My custom MPK249 control script for Ableton Live. Only tested on Windows 10 & Live 10. It fixes the automap for device knobs to automap to the knobs able the 249's sliders. Go to C:\ProgramData\Ableton\Live 10 Suite\Resources\MIDI Remote Scripts\MPK249 and make a backup of that folder and put this script in the folder and restart Ableton.

MPK249.py

# Embedded file name: c:\Jenkins\live\output\win_64_static\Release\python-bundle\MIDI Remote Scripts\MPK249\MPK249.py
from __future__ import absolute_import, print_function, unicode_literals
from _Framework.ControlSurface import ControlSurface
from _Framework.Layer import Layer
from _Framework.DrumRackComponent import DrumRackComponent
from _Framework.TransportComponent import TransportComponent
from _Framework.DeviceComponent import DeviceComponent
from _Framework.MixerComponent import MixerComponent
from _Framework.MidiMap import MidiMap as MidiMapBase
from _Framework.MidiMap import make_button, make_encoder, make_slider
from _Framework.InputControlElement import MIDI_NOTE_TYPE, MIDI_CC_TYPE

class MidiMap(MidiMapBase):

    def __init__(self, *a, **k):
        super(MidiMap, self).__init__(*a, **k)
        self.add_button(u'Play', 0, 118, MIDI_CC_TYPE)
        self.add_button(u'Record', 0, 119, MIDI_CC_TYPE)
        self.add_button(u'Stop', 0, 117, MIDI_CC_TYPE)
        self.add_button(u'Loop', 0, 114, MIDI_CC_TYPE)
        self.add_button(u'Forward', 0, 116, MIDI_CC_TYPE)
        self.add_button(u'Backward', 0, 115, MIDI_CC_TYPE)
        self.add_matrix(u'Sliders', make_slider, 0, [[12,
          13,
          14,
          15,
          16,
          17,
          18,
          19]], MIDI_CC_TYPE)
        self.add_matrix(u'Encoders', make_encoder, 0, [[22,
          23,
          24,
          25,
          26,
          27,
          28,
          29]], MIDI_CC_TYPE)
        self.add_matrix(u'Arm_Buttons', make_button, 0, [[32,
          33,
          34,
          35,
          36,
          37,
          38,
          39]], MIDI_CC_TYPE)
        self.add_matrix(u'Drum_Pads', make_button, 1, [[81,
          83,
          84,
          86],
         [74,
          76,
          77,
          79],
         [67,
          69,
          71,
          72],
         [60,
          62,
          64,
          65]], MIDI_NOTE_TYPE)


class MPK249(ControlSurface):

    def __init__(self, *a, **k):
        super(MPK249, self).__init__(*a, **k)
        with self.component_guard():
            midimap = MidiMap()
            drum_rack = DrumRackComponent(name=u'Drum_Rack', is_enabled=False, layer=Layer(pads=midimap[u'Drum_Pads']))
            drum_rack.set_enabled(True)        
            transport = TransportComponent(name=u'Transport', is_enabled=False, layer=Layer(play_button=midimap[u'Play'], record_button=midimap[u'Record'], stop_button=midimap[u'Stop'], seek_forward_button=midimap[u'Forward'], seek_backward_button=midimap[u'Backward'], loop_button=midimap[u'Loop']))
            transport.set_enabled(True)
            device = DeviceComponent(name='Device', is_enabled=False, layer=Layer(parameter_controls=midimap['Encoders']))
            device.set_enabled(True)
            mixer_size = len(midimap[u'Sliders'])
            mixer = MixerComponent(mixer_size, name=u'Mixer', is_enabled=False, layer=Layer(volume_controls=midimap[u'Sliders'], arm_buttons=midimap[u'Arm_Buttons']))
            mixer.set_enabled(True)

Hey, thanks for the hint. Still the macro knobs weren't moving. But adding the self.set_device_component(device) string made the trick also for me as maxcloutier13 pointed out!

Made an account just to thank you for this!! I just purchased an MPK249 yesterday and this solved so many issues I never would've solved on my own. Followed your instructions (placing in the MPK249 folder instead of the 261 folder) and it worked like a charm! Just need to figure out how to have additional mapped configs for other VSTs and plugins. Seriously, this is a lifesaver, thank you so much for your work!!!

Thank you sir <3