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| Title | Title_URL | novalegacyebadge | novalegacyebadge1 | novalegacyelist_item | novalegacyelist_item__acontains_class_novalegacyelink_URL | Name | novalegacyelist_item_URL | Author | novalegacyelist_item_URL2 | Author3 | novalegacyvpublicationitem_personlisttruncation | novalegacyelist_item_URL4 | Author5 | Description | Label | |
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| Disorders of Adhesions or Adhesion-Related Disorder: Monolithic Entities or Part of Something Bigger—CAPPS? | https://www.researchgate.net/publication/23222786_Disorders_of_Adhesions_or_Adhesion-Related_Disorder_Monolithic_Entities_or_Part_of_Something_Bigger-CAPPS | Article | Full-text available | Aug 2008 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | The purpose of this article is to review progress in the field of abdominopelvic adhesions and the validity of its two underlying assumptions: (1) The formation of adhesions results in infertility, bowel obstruction, or other complications. Reducing or avoiding adhesions will curb these sequelae. (2) “Adhesions” is a monolithic entity to be tackled... | View | ||||||||
| Adhesion Prevention: Past the Future | https://www.researchgate.net/publication/283169221_Adhesion_Prevention_Past_the_Future | Chapter | Jan 2000 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | Only recently has the prophylactic treatment of adhesions begun to gain acceptance by surgeons. Data continue to accumulate regarding the efficacy of film and fabric barriers (Interceed™, Seprafilm™, Preclude™), and are beginning to emerge regarding liquids such as Sepracoat™ and Intergel™ solutions. Newer film, gel, and liquid materials are in adv... | View | |||||||||
| Advances, Retreats and Challenges in Adhesions Research | https://www.researchgate.net/publication/314245600_Advances_Retreats_and_Challenges_in_Adhesions_Research | Article | Full-text available | Jul 2016 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | 1 SUMMARY The purpose of this paper is to review the progress being made to tackle adhesions, both in terms of advances and “retreats” and to list some of the challenges for the future. 1.1 Are adhesions still an extensive and costly problem? Advances: Several pharmacoeconomic analyses highlight the cost and burden of adhesions. While certain adhes... | View | ||||||||
| RapidDeploymentReduceLoadCOVIDStrategyLATEST | https://www.researchgate.net/publication/341627199_RapidDeploymentReduceLoadCOVIDStrategyLATEST | Preprint | Full-text available | May 2020 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | Wiseman, DM. Rapid deployment reduce load & secondary peak, low risk, multi stage COVID-19 Strategy. V9.6. Synechion, Inc., Dallas, TX. 2020 synechion.com/COVID/RapidDeploymentReduceLoadCOVIDStrategyLATEST.pdf Background: As COVID-19 lockdowns are relaxed, there are indications of secondary peaking. Although their reintroduction is economically uns... | View | ||||||||
| Re: Arshad S, Kilgore P, Chaudhry ZS et al. Treatment with Hydroxychloroquine, Azithromycin, and Combination in Patients Hospitalized with COVID-19. Int J Infect Dis: 2020. Epub 2020 Jul 1 http://doi.org/10.1016/j.ijid.2020.06.099 | https://www.researchgate.net/publication/343464944_Re_Arshad_S_Kilgore_P_Chaudhry_ZS_et_al_Treatment_with_Hydroxychloroquine_Azithromycin_and_Combination_in_Patients_Hospitalized_with_COVID-19_Int_J_Infect_Dis_2020_Epub_2020_Jul_1_httpdoiorg101016jiji | Article | Full-text available | Aug 2020 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | As its accompanying editorial (Lee et al., 2020) perceives, Arshad’s report (Arshad et al., 2020) indeed fuels the fire of the hydroxychloroquine (HCQ) controversy. It also fans the steroid controversy (Salton et al., 2020). The 2541 consecutive COVID-19 subjects included over seven weeks from 3/10/20 undoubtedly included 213 consecutive patients,... | View | ||||||||
| Chase safety not variants: Advisory Committee on Immunization Practice June 23, 2023. Strain selection for updated COVID-19 vaccines for the 2023-2024 season | https://www.researchgate.net/publication/372718751_Chase_safety_not_variants_Advisory_Committee_on_Immunization_Practice_June_23_2023_Strain_selection_for_updated_COVID-19_vaccines_for_the_2023-2024_season | Preprint | Full-text available | Jul 2023 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/scientific-contributions/L-Maria-Gutschi-2257212223 | L Maria Gutschi | These comments are submitted in advance of ACIP’s meeting of June 23 2023. Based on the outcome of FDA’s VRBPAC Meeting of June 15 2023, we revise and extend the comments submitted prior to that FDA meeting (1) and include slides and text for our oral remarks. The pandemic is over. Cases, hospitalizations, and deaths have declined despite only 17... | View | ||||||
| Slides for Wiseman & Gutschi - Oral remarks. FDA VRBPAC June 16 2023 | https://www.researchgate.net/publication/372719899_Slides_for_Wiseman_Gutschi_-_Oral_remarks_FDA_VRBPAC_June_16_2023 | Data | Jun 2023 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/scientific-contributions/L-Maria-Gutschi-2257212223 | L Maria Gutschi | View | ||||||||
| Vaccines and Related Biological Products Advisory Committee Meeting. June 15, 2023. Strain selection for updated COVID-19 vaccines for the 2023-2024 season | https://www.researchgate.net/publication/372720041_Vaccines_and_Related_Biological_Products_Advisory_Committee_Meeting_June_15_2023_Strain_selection_for_updated_COVID-19_vaccines_for_the_2023-2024_season | Preprint | Full-text available | Jun 2023 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/scientific-contributions/L-Maria-Gutschi-2257212223 | L Maria Gutschi | These comments are submitted in advance of VRBPAC’s meeting to consider updated Covid-19 pro-vaccines for the 2023-24 season. At the time of writing to meet the deadline of submission of comments for consideration by VRBPAC members (June 7), FDA have not yet disclosed their briefing materials that would allow more focused comments to be made. Acco... | View | ||||||
| ACIP April 19 2023: Bivalent primary series dosing with no directly supportive data and in the face of ever more resistant variants. Ischemic stroke signal in VAERS ignored. Written remarks CDC-2023-0028, v2 | https://www.researchgate.net/publication/370132212_ACIP_April_19_2023_Bivalent_primary_series_dosing_with_no_directly_supportive_data_and_in_the_face_of_ever_more_resistant_variants_Ischemic_stroke_signal_in_VAERS_ignored_Written_remarks_CDC-2023-0028 | Preprint | Full-text available | Apr 2023 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/profile/Joshua-Guetzkow | Joshua Guetzkow | https://www.researchgate.net/profile/Spiro-Pantazatos | Spiro Pantazatos | [...] | https://www.researchgate.net/profile/Herve-Seligmann | Herve Seligmann | FDA’s EUA for use of bivalent BA5 doses as a primary series is based on an extrapolative approach largely without any directly supportive data, and evolution of immune escape variants such as XBB from the now extinct BA5. There was no discussion of AEs and the cumulative toxicity of LNPs or pseudouridine-containing modRNA. CDC continues to ignore P... | View | |
