Error running TileMill 2 on OSX

error.log

WeeSofty:tm2 ryan$ brew upgrade mapnik
Error: mapnik-2.2.0 already installed
WeeSofty:tm2 ryan$ brew upgrade protobuf
Error: protobuf-2.5.0 already installed
WeeSofty:tm2 ryan$ brew upgrade node
Error: node-0.10.15 already installed
WeeSofty:tm2 ryan$ node index.js 

module.js:356
  Module._extensions[extension](this, filename);
                               ^
Error: dlopen(/Users/ryan/lib/tm2/node_modules/mapnik/lib/_mapnik.node, 1): Library not loaded: /usr/local/opt/icu4c/lib/libicuuc.50.1.dylib
  Referenced from: /usr/local/lib/libboost_regex-mt.dylib
  Reason: image not found
    at Module.load (module.js:356:32)
    at Function.Module._load (module.js:312:12)
    at Module.require (module.js:364:17)
    at require (module.js:380:17)
    at Object.<anonymous> (/Users/ryan/lib/tm2/node_modules/mapnik/lib/mapnik.js:15:14)
    at Module._compile (module.js:456:26)
    at Object.Module._extensions..js (module.js:474:10)
    at Module.load (module.js:356:32)
    at Function.Module._load (module.js:312:12)
    at Module.require (module.js:364:17)