Disable all “interests” Twitter thinks you are interested in.

disable-twitter-interests.js

/**
 * Copy into dev tools console and hit enter.
 * It may take a while and the page will be blocked while the script is running.
 *
 * Source:
 * https://twitter.com/ChrisFerdinandi/status/1417947102731190277
 * https://twitter.com/ChrisFerdinandi/status/1417947104111104002
 */

let checked = document.querySelectorAll('input:checked')

for (let box of checked) {
   box.click()
}