| National Academies Committee on Review of Relevant Literature Regarding Adverse Events Associated with Vaccines March 30 2023: Written material accompanying oral remarks. | https://www.researchgate.net/publication/369755622_National_Academies_Committee_on_Review_of_Relevant_Literature_Regarding_Adverse_Events_Associated_with_Vaccines_March_30_2023_Written_material_accompanying_oral_remarks | Preprint | Full-text available | Mar 2023 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/profile/Joshua-Guetzkow | Joshua Guetzkow | https://www.researchgate.net/profile/Spiro-Pantazatos | Spiro Pantazatos | [...] | https://www.researchgate.net/profile/Herve-Seligmann | Herve Seligmann | A committee of the National Academies convened on March 30 2023 to “review relevant literature regarding adverse events associated with [Covid-19] vaccines.” To supplement oral remarks delivered at the meeting and to assist the committee’s deliberations, further detail is provided here along with a summary (with original documents) of our written c... | View | |
| Autoimmune Inflammatory Reactions Triggered by the COVID-19 Genetic Vaccines in Terminally Differentiated Tissues | https://www.researchgate.net/publication/369066998_Autoimmune_Inflammatory_Reactions_Triggered_by_the_COVID-19_Genetic_Vaccines_in_Terminally_Differentiated_Tissues | Preprint | Full-text available | Mar 2023 | https://www.researchgate.net/profile/Panagis-Polykretis | Panagis Polykretis | https://www.researchgate.net/profile/Alberto-Donzelli | Alberto Donzelli | https://www.researchgate.net/scientific-contributions/Janci-C-Lindsay-2245970064 | Janci C Lindsay | [...] | https://www.researchgate.net/scientific-contributions/Peter-A-McCullough-38989664 | Peter A Mccullough | As a result of the spread of SARS-CoV-2, a global pandemic was declared. Indiscriminate COVID-19 vaccination has been extended to include age groups and naturally immune people with minimal danger of suffering serious complications due to COVID-19. Solid immuno-histopatholog-ical evidence demonstrates that the COVID-19 genetic vaccines can display... | View | |
| Covid-19 vaccine safety, bivalent primary series, future directions. Written comments submitted to CDC- ACIP February 24 2023. CDC-2023-0007-0496 | https://www.researchgate.net/publication/368904702_Covid-19_vaccine_safety_bivalent_primary_series_future_directions_Written_comments_submitted_to_CDC-_ACIP_February_24_2023_CDC-2023-0007-0496 | Preprint | Full-text available | Feb 2023 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | "It is time for a different approach." This document contains written comments submitted for the February 24 2023 meeting of CDC's Advisory Committee on Immunization Practices (ACIP) Contents 1.Introduction 2.Vaccine Safety Update 2.1.Ischemic stroke 3.Bivalent Vaccine Effectiveness 3.1.Clinical efficacy data 3.2.Neutralizing antibody studies 4.T... | View | ||||||||
| Annotations on FDA Briefing Document for VRBPAC Meeting January 26 2023: Future Vaccination Regimens Addressing COVID-19. FDA-2022-N-2810 | https://www.researchgate.net/publication/367433336_Annotations_on_FDA_Briefing_Document_for_VRBPAC_Meeting_January_26_2023_Future_Vaccination_Regimens_Addressing_COVID-19_FDA-2022-N-2810 | Preprint | Full-text available | Jan 2023 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | This document contains my annotations to FDA’s briefing document release prior to the January 26th 2023 VRBPAC meeting on the subject of future strain composition for Covid-19 vaccines, simplification of the different formulations and dose schedules, and plans for future COVID-19 vaccine composition recommendations. FDA’s justification for the use... | View | ||||||||
| ACIP October 19-20-2022. BA4/5 bivalent quasi-vaccines in yet younger children: Further erosion of scientific and ethical standards. Written and Oral Comments. | https://www.researchgate.net/publication/364676617_ACIP_October_19-20-2022_BA45_bivalent_quasi-vaccines_in_yet_younger_children_Further_erosion_of_scientific_and_ethical_standards_Written_and_Oral_Comments | Preprint | Full-text available | Oct 2022 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | Following FDA's September EUA of the BA4/5 boosters based on scant human BA1 data and limited murine BA4/5 data and using an "extrapolative" approach, FDA extended the EUA to children 5 years (Pfizer) and 6 years (Moderna) old, with no VRBPAC meeting. CDC endorsed this action, without convening an ACIP meeting. No efficacy data were presented to su... | View | ||||||||
| BA4/5 bivalent quasi-vaccines: Further relaxation of FDA standards, manufacturing changes and novel spike protein heterotrimers. Written comments to CDC ACIP meeting of September 1 2022. CDC-2022-0103 | https://www.researchgate.net/publication/363318992_BA45_bivalent_quasi-vaccines_Further_relaxation_of_FDA_standards_manufacturing_changes_and_novel_spike_protein_heterotrimers_Written_comments_to_CDC_ACIP_meeting_of_September_1_2022_CDC-2022-0103 | Preprint | Full-text available | Sep 2022 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | Significant questions are generated as to FDA’s ever relaxed standards in authorizing the new bivalent BA4/5 quasi-vaccine boosters. These include lack of clinical data, and reliance on unvalidated surge modelling, Contrary to FDAs guidelines, there are likely significant manufacturing process changes, In addition, at least from Moderna’s presentat... | View | ||||||||
| CDC scores own goals with Novavax. ACIP members fear another confusing label will add to dose errors, question high myocarditis rates and seek direction on Omicron boosters. NIH conducts PRR work CDC is denying. ACIP July 19 2022 - Written Remarks: Docket No. CDC-2022-0085 | https://www.researchgate.net/publication/362345005_CDC_scores_own_goals_with_Novavax_ACIP_members_fear_another_confusing_label_will_add_to_dose_errors_question_high_myocarditis_rates_and_seek_direction_on_Omicron_boosters_NIH_conducts_PRR_work_CDC_is_ | Preprint | Full-text available | Jul 2022 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/profile/Joshua-Guetzkow | Joshua Guetzkow | CDC scores own goals with Novavax. ACIP members fear another confusing label will add to dose errors, question high myocarditis rates and seek direction on Omicron boosters. Ongoing issues with inadequate vial labelling with now three Covid-19 vaccines described as “not acceptable” by ACIP members. threaten patient safety. High myocarditis rates w... | View | ||||||
| Stunningly poor data. Labelling confusion. What could possibly go wrong? ACIP June 23 2022 - Oral and Written Remarks | https://www.researchgate.net/publication/362263618_Stunningly_poor_data_Labelling_confusion_What_could_possibly_go_wrong_ACIP_June_23_2022_-_Oral_and_Written_Remarks | Preprint | Full-text available | Jun 2022 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | Stunningly poor data. Labelling confusion. What could possibly go wrong? Written and oral comments to CDC ACIP June 23 2022 - Dr. David Wiseman Docket No. CDC-2022-0062 (update 7/26/22, to correct typos) Tracking: l4r-xbl4-kmpf (unposted at 7/26/22) Posted as: https://downloads.regulations.gov/CDC-2022-0085-0017/attachment_1.pdf Capsule: CDC assert... | View | ||||||||
