Use HumanMade S3 plugin with Digital Ocean Spaces

HumanMade S3 Digital Ocean Instructions

These are the two steps you need to take to get S3 to work with Digital Ocean Spaces.
https://github.com/humanmade/S3-Uploads

s3-uploads.php

<?php
/**
* Plugin Name: S3 Uploads DigitalOcean Helper
* Plugin URI: https://www.pixeldevs.io
* Description: Helper file to get DigitalOcean Spaces working with S3 Uploads
* Version: 1.0
* Author: PixelDevs
* Author URI: https://www.pixeldevs.io
**/

// Filter S3 Uploads params.
add_filter( 's3_uploads_s3_client_params', function ( $params ) {
	if ( defined( 'S3_UPLOADS_ENDPOINT' ) ) {
		$params['endpoint'] = S3_UPLOADS_ENDPOINT;
		$params['use_path_style_endpoint'] = true;
		$params['debug'] = false; // Set to true if uploads are failing.
	}
	return $params;
}, 5, 1 );

// ADD THIS FILE TO mu-plugins folder in wp-content

wp-config.php

// ADD THIS TO wp-config.php

define( 'S3_UPLOADS_BUCKET', 'aaaccdn' );
define( 'S3_UPLOADS_REGION', 'sfo3' ); // the s3 bucket region (excluding the rest of the URL)

// You can set key and secret directly:
// THESE ARE YOUR SPACES ACCESS KEYS IN DIGITAL OCEAN | API > SPACES ACCESS KEYS
define( 'S3_UPLOADS_KEY', 'itsTheSmallerOne' );
define( 'S3_UPLOADS_SECRET', 'ItsTheLargerOne' );

// Or if using IAM instance profiles, you can use the instance's credentials:
define( 'S3_UPLOADS_USE_INSTANCE_PROFILE', true );

define('S3_UPLOADS_BUCKET_URL', 'https://aaaccdn.sfo3.digitaloceanspaces.com');
define('S3_UPLOADS_ENDPOINT', 'https://sfo3.digitaloceanspaces.com');