pcdoyle

# Navigate to the profiles directory
cd ~/Library/Application\ Support/Microsoft\ Edge

# List out the profile directories. Note that the directory name is what is used in the launch command, *not* necessarily the friendly name of the profile you see in Microsoft Edge.app
find ./ -type f -name Preferences

# Let's say "Profile 1" is one of our directories
"/Applications/Microsoft Edge.app/Contents/MacOS/Microsoft Edge" --profile-directory="Profile 1"