| COVID-19 vaccine booster and new variant doses. Confusion and lack of a plan evident to ACIP | https://www.researchgate.net/publication/360580923_COVID-19_vaccine_booster_and_new_variant_doses_Confusion_and_lack_of_a_plan_evident_to_ACIP | Preprint | Full-text available | Apr 2022 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/profile/Herve-Seligmann | Herve Seligmann | https://www.researchgate.net/profile/Spiro-Pantazatos | Spiro Pantazatos | Capsule As CDC's ACIP met to discuss the use of booster and new variant doses, we show that key vaccine efficacy and safefy data were again withheld from that could have better guided their discussion. We discuss continuing and unanswered safety concerns, particularly with regard to the gene therapy nature of the Covid-19 vaccines. In the face of p... | View | ||||
| ACIP recommends Spikevax based on CDC review omitting negative efficacy Omicron data. Regulators drift further from the science of all risk-no-benefit as infant vaccination is considered. ACIP Feb 4, VRBPAC Feb 15 2022 | https://www.researchgate.net/publication/358815048_ACIP_recommends_Spikevax_based_on_CDC_review_omitting_negative_efficacy_Omicron_data_Regulators_drift_further_from_the_science_of_all_risk-no-benefit_as_infant_vaccination_is_considered_ACIP_Feb_4_VRB | Technical Report | Full-text available | Feb 2022 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | ACIP recommends Spikevax based on CDC review omitting negative efficacy Omicron data by setting an unusually diatant data cut-off. The quasi-vaccine appears obsolete, leaving risk without benefit. We find CDC’s risk benefit analysis to be in error by 692 times, yielding a 7.7 times more risk than benefit. CDC and FDA have failed to incorporate pote... | View | ||||||||
| The last wackamole of boosting in an omicron environment of negative quasi-vaccine efficacy and possible immunological addiction. Transparency concerns remain. A third open letter to Dr. Grace Lee, ACIP Chair: CDC-ACIP Written comments Docket CDC-2022-0002 | https://www.researchgate.net/publication/357824766_The_last_wackamole_of_boosting_in_an_omicron_environment_of_negative_quasi-vaccine_efficacy_and_possible_immunological_addiction_Transparency_concerns_remain_A_third_open_letter_to_Dr_Grace_Lee_ACIP_C | Technical Report | Full-text available | Jan 2022 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/profile/Jessica-Rose-24 | Jessica Rose | https://www.researchgate.net/profile/Joshua-Guetzkow | Joshua Guetzkow | A third open letter to Dr. Grace Lee, ACIP Chair - Oral Comments: David Wiseman ACIP Jan 5 2022 The last wackamole of boosting in an omicron environment of negative quasi-vaccine efficacy and possible immunological addiction. Transparency concerns remain. David Wiseman PhD, MRPharmS (Synechion@aol.com)Jessica Rose, PhD, MSc., BSc. Josh Guetzkow Ph... | View | ||||
| Why limit contraindication to Janssen? Using same criteria revisit EUA/BLA for all C19 quasi-vaccines. Transparency: Emergency ACIP Meeting Dec 16 2021: A second open letter to Dr. Grace Lee, ACIP Chair | https://www.researchgate.net/publication/357300150_Why_limit_contraindication_to_Janssen_Using_same_criteria_revisit_EUABLA_for_all_C19_quasi-vaccines_Transparency_Emergency_ACIP_Meeting_Dec_16_2021_A_second_open_letter_to_Dr_Grace_Lee_ACIP_Chair | Preprint | Full-text available | Dec 2021 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/profile/Jessica-Rose-24 | Jessica Rose | https://www.researchgate.net/profile/Joshua-Guetzkow | Joshua Guetzkow | Dear ACIP Chairperson Dr. Lee, We refer to the letter to you from one of us (DW) of November 19, submitted to the docket (once a number had been assigned) and published as on Trial Site News.(1) DW remains in anticipation of the pleasure of your reply to that, and this letter, as to your proposed actions. We welcome an honest discussion of our ana... | View | ||||
| Development of a Chronic Canine Ovariohysterectomy Model to Evaluate Vaginal Cuff Healing Using Two Closure Systems | https://www.researchgate.net/publication/354035942_Development_of_a_Chronic_Canine_Ovariohysterectomy_Model_to_Evaluate_Vaginal_Cuff_Healing_Using_Two_Closure_Systems | Article | Aug 2021 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/profile/Josa-Hanzlik | Josa Hanzlik | https://www.researchgate.net/scientific-contributions/James-A-Richardson-39674840 | James A. Richardson | [...] | https://www.researchgate.net/profile/Dan-Mazzucco | Dan Mazzucco | Background and Purpose. This study established a suitable animal model of ovariohysterectomy; characterized the course and pattern of vaginal healing after ovariohysterectomy; and compared healing obtained after closure of the vaginal cuff with a novel cuff-closure device (Zip-stitch® clips) and VICRYL ® sutures. Research Design and Study Sample. T... | View | ||
| Possible clustering and/or drug switching confounding obscures up to 56% reduction of symptom persistence by ivermectin. Data Summary for comment posted to JAMA re: Lopez-Medina et al. | https://www.researchgate.net/publication/350712850_Possible_clustering_andor_drug_switching_confounding_obscures_up_to_56_reduction_of_symptom_persistence_by_ivermectin_Data_Summary_for_comment_posted_to_JAMA_re_Lopez-Medina_et_al | Preprint | Full-text available | Apr 2021 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/scientific-contributions/Pierre-Kory-2179716661 | Pierre Kory | This is a summary of our analysis of the dataset obtained from the study by López-Medina et al. (Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: A Randomized Clinical Trial, JAMA, 2021) supporting our comment posted to the JAMA web site: "Possible clustering and/or drug switching confounding obscures up to 56... | View | ||||||
| Effective post-exposure prophylaxis of Covid-19 is associated with use of hydroxychloroquine: Prospective re-analysis of a public dataset incorporating novel data | https://www.researchgate.net/publication/346577590_Effective_post-exposure_prophylaxis_of_Covid-19_is_associated_with_use_of_hydroxychloroquine_Prospective_re-analysis_of_a_public_dataset_incorporating_novel_data | Article | Full-text available | Dec 2020 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/scientific-contributions/Pierre-Kory-2179716661 | Pierre Kory | https://www.researchgate.net/profile/Sam-Saidi-2 | Sam Saidi | BACKGROUND A recent trial ( NCT04308668 ) found that post-exposure prophylaxis with hydroxychloroquine (HCQ) was associated with a reduced incidence of Covid-19 by 17% overall; 36% in younger subjects, 31% in household contacts and 49% given within one day. To understand these trends, we re-analyzed the released dataset. METHODS Our protocol confo... | View | ||||
| Treatment and prevention of early disease before and after exposure to COVID-19 using hydroxychloroquine: A protocol for exploratory re-analysis of age and time-nuanced effects: Update based on initial dataset review | https://www.researchgate.net/publication/344634616_Treatment_and_prevention_of_early_disease_before_and_after_exposure_to_COVID-19_using_hydroxychloroquine_A_protocol_for_exploratory_re-analysis_of_age_and_time-nuanced_effects_Update_based_on_initial_ | Article | Full-text available | Oct 2020 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/scientific-contributions/Pierre-Kory-2179716661 | Pierre Kory | https://www.researchgate.net/profile/Dan-Mazzucco | Dan Mazzucco | [...] | https://www.researchgate.net/scientific-contributions/David-Wiseman-2248155771 | David Wiseman | Three companion clinical studies from the University of Minnesota examined the effect of hydroxychloroquine (HCQ) when given to treat early cases of COVID-19 or to prevent it from occurring either before or just after exposure to someone with coronavirus. Although reductions in COVID-19 between 17% and 27% were found when HCQ was used before or jus... | View | |
