Hormone DOT file

gistfile1.txt

// Hormone graph
digraph G {
	//rankdir=LR;
	node[color="green"];
	GH; FSH; LH; TSH;Melatonin;ACTH;OX;ADH;ENDOR;PRO;CALCI;PTH;ANP;THYM;INS;SOM;GLU;
	node[shape="plaintext"];
	H;AP;PP;G;T;KIDNEY;AC;BM;PG;AM;BMa;PT;B;HEART;URINE;Thymus;TCELL;PAN;UTERUS;MAMMARY;IMMUNE;
	node[shape="oval",color="black"];
	BMa[label="Bone Marrow"];
	H [label="Hypothalamus"];
	AP [label="Anterior Pituitary"];
	PP [label="Posterior Pituitary"];
	BM [label="Bones\nMuscle"];
	PG [label="Pineal Gland"];
	GH [label="Growth\nhormone (GH)"];
	TSH [label="Thyroid-stimulating\nhormone (TSH)"];
    LH [label="Luteinizing\nhormone (LH)"];
	FSH [label="Follicle-stimulating\nhormone (FSH)"];
	ACTH [label="Adrenocorticotropic\nhormone (ACTH)"];
	ADH [label="Antidiuretic\nhormone (ADH)"];
	G [label="Gonads"];
	T [label="Thyroid"];
	GHRH[label="Growth hormone-releasing\nhormone (GHRH)"];
	TRH[label="Thyroid-releasing\nhormone (TRH)"];
	GNRH[label="Gonadotropin-releasing\nhormone (GnRH)"];
	CRF[label="Corticotropin-releasing\nhormone (CRF)"];
	PT[label="Parathyroid"];
	PTH[label="Parathyroid\nhormone (PTH)"];
	B[label="Blood"];
	PAN[label="Pancreas"];
	INS[label="Insulin"];
	SOM[label="Somatostatin"];
	GLU[label="Glucagon"];
	HEART[label="Heart"];
	ANP[label="Atrial Natriuretic\nPeptide (ANP)"];
	URINE[label="Urine"];
	TCELL[label="T-Cell"];
	THYM[label="Thymosin"];
	KIDNEY[label="Kidney"];
	AM[label="Adrenal Medulla"];
	OX[label="Oxytocin"];
	ENDOR[label="Endorphins"];
	PRO[label="Prolactin"];
	AC [label="Adrenal Cortex"];
	CALCI[label="Calcitonin"];
	T4[label="T4 Thyroxine\n(AAd)"];
	UTERUS[label="Uterus"];
	MAMMARY[label="Mammary\nGlands"];
	IMMUNE[label="Immune\nSystem"];
	CORTISONE[label="Cortisone"];
	EPO[label="EPO Erythropoietin"];
	ALDOSTERONE[label="Aldosterone"];

    H -> PP[label="soma\naxon", style="dotted"];
	PP -> {OX ADH};
	OX -> UTERUS[label="Contractions"];
	ADH -> KIDNEY[label="Increased\nH2O\nreabsorption"];

   	subgraph cluster_portal {
	   label="Portal System/ Stalk";
       GHRH; GNRH; TRH; CRF; 
   	}
	H -> {GHRH GNRH TRH CRF};
	GHRH -> AP[color="red"];
	GNRH -> AP[color="orange"];
	TRH -> AP[color="blue"];
	CRF -> AP[color="brown"];

	// Anterior Pituitary
	AP -> GH[color="red"];
	GH -> BM;
	AP -> LH[color="orange"];
	LH -> G;
	AP -> FSH[color="orange"];
	FSH -> G;
	AP -> TSH[color="blue"];
	TSH -> T;
	AP -> ACTH[color="brown"];
	ACTH -> AC;
	AP -> ENDOR;
	AP -> PRO[color="blue"];
	PRO -> MAMMARY[label="Milk\nproduction"];

	T -> "T3 Triiodothyronine\n(AAd)";
	T ->  T4;
	T -> CALCI;
	CALCI -> B[label="Decreased\nCa2+"];

	PG  -> Melatonin;

	subgraph cluster_glucocorticoids {
		label="Glucocorticoids";
		CORTISONE;Cortisol;
	}
		
	AC -> {CORTISONE Cortisol};
	CORTISONE -> IMMUNE[label="Suppresses"];
	CORTISONE -> B[label="Increased\npressure"];

	subgraph cluster_mineralcorticoids {
		label="Mineralcorticoids";
		ALDOSTERONE;
	}

	AC -> ALDOSTERONE;
	ALDOSTERONE -> KIDNEY[color="red", style="dashed"];
	KIDNEY -> EPO;
	KIDNEY -> URINE[label="Conserve Na+\nSecrete K+\nHold H2O", color="red", style="dashed"];
	EPO -> BMa[label="RBC\nproduction"];

	AM -> "Norepinephrine";
	AM -> "Epinephrine";

	G -> {Estrogen, Progesterone};

	PT -> PTH;
	PTH -> B[label="Increased\nCa2+"];

	subgraph cluster_pan {
		style=filled;
		color=white;
		PAN -> INS;
		INS -> B[label="Decreases\nGlucose"];

		PAN -> GLU;
		GLU -> B[label="Increases\nGlucose"];

		PAN -> SOM;
		SOM -> GLU[label="Suppresses"];
		SOM -> INS[label="Suppresses"];
	}

	HEART -> ANP;
	ANP -> KIDNEY[color="blue", style="dashed"];
	ANP -> ALDOSTERONE[label="Inhibits"];
	KIDNEY -> URINE[label="Release Na+\nIncreased volume", color="blue", style="dashed"];

	Thymus -> THYM;
	THYM -> TCELL[label="Development\nDifferentiation"];
}