = 233133.813281
[ 6.49338750e+05 1.71205268e+06 2.75005724e+04 6.14319776e+04
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iteration # 2400; log-lik = 233135.695276
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iteration # 2500; log-lik = 233136.831060
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iteration # 2600; log-lik = 233138.456119
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iteration # 2700; log-lik = 233139.361638
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iteration # 2800; log-lik = 233139.839857
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iteration # 2900; log-lik = 233140.254281
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iteration # 3000; log-lik = 233141.048428
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iteration # 3100; log-lik = 233141.844952
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iteration # 3200; log-lik = 233142.643585
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iteration # 3300; log-lik = 233143.624095
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iteration # 3400; log-lik = 233144.116111
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iteration # 3500; log-lik = 233144.661394
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iteration # 3600; log-lik = 233144.849162
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iteration # 3700; log-lik = 233144.975757
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iteration # 3800; log-lik = 233145.024746
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iteration # 3900; log-lik = 233145.143485
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iteration # 4000; log-lik = 233145.329902
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iteration # 4100; log-lik = 233145.466481
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iteration # 4200; log-lik = 233145.579027
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iteration # 4300; log-lik = 233145.677676
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iteration # 4400; log-lik = 233145.764848
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iteration # 4500; log-lik = 233145.828877
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iteration # 4600; log-lik = 233145.896551
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iteration # 4700; log-lik = 233146.032343
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iteration # 4800; log-lik = 233146.123677
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iteration # 4900; log-lik = 233146.188024
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iteration # 5000; log-lik = 233146.275565
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iteration # 5100; log-lik = 233146.404584
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iteration # 5200; log-lik = 233146.752625
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iteration # 5300; log-lik = 233147.214224
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iteration # 5400; log-lik = 233147.761666
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iteration # 5500; log-lik = 233148.024699
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iteration # 5600; log-lik = 233148.236252
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iteration # 5700; log-lik = 233148.411315
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iteration # 5800; log-lik = 233148.470665
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iteration # 5900; log-lik = 233148.491486
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iteration # 6000; log-lik = 233148.501947
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iteration # 6100; log-lik = 233148.508076
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iteration # 6200; log-lik = 233148.517431
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iteration # 6300; log-lik = 233148.540807
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iteration # 6400; log-lik = 233148.558988
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iteration # 6500; log-lik = 233148.585978
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iteration # 6600; log-lik = 233148.690998
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iteration # 6700; log-lik = 233148.800957
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iteration # 6800; log-lik = 233148.995978
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iteration # 6900; log-lik = 233149.085682
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iteration # 7000; log-lik = 233149.160933
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iteration # 7100; log-lik = 233149.196825
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iteration # 7200; log-lik = 233149.208746
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iteration # 7300; log-lik = 233149.222066
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iteration # 7400; log-lik = 233149.228201
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iteration # 7500; log-lik = 233149.234081
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iteration # 7600; log-lik = 233149.237222
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iteration # 7700; log-lik = 233149.240819
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iteration # 7800; log-lik = 233149.243068
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iteration # 7900; log-lik = 233149.244472
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iteration # 8000; log-lik = 233149.245403
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iteration # 8100; log-lik = 233149.247221
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iteration # 8200; log-lik = 233149.249009
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iteration # 8300; log-lik = 233149.251940
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iteration # 8400; log-lik = 233149.255261
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iteration # 8500; log-lik = 233149.261308
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iteration # 10000; log-lik = 233150.232121
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iteration # 14700; log-lik = 233155.061429
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iteration # 17800; log-lik = 233160.551162
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iteration # 20900; log-lik = 233161.595751
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iteration # 24000; log-lik = 233161.597155
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iteration # 24100; log-lik = 233161.597437
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iteration # 24200; log-lik = 233161.597850
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iteration # 24300; log-lik = 233161.598297
