Python email validation

is_email_valid.py

import re

def is_email_valid(email):

    email_regex = ('^[-a-z0-9~!$%^&*_=+}{\'?]+(\.[-a-z0-9~!$%^&*_=+}{\'?]+)*@('
                    '[a-z0-9_][-a-z0-9_]*(\.[-a-z0-9_]+)*\.(aero|arpa|biz|com|c'
                    'oop|edu|gov|info|int|mil|museum|name|net|org|pro|travel|mo'
                    'bi|[a-z][a-z])|([0-9]{1,3}\.[0-9]{1,3}\.[0-9]{1,3}\.[0-9]{'
                    '1,3}))(:[0-9]{1,5})?$')

    return re.match(email_regex, email, re.IGNORECASE) is not None

r = is_email_valid('Marco@gmail.com')

print(r)