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Hormone DOT file
// Hormone graph
digraph G {
//rankdir=LR;
node[color="green"];
GH; FSH; LH; TSH;Melatonin;ACTH;OX;ADH;ENDOR;PRO;CALCI;PTH;ANP;THYM;INS;SOM;GLU;
node[shape="plaintext"];
H;AP;PP;G;T;KIDNEY;AC;BM;PG;AM;BMa;PT;B;HEART;URINE;Thymus;TCELL;PAN;UTERUS;MAMMARY;IMMUNE;
node[shape="oval",color="black"];
BMa[label="Bone Marrow"];
H [label="Hypothalamus"];
AP [label="Anterior Pituitary"];
PP [label="Posterior Pituitary"];
BM [label="Bones\nMuscle"];
PG [label="Pineal Gland"];
GH [label="Growth\nhormone (GH)"];
TSH [label="Thyroid-stimulating\nhormone (TSH)"];
LH [label="Luteinizing\nhormone (LH)"];
FSH [label="Follicle-stimulating\nhormone (FSH)"];
ACTH [label="Adrenocorticotropic\nhormone (ACTH)"];
ADH [label="Antidiuretic\nhormone (ADH)"];
G [label="Gonads"];
T [label="Thyroid"];
GHRH[label="Growth hormone-releasing\nhormone (GHRH)"];
TRH[label="Thyroid-releasing\nhormone (TRH)"];
GNRH[label="Gonadotropin-releasing\nhormone (GnRH)"];
CRF[label="Corticotropin-releasing\nhormone (CRF)"];
PT[label="Parathyroid"];
PTH[label="Parathyroid\nhormone (PTH)"];
B[label="Blood"];
PAN[label="Pancreas"];
INS[label="Insulin"];
SOM[label="Somatostatin"];
GLU[label="Glucagon"];
HEART[label="Heart"];
ANP[label="Atrial Natriuretic\nPeptide (ANP)"];
URINE[label="Urine"];
TCELL[label="T-Cell"];
THYM[label="Thymosin"];
KIDNEY[label="Kidney"];
AM[label="Adrenal Medulla"];
OX[label="Oxytocin"];
ENDOR[label="Endorphins"];
PRO[label="Prolactin"];
AC [label="Adrenal Cortex"];
CALCI[label="Calcitonin"];
T4[label="T4 Thyroxine\n(AAd)"];
UTERUS[label="Uterus"];
MAMMARY[label="Mammary\nGlands"];
IMMUNE[label="Immune\nSystem"];
CORTISONE[label="Cortisone"];
EPO[label="EPO Erythropoietin"];
ALDOSTERONE[label="Aldosterone"];
H -> PP[label="soma\naxon", style="dotted"];
PP -> {OX ADH};
OX -> UTERUS[label="Contractions"];
ADH -> KIDNEY[label="Increased\nH2O\nreabsorption"];
subgraph cluster_portal {
label="Portal System/ Stalk";
GHRH; GNRH; TRH; CRF;
}
H -> {GHRH GNRH TRH CRF};
GHRH -> AP[color="red"];
GNRH -> AP[color="orange"];
TRH -> AP[color="blue"];
CRF -> AP[color="brown"];
// Anterior Pituitary
AP -> GH[color="red"];
GH -> BM;
AP -> LH[color="orange"];
LH -> G;
AP -> FSH[color="orange"];
FSH -> G;
AP -> TSH[color="blue"];
TSH -> T;
AP -> ACTH[color="brown"];
ACTH -> AC;
AP -> ENDOR;
AP -> PRO[color="blue"];
PRO -> MAMMARY[label="Milk\nproduction"];
T -> "T3 Triiodothyronine\n(AAd)";
T -> T4;
T -> CALCI;
CALCI -> B[label="Decreased\nCa2+"];
PG -> Melatonin;
subgraph cluster_glucocorticoids {
label="Glucocorticoids";
CORTISONE;Cortisol;
}
AC -> {CORTISONE Cortisol};
CORTISONE -> IMMUNE[label="Suppresses"];
CORTISONE -> B[label="Increased\npressure"];
subgraph cluster_mineralcorticoids {
label="Mineralcorticoids";
ALDOSTERONE;
}
AC -> ALDOSTERONE;
ALDOSTERONE -> KIDNEY[color="red", style="dashed"];
KIDNEY -> EPO;
KIDNEY -> URINE[label="Conserve Na+\nSecrete K+\nHold H2O", color="red", style="dashed"];
EPO -> BMa[label="RBC\nproduction"];
AM -> "Norepinephrine";
AM -> "Epinephrine";
G -> {Estrogen, Progesterone};
PT -> PTH;
PTH -> B[label="Increased\nCa2+"];
subgraph cluster_pan {
style=filled;
color=white;
PAN -> INS;
INS -> B[label="Decreases\nGlucose"];
PAN -> GLU;
GLU -> B[label="Increases\nGlucose"];
PAN -> SOM;
SOM -> GLU[label="Suppresses"];
SOM -> INS[label="Suppresses"];
}
HEART -> ANP;
ANP -> KIDNEY[color="blue", style="dashed"];
ANP -> ALDOSTERONE[label="Inhibits"];
KIDNEY -> URINE[label="Release Na+\nIncreased volume", color="blue", style="dashed"];
Thymus -> THYM;
THYM -> TCELL[label="Development\nDifferentiation"];
}
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