Open a Chrome window with a temporary profile and several security checks disabled.

chrome-unsafe.plugin.zsh

#
# Author: Riyad Preukschas <riyad@informatik.uni-bremen.de>
# License: Mozilla Public License 2.0
#
# Loads an unsafe (i.e. with several security features disabled) instance of
# Chrome with a temporary profile (i.e. all data is lost once Chrome is closed)

chrome-unsafe() {
    # for Homebrew Cask (see http://caskroom.io/) compatibility
    local -a CHROME_PATHS
    CHROME_PATHS=( \
      "/opt/homebrew-cask/Caskroom/google-chrome-dev/latest/Google Chrome.app/Contents/MacOS/Google Chrome" \
      "/opt/homebrew-cask/Caskroom/google-chrome/latest/Google Chrome.app/Contents/MacOS/Google Chrome" \
      "/Applications/Google Chrome.app/Contents/MacOS/Google Chrome" \
      "chrome" \
      "chromium" \
    )
    local CHROME="${CHROME_PATHS[1]}"
    while [[ -n CHROME_PATHS ]] && ! type ${CHROME} > /dev/null; do
      shift CHROME_PATHS
      CHROME="${CHROME_PATHS[1]}"
    done
    local DATA_DIR="$(mktemp -d -t 'chrome-unsafe_data_dir.XXXXXXXXXX')"
    # for a listing of command line switches see:
    # https://peter.sh/experiments/chromium-command-line-switches/
    "${CHROME}" \
        --disable-bundled-ppapi-flash \
        --disable-popup-blocking \
        --disable-sync \
        --disable-web-security \
        --ignore-certificate-errors \
        --no-default-browser-check \
        --no-first-run \
        --non-secure \
        --user-data-dir="${DATA_DIR}" \
        $@ >/dev/null 2>&1 &!
    # for now the window will not be brought to the front
}

If you use oh my ZSH you can save this file in ~/.oh-my-zsh/custom/plugins/chrome-unsafe/chrome-unsafe.plugin.zsh and add chrome-unsafe to your list of used plugins in ~/.zshrc