Repro of failing Katana app in Xamarin Studio

packages.config

<?xml version="1.0" encoding="utf-8"?>
<packages>
  <package id="Microsoft.AspNet.WebApi.Client" version="5.2.2" targetFramework="net45" />
  <package id="Microsoft.AspNet.WebApi.Core" version="5.2.2" targetFramework="net45" />
  <package id="Microsoft.AspNet.WebApi.Owin" version="5.2.2" targetFramework="net45" />
  <package id="Microsoft.Owin" version="3.0.0" targetFramework="net45" />
  <package id="Microsoft.Owin.Host.SystemWeb" version="3.0.0" targetFramework="net45" />
  <package id="Microsoft.Web.Infrastructure" version="1.0.0.0" targetFramework="net45" />
  <package id="Newtonsoft.Json" version="6.0.4" targetFramework="net45" />
  <package id="Owin" version="1.0" targetFramework="net45" />
</packages>

Runtime exception

System.MissingMethodException
Method not found: 'System.Web.HttpApplication.RegisterModule'.

Description: HTTP 500.Error processing request.
Details: Non-web exception. Exception origin (name of application or object): mscorlib.
Exception stack trace:
  at (wrapper managed-to-native) System.Reflection.MonoMethod:InternalInvoke (System.Reflection.MonoMethod,object,object[],System.Exception&)
  at System.Reflection.MonoMethod.Invoke (System.Object obj, BindingFlags invokeAttr, System.Reflection.Binder binder, System.Object[] parameters, System.Globalization.CultureInfo culture) [0x00054] in /Volumes/build-root-ramdisk/mono-3.8.0/mcs/class/corlib/System.Reflection/MonoMethod.cs:230 

Startup.cs

using System;
using System.Net;
using System.Net.Http;
using System.Reflection;
using System.Web.Http;
using System.Web.Http.Owin;
using Microsoft.Owin;
using Owin;

[assembly: OwinStartup (typeof(mvc.Startup))]

namespace mvc
{
	public class HomeController
	{
		public HttpResponseMessage Get (HttpRequestMessage request)
		{
			return request.CreateResponse (HttpStatusCode.OK, new { message = "Hello, world!" });
		}
	}

	public sealed class Startup
	{
		public void Configuration (IAppBuilder builder)
		{
			var config = new HttpConfiguration ();
			config.MapHttpAttributeRoutes ();
			builder.UseWebApi (config);
		}
	}
}

Web.config

<?xml version="1.0" encoding="utf-8"?>
<configuration>
  <system.web>
    <customErrors mode="RemoteOnly">
    </customErrors>
    <trace enabled="false" localOnly="true" pageOutput="false" requestLimit="10" traceMode="SortByTime" />
    <globalization requestEncoding="utf-8" responseEncoding="utf-8" />
  </system.web>
  <system.webServer>
    <handlers>
      <remove name="ExtensionlessUrlHandler-Integrated-4.0" />
      <remove name="OPTIONSVerbHandler" />
      <remove name="TRACEVerbHandler" />
      <add name="ExtensionlessUrlHandler-Integrated-4.0" path="*." verb="*" type="System.Web.Handlers.TransferRequestHandler" preCondition="integratedMode,runtimeVersionv4.0" />
    </handlers>
  </system.webServer>
</configuration>