| Preventing disease after exposure to COVID-19 using hydroxychloroquine: A summary of a protocol for exploratory re-analysis of age and time-nuanced effects | https://www.researchgate.net/publication/343890007_Preventing_disease_after_exposure_to_COVID-19_using_hydroxychloroquine_A_summary_of_a_protocol_for_exploratory_re-analysis_of_age_and_time-nuanced_effects | Article | Full-text available | Aug 2020 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/scientific-contributions/Pierre-Kory-2179716661 | Pierre Kory | https://www.researchgate.net/profile/Dan-Mazzucco | Dan Mazzucco | BACKGROUND: A recently published randomized trial (Boulware et al., 2020, NCT04308668) of hydroxychloroquine (HCQ) for post-exposure prophylaxis found a reduction in Covid-19 of 17%. In the context of ambitious powering to detect a 50% reduction, this non-statistically significant finding could translate to a reduction of 22,000/130,828 cases (CDC... | View | ||||
| Preventing disease after exposure to COVID-19 using hydroxychloroquine: exploratory re-analysis of age and time-nuanced effects. | https://www.researchgate.net/publication/343648389_Preventing_disease_after_exposure_to_COVID-19_using_hydroxychloroquine_exploratory_re-analysis_of_age_and_time-nuanced_effects | Article | Full-text available | Aug 2020 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | A recently published randomized trial found a non-statistically significant reduction in Covid-19 of 17% when hydroxychloroquine (HCQ) was used for postexposure prophylaxis. Based on practical considerations rather than considerations of clinical meaningfulness, the study was powered to reduce development of COVID-19 by 50%. Since this was a “pragm... | View | ||||||||
| Hydroxychloroquine: an age- and stage- nuanced, clinically and economically meaningful COVID-19 strategy? Comments on Skipper et al. | https://www.researchgate.net/publication/343514156_Hydroxychloroquine_an_age-_and_stage-_nuanced_clinically_and_economically_meaningful_COVID-19_strategy_Comments_on_Skipper_et_al | Article | Full-text available | Jul 2020 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | Hydroxychloroquine: an age and stage nuanced, clinically and economically meaningful COVID19 strategy? Hydroxychloroquine's (HCQ) apparent inefficacy, with generally safe use in mild COVID-19, reported by Skipper et al. 1 and similar RCTs (Tang, cited in 2 ; Mitja 3), might be unsurprising given data in more severe disease cited by the accompanying... | View | ||||||||
| An Evaluation of the Zip-Stitch Vaginal Cuff Closure System in a Chronic Canine Ovariohysterectomy Model | https://www.researchgate.net/publication/328671037_An_Evaluation_of_the_Zip-Stitch_Vaginal_Cuff_Closure_System_in_a_Chronic_Canine_Ovariohysterectomy_Model | Article | Nov 2018 | https://www.researchgate.net/profile/Dan-Mazzucco | Dan Mazzucco | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/profile/Josa-Hanzlik | Josa Hanzlik | [...] | https://www.researchgate.net/scientific-contributions/John-M-Shelton-39503839 | J. Shelton | View | |||
| Can CDC Guidelines on Opioid Use Be Applied to Patients with Chronic Pelvic Pain? | https://www.researchgate.net/publication/309171302_Can_CDC_Guidelines_on_Opioid_Use_Be_Applied_to_Patients_with_Chronic_Pelvic_Pain | Article | Nov 2016 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | View | ||||||||||
| Strategies for treating chronic pelvic, urological, neurological and GI pain using wearable therapeutic ultrasound | https://www.researchgate.net/publication/271443715_Strategies_for_treating_chronic_pelvic_urological_neurological_and_GI_pain_using_wearable_therapeutic_ultrasound | Conference Paper | Full-text available | Oct 2014 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | STRATEGIES FOR TREATING CHRONIC PELVIC, UROLOGICAL, NEUROLOGICAL AND GI PAIN USING WEARABLE THERAPEUTIC ULTRASOUND David Wiseman, PhD, MRPharmS (Presented By: David Wiseman) KevMed, LLC,, International Adhesions Society Summary: PainShield® MD Wearable Ultrasound has been used for over four years to treat chronic pelvic, urologic, neurologic an... | View | ||||||||
| Reduction of Chronic Abdominal, Pelvic, Urological and GI Pain Using Wearable Therapeutic Ultrasound up to 17 Months | https://www.researchgate.net/publication/271443684_Reduction_of_Chronic_Abdominal_Pelvic_Urological_and_GI_Pain_Using_Wearable_Therapeutic_Ultrasound_up_to_17_Months | Article | Full-text available | Nov 2013 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/scientific-contributions/Teena-Petree-2064909063 | Teena Petree | REDUCTION OF CHRONIC ABDOMINAL, PELVIC, UROLOGICAL AND GI PAIN USING WEARABLE THERAPEUTIC ULTRASOUND UP TO 17 MONTHS David M Wiseman, PhD, MRPharmS1 and Teena Petree, PT2. 1International Adhesions Society, Dallas, TX, United States, 75248 and 2Summit Physical Therapy, Dallas, TX, United States, 75252. Objective: To assess the efficacy of a wearab... | View | ||||||
| Association of Lifestyle Factors with Components of Complex Abdomino-Pelvic and Pain Syndrome (CAPPS): An Internet-Based Study | https://www.researchgate.net/publication/274349865_Association_of_Lifestyle_Factors_with_Components_of_Complex_Abdomino-Pelvic_and_Pain_Syndrome_CAPPS_An_Internet-Based_Study | Article | Nov 2013 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | View | ||||||||||
| Reduction of chronic pelvic, urological and GI pain using wearable therapeutic ultrasound in women with extended follow−up to 17 months | https://www.researchgate.net/publication/271443728_Reduction_of_chronic_pelvic_urological_and_GI_pain_using_wearable_therapeutic_ultrasound_in_women_with_extended_follow-up_to_17_months | Conference Paper | Full-text available | Oct 2013 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/scientific-contributions/Teena-Petree-2064909063 | Teena Petree | REDUCTION OF CHRONIC PELVIC, UROLOGICAL AND GI PAIN USING WEARABLE THERAPEUTIC ULTRASOUND IN WOMEN WITH EXTENDED FOLLOW−UP TO 17 MONTHS David Wiseman, PhD, MRPharmS1 and Teena Petree, PT2 (Presented By: David Wiseman) 1International Adhesions Society; 2Summit Physical Therapy, Dallas Objective: To assess the efficacy of a wearable low−frequency,... | View | ||||||
| EP8.61 Barrier agents prevent adhesion formation after gynaecological surgery | https://www.researchgate.net/publication/311535045_EP861_Barrier_agents_prevent_adhesion_formation_after_gynaecological_surgery | Conference Paper | Jun 2013 | https://www.researchgate.net/profile/Garba-Ahmad-2 | Garba Ibrahim Ahmad | https://www.researchgate.net/scientific-contributions/Helena-OFlynn-45320153 | O’Flynn H | https://www.researchgate.net/scientific-contributions/Marckie-F-2119069361 | Marckie F | [...] | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | View | |||
| M441 A NEW SPRAYABLE ADHESION BARRIER FOR LAPAROSCOPIC PROCEDURES | https://www.researchgate.net/publication/270974551_M441_A_NEW_SPRAYABLE_ADHESION_BARRIER_FOR_LAPAROSCOPIC_PROCEDURES | Article | Full-text available | Oct 2012 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/scientific-contributions/M-P-Diamond-2035033768 | M.P. Diamond | https://www.researchgate.net/scientific-contributions/CV-Cassingham-2064159940 | C.V. Cassingham | View | |||||
