Byobu keybindings can be user defined in /usr/share/byobu/keybindings/. The following are the default keybindings found in Byobu Ver. 5.125. Some key combinations might not work on some distros, Mac users beware. However, there's plenty of support and troubleshooting information available on the Web.
F2: Create a new window
F3: Move to the previous window
F4: Move to the next window
F5: Refresh all status notifications
F6: Detach from the session and logout
F7: Enter scrollback/search mode
F8: Rename the current window
F9: Launch the Byobu Configuration Menu
F12: Escape Key
Ctrl-F2: Split the screen vertically
Ctrl-F3: Move focus to the next split
Ctrl-F4: Move focus to the previous split
Ctrl-F5: Reconnect any SSH/GPG/dbus sockets
Ctrl-F6: Kill Split in focus
Ctrl-F8: Rename the current session
Ctrl-F9: Enter a command and run in all windows
Ctrl-F11: Join a window into a vertical split
Shift-F1: Help Screen
Shift-F2: Split the screen horizontally
Shift-F3: Move focus to the next split
Shift-F4: Move focus to the previous split
Shift-F5: Collapse all splits
Shift-F6: Detach from the session, but do not logout
Shift-F7: Save History to $BYOBU_RUN_DIR/printscreen
Shift-F8: Toggle through split arrangements
Shift-F9: Enter a command and run in all split
Shift-F11: Zoom into a split, zoom out of a split
Shift-F12: Toggle on/off Byobu's keybindings
Alt-Pageup: Scroll back through this window's history
Alt-Pagedown: Scroll forward through this window's history
Alt-Left: Scroll back through this window's history
Alt-Right: Scroll forward through this window's history
Alt-F5: Toggle UTF-8 support, refresh status
Alt-F6: Detach all client
Alt-F9: Toggle sending keyboard input to all splits
Alt-F11: Expand split to a full window
Alt-F12 : Toggle on/off Byobu's mouse
Ctrl-Shift-F2 : Create a new session
Ctrl-Shift-F3 : Move window left
Ctrl-Shift-F4: Move window right
Ctrl-Shift-F5: Change Status bar's color randomly
Ctrl-a $ : show detailed status
Ctrl-a R : Reload profile
Ctrl-a ! : Toggle key bindings on and off
Ctrl-a k : Kill the current window
Ctrl-a ~ : Save the current window's scrollback buffer
Source: https://www.byobu.org/documentation
BYOBU @ StackExchange: http://stackexchange.com/search?q=byobu
Byobu is GPLv3 software, authored and maintained by Dustin Kirkland