mysql configuration for a 16gb RAM machine

my.cfg

[mysqld]
safe-show-database old-passwords = 1
max_connections =2048
max_user_connections = 1024
key_buffer_size = 2048M
myisam_sort_buffer_size = 64M
join_buffer_size = 1M
read_buffer_size = 1M
sort_buffer_size = 2M
table_cache = 4000
thread_cache_size = 384
wait_timeout = 20
connect_timeout = 10
tmp_table_size = 2048M
max_heap_table_size = 512M
max_allowed_packet = 64M
net_buffer_length = 16384
max_connect_errors = 10
thread_concurrency = 16
concurrent_insert = 2
table_lock_wait_timeout = 30
read_rnd_buffer_size = 786432
bulk_insert_buffer_size = 8M
query_cache_limit = 7M
query_cache_size = 64M
query_cache_type = 1
query_prealloc_size = 262144
query_alloc_block_size = 65536
transaction_alloc_block_size = 8192
transaction_prealloc_size = 4096
max_write_lock_count = 16
long_query_time = 5
skip-name-resolve 
skip-locking 

[mysqld_safe] 
open_files_limit = 8192 
[mysqldump] 
quick max_allowed_packet = 16M 
[myisamchk] key_buffer = 384M 
sort_buffer = 384M 
read_buffer = 256M 
write_buffer = 256M