| O186 SAFETY AND FEASIBILITY OF PROGEL AB™ IN REDUCING ADHESIONS AFTER LAPAROSCOPIC MYOMECTOMY | https://www.researchgate.net/publication/274005490_O186_SAFETY_AND_FEASIBILITY_OF_PROGEL_AB_IN_REDUCING_ADHESIONS_AFTER_LAPAROSCOPIC_MYOMECTOMY | Article | Full-text available | Oct 2012 | https://www.researchgate.net/scientific-contributions/J-Garza-Leal-2011551342 | J. Garza-Leal | https://www.researchgate.net/profile/Irvin-Hernandez | Irvin ceron Hernandez | https://www.researchgate.net/scientific-contributions/L-Castillo-2011535119 | L. Castillo | [...] | https://www.researchgate.net/scientific-contributions/PG-Davis-2063844681 | P.G. Davis | View | ||
| The Augmentation of Laparoscopic Skill Acquisition Using the Mozart Effect | https://www.researchgate.net/publication/251689579_The_Augmentation_of_Laparoscopic_Skill_Acquisition_Using_the_Mozart_Effect | Article | Nov 2011 | https://www.researchgate.net/scientific-contributions/M-C-Wiseman-2024451125 | M. C. Wiseman | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/profile/Leib-Litman | Leib Litman | The Augmentation of Laparoscopic Skill Acquisition Using the Mozart Effect Wiseman MC,1 Wiseman DM,2 Litman L.1 1Psychology, Lander College for Men, Touro College, Flushing, New York; 2Synechion, Inc., Dallas, Texas Study Objective: The ‘‘Mozart Effect’’ (ME) describes a temporary enhancement in spatial-temporal reasoning originally found after exp... | View | |||||
| Prevention of Post-Myomectomy Adhesions: Safety and Feasibility of ProGEL AB in Laparoscopic Uterine Surgery | https://www.researchgate.net/publication/251689102_Prevention_of_Post-Myomectomy_Adhesions_Safety_and_Feasibility_of_ProGEL_AB_in_Laparoscopic_Uterine_Surgery | Article | Full-text available | Nov 2010 | https://www.researchgate.net/scientific-contributions/J-Garza-Leal-2011551342 | J. G. Garza-Leal | https://www.researchgate.net/scientific-contributions/I-Hernandez-Leon-2024449010 | I. Hernandez-Leon | https://www.researchgate.net/scientific-contributions/L-Castillo-Saenz-2024463633 | L. Castillo-Saenz | [...] | https://www.researchgate.net/scientific-contributions/J-A-Anderson-2024271497 | J. A. Anderson | View | ||
| A Prospective, Controlled, Randomized, MultiCenter, Pilot Study Evaluating the Safety and Potential Trends in Efficacy of Adhexil™ in Prevention and Reduction of Adhesions | https://www.researchgate.net/publication/245750818_A_Prospective_Controlled_Randomized_MultiCenter_Pilot_Study_Evaluating_the_Safety_and_Potential_Trends_in_Efficacy_of_Adhexil_in_Prevention_and_Reduction_of_Adhesions | Article | Nov 2009 | https://www.researchgate.net/scientific-contributions/M-P-Diamond-2035033768 | M. P. Diamond | https://www.researchgate.net/scientific-contributions/Eran-Kurman-2018431816 | E. Kurman | https://www.researchgate.net/profile/M-Korell | M. Korell | [...] | https://www.researchgate.net/scientific-contributions/Adhexil-2018698640 | Adhexil | View | |||
| Evaluation of ProGEL AB, Novel PEG-Albumin Spray for Adhesion Prevention in Rabbit Uterine Horn Models in the Presence and Absence of Bleeding | https://www.researchgate.net/publication/245752722_Evaluation_of_ProGEL_AB_Novel_PEG-Albumin_Spray_for_Adhesion_Prevention_in_Rabbit_Uterine_Horn_Models_in_the_Presence_and_Absence_of_Bleeding | Article | Nov 2009 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/profile/Vaughn-Cassingham | Vaughn Cassingham | https://www.researchgate.net/scientific-contributions/W-J-Mezger-2018630039 | W. J. Mezger | View | ||||||
| Intra-Rater and Inter-Rater Variability in Adhesion Scoring | https://www.researchgate.net/publication/245753318_Intra-Rater_and_Inter-Rater_Variability_in_Adhesion_Scoring | Article | Nov 2009 | https://www.researchgate.net/scientific-contributions/M-P-Diamond-2035033768 | M. P. Diamond | https://www.researchgate.net/scientific-contributions/Eran-Kurman-2018431816 | E. Kurman | https://www.researchgate.net/profile/Dennis-Chanter | Dennis Chanter | [...] | https://www.researchgate.net/profile/Moshe-Kamar-2 | Moshe Kamar | View | |||
| Evaluation of Models, Methodologies, Devices and New Surgical Concepts: Time-Dependent Effect of Tolmetin Sodium in a Rabbit Uterine Adhesion Model | https://www.researchgate.net/publication/232057193_Evaluation_of_Models_Methodologies_Devices_and_New_Surgical_Concepts_Time-Dependent_Effect_of_Tolmetin_Sodium_in_a_Rabbit_Uterine_Adhesion_Model | Article | Full-text available | Jul 2009 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/scientific-contributions/W-James-Huang-2163515642 | W. James Huang | https://www.researchgate.net/scientific-contributions/Douglas-B-Johns-2163365361 | Douglas B. Johns | [...] | https://www.researchgate.net/profile/Gere-Dizerega | Gere Dizerega | Tolmetin is a nonsteroidal anti-inflammatory drug (NSAID) that reduces adhesion formation in several animal models after a single intraperitoneal (i.p.) dose delivered at the time of surgery. We set out to determine the period during which tolmetin could prevent adhesions. Adhesions were induced in New Zealand White rabbits (2-3 kg) by abrading the... | View | |
| Evaluation of a fibrin preparation containing tranexamic acid (Adhexil) in a rabbit uterine horn model of adhesions with and without bleeding and in a model with two surgical loci | https://www.researchgate.net/publication/23791090_Evaluation_of_a_fibrin_preparation_containing_tranexamic_acid_Adhexil_in_a_rabbit_uterine_horn_model_of_adhesions_with_and_without_bleeding_and_in_a_model_with_two_surgical_loci | Article | Feb 2009 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/scientific-contributions/Roberto-Meidler-15378834 | Roberto Meidler | https://www.researchgate.net/scientific-contributions/Yacov-Lyahovetsky-33161198 | Yacov Lyahovetsky | [...] | https://www.researchgate.net/profile/Israel-Nur | Israel Nur | To compare the efficacy of a fibrin preparation supplemented with tranexamic acid (Adhexil) with that of established devices, and to determine whether its effect is limited to the site of application. Rabbit uterine horns were abraded in nonbleeding and bleeding variants of an established adhesions model. In a separate study, a sidewall excision wi... | View | ||
| Barrier agents for adhesion prevention after gynaecological surgery (Review) | https://www.researchgate.net/publication/5426720_Barrier_agents_for_adhesion_prevention_after_gynaecological_surgery_Review | Article | Feb 2008 | https://www.researchgate.net/profile/Garba-Ahmad-2 | Garba Ibrahim Ahmad | https://www.researchgate.net/profile/James-Duffy-6 | James M N Duffy | https://www.researchgate.net/profile/Cindy-Farquhar | Cindy Farquhar | [...] | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | Pelvic adhesion can form as a result of inflammation, endometriosis or surgical trauma. During pelvic surgery, strategies to reduce pelvic adhesion formation may include placing synthetic barrier agents such as oxidised regenerated cellulose, polytetrafluoroethylene or Fibrin sheets between the pelvic structures. To assess the effect of physical ba... | View | ||
