gistfile1.txt

julia> o_ode = fit(iv_ode,data,param,Pumas.FOCEI())
ERROR: MethodError: no method matching Float64(::ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##176#181")){Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},1},Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},2})
Closest candidates are:
  Float64(::Real, ::RoundingMode) where T<:AbstractFloat at rounding.jl:194
  Float64(::T<:Number) where T<:Number at boot.jl:718
  Float64(::Int8) at float.jl:60
  ...
Stacktrace:
 [1] convert(::Type{Float64}, ::ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##176#181")){Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},1},Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},2}) at ./number.jl:7
 [2] convert(::Type{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6}}, ::ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##176#181")){Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},1},Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},2}) at /home/pkofod/.julia/packages/ForwardDiff/N0wMF/src/dual.jl:357
 [3] setproperty!(::OrdinaryDiffEq.ODEIntegrator{CompositeAlgorithm{Tuple{Tsit5,Rosenbrock23{0,true,DefaultLinSolve,DataType}},AutoSwitch{Tsit5,Rosenbrock23{0,true,DefaultLinSolve,DataType},Rational{Int64},Float64}},false,LabelledArrays.SLArray{Tuple{1},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##176#181")){Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},1},Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},2},1,1,(:Central,)},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},NamedTuple{(:CL, :V, :duration, :tvcl, :tvv, :dur, :Ω, :σ_prop, :η, :Wt),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##176#181")){Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, 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Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},1}},LabelledArrays.SLArray{Tuple{1},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##176#181")){Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},1},Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},2},1,1,(:Central,)},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##176#181")){Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},1},Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},2},Nothing}, ::Symbol, ::ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##176#181")){Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},1},Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},2}) at ./Base.jl:21
 [4] perform_step!(::OrdinaryDiffEq.ODEIntegrator{CompositeAlgorithm{Tuple{Tsit5,Rosenbrock23{0,true,DefaultLinSolve,DataType}},AutoSwitch{Tsit5,Rosenbrock23{0,true,DefaultLinSolve,DataType},Rational{Int64},Float64}},false,LabelledArrays.SLArray{Tuple{1},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##176#181")){Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},1},Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, 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Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},1},Array{Float64,1},Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},1}},LabelledArrays.SLArray{Tuple{1},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##176#181")){Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},1},Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},2},1,1,(:Central,)},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##176#181")){Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},1},Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},2},Nothing}, ::OrdinaryDiffEq.Tsit5ConstantCache{Float64,Float64}, ::Bool) at /home/pkofod/.julia/packages/OrdinaryDiffEq/aTiKO/src/perform_step/low_order_rk_perform_step.jl:599
 [5] solve!(::OrdinaryDiffEq.ODEIntegrator{CompositeAlgorithm{Tuple{Tsit5,Rosenbrock23{0,true,DefaultLinSolve,DataType}},AutoSwitch{Tsit5,Rosenbrock23{0,true,DefaultLinSolve,DataType},Rational{Int64},Float64}},false,LabelledArrays.SLArray{Tuple{1},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##176#181")){Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},1},Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, 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:σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},1}},LabelledArrays.SLArray{Tuple{1},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##176#181")){Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},1},Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},2},1,1,(:Central,)},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##176#181")){Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},1},Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},2},Nothing}) at /home/pkofod/.julia/packages/OrdinaryDiffEq/aTiKO/src/perform_step/composite_perform_step.jl:43
 [6] #__solve#348(::Base.Iterators.Pairs{Symbol,Any,NTuple{5,Symbol},NamedTuple{(:saveat, :save_first, :tstops, :reltol, :abstol),Tuple{Array{Float64,1},Bool,Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},1},Float64,Float64}}}, ::typeof(DiffEqBase.__solve), ::ODEProblem{LabelledArrays.SLArray{Tuple{1},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##176#181")){Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},1},Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},2},1,1,(:Central,)},Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6}},false,NamedTuple{(:CL, :V, :duration, :tvcl, :tvv, :dur, :Ω, :σ_prop, :η, :Wt),Tuple{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##176#181")){Array{ForwardDiff.Dual{ForwardDiff.Tag{getfield(Pumas, Symbol("##175#180")){Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{RealDomain{Float64},RealDomain{Float64},RealDomain{Float64},PDiagDomain{PDMats.PDiagMat{Float64,Array{Float64,1}}},RealDomain{Float64}}}},getfield(Main, Symbol("##53#58")),getfield(Main, Symbol("##54#59")),getfield(Main, Symbol("##55#60")),ODEProblem{Nothing,Tuple{Nothing,Nothing},false,Nothing,ODEFunction{false,getfield(ModelingToolkit, Symbol("#out_f_safe#66")){getfield(ModelingToolkit, Symbol("###396"))},UniformScaling{Bool},Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing,Nothing},Nothing,DiffEqBase.StandardODEProblem},getfield(Main, Symbol("##56#61")),getfield(Main, Symbol("##57#62"))},Subject{NamedTuple{(:dv,),Tuple{Array{Union{Missing, Float64},1}}},NamedTuple{(:Wt, :route),Tuple{Int64,String}},Array{Pumas.Event{Float64,Float64,Float64,Float64,Float64,Float64,Int64},1},Array{Float64,1}},NamedTuple{(:η,),Tuple{Array{Float64,1}}},Pumas.FOCEI,TransformVariables.TransformTuple{NamedTuple{(:tvcl, :tvv, :dur, :Ω, :σ_prop),Tuple{TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},TransformVariables.ShiftedExp{true,Float64},Pumas.PDiagTransform,TransformVariables.ShiftedExp{true,Float64}}}},Tuple{}},Float64},Float64,6},1},Float64,Base.Iterators.Pairs{Union{},Union{},Tuple{},NamedTuple{(),Tuple{}}},PumasModel{ParamSet{NamedTuple{(:tvcl, :tvv, :dur, :Ω, 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