create_custom_origin.py

import boto
# requires cf_customorigin branch
# https://github.com/boto/boto/tree/cf_customorigin

origin_domain = 'www.example.org'
cdn_cname = ['media.example.org']
caller_reference = 'exmaple Distribution'

c = boto.connect_cloudfront()
d = c.create_custom_distribution( 
        dns_name=origin_domain,
        enabled=True,
        caller_reference=caller_reference,
        cnames=cdn_cname
        )
print 'cname '+ cdn_cname + ' to ' d.domain_name

invalidate_cf_cdn.py

import datetime
from boto.cloudfront import CloudFrontConnection

AWS_CF_DISTRIBUTION_ID = 'LKJHSADLIUYWE(*&QW(E*'

files = ['/css/style.css','/filename/otherfile.name' ]

conn = CloudFrontConnection()
print conn.create_invalidation_request(AWS_CF_DISTRIBUTION_ID, files)