Comparing DPWG vs CPIC functions

function_comparison.md

VKORC1

• not in CPIC!

TPMT

• *10: No function vs. Uncertain Function
• *12: No function vs. Uncertain Function
• *13: No function vs. Uncertain Function
• *16: No function vs. Uncertain Function
• *17: No function vs. Uncertain Function
• *18: No function vs. Uncertain Function
• *3D: not in CPIC
• *5: No function vs. Uncertain Function
• *6: No function vs. Uncertain Function
• *7: No function vs. Uncertain Function
• *8: No function vs. Uncertain Function
• *9: No function vs. Uncertain Function

UGT1A1

• *10: not in CPIC
• *11: not in CPIC
• *12: not in CPIC
• *13: not in CPIC
• *14: not in CPIC
• *15: not in CPIC
• *16: not in CPIC
• *17: not in CPIC
• *18: not in CPIC
• *19: not in CPIC
• *2: not in CPIC
• *20: not in CPIC
• *21: not in CPIC
• *22: not in CPIC
• *23: not in CPIC
• *24: not in CPIC
• *25: not in CPIC
• *26: not in CPIC
• *28: Decreased function (UGT1A1*28) vs. Decreased Function
• *29: not in CPIC
• *3: not in CPIC
• *30: not in CPIC
• *31: not in CPIC
• *32: not in CPIC
• *33: not in CPIC
• *34: not in CPIC
• *35: not in CPIC
• *4: not in CPIC
• *5: not in CPIC
• *7: not in CPIC
• *8: not in CPIC
• *9: not in CPIC

HLA-B

• not in CPIC!

HLA-A

• not in CPIC!

CYP2C19

CYP3A4

• not in CPIC!

CYP3A5

• *2: not in CPIC
• *4: not in CPIC
• *5: not in CPIC

F5

• not in CPIC!

CYP2C9

• *1: Normal function (CYP2C9*1) vs. Normal function
• *13: Decreased function vs. No function
• *2: Decreased function (CYP2C9*2) vs. Decreased function
• *3: Decreased function (CYP2C9*3) vs. No function

SLCO1B1

• c.521 C: not in CPIC
• c.521 T: not in CPIC

CYP2B6

• *5: Substrate dependent vs. Normal function
• *7: Decreased function (*7) vs. Decreased function

CYP2D6

• *10x2: Normal function vs. Decreased function
• *1x2: Increased function (AV 2) vs. Increased function
• *1x≥3: Increased function (AV ≥3) vs. Increased function
• *2x2: Increased function (AV 2) vs. Increased function
• *2x≥3: Increased function (AV ≥3) vs. Increased function
• *35x2: Increased function (AV 2) vs. Increased function

DPYD

NUDT15

• *4: Strongly decreased function vs. Uncertain Function
• *5: Strongly decreased function vs. Uncertain Function
• *6: Strongly decreased function vs. Uncertain Function
• Arg34Thr: not in CPIC
• Gly17_Val18del: not in CPIC
• Lys35Glu: not in CPIC

ABCG2

• c.421 G (141Q): not in CPIC
• c.421 T (141K): not in CPIC