My Sublime Text 2 user preferences will automatically trim trailing whitespace on every save, and the Node.js build system allows running JavaScript files by hitting command-b. If your Node installation is in a different location you may have to change the path in the "cmd" line.

node.sublime-build

{
    "cmd": ["/usr/local/bin/node", "$file", "$file_base_name"],
    "working_dir": "${project_path:${folder}}",
    "selector": "*.js"
}

Preferences.sublime-settings

{
	"font_size": 13.0,
	"tab_size": 2,
	"translate_tabs_to_spaces": true,
	"trim_automatic_white_space": true,
	"trim_trailing_white_space_on_save": true,
	"use_tab_stops": true
}