isoquercetin.md

• Potential Inhibitor of COVID-19 Main Protease (Mpro) From Several Medicinal Plant Compounds by Molecular Docking Study

  kaempferol, quercetin, luteolin-7-glucoside, demethoxycurcumin, naringenin, apigenin-7-glucoside, oleuropein, curcumin, catechin, and epicatechin-gallate appeared to have the best potential to act as COVID-19 Mpro inhibitors

• Antiviral effect of flavonoids on human viruses

  Quercetin caused a concentration‐dependent reduction in the infectivity of each virus. In addition, it reduced intracellular replication of each virus when monolayers were infected and subsequently cultured in medium containing quercetin.

• Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry

  Here we found that quercetin inhibited influenza infection with a wide spectrum of strains

• Quercetin: A Promising Treatment for the Common Cold

  Recent research points to a flavanol anti-oxidant, quercetin, as having therapeutic properties. Quercetinhas been shown to reduce viral internalization and replication in vitro, and viral load, lung inflammation and airwayshyper-responsiveness in vivo.

• Prophylactic Efficacy of Quercetin 3-β-O-d-Glucoside against Ebola Virus Infection

  We have found that a flavonoid derivative called quercetin 3-β-O-d-glucoside (Q3G) has the ability to protect mice from Ebola even when given as little as 30 min prior to infection. Furthermore, we have demonstrated that this compound targets the early steps of viral entry. Most promisingly, antiviral activity against two distinct species of Ebola virus was seen.

• As coronavirus spread speeds up, Montreal researchers will trial an anti-viral treatment for COVID-19 in China

  "We believe that this particular drug interrupts the entry of viruses … so that you can attack several viruses at the same time,"

• Small Molecules Blocking the Entry of Severe Acute Respiratory Syndrome Coronavirus into Host Cells

  we sought to determine whether quercetin could also antagonize SARS-CoV entry. Assays with the HIV-luc/SARS pseudotyped virus showed that quercetin also had antiviral activity against HIV-luc/SARS

• Antiviral activity of quercetin-3-β-O-D-glucoside against Zika virus infection

  Our results clearly demonstrated that Q3G exerts antiviral activity against ZIKV in both tissue culture and knockout mice, and that post-exposure in vivo treatment with Q3G could have a beneficial effect.

• Flavonoids as Antiviral Agents for Enterovirus A71

  quercetin and quercitrin were first demonstrated by Cutting et al. (1949) to prophylactically inhibit rabies virus in mice ... quercetin was found to exhibit its antiviral activity against vesicular stomatitis virus (VSV) by activation of macrophages

• A Phase I Dose Escalation Study Demonstrates Quercetin Safety and Explores Potential for Bioflavonoid Antivirals in Patients with Chronic Hepatitis C

  Quercetin displayed safety in all trial participants. Additionally, 8 patients showed a “clinically meaningful” 0.41-log viral load decrease.

• Safety Aspects of the Use of Quercetin as a Dietary Supplement

  Among the numerous published human intervention studies, adverse effects following supplemental quercetin intake have been rarely reported and any such effects were mild in nature.

• Quercetin and derivatives: useful tools in inflammation and pain management

  In this review, we have highlighted its efficacy in various models of inflammation

• Computational screen and experimental validation of anti-influenza effects of quercetin and chlorogenic acid from traditional Chinese medicine

  The experiments in vitro, in vivo have validated the anti-influenza effect of quercetin and chlorogenic acid, which indicating comparable protection effects as zanamivir.

• Quercetin inhibits rhinovirus replication in vitro and in vivo

  In mice infected with RV, quercetin treatment decreased viral replication as well as expression of chemokines and cytokines

• Epimedium koreanum Nakai displays broad spectrum of antiviral activity in vitro and in vivo by inducing cellular antiviral state

  Among various components present in the extract, quercetin was confirmed to have striking antiviral properties. The oral administration of Epimedium koreanum Nakai exhibited preventive effects on BALB/c mice against lethal doses of highly pathogenic influenza A subtypes (H1N1, H5N2, H7N3 and H9N2).

• Discovery of Potent Inhibitors for the Inhibition of Dengue Envelope Protein: An In Silico Approach

  Hence, from the results, it is evident that the compounds DB00179, Quercetin, Silymarin, Dapagliflozlin and Fisetin could be novel and potent candidates to inhibit the DENV envelope protein.

• The Flavonoid Isoquercitrin Precludes Initiation of Zika Virus Infection in Human Cells

  Our data also suggest that the glycosylated moiety of isoquercitrin might play a role in the antiviral effect of the flavonoid against ZIKV. Our results highlight the importance of isoquercitrin as a promising natural antiviral compound to prevent ZIKV infection.

• Immunomodulatory properties of quercetin-3-O-α-L-rhamnopyranoside from Rapanea melanophloeos against influenza a virus.

  This is the first report of quercetin-3-O-α-L-rhamnopyranoside from RM and its immunomodulatory properties against influenza A virus.

• Quercetin-induced apoptosis prevents EBV infection

  These results indicate that quercetin could be a promising candidate for antiviral and antitumor agents against EBV (Epstein-Barr virus) and human gastric carcinoma.

• Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma

  Quercetin and isoquercitrin are effective eosinophilic inflammation suppressors, suggesting a potential for treating allergies.

• Quercetin and Its Anti-Allergic Immune Response

  Quercetin is known for its antioxidant activity in radical scavenging and anti-allergic properties characterized by stimulation of immune system, antiviral activity, inhibition of histamine release, decrease in pro-inflammatory cytokines, leukotrienes creation, and suppresses interleukin IL-4 production.

• Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans

  Que is a promising candidate as an effective mast cell inhibitor for allergic and inflammatory diseases, especially in formulations that permit more sufficient oral absorption.

• Quercetin exerts cardiovascular protective effects in LPS-induced dysfunction in vivo by regulating inflammatory cytokine expression, NF-κB phosphorylation, and caspase activity

  Our observation from the present research work reveals that Quercetin suppressed the production of proinflammatory cytokines

• Characteristics of flavonoids as potent MERS-CoV 3C-like protease inhibitors

  Herbacetin, isobavachalcone, quercetin 3-β-d-glucoside and helichrysetin were found to block the enzymatic activity of MERS-CoV 3CLpro

• Hsp70 protein positively regulates rabies virus infection

  We have shown that rabies virus infection induced the cellular expression of Hsp70 ... The downregulation of Hsp70, using specific chaperone inhibitors, such as quercetin or RNA interference, resulted in a significant decrease of the amount of viral mRNAs, viral proteins, and virus particles.

• Zinc Ionophore Activity of Quercetin and Epigallocatechin-gallate:From Hepa 1‑6 Cells to a Liposome Model
• Rapid, Antibody-free, Flavonoid-basedDiagnosticTestfor 2019 Novel Coronavirus SARS-CoV-2–Proof of Concept

  Luteolin and Quercetin have demonstrated high affinity and inhibitory effect on the S2 subunit of the SARS-CoV S protein