It might not work as is, but I'm trying to remember what I did to get homeserver running on fedora 34.

matrix-setup-fedora.sh

pip install --upgrade pip virtualenv six packaging appdirs
pip install --upgrade setuptools
pip install matrix-synapse

mkdir ~/synapse
pushd ~/synapse

python -m synapse.app.homeserver --server-name matrix.koski.co --config-path homeserver.yaml --generate-config --report-stats=yes

# Edit ~/synapse/homeserver.yaml
# sleep 1000

sudo dnf install -y snapd
sudo snap install core; sudo snap refresh core
sudo snap install --classic certbot
sudo certbot certonly --nginx -d matrix.example.com

sudo dnf groupinstall "Development Tools" "Development Libraries" -y
sudo dnf install libolm-devel libjpeg-turbo-devel zlib-devel nginx -y

pip install --upgrade mautrix-telegram[all]
pip uninstall sqlalchemy
pip install --upgrade sqlalchemy==1.3.24

# Edit https://github.com/tulir/mautrix-telegram/blob/master/mautrix_telegram/example-config.yaml

python -m mautrix_telegram -g

#Add the path to the registration file (registration.yaml by default) to your Synapse's homeserver.yaml under app_service_config_files. Restart Synapse to apply changes.

synctl start

alembic upgrade head
python -m mautrix_telegram