asm-mode-extensions.el

;;;; Just copy paste this to the end of your ~/.emacs or ~/.emacs.d/init.el
;;;;   These are not really a "library" yet.
;;;;
;;;;   Both parts of code in this gist are released into the public domain,
;;;;       assuming any parts of it are even copyrightable.

(require 'asm-mode)
(defun my-asm-mode-function ()
  (set (make-local-variable 'compile-command)
       (concat "make -k -e ASM_FILENAME="
               (file-name-sans-extension
                (file-name-nondirectory buffer-file-name)))))

(add-hook 'asm-mode-hook 'my-asm-mode-function)

(define-key asm-mode-map (kbd "C-c C-c")
  (lambda () (interactive)
    (let* ((file buffer-file-name)
          (lst (concat (file-name-sans-extension (file-name-nondirectory file)) ".lst")))
      ;; save all buffers
      (save-some-buffers t)
      (compile compile-command))))

Makefile

all:
	nasm -f elf -g -l ${ASM_FILENAME}.lst ${ASM_FILENAME}.asm
	ld -melf_i386 ${ASM_FILENAME}.o -o ${ASM_FILENAME}

	cat ${ASM_FILENAME}.lst
	./${ASM_FILENAME}

clean:
	rm *.o