Best Zend OpCache Settings / Tuning / Configurations

opcache.ini

[opcache]
; Determines if Zend OPCache is enabled
opcache.enable=1

; Determines if Zend OPCache is enabled for the CLI version of PHP
;opcache.enable_cli=1

; The OPcache shared memory storage size.
opcache.memory_consumption=512

; The amount of memory for interned strings in Mbytes.
opcache.interned_strings_buffer=64

; The maximum number of keys (scripts) in the OPcache hash table.
; Only numbers between 200 and 1000000 are allowed.
;If you have multiple PHP sites on the server then consider the value 130986
; for magento 2, keep 65406
opcache.max_accelerated_files=50000

; The maximum percentage of "wasted" memory until a restart is scheduled.
opcache.max_wasted_percentage=15

; When this directive is enabled, the OPcache appends the current working
; directory to the script key, thus eliminating possible collisions between
; files with the same name (basename). Disabling the directive improves
; performance, but may break existing applications.
;opcache.use_cwd=1

; When disabled, you must reset the OPcache manually or restart the
; webserver for changes to the filesystem to take effect.
; For Development / testing, keep 1
; For performance / production, keep 0
opcache.validate_timestamps=0

;opcache.revalidate_freq How often in seconds should the code
;cache expire and check if your code has changed. 0 means it
;checks your PHP code every single request IF YOU HAVE 
;opcache.validate_timestamps ENABLED. opcache.validate_timestamps
;should not be enabled by default, as long as it's disabled then any value for opcache.
;revalidate_freq will basically be ignored. You should really only ever enable
;this during development, you don't really want to enable this setting for a production application.
opcache.revalidate_freq=0

; Enables or disables file search in include_path optimization
;opcache.revalidate_path=0

; If disabled, all PHPDoc comments are dropped from the code to reduce the
; size of the optimized code.
opcache.save_comments=1

; If enabled, a fast shutdown sequence is used for the accelerated code
; Depending on the used Memory Manager this may cause some incompatibilities.
opcache.fast_shutdown=1

; Allow file existence override (file_exists, etc.) performance feature.
;opcache.enable_file_override=0

; A bitmask, where each bit enables or disables the appropriate OPcache
; passes
;opcache.optimization_level=0xffffffff

;opcache.inherited_hack=1
;opcache.dups_fix=0

; The location of the OPcache blacklist file (wildcards allowed).
; Each OPcache blacklist file is a text file that holds the names of files
; that should not be accelerated. The file format is to add each filename
; to a new line. The filename may be a full path or just a file prefix
; (i.e., /var/www/x  blacklists all the files and directories in /var/www
; that start with 'x'). Line starting with a ; are ignored (comments).
;opcache.blacklist_filename=

; Allows exclusion of large files from being cached. By default all files
; are cached.
;opcache.max_file_size=0

; Check the cache checksum each N requests.
; The default value of "0" means that the checks are disabled.
;opcache.consistency_checks=0

; How long to wait (in seconds) for a scheduled restart to begin if the cache
; is not being accessed.
;opcache.force_restart_timeout=180

; OPcache error_log file name. Empty string assumes "stderr".
;opcache.error_log=

; All OPcache errors go to the Web server log.
; By default, only fatal errors (level 0) or errors (level 1) are logged.
; You can also enable warnings (level 2), info messages (level 3) or
; debug messages (level 4).
;opcache.log_verbosity_level=1

; Preferred Shared Memory back-end. Leave empty and let the system decide.
;opcache.preferred_memory_model=

; Protect the shared memory from unexpected writing during script execution.
; Useful for internal debugging only.
;opcache.protect_memory=0

; Allows calling OPcache API functions only from PHP scripts which path is
; started from specified string. The default "" means no restriction
;opcache.restrict_api=

; Mapping base of shared memory segments (for Windows only). All the PHP
; processes have to map shared memory into the same address space. This
; directive allows to manually fix the "Unable to reattach to base address"
; errors.
opcache.mmap_base=0x20000000

; Enables and sets the second level cache directory.
; It should improve performance when SHM memory is full, at server restart or
; SHM reset. The default "" disables file based caching.
;opcache.file_cache=

; Enables or disables opcode caching in shared memory.
;opcache.file_cache_only=0

; Enables or disables checksum validation when script loaded from file cache.
;opcache.file_cache_consistency_checks=1

; Implies opcache.file_cache_only=1 for a certain process that failed to
; reattach to the shared memory (for Windows only). Explicitly enabled file
; cache is required.
opcache.file_cache_fallback=1

; Enables or disables copying of PHP code (text segment) into HUGE PAGES.
; This should improve performance, but requires appropriate OS configuration.
;opcache.huge_code_pages=1

; Validate cached file permissions.
; opcache.validate_permission=0

; Prevent name collisions in chroot'ed environment.
; opcache.validate_root=0

Thanks for sharing!

Thanks guys!
Here in a script:

#!/bin/sh
#source: https://gist.github.com/rohankhudedev/1a9c0a3c7fb375f295f9fc11aeb116f
#TODO: change the php_file_path and run
php_file_path=/etc/php/8.2/cli/php.ini
n2 sed -i '/opcache.enable/c opcache.enable=1' $php_file_path
n2 sed -i '/opcache.memory_consumption/c opcache.memory_consumption=512' $php_file_path
n2 sed -i '/opcache.interned_strings_buffer/c opcache.interned_strings_buffer=64' $php_file_path
n2 sed -i '/opcache.max_accelerated_files/c opcache.max_accelerated_files=5000' $php_file_path
n2 sed -i '/opcache.max_wasted_percentage/c opcache.max_wasted_percentage=15' $php_file_path
n2 sed -i '/opcache.validate_timestamps/c opcache.validate_timestamps=0' $php_file_path
n2 sed -i '/opcache.revalidate_freq/c opcache.revalidate_freq=0' $php_file_path
n2 sed -i '/opcache.save_comments/c opcache.save_comments=1' $php_file_path
n2 sed -i '/opcache.fast_shutdown/c opcache.fast_shutdown=1' $php_file_path
n2 sed -i '/opcache.mmap_base/c opcache.mmap_base=0x20000000' $php_file_path
n2 sed -i '/opcache.file_cache_fallback/c opcache.file_cache_fallback=1' $php_file_path
systemctl restart apache2

Great config, thanks. One warning is that on a Wordpresss site or other systems with auto-updates, the opcache.validate_timestamps needs to be 1 (default) or else a third party plugin update with significant code edits will need a manual PHP service restart, showing 500 error until restarted. Set opcache.validate_timestamps=1 and a opcache.revalidate_freq=60 for a max of one minute downtime but picking up some opcache gains