result

$ node
> .load test.js
...
> connection opened!
[ { ... } ]
done
> .load test.js
...
> { [Error: [IBM][CLI Driver] SQL1776N  The command cannot be issued on an HADR database. Reason code = "1".
]
  error: '[node-odbc] SQL_ERROR',
  message: '[IBM][CLI Driver] SQL1776N  The command cannot be issued on an HADR database. Reason code = "1".\n',
  state: '     ' }

test.js

var util = require('util');
var ibmdb = require('ibm_db');

var database = "";
var hostname = "";
var username = "";
var password = "";
var port = "";

var connString = util.format("DRIVER={DB2};DATABASE=%s;HOSTNAME=%s;UID=%s;PWD=%s;PORT=%s;PROTOCOL=TCPIP", 
                              database, hostname, username, password, port);

ibmdb.open(connString, function (err,conn) {
  if (err) return console.log(err);

  console.log('connection opened!');
  conn.query('select * from mdl_user where id = ? with ur', [1], function (err, data) {
    if (err) console.log(err);

    console.log(data);

    conn.close(function () {
      console.log('done');
    });
  });
});