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iteration # 24400; log-lik = 233161.599366
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iteration # 24500; log-lik = 233161.600510
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iteration # 24600; log-lik = 233161.602574
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iteration # 24700; log-lik = 233161.606030
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iteration # 24800; log-lik = 233161.607883
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iteration # 24900; log-lik = 233161.609842
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iteration # 25000; log-lik = 233161.612442
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iteration # 25100; log-lik = 233161.616417
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iteration # 25200; log-lik = 233161.628056
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iteration # 25300; log-lik = 233161.634137
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iteration # 25400; log-lik = 233161.643240
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iteration # 25500; log-lik = 233161.648649
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iteration # 25600; log-lik = 233161.653461
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iteration # 25700; log-lik = 233161.655629
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iteration # 25800; log-lik = 233161.658822
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iteration # 25900; log-lik = 233161.662348
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iteration # 26000; log-lik = 233161.664996
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iteration # 26100; log-lik = 233161.670132
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iteration # 26200; log-lik = 233161.677561
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iteration # 26300; log-lik = 233161.684870
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iteration # 26400; log-lik = 233161.688542
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^[[A^[[Biteration # 26500; log-lik = 233161.690343
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iteration # 26600; log-lik = 233161.695339
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iteration # 26700; log-lik = 233161.702117
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iteration # 26800; log-lik = 233161.710822
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iteration # 26900; log-lik = 233161.714824
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iteration # 27000; log-lik = 233161.725633
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iteration # 27100; log-lik = 233161.738824
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iteration # 33300; log-lik = 233166.231028
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1.31505157e+06 6.43666582e+03 6.84040919e-02 6.36388236e+02
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3.08119942e+03 1.27715209e+07 1.07416634e-01 2.76898237e-02
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iteration # 33400; log-lik = 233166.240569
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1.28319489e+06 6.46708741e+03 7.03164027e-02 6.36995717e+02
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iteration # 33500; log-lik = 233166.245116
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1.27853273e+06 6.46832644e+03 7.06100007e-02 6.37927075e+02
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iteration # 33600; log-lik = 233166.248431
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3.07078149e+03 1.21396368e+07 1.07910422e-01 2.78363922e-02
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iteration # 33700; log-lik = 233166.252476
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iteration # 33800; log-lik = 233166.255307
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1.26035129e+06 6.45773105e+03 7.09465734e-02 6.40176517e+02
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iteration # 33900; log-lik = 233166.257496
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1.26022378e+06 6.45715824e+03 7.06181623e-02 6.40378561e+02
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3.06013238e+03 1.22406741e+07 1.07856707e-01 2.78544475e-02
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iteration # 34000; log-lik = 233166.258453
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1.26371290e+06 6.44772312e+03 7.02159231e-02 6.39915051e+02
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3.05834686e+03 1.23219200e+07 1.07775958e-01 2.78378867e-02
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iteration # 34100; log-lik = 233166.258953
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1.25926348e+06 6.44970827e+03 7.03844413e-02 6.39998916e+02
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iteration # 34200; log-lik = 233166.259121
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iteration # 34300; log-lik = 233166.259241
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iteration # 34400; log-lik = 233166.259352
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iteration # 34500; log-lik = 233166.259410
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iteration # 34600; log-lik = 233166.259521
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iteration # 34700; log-lik = 233166.259698
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iteration # 34800; log-lik = 233166.259914
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iteration # 34900; log-lik = 233166.260124
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iteration # 35000; log-lik = 233166.260347
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iteration # 35100; log-lik = 233166.260619
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iteration # 35200; log-lik = 233166.260981
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iteration # 35300; log-lik = 233166.261128
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iteration # 35400; log-lik = 233166.261257
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iteration # 35500; log-lik = 233166.261354
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iteration # 35600; log-lik = 233166.261395
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iteration # 35700; log-lik = 233166.261435
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iteration # 35800; log-lik = 233166.261477
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iteration # 35900; log-lik = 233166.261492
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iteration # 36000; log-lik = 233166.261501
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3.05817484e+03 1.25408727e+
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