| 293: Evaluation of Pro/GEL-AB, Novel PEG-Albumin Spray for Adhesion Prevention in Two Rat Models | https://www.researchgate.net/publication/239474197_293_Evaluation_of_ProGEL-AB_Novel_PEG-Albumin_Spray_for_Adhesion_Prevention_in_Two_Rat_Models | Article | Nov 2007 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/profile/Vaughn-Cassingham | Vaughn Cassingham | View | ||||||||
| 294: Evaluation of Pro/GEL-AB, a Novel PEG-Albumin Spray for Adhesion Prevention in Rabbit and Pig Models Involving Laparoscopy by CO 2 Pneumoperitoneum | https://www.researchgate.net/publication/239474201_294_Evaluation_of_ProGEL-AB_a_Novel_PEG-Albumin_Spray_for_Adhesion_Prevention_in_Rabbit_and_Pig_Models_Involving_Laparoscopy_by_CO_2_Pneumoperitoneum | Article | Nov 2007 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | View | ||||||||||
| Possible Intergel Reaction Syndrome (pIRS) [4] | https://www.researchgate.net/publication/6796945_Possible_Intergel_Reaction_Syndrome_pIRS_4 | Article | Nov 2006 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | View | ||||||||||
| Registries for anti-adhesion products? | https://www.researchgate.net/publication/6836626_Registries_for_anti-adhesion_products | Article | Oct 2006 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | View | ||||||||||
| The Effect of Tranexamic Acid in Fibrin Sealant on Adhesion Formation in the Rat | https://www.researchgate.net/publication/8907308_The_Effect_of_Tranexamic_Acid_in_Fibrin_Sealant_on_Adhesion_Formation_in_the_Rat | Article | Feb 2004 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/scientific-contributions/Yacov-Lyachovetsky-33161197 | Yacov Lyachovetsky | https://www.researchgate.net/profile/Ilan-Keidan | Ilan Keidan | [...] | https://www.researchgate.net/profile/Israel-Nur | Israel Nur | The objective of the research was to determine the effect of the type, dose, and volume of anti-fibrinolytic agents (tranexamic acid, aprotinin) added to fibrin formulations, on adhesion development. Adhesions were induced in 228 male rats by creating apposing parietal and visceral peritoneal defects. Animals were randomized to receive no treatment... | View | ||
| Next-Generation HydroGel Films as Tissue Sealants and Adhesion Barriers | https://www.researchgate.net/publication/8681816_Next-Generation_HydroGel_Films_as_Tissue_Sealants_and_Adhesion_Barriers | Article | Full-text available | Nov 2003 | https://www.researchgate.net/scientific-contributions/Steven-L-Bennett-32653811 | Steven L Bennett | https://www.researchgate.net/scientific-contributions/David-A-Melanson-29119476 | David A Melanson | https://www.researchgate.net/scientific-contributions/David-F-Torchiana-5895823 | David F Torchiana | [...] | https://www.researchgate.net/scientific-contributions/Amarpreet-S-Sawhney-2035962136 | Amarpreet S Sawhney | The development of conveniently sprayed, tissue-adherent, inert hydrogel films has made possible the creation of novel products that can serve a dual function, as a surgical sealant to achieve immediate hemostasis, and as a barrier to prevent adhesion formation over time. A sprayable, in situ formed absorbable hydrogel film was evaluated as a tissu... | View | |
| Effects of crystalloids on rates of adhesion development in abdominopelvic surgery | https://www.researchgate.net/publication/251637867_Effects_of_crystalloids_on_rates_of_adhesion_development_in_abdominopelvic_surgery | Article | Jul 2003 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/profile/Richard-Trout-2 | Richard Trout | https://www.researchgate.net/profile/Michael_Diamond | Michael Diamond | Within the limitations of the study, the rate of adhesion development appears to be highest for reformed adhesions, lower for de novo 1b adhesions, and lowest for de novo 1a adhesions. Adhesions developed slightly more frequently in laparoscopy than in laparotomy for both de novo 1b and reformed adhesions. This might be a reflection of a reduced ab... | View | |||||
| Correlations between animal and human models of adhesions | https://www.researchgate.net/publication/283874034_Correlations_between_animal_and_human_models_of_adhesions | Article | Full-text available | Jul 2003 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | Most data were available for the rabbit uterine simple abrasion model, which was generally predictive of clinical outcome for most gynecologic clinical models. Important technical differences between models - even in the same species - might determine the behaviors and interpretation of the model. Cecal/sidewall models in rats or rabbits were found... | View | ||||||||
| PRECLINICAL ANIMAL STUDIES ON INCERT® ADHESION PREVENTION GEL | https://www.researchgate.net/publication/300977303_PRECLINICAL_ANIMAL_STUDIES_ON_INCERTR_ADHESION_PREVENTION_GEL | Chapter | Dec 2002 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/scientific-contributions/Charles-H-Sherwood-2106947467 | Charles H. Sherwood | https://www.researchgate.net/scientific-contributions/Khalid-K-Sadozat-2106744565 | Khalid K. Sadozat | View | ||||||
| Humidity and temperature of insufflation gas on intact peritoneum | https://www.researchgate.net/publication/245773767_Humidity_and_temperature_of_insufflation_gas_on_intact_peritoneum | Article | Aug 2002 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | Objective: To determine the effect of insufflation gas humidity and temperature on intact peritoneum. Design: Histologic study of peritoneum by light microscopy. Setting: Laboratory Patients: Freshly explanted tissue (large bowel, abdominal sidewall) from dogs sacrificed for other reasons. Interventions: Standard carbon dioxide gas was painted onto... | View | |||||||||
| Collagen membrane/fleece composite film reduces adhesions in the presence of bleeding in a rabbit uterine horn model | https://www.researchgate.net/publication/11903410_Collagen_membranefleece_composite_film_reduces_adhesions_in_the_presence_of_bleeding_in_a_rabbit_uterine_horn_model | Article | Aug 2001 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/scientific-contributions/Philippe-Gravagna-2109649046 | Philippe Gravagna | https://www.researchgate.net/profile/Yves-Bayon | Yves Bayon | Determination of efficacy in presence of bleeding of CDS, a collagen/membrane fleece composite, in a rabbit uterine horn simple abrasion model. Randomized, controlled, and blinded study involving standard abrasion of the uterine horns with induction of moderate mesouterine bleeding. Research laboratory. New Zealand White rabbits. No treatment (surg... | View | |||||
| Barrier agents for preventing adhesions after surgery for subfertility | https://www.researchgate.net/publication/12519943_Barrier_agents_for_preventing_adhesions_after_surgery_for_subfertility | Article | Feb 2000 | https://www.researchgate.net/profile/Cindy-Farquhar | Cindy Farquhar | https://www.researchgate.net/profile/Patrick-Vandekerckhove | Patrick Vandekerckhove | https://www.researchgate.net/scientific-contributions/A-Watson-60538525 | A Watson | [...] | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | Pelvic adhesions can be the result of inflamation, endometriosis or surgical trauma. Prevention of postoperative adhesions (either new or reoccurance) has been postulated by using barriers to prevent two surfaces being in contact. When pelvic surgery is being undertaken strategies to reduce pelvic adhesions occurring may be undertaken and these inc... | View | ||
