index.js

var nodemailer = require('nodemailer');
var smtpTransport = require('nodemailer-smtp-transport');

var transporter = nodemailer.createTransport(smtpTransport({
   host: 'host.nombre.com',
   port: 465,
   secure: true,
   tls: { rejectUnauthorized: false },
   debug: false,
   logger: false,
   auth: {
       user: 'no_reply@nombre.com',
       pass: 'xxxxxxxxxxxxxx'
   }
}));

transporter.verify(function(error, success) {
   if (error) {
        console.log(error);
   } else {
        console.log('Server is ready to take our messages');
		var mailOptions = {
		    from: '"NO-REPLY" <no_reply@nombre.com>',
		    to: 'cuenta1@nombre.com, cuenta2@nombre.com',
		    subject: 'Test desde NodeMailer',
		    text: 'Test desde NodeMailer ',
		    html: '<b>Test desde NodeMailer</b>'
		};

		// send mail with defined transport object
		transporter.sendMail(mailOptions, function(error, info){
		    if(error){
		        return console.log(error);
		    }
		    console.log('Message sent: ' + info.response);
		});
   }
});

package.json

{
  "name": "test",
  "version": "1.0.0",
  "description": "",
  "main": "index.js",
  "scripts": {
    "test": "echo \"Error: no test specified\" && exit 1"
  },
  "author": "",
  "license": "ISC",
  "dependencies": {
    "nodemailer": "^2.3.2",
    "nodemailer-smtp-transport": "^2.4.2"
  }
}