Subdomain middleware

settings.py

# ...

SUBDOMAINS = {
    'manager': {
        'urlconf': 'urls',
        'domain': 'manager.domain.com'
    },
    'clients': {
        'urlconf': 'clients.urls',
        'domain': 'clients.domain.com'
    }
}

# ...

subdomain.py

from django.conf import settings
import re

class SubdomainsMiddleware:
    def process_request(self, request):
        httphost = request.META['HTTP_HOST'] if 'HTTP_HOST' in request.META else ''

        request.domain = httphost
        request.subdomain = ''
        parts = request.domain.split('.')
        
        if len(parts) > 1 and parts[0] in settings.SUBDOMAINS.keys() and not '__debug__' in request.get_full_path():
            request.subdomain = parts[0]
            request.domain = settings.SUBDOMAINS[request.subdomain]['domain']
            request.urlconf = settings.SUBDOMAINS[request.subdomain]['urlconf']