| Animal Adhesion Models: Design, Variables, and Relevance | https://www.researchgate.net/publication/289637468_Animal_Adhesion_Models_Design_Variables_and_Relevance | Chapter | Full-text available | Jan 2000 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | Perhaps the most commonly asked question in adhesions research is “Which is the best animal model of adhesions?” The reply “What result are you looking for?” is not intended as a facetious retort, but rather as a suggestion to the questioner to consider carefully the objectives for a particular inquiry (Table 38.1 ). Thus, models in which a favorab... | View | ||||||||
| Effect of Different Barriers of Oxidized Regenerated Cellulose (ORC) on Cecal and Sidewall Adhesions in the Presence and Absence of Bleeding | https://www.researchgate.net/publication/12877102_Effect_of_Different_Barriers_of_Oxidized_Regenerated_Cellulose_ORC_on_Cecal_and_Sidewall_Adhesions_in_the_Presence_and_Absence_of_Bleeding | Article | May 1999 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/scientific-contributions/L-Gottlick-Iarkowski-30873084 | L Gottlick-Iarkowski | https://www.researchgate.net/scientific-contributions/L-Kamp-5631331 | L Kamp | Adhesion formation after bowel surgery is a significant problem. The objective of this study was to evaluate two adhesion barriers composed of oxidized regenerated cellulose (ORC) in a model of bowel surgery, with and without bleeding. Ceca of female New Zealand White rabbits were abraded with gauze and a 3 x 5 cm patch of peritoneum and underlying... | View | |||||
| Metaanalysis of safety and efficacy of an absorbable adhesion barrier (INTERCEED TC7) in laparotomy | https://www.researchgate.net/publication/12979956_Metaanalysis_of_safety_and_efficacy_of_an_absorbable_adhesion_barrier_INTERCEED_TC7_in_laparotomy | Article | Full-text available | Apr 1999 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/scientific-contributions/J-Richard-Trout-2028862456 | J R Trout | https://www.researchgate.net/scientific-contributions/R-R-Franklin-66882683 | R R Franklin | To evaluate the safety and efficacy of an oxidized, regenerated, cellulose adhesion barrier (Interceed TC7) in the reduction of pelvic adhesions. Clinical studies published or completed by December 31, 1994, evaluating the barrier used at laparotomy were considered for a metaanalysis. Of 10 studies (n = 560) identified, data from 7 (n = 389) met th... | View | ||||
| The rates of adhesion development and the effects of crystalloid solutions on adhesion development in pelvic surgery | https://www.researchgate.net/publication/13489573_The_rates_of_adhesion_development_and_the_effects_of_crystalloid_solutions_on_adhesion_development_in_pelvic_surgery | Article | Nov 1998 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/scientific-contributions/J-Richard-Trout-2028862456 | J.Richard Trout | https://www.researchgate.net/scientific-contributions/Michael-P-Diamond-2044428549 | Michael P Diamond | To document rates of adhesion development after abdomino-pelvic surgery, stratified by adhesion type, access method, and use of crystalloid solution instillates. Reports from a MEDLINE search (1/1/1966-12/18/1996) detailing rates of adhesion development and meeting the inclusion criteria were subjected to meta-analysis. Meta-analysis. Patients unde... | View | |||||
| Evaluation of De Novo Adhesion Prevention in a Rabbit Model by Precoating With a Tissue Protective Hyaluronate Solution | https://www.researchgate.net/publication/233671788_Evaluation_of_De_Novo_Adhesion_Prevention_in_a_Rabbit_Model_by_Precoating_With_a_Tissue_Protective_Hyaluronate_Solution | Article | Oct 1997 | https://www.researchgate.net/scientific-contributions/Burns-J-2003359419 | Burns J | https://www.researchgate.net/scientific-contributions/Colt-MJ-2003329296 | Colt M.J | https://www.researchgate.net/scientific-contributions/Skrabut-E-2003321574 | Skrabut E | View | ||||||
| A randomized clinical trial of oxidized regenerated cellulose adhesion barrier (Interceed, TC7)* alone or in combination with heparin | https://www.researchgate.net/publication/14220815_A_randomized_clinical_trial_of_oxidized_regenerated_cellulose_adhesion_barrier_Interceed_TC7_alone_or_in_combination_with_heparin | Article | Feb 1997 | https://www.researchgate.net/profile/Robert-Reid | Robert Reid | https://www.researchgate.net/scientific-contributions/Philip-M-Hahn-2162690115 | Philip M. Hahn | https://www.researchgate.net/scientific-contributions/JEH-Spence-2162908891 | John E.H. Spence | [...] | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | To compare the efficacy of heparin-saturated oxidized regenerated cellulose absorbable adhesion barrier, Interceed (TC7; Johnson and Johnson Medical Inc., New Brunswick, NJ) to oxidized regenerated cellulose alone for the prevention of postoperative adhesions. Clinical trial. By random assignment, one ovary was wrapped in oxidized regenerated cellu... | View | ||
| Hazards and Prevention of Postsurgical Pericardial Adhesions | https://www.researchgate.net/publication/301112719_Hazards_and_Prevention_of_Postsurgical_Pericardial_Adhesions | Chapter | Full-text available | Jan 1997 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | The formation of adhesions following cardiothoracic surgery places the mediastinal structures and grafts at risk of catastrophic injury [91] during a second sternotomy, making it a bloody, time-consuming, and hazardous procedure [20, 51]. Over 360 000 cardiac procedures are performed annually in the United States [37, 88] up to 10% of which are reo... | View | ||||||||
| Time-dependent effect of tolmetin sodium in a rabbit uterine adhesion model | https://www.researchgate.net/publication/15304868_Time-dependent_effect_of_tolmetin_sodium_in_a_rabbit_uterine_adhesion_model | Article | Nov 1994 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/scientific-contributions/W-J-Huang-50942133 | W J Huang | https://www.researchgate.net/scientific-contributions/Douglas-B-Johns-2163365361 | D B Johns | [...] | https://www.researchgate.net/profile/Gere-Dizerega | Gere Dizerega | Tolmetin is a nonsteroidal anti-inflammatory drug (NSAID) that reduces adhesion formation in several animal models after a single intraperitoneal (i.p.) dose delivered at the time of surgery. We set out to determine the period during which tolmetin could prevent adhesions. Adhesions were induced in New Zealand White rabbits (2-3 kg) by abrading the... | View | ||
| Improving the efficacy of INTERCEED Barrier in the presence of blood using thrombin, heparin or a blood insensitive barrier, modified INTERCEED (nTC7) | https://www.researchgate.net/publication/14881864_Improving_the_efficacy_of_INTERCEED_Barrier_in_the_presence_of_blood_using_thrombin_heparin_or_a_blood_insensitive_barrier_modified_INTERCEED_nTC7 | Article | Feb 1993 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/scientific-contributions/L-Kamp-5631331 | L F Kamp | https://www.researchgate.net/scientific-contributions/L-Saferstein-6192344 | L Saferstein | [...] | https://www.researchgate.net/scientific-contributions/Michael-P-Diamond-2044428549 | M P Diamond | View | |||
| Anatomical synergy between sodium hyaluronate (HA) and INTERCEED barrier in rabbits with two types of adhesions | https://www.researchgate.net/publication/281168340_Anatomical_synergy_between_sodium_hyaluronate_HA_and_INTERCEED_barrier_in_rabbits_with_two_types_of_adhesions | Article | Jan 1993 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/scientific-contributions/Douglas-B-Johns-2163365361 | D.B. Johns | View | ||||||||
