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kenthorvath/defense_qna.md

Created May 1, 2013 18:54
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Defense Questions
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defense_qna.md

#Kent's Thesis Defense ##Questions and Answers to Consider

###[Q1] - Is there any evidence for SLX4 involvement in ALT cancers? Or more specifically, do Fanconi patients have any increased/decreased incidence of ALT-cancers?

Our findings indicate that ALT-type cancers have an abundance of SLX4 localization to telomeres. Other members of our lab have found SLX4 knockdown results in substantial impairment of ALT-cell proliferation and colony survival. As ALT-type cancers typically have extremely long telomeres, we believe SLX4 may be involved in telomere maintenance in these cells. Thus, Fanconi patients with defects in SLX4/FANCP may be less likely to develop ALT-type cancers. However, the first FANCP patients have only been recently identified, and there is not much literature regarding the telomeric maintenance pathways in FANCP-related cancers.

###[Q2] - What kinds of cancers do SLX4 knockout mice develop? Is there any information about the telomeric maintenance pathways in these mice?

###[Q3] - Do SLX4 knockout mice have any telomere length abnormalities?

###[Q4] - Do FANCP patients have any telomere length abnormalities?

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