mojojoseph

def crypto_aead_chacha20poly1305_encrypt(message,
                                         ad,
                                         nonce,
                                         key):

    mlen  = ctypes.c_ulonglong(len(message))
    adlen = ctypes.c_ulonglong(len(ad))

    c    =  ctypes.create_string_buffer(mlen.value+16L)
    clen  = ctypes.c_ulonglong(0)

mojojoseph

from pysodium import  crypto_aead_chacha20poly1305_encrypt
from bitstring import BitStream

key = BitStream(hex="4290bcb154173531f314af57f3be3b5006da371ece272afa1b5dbdd1100a1007")
nonce = BitStream(hex="cd7cf67be39c794a")
ad = BitStream(hex="87e229d4500845a079c0")
msg = BitStream(hex="86d09974840bded2a5ca")

print(key)
print(nonce)