| Fibrinolytic drugs prevent pericardial adhesions in the rabbit | https://www.researchgate.net/publication/21749332_Fibrinolytic_drugs_prevent_pericardial_adhesions_in_the_rabbit | Article | Nov 1992 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/scientific-contributions/L-Kamp-5631331 | L Kamp | https://www.researchgate.net/scientific-contributions/Cary-B-Linsky-39682520 | C.B. Linsky | [...] | https://www.researchgate.net/scientific-contributions/PM-Scholz-48691233 | P.M. Scholz | Epicardial adhesions are believed to form secondarily to impaired pericardial fibrinolytic activity. This activity was reconstituted in a rabbit pericardial adhesion model with single doses of the fibrinolytic agents tissue plasminogen activator (t-PA), t-PA analog (Fb-Fb-CF), and streptokinase (SK), resulting in reductions in the extent and tenaci... | View | ||
| Effect of thrombin-induced hemostasis on the efficacy of an absorbable adhesion barrier | https://www.researchgate.net/publication/21703114_Effect_of_thrombin-induced_hemostasis_on_the_efficacy_of_an_absorbable_adhesion_barrier | Article | Oct 1992 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/scientific-contributions/L-E-Gottlick-34647659 | L E Gottlick | https://www.researchgate.net/scientific-contributions/Michael-P-Diamond-2044428549 | M P Diamond | Serosal injury, bleeding and fibrin deposition are major factors in the development of surgical adhesions; meticulous hemostasis is desirable but not always achievable. The effects of thrombin on adhesion formation and the performance of Interceed Barrier were tested in separate series using a standard model and two levels of bleeding: an "oozing"... | View | |||||
| A biomechanical study of tendon adhesion reduction using a biodegradable barrier in a rabbit model | https://www.researchgate.net/publication/13149035_A_biomechanical_study_of_tendon_adhesion_reduction_using_a_biodegradable_barrier_in_a_rabbit_model | Article | Feb 1990 | https://www.researchgate.net/profile/Robert-Meislin | Robert J Meislin | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/profile/Harold-Alexander-3 | Harold Alexander | [...] | https://www.researchgate.net/scientific-contributions/Robert-S-Casar-2034975645 | Robert Casar | Adhesion formation associated with tendon surgery is a widespread problem in which a healing tendon becomes adherent via scar tissue to surrounding structures such as bone, muscle, skin, tendon sheath, or other tendons. A model is described in which adhesions were generated reproducibly between the plantaris and Achilles tendons of the rabbit using... | View | ||
| Communication: Comment on “A biomechanical study of tendon adhesion reduction using a biodegradable barrier in a rabbit model” | https://www.researchgate.net/publication/13149047_Communication_Comment_on_A_biomechanical_study_of_tendon_adhesion_reduction_using_a_biodegradable_barrier_in_a_rabbit_model | Article | Feb 1990 | https://www.researchgate.net/scientific-contributions/Paul-R-Manske-38841494 | Paul R. Manske | https://www.researchgate.net/scientific-contributions/Greg-T-Jones-44791373 | Greg T. Jones | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | View | ||||||
| Transforming growth factor-beta (TGF??) is chemotactic for human monocytes and induces their expression of angiogenic activity | https://www.researchgate.net/publication/20694554_Transforming_growth_factor-beta_TGF_is_chemotactic_for_human_monocytes_and_induces_their_expression_of_angiogenic_activity | Article | Full-text available | Jan 1989 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/profile/Peter-Polverini | Peter Polverini | https://www.researchgate.net/profile/David-Kamp | David W Kamp | TGF beta stimulates human blood monocyte migration, with peak migratory response occurring consistently at a concentration of 16-100 fg/ml. Checkerboard analysis revealed both chemotactic and chemokinetic components to this response. At higher concentrations (10-100 pg/ml), TGF beta stimulated expression of angiogenic activity by monocytes. While m... | View | ||||
| Moist environment for healing: Matching the dressing to the wound | https://www.researchgate.net/publication/284937416_Moist_environment_for_healing_Matching_the_dressing_to_the_wound | Article | Jan 1989 | https://www.researchgate.net/profile/Oscar-Alvarez-22 | Oscar Alvarez | https://www.researchgate.net/scientific-contributions/J-Rozint-2090191597 | J. Rozint | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | View | ||||||
| The Gemini conundrum — A problem of unpairable data: Statistical comparison of ratios each derived from two separately estimated parameters | https://www.researchgate.net/publication/19760672_The_Gemini_conundrum_-_A_problem_of_unpairable_data_Statistical_comparison_of_ratios_each_derived_from_two_separately_estimated_parameters | Article | Feb 1988 | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | https://www.researchgate.net/scientific-contributions/ACC-Gibbs-60093003 | A.C.C. Gibbs | In biological studies it may be necessary to compare ratios of two separately estimated parameters under test and control conditions. Since it is not always possible technically to obtain paired data for the two parameters, how does one take account of their variances? By extending previously described approximations in a modified t-test we present... | View | |||||||
| Macrophages, wound repair and angiogenesis | https://www.researchgate.net/publication/20700631_Macrophages_wound_repair_and_angiogenesis | Article | Feb 1988 | https://www.researchgate.net/profile/Samuel-Leibovich | Samuel Joseph Leibovich | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | View | ||||||||
| Macrophage-Induced Angiogenesis is Mediated by Tumor Necrosis Factor Alpha | https://www.researchgate.net/publication/20711967_Macrophage-Induced_Angiogenesis_is_Mediated_by_Tumor_Necrosis_Factor_Alpha | Article | Oct 1987 | https://www.researchgate.net/profile/Samuel-Leibovich | Samuel Joseph Leibovich | https://www.researchgate.net/profile/Peter-Polverini | Peter Polverini | https://www.researchgate.net/profile/H-Michael-Shepard | H Michael Shepard | [...] | https://www.researchgate.net/scientific-contributions/Nureddin-Nuseir-31645119 | Nureddin Nuseir | Macrophages are important in the induction of new blood vessel growth during wound repair, inflammation and tumour growth. We show here that tumour necrosis factor-alpha (TNF-alpha), a secretory product of activated macrophages that is believed to mediate tumour cytotoxicity, is a potent inducer of new blood vessel growth (angiogenesis). In vivo, T... | View | ||
| Angiogenic factor in ocular fluid | https://www.researchgate.net/publication/20289903_Angiogenic_factor_in_ocular_fluid | Article | Dec 1985 | https://www.researchgate.net/scientific-contributions/J-B-Weiss-63344715 | J B Weiss | https://www.researchgate.net/scientific-contributions/C-M-Taylor-61057651 | C M Taylor | https://www.researchgate.net/profile/David-Wiseman | David M Wiseman | [...] | https://www.researchgate.net/scientific-contributions/S-F-Elstow-2067134779 | Simon Elstow | View |
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