create_virtual_ports.sh

#!/bin/bash

socat -d -d pty,raw,echo=0,link=/tmp/ttysA1 pty,raw,echo=0,link=/tmp/ttysB1 &
socat -d -d pty,raw,echo=0,link=/tmp/ttysA2 pty,raw,echo=0,link=/tmp/ttysB2 &
socat -d -d pty,raw,echo=0,link=/tmp/ttysA3 pty,raw,echo=0,link=/tmp/ttysB3 &
socat -d -d pty,raw,echo=0,link=/tmp/ttysA4 pty,raw,echo=0,link=/tmp/ttysB4 &
socat -d -d pty,raw,echo=0,link=/tmp/ttysA5 pty,raw,echo=0,link=/tmp/ttysB5 &

multiple_ports.js

var SerialPort = require('serialport').SerialPort;

function datalistener() {
  console.log('data received:');
  console.log(arguments);
}

// Use create_virtual_ports.sh to create these serial ports first
var sp2 = new SerialPort("/tmp/ttysA1", {});
sp2.on("data", datalistener);

var sp3 = new SerialPort("/tmp/ttysA2", {});
sp3.on("data", datalistener);

var sp4 = new SerialPort("/tmp/ttysA3", {});
sp4.on("data", datalistener);

var sp5 = new SerialPort("/tmp/ttysA4", {});
sp5.on("data", datalistener);

var sp5 = new SerialPort("/tmp/ttysA5", {});
sp5.on("data", datalistener);

multiple_ports.py

import serial
import select

paths = [ '/tmp/ttysA1', '/tmp/ttysA2', '/tmp/ttysA3', '/tmp/ttysA4', '/tmp/ttysA5' ]

fp_map = {}
fps = []

for path in paths:
    port = serial.Serial(path)
    fp = port.fileno()
    fp_map[fp] = port
    fps.append(fp)

while True:
    input_ready, _, _ = select.select(fps, [], []) 
    for fp in input_ready:
        port = fp_map[fp]
        data = port.read()
        print 'Received from %s: %s' % (port.port, data)