VSDeploy.xml

 <PropertyGroup>
    <UseMsDeployExe>true</UseMsDeployExe>
  </PropertyGroup>

  <PropertyGroup>
    <AfterAddIisSettingAndFileContentsToSourceManifest>AddCustomSkipRules</AfterAddIisSettingAndFileContentsToSourceManifest>
  </PropertyGroup>
  <Target Name="AddCustomSkipRules">
    <ItemGroup>
      <MsDeploySkipRules Include="SkipDownloadsFiles">
        <SkipAction>Delete</SkipAction>
        <ObjectName>filePath</ObjectName>
        <AbsolutePath>.*\\Content\\UserPictures\\.*$</AbsolutePath>
        <XPath></XPath>
      </MsDeploySkipRules>
      <MsDeploySkipRules Include="SkipDownloadsFolder">
        <SkipAction>Delete</SkipAction>
        <ObjectName>dirPath</ObjectName>
        <AbsolutePath>.*\\Content\\UserPictures\\.*$</AbsolutePath>
        <XPath></XPath>
      </MsDeploySkipRules>
    </ItemGroup>
  </Target>
  
  
 
 Working:
 
  I want to include Remove Additional Files at destination but i don't want to delete the folders 
  and content from Content\UserPictures\ directory.
  
  It needs to work from VS Publish not command line.
  

Not working:
  
  In Web Publish dialog Preview is not showing any changes.
  
 

Just tried your solution but it didn't work ;(

I get the

Web deployment task failed. An error occurred when the request was processed on the remote computer.
An error was encountered when processing operation 'Delete Directory' on 'UserPictures'.
I/O error occurred.

Note that in your publish profile you use
<SkipExtraFilesOnServer>True</SkipExtraFilesOnServer>

while i want this to be

false

so i have used

<UseMsDeployExe>true</UseMsDeployExe>

which allows <SkipAction>Delete</SkipAction> to be used but i suspect that this causes VS Publish preview window and output window to not show any info.

Summary

My solution is working but i would really like Preview window and output window to show detailed info.