gistfile1.py

@defer.inlineCallbacks
def query():
    reactor.run()
    r = yield resolver.lookupAddress('google.com')
    reactor.stop()
    return socket.inet_ntop(socket.AF_INET6, r[0][0].payload.address)

from threading import Thread

from twisted.internet import reactor
from twisted.internet.threads import blockingCallFromThread
from twisted.names.client import resolver

running = False

def query():
global running
if not running:
Thread(target=reactor.run, args=()).start()
return blockingCallFromThread(resolver.lookupAddress, 'google.com')