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December 15, 2015 19:12
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# `Coding Test : Hamming Distance | |
# Write a program that can calculate the Hamming distance between two DNA | |
# strands. | |
# | |
# A mutation is simply a mistake that occurs during the creation or copying of a | |
# nucleic acid, in particular DNA. Because nucleic acids are vital to cellular | |
# functions, mutations tend to cause a ripple effect throughout the cell. | |
# Although mutations are technically mistakes, a very rare mutation may equip | |
# the cell with a beneficial attribute. In fact, the macro effects of | |
# evolution are attributable by the accumulated result of beneficial | |
# microscopic mutations over many generations. | |
# | |
# The simplest and most common type of nucleic acid mutation is a point | |
# mutation, which replaces one base with another at a single nucleotide. | |
# | |
# By counting the number of differences between two homologous DNA strands taken | |
# from different genomes with a common ancestor, we get a measure of the | |
# minimum number of point mutations that could have occurred on the | |
# evolutionary path between the two strands. | |
# | |
# This is called the “Hamming Distance”. | |
# | |
# GAGCCTACTAACGGGAT | |
# CATCGTAATGACGGCCT | |
# ^ ^ ^ ^ ^ ^^ | |
# | |
# The Hamming distance between these two DNA strands is 7.` | |
# | |
# | |
class HammingDistance | |
def self.hammit(left, right) | |
fail 'lengths don\'t match' if different_lengths?(left, right) | |
(0..compare_length(left, right)).map { |index| | |
left[index] == right[index] | |
}.select { |result| result == false }.count | |
end | |
def self.compare_length(left, _) | |
left.size | |
end | |
def self.different_lengths?(left, right) | |
left.size != right.size | |
end | |
end | |
left = 'GAGCCTACTAACGGGAT' | |
right = 'CATCGTAATGACGGCCT' | |
HammingDistance.hammit(left, right) == 7 |
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